Expression of EpCAM and wnt/ β-catenin in human colon cancer

Genetics and Molecular Research

Volumn 14, Issue 2, 2015, Pages 4485-4494

  Zhou, F Q ^a   Qi, Y M ^a   Xu, H ^a   Wang, Q Y ^a   Gao, X S ^a   Guo, H G ^a  

^a Department of Gastroenterology Shandong Province Binzhou People s Hospital   (China)

Author keywords

Colon cancer; EpCAM; Wnt catenin

Indexed keywords

BETA CATENIN; EPITHELIAL CELL ADHESION MOLECULE; SMALL INTERFERING RNA; WNT PROTEIN; CELL ADHESION MOLECULE; CTNNB1 PROTEIN, HUMAN; EPCAM PROTEIN, HUMAN; TUMOR ANTIGEN;

ARTICLE; CANCER PROGNOSIS; CELL PROLIFERATION; CLINICAL ARTICLE; COLON CANCER; COLON CARCINOGENESIS; CONTROLLED STUDY; DISEASE ACTIVITY; DISEASE ASSOCIATION; FOLLOW UP; GENE IDENTIFICATION; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; MOLECULAR DYNAMICS; MOLECULAR PATHOLOGY; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; TISSUE LEVEL; COLONIC NEOPLASMS; GENE SILENCING; METABOLISM; PROGNOSIS; WNT SIGNALING PATHWAY;

ANTIGENS, NEOPLASM; BETA CATENIN; CELL ADHESION MOLECULES; COLONIC NEOPLASMS; GENE SILENCING; HUMANS; PROGNOSIS; WNT SIGNALING PATHWAY;

EID: 84929497812     PISSN: None     EISSN: 16765680     Source Type: Journal    
DOI: 10.4238/2015.May.4.6     Document Type: Article

References (14)

1. Carmon KS, Gong X, Lin Q, Thomas A, et al. (2011). R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/beta-catenin signaling. Proc. Natl. Acad. Sci. U. S. A. 108: 11452-11457.
2. Clevers H and Nusse R (2012). Wnt/beta-catenin signaling and disease. Cell 149: 1192-1205.
3. Imrich S, Hachmeister M and Gires O (2012). EpCAM and its potential role in tumor-initiating cells. Cell Adh. Migr. 6: 30-38.
4. Jawhari AU, Noda M, Farthing MJ and Pignatelli M (1999). Abnormal expression and function of the E-cadherin-catenin complex in gastric carcinoma cell lines. Br. J. Cancer 80: 322-330.
5. Ji J, Yamashita T and Wang XW (2011). Wnt/beta-catenin signaling activates microRNA-181 expression in hepatocellular carcinoma. Cell Biosci. 1: 4.
6. Lavergne E, Hendaoui I, Coulouarn C, Ribault C, et al. (2011). Blocking Wnt signaling by SFRP-like molecules inhibits in vivo cell proliferation and tumor growth in cells carrying active beta-catenin. Oncogene 30: 423-433.
7. Lu H, Ma J, Yang Y, Shi W, et al. (2013). EpCAM is an endoderm-specific Wnt derepressor that licenses hepatic development. Dev. Cell 24: 543-553.
8. Lugli A, Iezzi G, Hostettler I, Muraro MG, et al. (2010). Prognostic impact of the expression of putative cancer stem cell markers CD133, CD166, CD44s, EpCAM, and ALDH1 in colorectal cancer. Br. J. Cancer 103: 382-390.
9. Mikolajczyk SD, Millar LS, Tsinberg P, Coutts SM, et al. (2011). Detection of EpCAM-negative and cytokeratin-negative circulating tumor cells in peripheral blood. J. Oncol. 2011: 252361.
10. Petsch S, Gires O, Ruttinger D, Denzel S, et al. (2011). Concentrations of EpCAM ectodomain as found in sera of cancer patients do not significantly impact redirected lysis and T-cell activation by EpCAM/CD3-bispecific BiTE antibody MT110. MAbs. 3: 31-37.
11. Spizzo G, Fong D, Wurm M, Ensinger C, et al. (2011). EpCAM expression in primary tumour tissues and metastases: an immunohistochemical analysis. J. Clin. Pathol. 64: 415-420.
12. Terris B, Cavard C and Perret C (2010). EpCAM, a new marker for cancer stem cells in hepatocellular carcinoma. J. Hepatol. 52: 280-281.
13. van Amerongen R, Bowman AN and Nusse R (2012). Developmental stage and time dictate the fate of Wnt/beta-catenin-responsive stem cells in the mammary gland. Cell Stem Cell. 11: 387-400.
14. Yoon SM, Gerasimidou D, Kuwahara R, Hytiroglou P, et al. (2011). Epithelial cell adhesion molecule (EpCAM) marks hepatocytes newly derived from stem/ progenitor cells in humans. Hepatology 53: 964-973.