Hearts from DCD donors display acceptable biventricular function after heart transplantation in pigs

American Journal of Transplantation

Volumn 11, Issue 8, 2011, Pages 1621-1632

  Ali, A A ^a   White, P ^a   Xiang, B ^b   Lin, H Y ^b   Tsui, S S ^a   Ashley, E ^c   Lee, T W ^d   Klein, J R H ^d   Kumar, K ^d   Arora, R C ^b,d   Large, S R ^a   Tian, G ^b,d   Freed, D H ^b,d  

^a PAPWORTH HOSPITAL   (United Kingdom)

^b NATIONAL RESEARCH COUNCIL CANADA   (Canada)

^c STANFORD UNIVERSITY   (United States)

^d UNIVERSITY OF MANITOBA   (Canada)

Author keywords

Donation after circulatory death; heart transplantation

Indexed keywords

CREATINE PHOSPHATE; PHOSPHATE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIVENTRICULAR ASSIST DEVICE; BRAIN DEATH; CARDIOPULMONARY BYPASS; CONTROLLED STUDY; DONATION AFTER CIRCULATORY DEATH; FEMALE; HEART ARREST; HEART FUNCTION; HEART MUSCLE ISCHEMIA; HEART TRANSPLANTATION; HYPOXIA; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; RESUSCITATION; SPECTROSCOPY; SWINE;

ANIMALS; BRAIN DEATH; CARDIOVASCULAR DISEASES; FEMALE; HEART TRANSPLANTATION; HEART VENTRICLES; MAGNETIC RESONANCE IMAGING; SWINE;

EID: 79961031309     PISSN: 16006135     EISSN: 16006143     Source Type: Journal    
DOI: 10.1111/j.1600-6143.2011.03622.x     Document Type: Article

References (23)

1. Gok MA, Buckley PE, Shenton BK, et al,. Long-term renal function in kidneys from non-heart-beating donors: A single-center experience. Transplantation 2002; 74: 664-669.
2. Fujita S, Mizuno S, Fujikawa T, et al,. Liver transplantation from donation after cardiac death: A single center experience. Transplantation 2007; 84 46-49. (Pubitemid 47094640)
3. De Vleeschauwer S, Van Raemdonck D, Vanaudenaerde B, et al,. Early outcome after lung transplantation from non-heart-beating donors is comparable to heart-beating donors. J Heart Lung Transplant 2009; 28: 380-387.
4. Barnard CN,. The operation. A human cardiac transplant: An interim report of a successful operation performed at Groote Schuur Hospital, Cape Town. S Afr Med J 1967; 41: 1271-1274.
5. Barnard CN,. Human cardiac transplantation. An evaluation of the first two operations performed at the Groote Schuur Hospital, Cape Town. Am J Cardiol 1968; 22: 584-596.
6. Martin J, Lutter G, Ihling C, et al,. Myocardial viability twenty-four hours after orthotopic heart transplantation from non-heart-beating donors. J Thorac Cardiovasc Surg 2003; 125: 1217-1228. (Pubitemid 36759219)
7. Martin J, Sarai K, Yoshitake M, et al,. Orthotopic transplantation of pig hearts harvested after 30 min of normothermic ischemia: controlled reperfusion with blood cardioplegia containing the Na+-H+-exchange inhibitor HOE 642. Eur J Cardiothorac Surg 1998; 14: 607-614. (Pubitemid 29005418)
8. Gundry SR, Fukushima N, Eke CC, Hill AC, Zuppan C, Bailey LL,. Successful survival of primates receiving transplantation with "dead," nonbeating donor hearts. J Thorac Cardiovasc Surg 1995; 109: 1097-1010; discussion 1101-1092.
9. Osaki S, Ishino K, Kotani Y, et al,. Circulatory load during hypoxia impairs post-transplant myocardial functional recovery in donation after cardiac death. J Heart Lung Transplant 2009; 28: 266-272.
10. Kotani Y, Ishino K, Osaki S, et al,. Efficacy of MCI-186, a free-radical scavenger and antioxidant, for resuscitation of nonbeating donor hearts. J Thorac Cardiovasc Surg 2007; 133: 1626-1632. (Pubitemid 46802622)
11. Osaki S, Ishino K, Kotani Y, et al,. Resuscitation of non-beating donor hearts using continuous myocardial perfusion: The importance of controlled initial reperfusion. Ann Thorac Surg 2006; 81: 2167-2171. (Pubitemid 44218619)
12. Hirota M, Ishino K, Fukumasu I, et al,. Prediction of functional recovery of 60-minute warm ischemic hearts from asphyxiated canine non-heart-beating donors. J Heart Lung Transplant 2006; 25: 339-344. (Pubitemid 43290666)
13. Magliocca JF, Magee JC, Rowe SA, et al,. Extracorporeal support for organ donation after cardiac death effectively expands the donor pool. J Trauma 2005; 58: 1095-1101; discussion 1101-1092.
14. Ali A, White P, Dhital K, Ryan M, Tsui S, Large S,. Cardiac recovery in a human non-heart-beating donor after extracorporeal perfusion: source for human heart donation? J Heart Lung Transplant 2009; 28: 290-293.
15. Novitzky D, Horak A, Cooper DK, Rose AG,. Electrocardiographic and histopathologic changes developing during experimental brain death in the baboon. Transplant Proc 1989; 21 (1 Pt 3): 2567-2569. (Pubitemid 19124462)
16. Shivalkar B, van LJ, Wieland W, et al,. Variable effects of explosive or gradual increase of intracranial pressure on myocardial structure and function. Circulation 1993; 87: 230-239. (Pubitemid 23019354)
17. Szabo G, Hackert T, Sebening C, Vahl CF, Hagl S,. Modulation of coronary perfusion pressure can reverse cardiac dysfunction after brain death. Ann Thorac Surg 1999; 67: 18-25.
18. Baroldi G, Di PG, Silver MD, Pinelli G, Lusa AM, Fineschi V,. Type and extent of myocardial injury related to brain damage and its significance in heart transplantation: A morphometric study. J Heart Lung Transplant 1997; 16: 994-1000. (Pubitemid 27465454)
19. Todd GL, Baroldi G, Pieper GM, Clayton FC, Eliot RS,. Experimental catecholamine-induced myocardial necrosis. I. Morphology, quantification and regional distribution of acute contraction band lesions. J Mol Cell Cardiol 1985; 17: 317-338. (Pubitemid 15030722)
20. Stoica SC, Satchithananda DK, White PA, et al,. Brain death leads to abnormal contractile properties of the human donor right ventricle. J Thorac Cardiovasc Surg 2006; 132: 116-123.
21. Boucek MM, Mashburn C, Dunn SM, et al,. Pediatric heart transplantation after declaration of cardiocirculatory death. N Engl J Med 2008; 359: 709-714.
22. Fedalen PA, Piacentino V, 3rd, Jeevanandam V, et al,. Pharmacologic pre-conditioning and controlled reperfusion prevent ischemia-reperfusion injury after 30 minutes of hypoxia/ischemia in porcine hearts. J Heart Lung Transpl 2003; 22: 1234-1244. (Pubitemid 37324698)
23. Reddy S, Greenwood J, Maniakin N, et al,. Non-heart-beating donor porcine livers: The adverse effect of cooling. Liver Transpl 2005; 11: 35-38. (Pubitemid 40124440)