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Volumn 27, Issue 1, 2015, Pages 46-52

Effects of curcumin on growth performance, jejunal mucosal membrane integrity, morphology and immune status in weaned piglets challenged with enterotoxigenic Escherichia coli

Author keywords

Curcumin; Growth performance; Immune status; Intestinal mucosae; Weaned piglets

Indexed keywords

AMINE OXIDASE (COPPER CONTAINING); CURCUMIN; INTERLEUKIN 10; INTERLEUKIN 1BETA; LACTIC ACID; MESSENGER RNA; SECRETORY IMMUNOGLOBULIN; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA; CYTOKINE; IMMUNOGLOBULIN A; QUINOCETONE; QUINOXALINE DERIVATIVE;

EID: 84929485582     PISSN: 15675769     EISSN: 18781705     Source Type: Journal    
DOI: 10.1016/j.intimp.2015.04.038     Document Type: Article
Times cited : (87)

References (49)
  • 1
    • 26044455874 scopus 로고    scopus 로고
    • Escherichia coli in postweaning diarrhea in pigs: An update on bacterial types, pathogenesis, and prevention strategies
    • J.M. Fairbrother, E. Nadeau, and C.L. Gyles Escherichia coli in postweaning diarrhea in pigs: an update on bacterial types, pathogenesis, and prevention strategies Anim. Health Res. Rev. 6 2005 17 39
    • (2005) Anim. Health Res. Rev. , vol.6 , pp. 17-39
    • Fairbrother, J.M.1    Nadeau, E.2    Gyles, C.L.3
  • 2
    • 84858290120 scopus 로고    scopus 로고
    • Nutrition and pathology of weaner pigs: Nutritional strategies to support barrier function in the gastrointestinal tract
    • J.C. Kim, C.F. Hansen, B.P. Mullana, and J.R. Pluske Nutrition and pathology of weaner pigs: nutritional strategies to support barrier function in the gastrointestinal tract Anim. Feed Sci. Technol. 173 2012 3 16
    • (2012) Anim. Feed Sci. Technol. , vol.173 , pp. 3-16
    • Kim, J.C.1    Hansen, C.F.2    Mullana, B.P.3    Pluske, J.R.4
  • 3
    • 0035004641 scopus 로고    scopus 로고
    • Small intestine epithelial barrier function is compromised in pigs with low feed intake at weaning
    • M.A.M. Spreeuwenberg, J.M.A.J. Verdonk, H.R. Gaskins, and M.W.A. Verstegen Small intestine epithelial barrier function is compromised in pigs with low feed intake at weaning J. Nutr. 131 2001 1520 1527
    • (2001) J. Nutr. , vol.131 , pp. 1520-1527
    • Spreeuwenberg, M.A.M.1    Verdonk, J.M.A.J.2    Gaskins, H.R.3    Verstegen, M.W.A.4
  • 4
    • 4444240732 scopus 로고    scopus 로고
    • Weaning induces both transient and long-lasting modifications of absorptive, secretory, and barrier properties of piglet intestine
    • G. Boudry, V. Péron, I. Huërou-Luron, J.P. Lallès, and B. Sève Weaning induces both transient and long-lasting modifications of absorptive, secretory, and barrier properties of piglet intestine J. Nutr. 134 2004 2256 2262
    • (2004) J. Nutr. , vol.134 , pp. 2256-2262
    • Boudry, G.1    Péron, V.2    Huërou-Luron, I.3    Lallès, J.P.4    Sève, B.5
  • 5
    • 0002243515 scopus 로고    scopus 로고
    • The impact of feed additives on the microbial ecology of the gut in young pigs
    • B.B. Jensen The impact of feed additives on the microbial ecology of the gut in young pigs J. Anim. Feed Sci. 7 1998 45 64
    • (1998) J. Anim. Feed Sci. , vol.7 , pp. 45-64
    • Jensen, B.B.1
  • 6
    • 51349101820 scopus 로고    scopus 로고
    • Ecophysiology of the developing total bacterial and Lactobacillus communities in the terminal small intestine of weaning piglets
    • R. Pieper, P. Janczyk, A. Zeyner, H. Smidt, V. Guiard, and W.B. Souffrant Ecophysiology of the developing total bacterial and Lactobacillus communities in the terminal small intestine of weaning piglets Microb. Ecol. 56 2008 474 483
    • (2008) Microb. Ecol. , vol.56 , pp. 474-483
    • Pieper, R.1    Janczyk, P.2    Zeyner, A.3    Smidt, H.4    Guiard, V.5    Souffrant, W.B.6
  • 7
    • 0025928518 scopus 로고
    • Relationship between virulence and adherence of various enterotoxigenic Escherichia coli: Strains to isolated intestinal epithelial cells from Chinese Meishan and European large white pigs
    • A.M. Benin, and M.F. Ducher-Suchaux Relationship between virulence and adherence of various enterotoxigenic Escherichia coli: strains to isolated intestinal epithelial cells from Chinese Meishan and European large white pigs Am. J. Vet. Res. 52 1 1991 45 49
    • (1991) Am. J. Vet. Res. , vol.52 , Issue.1 , pp. 45-49
    • Benin, A.M.1    Ducher-Suchaux, M.F.2
  • 8
    • 23844472369 scopus 로고    scopus 로고
    • Quinoxaline 1,4-dioxide: A versatile scaffold endowed with manifold activities
    • A. Carta, P. Corona, and M. Loriga Quinoxaline 1,4-dioxide: a versatile scaffold endowed with manifold activities Curr. Med. Chem. 12 19 2005 2259 2272
    • (2005) Curr. Med. Chem. , vol.12 , Issue.19 , pp. 2259-2272
    • Carta, A.1    Corona, P.2    Loriga, M.3
  • 10
    • 0033790692 scopus 로고    scopus 로고
    • Antimicrobial use and bacterial resistance
    • S. Monroe, and R. Polk Antimicrobial use and bacterial resistance Curr. Opin. Microbiol. 3 5 2000 496 501
    • (2000) Curr. Opin. Microbiol. , vol.3 , Issue.5 , pp. 496-501
    • Monroe, S.1    Polk, R.2
  • 11
    • 0035010048 scopus 로고    scopus 로고
    • Use of antimicrobial agents in veterinary medicine and food animal production
    • S. Schwarz, C. Kehrenberg, and T.R. Walsh Use of antimicrobial agents in veterinary medicine and food animal production Int. J. Antimicrob. Agents 17 2001 431 437
    • (2001) Int. J. Antimicrob. Agents , vol.17 , pp. 431-437
    • Schwarz, S.1    Kehrenberg, C.2    Walsh, T.R.3
  • 12
    • 35148833587 scopus 로고    scopus 로고
    • Veterinary antibiotics in the aquatic and terrestrial environment
    • N. Kemper Veterinary antibiotics in the aquatic and terrestrial environment Ecol. Indic. 8 2008 1 13
    • (2008) Ecol. Indic. , vol.8 , pp. 1-13
    • Kemper, N.1
  • 13
    • 0026029402 scopus 로고
    • Inhibitory effects of curcumin on in vitro lipoxygenase and cyclooxygenase activities in mouse epidermis
    • M.T. Huang, T. Lysz, T. Ferraro, T.F. Abidi, J.D. Laskin, and A.H. Conney Inhibitory effects of curcumin on in vitro lipoxygenase and cyclooxygenase activities in mouse epidermis Cancer Res. 51 1991 813 819
    • (1991) Cancer Res. , vol.51 , pp. 813-819
    • Huang, M.T.1    Lysz, T.2    Ferraro, T.3    Abidi, T.F.4    Laskin, J.D.5    Conney, A.H.6
  • 14
    • 0030032384 scopus 로고    scopus 로고
    • Effects of curcumin on cytochrome P450 and glutathione S-transferase activities in rat liver
    • S. Oetari, M. Sudibyo, J.N. Commandeur, R. Samhoedi, and N.P. Vermeulen Effects of curcumin on cytochrome P450 and glutathione S-transferase activities in rat liver Biochem. Pharmacol. 51 1996 39 45
    • (1996) Biochem. Pharmacol. , vol.51 , pp. 39-45
    • Oetari, S.1    Sudibyo, M.2    Commandeur, J.N.3    Samhoedi, R.4    Vermeulen, N.P.5
  • 15
    • 0347300712 scopus 로고    scopus 로고
    • Protection of pancreatich beta-cell by the potential antioxidant bis-o-hydroxycinnamoyl methane, analogue of natural curcuminoid in experimental diabetes
    • A. Srinivasan, V.P. Menon, V. Periaswamy, and K.N. Rajasekaran Protection of pancreatich beta-cell by the potential antioxidant bis-o-hydroxycinnamoyl methane, analogue of natural curcuminoid in experimental diabetes J. Pharm. Pharm. Sci. 6 2003 327 333
    • (2003) J. Pharm. Pharm. Sci. , vol.6 , pp. 327-333
    • Srinivasan, A.1    Menon, V.P.2    Periaswamy, V.3    Rajasekaran, K.N.4
  • 16
    • 84879789194 scopus 로고    scopus 로고
    • Curcumin protects mice against concanavalin A-induced hepatitis by inhibiting intrahepatic intercellular adhesion molecule-1 (ICAM-1) and CXCL10 expression
    • C.T. Tu, B. Han, H.C. Liu, and S.C. Zhang Curcumin protects mice against concanavalin A-induced hepatitis by inhibiting intrahepatic intercellular adhesion molecule-1 (ICAM-1) and CXCL10 expression Mol. Cell. Biochem. 358 2011 53 60
    • (2011) Mol. Cell. Biochem. , vol.358 , pp. 53-60
    • Tu, C.T.1    Han, B.2    Liu, H.C.3    Zhang, S.C.4
  • 17
    • 59349120231 scopus 로고    scopus 로고
    • Pharmacological basis for the role of curcumin in chronic diseases: An age-old spice with modern targets
    • B.B. Aggarwal, and B. Sung Pharmacological basis for the role of curcumin in chronic diseases: an age-old spice with modern targets Trends Pharmacol. Sci. 30 2009 85 94
    • (2009) Trends Pharmacol. Sci. , vol.30 , pp. 85-94
    • Aggarwal, B.B.1    Sung, B.2
  • 18
    • 55949117806 scopus 로고    scopus 로고
    • Potential therapeutic effects of curcumin, the anti-inflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases
    • B.B. Aggarwal, and K.B. Harikumar Potential therapeutic effects of curcumin, the anti-inflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases Int. J. Biochem. Cell Biol. 41 2009 40 59
    • (2009) Int. J. Biochem. Cell Biol. , vol.41 , pp. 40-59
    • Aggarwal, B.B.1    Harikumar, K.B.2
  • 19
    • 84934437976 scopus 로고    scopus 로고
    • Curcumin and autoimmune disease
    • J.J. Bright Curcumin and autoimmune disease Adv. Exp. Med. Biol. 595 2007 425 451
    • (2007) Adv. Exp. Med. Biol. , vol.595 , pp. 425-451
    • Bright, J.J.1
  • 20
    • 1242352473 scopus 로고    scopus 로고
    • Role of curcumin and the inhibition of NF-kappaB in the onset of chemotherapy-induced mucosal barrier injury
    • B. van't Land, N.M. Blijlevens, J. Marteijn, S. Timal, J.P. Donnelly, T.J. de Witte, and L. M'Rabet Role of curcumin and the inhibition of NF-kappaB in the onset of chemotherapy-induced mucosal barrier injury Leukemia 18 2 2004 276 284
    • (2004) Leukemia , vol.18 , Issue.2 , pp. 276-284
    • Van'T Land, B.1    Blijlevens, N.M.2    Marteijn, J.3    Timal, S.4    Donnelly, J.P.5    De Witte, T.J.6    M'Rabet, L.7
  • 21
    • 77958561665 scopus 로고    scopus 로고
    • Curcumin protects intestinal mucosal barrier function of rat enteritis via activation of MKP-1 and attenuation of p38 and NF-κB activation
    • W.B. Song, Y.Y. Wang, F.S. Meng, Q.H. Zhang, J.Y. Zeng, L.P. Xiao, X.P. Yu, D.D. Peng, L. Su, B. Xiao, and Z.S. Zhang Curcumin protects intestinal mucosal barrier function of rat enteritis via activation of MKP-1 and attenuation of p38 and NF-κB activation PLoS One 5 9 2010 e12969
    • (2010) PLoS One , vol.5 , Issue.9 , pp. e12969
    • Song, W.B.1    Wang, Y.Y.2    Meng, F.S.3    Zhang, Q.H.4    Zeng, J.Y.5    Xiao, L.P.6    Yu, X.P.7    Peng, D.D.8    Su, L.9    Xiao, B.10    Zhang, Z.S.11
  • 23
    • 84864285568 scopus 로고    scopus 로고
    • Curcumin ameliorates hydrogen peroxide-induced epithelial barrier disruption by upregulating heme oxygenase-1 expression in human intestinal epithelial cells
    • N. Wang, G. Wang, J. Hao, J. Ma, Y. Wang, X. Jiang, and H. Jiang Curcumin ameliorates hydrogen peroxide-induced epithelial barrier disruption by upregulating heme oxygenase-1 expression in human intestinal epithelial cells Dig. Dis. Sci. 57 7 2012 1792 1801
    • (2012) Dig. Dis. Sci. , vol.57 , Issue.7 , pp. 1792-1801
    • Wang, N.1    Wang, G.2    Hao, J.3    Ma, J.4    Wang, Y.5    Jiang, X.6    Jiang, H.7
  • 24
    • 84861193675 scopus 로고    scopus 로고
    • Effects of the antimicrobial peptide cecropin AD on performance and intestinal health in weaned piglets challenged with Escherichia coli
    • S. Wu, F. Zhang, Z. Huang, H. Liu, C. Xie, J. Zhang, P.A. Thacker, and S. Qiao Effects of the antimicrobial peptide cecropin AD on performance and intestinal health in weaned piglets challenged with Escherichia coli Peptides 35 2 2012 225 230
    • (2012) Peptides , vol.35 , Issue.2 , pp. 225-230
    • Wu, S.1    Zhang, F.2    Huang, Z.3    Liu, H.4    Xie, C.5    Zhang, J.6    Thacker, P.A.7    Qiao, S.8
  • 25
    • 84867572944 scopus 로고    scopus 로고
    • Zinc oxide-montmorillonite hybrid influences diarrhea, intestinal mucosal integrity and digestive enzyme activity in weaned pigs
    • C.H. Hu, J. Song, Z.T. You, Z.S. Luan, and W.F. Li Zinc oxide-montmorillonite hybrid influences diarrhea, intestinal mucosal integrity and digestive enzyme activity in weaned pigs Biol. Trace Elem. Res. 149 2 2012 190 196
    • (2012) Biol. Trace Elem. Res. , vol.149 , Issue.2 , pp. 190-196
    • Hu, C.H.1    Song, J.2    You, Z.T.3    Luan, Z.S.4    Li, W.F.5
  • 26
    • 12244265092 scopus 로고    scopus 로고
    • Effects of dietary quillaja saponin and curcumin on the performance and immune status of weaned piglets
    • S.E. Ilsley, H.M. Miller, and C. Kamel Effects of dietary quillaja saponin and curcumin on the performance and immune status of weaned piglets J. Anim. Sci. 83 1 2005 82 88
    • (2005) J. Anim. Sci. , vol.83 , Issue.1 , pp. 82-88
    • Ilsley, S.E.1    Miller, H.M.2    Kamel, C.3
  • 27
    • 84887002444 scopus 로고    scopus 로고
    • Dietary plant extracts alleviate diarrhea and alter immune responses of weaned pigs experimentally infected with a pathogenic Escherichia coli
    • Y. Liu, M. Song, T.M. Che, J.A. Almeida, J.J. Lee, D. Bravo, C.W. Maddox, and J.E. Pettigrew Dietary plant extracts alleviate diarrhea and alter immune responses of weaned pigs experimentally infected with a pathogenic Escherichia coli J. Anim. Sci. 91 11 2013 5294 5306
    • (2013) J. Anim. Sci. , vol.91 , Issue.11 , pp. 5294-5306
    • Liu, Y.1    Song, M.2    Che, T.M.3    Almeida, J.A.4    Lee, J.J.5    Bravo, D.6    Maddox, C.W.7    Pettigrew, J.E.8
  • 28
    • 0030021848 scopus 로고    scopus 로고
    • Influence of dietary spices or their active principles on digestive enzymes of small intestinal mucosa in rats
    • K. Platel, and K. Srinivansan Influence of dietary spices or their active principles on digestive enzymes of small intestinal mucosa in rats Int. J. Food Sci. Nutr. 47 1996 55 59
    • (1996) Int. J. Food Sci. Nutr. , vol.47 , pp. 55-59
    • Platel, K.1    Srinivansan, K.2
  • 29
    • 84869129239 scopus 로고    scopus 로고
    • Fish oil enhances intestinal integrity and inhibits TLR4 and NOD2 signaling pathways in weaned pigs after LPS challenge
    • Y. Liu, F. Chen, J. Odle, X. Lin, S.K. Jacobi, H. Zhu, Z. Wu, and Y. Hou Fish oil enhances intestinal integrity and inhibits TLR4 and NOD2 signaling pathways in weaned pigs after LPS challenge J. Nutr. 142 2012 2017 2024
    • (2012) J. Nutr. , vol.142 , pp. 2017-2024
    • Liu, Y.1    Chen, F.2    Odle, J.3    Lin, X.4    Jacobi, S.K.5    Zhu, H.6    Wu, Z.7    Hou, Y.8
  • 31
    • 43949167351 scopus 로고
    • Lactoferrin receptors in piglet small intestine: Lactoferrin binding properties, ontogeny, and regional distribution in the gastrointestinal tract
    • J. Gislason, S. Iyer, W. Hutchens, and B. Lonnerdal Lactoferrin receptors in piglet small intestine: lactoferrin binding properties, ontogeny, and regional distribution in the gastrointestinal tract J. Nutr. Biochem. 4 1993 528 533
    • (1993) J. Nutr. Biochem. , vol.4 , pp. 528-533
    • Gislason, J.1    Iyer, S.2    Hutchens, W.3    Lonnerdal, B.4
  • 34
    • 79955665201 scopus 로고    scopus 로고
    • Intestinal barrier function and absorption in pigs after weaning: A review
    • P.J. Wijtten, J. van der Meulen, and M.W. Verstegen Intestinal barrier function and absorption in pigs after weaning: a review Br. J. Nutr. 105 2011 967 981
    • (2011) Br. J. Nutr. , vol.105 , pp. 967-981
    • Wijtten, P.J.1    Van Der Meulen, J.2    Verstegen, M.W.3
  • 35
    • 84903541765 scopus 로고    scopus 로고
    • Diamine oxidase as a marker of intestinal mucosal injury and the effect of soluble dietary fiber on gastrointestinal tract toxicity after intravenous 5-fluorouracil treatment in rats
    • I. Fukudome, M. Kobayashi, K. Dabanaka, H. Maeda, K. Okamoto, T. Okabayashi, R. Baba, N. Kumagai, K. Oba, M. Fujita, and K. Hanazaki Diamine oxidase as a marker of intestinal mucosal injury and the effect of soluble dietary fiber on gastrointestinal tract toxicity after intravenous 5-fluorouracil treatment in rats Med. Mol. Morphol. 47 2014 100 107
    • (2014) Med. Mol. Morphol. , vol.47 , pp. 100-107
    • Fukudome, I.1    Kobayashi, M.2    Dabanaka, K.3    Maeda, H.4    Okamoto, K.5    Okabayashi, T.6    Baba, R.7    Kumagai, N.8    Oba, K.9    Fujita, M.10    Hanazaki, K.11
  • 37
    • 0034029849 scopus 로고    scopus 로고
    • Effects of hydrogen peroxide scavenger catalase on villous microcirculation in the rat small intestine in a model of inflammation bowel disease
    • J. Ruh, F. Vogel, E. Schmidt, M. Werner, E. Klar, A. Secchi, M.M. Gebhard, F. Glaser, and C. Herfarth Effects of hydrogen peroxide scavenger catalase on villous microcirculation in the rat small intestine in a model of inflammation bowel disease Microvasc. Res. 59 2000 329 337
    • (2000) Microvasc. Res. , vol.59 , pp. 329-337
    • Ruh, J.1    Vogel, F.2    Schmidt, E.3    Werner, M.4    Klar, E.5    Secchi, A.6    Gebhard, M.M.7    Glaser, F.8    Herfarth, C.9
  • 38
    • 44349132270 scopus 로고    scopus 로고
    • Epithelial-cell recognition of commensal bacteria and maintenance of immune homeostasis in the gut
    • D. Artis Epithelial-cell recognition of commensal bacteria and maintenance of immune homeostasis in the gut Nat. Rev. Immunol. 8 2008 411 420
    • (2008) Nat. Rev. Immunol. , vol.8 , pp. 411-420
    • Artis, D.1
  • 39
    • 0034994474 scopus 로고    scopus 로고
    • Microbial modulation of innate defense: Goblet cells and the intestinal mucus layer
    • B. Deplancke, and H.R. Gaskins Microbial modulation of innate defense: goblet cells and the intestinal mucus layer Am. J. Clin. Nutr. 73 2001 1131 1141
    • (2001) Am. J. Clin. Nutr. , vol.73 , pp. 1131-1141
    • Deplancke, B.1    Gaskins, H.R.2
  • 40
    • 83655191565 scopus 로고    scopus 로고
    • Epithelial barrier: An interface for the cross-communication between gut flora and immune system
    • Y. Goto, and H. Kiyono Epithelial barrier: an interface for the cross-communication between gut flora and immune system Immunol. Rev. 245 1 2012 147 163
    • (2012) Immunol. Rev. , vol.245 , Issue.1 , pp. 147-163
    • Goto, Y.1    Kiyono, H.2
  • 41
    • 0031937067 scopus 로고    scopus 로고
    • Small bowel enteropathy: Role of intraepithelial lymphocytes and of cytokines (IL-12, IFN-gamma, TNF) in the induction of epithelial cell death and renewal
    • D. Guy-Grand, J.P. DiSanto, P. Henchoz, M. Malassis-Séris, and P. Vassalli Small bowel enteropathy: role of intraepithelial lymphocytes and of cytokines (IL-12, IFN-gamma, TNF) in the induction of epithelial cell death and renewal Eur. J. Immunol. 28 2 1998 730 744
    • (1998) Eur. J. Immunol. , vol.28 , Issue.2 , pp. 730-744
    • Guy-Grand, D.1    Disanto, J.P.2    Henchoz, P.3    Malassis-Séris, M.4    Vassalli, P.5
  • 42
    • 84870252354 scopus 로고    scopus 로고
    • New concepts in the generation and functions of IgA
    • O. Pabst New concepts in the generation and functions of IgA Nat. Rev. Immunol. 12 12 2012 821 832
    • (2012) Nat. Rev. Immunol. , vol.12 , Issue.12 , pp. 821-832
    • Pabst, O.1
  • 43
    • 49649100463 scopus 로고    scopus 로고
    • Dietary arginine supplementation alleviates intestinal mucosal disruption induced by Escherichia coli lipopolysaccharide in weaned pigs
    • Y.L. Liu, J.J. Huang, Y.Q. Hou, H.L. Zhu, S.J. Zhao, B.Y. Ding, Y.L. Yin, G.F. Yi, J.X. Shi, and W. Fan Dietary arginine supplementation alleviates intestinal mucosal disruption induced by Escherichia coli lipopolysaccharide in weaned pigs Br. J. Nutr. 100 2008 552 560
    • (2008) Br. J. Nutr. , vol.100 , pp. 552-560
    • Liu, Y.L.1    Huang, J.J.2    Hou, Y.Q.3    Zhu, H.L.4    Zhao, S.J.5    Ding, B.Y.6    Yin, Y.L.7    Yi, G.F.8    Shi, J.X.9    Fan, W.10
  • 45
    • 85047692516 scopus 로고    scopus 로고
    • Signalling pathways of the TNF superfamily: A double-edges word
    • B.B. Aggarwal Signalling pathways of the TNF superfamily: a double-edges word Nat. Rev. 3 2003 745 756
    • (2003) Nat. Rev. , vol.3 , pp. 745-756
    • Aggarwal, B.B.1
  • 47
    • 28244493047 scopus 로고    scopus 로고
    • Transforming growth factor-beta regulation of epithelial tight junction proteins enhances barrier function and blocks enterohemorrhagic Escherichia coli O157:H7-induced increased permeability
    • K.L. Howe, C. Reardon, A. Wang, A. Nazli, and D.M. McKay Transforming growth factor-beta regulation of epithelial tight junction proteins enhances barrier function and blocks enterohemorrhagic Escherichia coli O157:H7-induced increased permeability Am. J. Pathol. 167 2005 1587 1597
    • (2005) Am. J. Pathol. , vol.167 , pp. 1587-1597
    • Howe, K.L.1    Reardon, C.2    Wang, A.3    Nazli, A.4    McKay, D.M.5


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