Effect of inhibiting NGAL gene expression on A549 lung cancer cell migration and invasion

Chinese Journal of Lung Cancer

Volumn 18, Issue 4, 2015, Pages 187-192

  Tang, Jian ^a,b   Li, Jie ^b   Li, Shaojun ^b   Li, Jingbo ^b   Yu, Changhai ^b   Wei, Chengze ^a  

^a BEIJING INSTITUTE OF MICROBIOLOGY AND EPIDEMIOLOGY   (China)

^b CHINESE PLA GENERAL HOSPITAL   (China)

Author keywords

Epithelial mesenchymal transition; Invasion; Lung neoplasms; Migration; Neutrophil gelatinase associated lipocalin

Indexed keywords

GELATINASE A; GELATINASE B; NEUTROPHIL GELATINASE ASSOCIATED LIPOCALIN; UVOMORULIN; VIMENTIN; ACUTE PHASE PROTEIN; LCN2 PROTEIN, HUMAN; LIPOCALIN; ONCOPROTEIN; SMALL INTERFERING RNA;

A549 CELL LINE; ARTICLE; CELL INVASION; CELL MIGRATION; CONTROLLED STUDY; GENE EXPRESSION; HUMAN; HUMAN CELL; IMMUNOCHEMISTRY; IMMUNOFLUORESCENCE; LUNG CANCER; METASTASIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING; CELL MOTION; DOWN REGULATION; GENE EXPRESSION REGULATION; GENETICS; LUNG TUMOR; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; TUMOR CELL LINE; TUMOR INVASION;

ACUTE-PHASE PROTEINS; CELL LINE, TUMOR; CELL MOVEMENT; DOWN-REGULATION; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LIPOCALINS; LUNG NEOPLASMS; NEOPLASM INVASIVENESS; PROTO-ONCOGENE PROTEINS; RNA, SMALL INTERFERING; VIMENTIN;

EID: 84929467349     PISSN: 10093419     EISSN: 19996187     Source Type: Journal    
DOI: 10.3779/j.issn.1009-3419.2015.04.03     Document Type: Article

References (13)

1. Jemal A, Bray F, Center MM, et al. Global cancer statistics. CA Cancer J Clin, 2011, 61(2): 69-90.
2. Kjeldsen L, Johnsen AH, Sengel VH, et al. Isolation and primary structure of NGAL, a novel protein associated with human neutrophil gelatinase. Biol Chem, 1993, 268(14): 10425-10432.
3. Friedl A, Stoesz SP, Buckley P, et al. Neutrophil geltinase-associated lipocalin in normal and neoplastic human tissues. Cell type-specific pattern of expression. Histochem J, 1999, 31(7): 433-441.
4. Gwira JA, Wei F, Ishibe S, et al. Expression of neutrophil gelatinaseassociated lipocalin regulates epithelial morphogenesis in vitro. J Biol Chem, 2005, 280(9): 7875-7882.
5. Volpe V, Raia Z, Sanguigno L, et al. NGAL controls the metastatic potential of anaplastic thyroid carcinoma cells. J Clin Endocrinol Metab, 2013, 98(1): 228-235.
6. Berger T, Cheung CC, Elia AJ, et al. Disruption of the lcn 2 gene in mice suppresses primary tumor formation but does not decrease lung metastasis. Proc Natl Acad Sci USA, 2010, 107(7): 2995-3000.
7. Bauer M, Eickhoff JC, Gould MN, et al. Neutrophil gelatin ase-associated lipocalin (NGAL) is a predictor of poor prognosis in hum an primary breast cancer. Breast Cancer Res Treat, 2008, 108(3): 389-397.
8. Lee JM, Dedhar S, Kalluri R, et al. The epithelial-mesenchymal transition: new insights in signaling, development, and disease. J Cell Biol, 2006, 172(7): 973-998.
9. Yang J, Bielenberg DR, Rodig SJ, et al. Lipocalin 2 promotes breast cancer progression. Proc Natl Acad Sci USA, 2009, 106(10): 3913-3918.
10. Kubben FJ, Sier CF, Hawinkels LJ, et al. C linical evidence for a protective role of lipocalin-2 against MMP-9 autodegradation and the impact for gastric cancer. Eur J Cancer, 2007, 43(12): 1869-1876.
11. Bergers G, Brekken R, McMahon G, et al. Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis. Nat Cell Biol, 2000, 2(10): 737-744.
12. Miethke M, Skerra A. Neutrophil gelatinase-associated lipocalin expresses antimicrobial activity by interfering with L-nore-pinephrinemediated bacterial iron acquisition. Antimicrob Agents Chemother, 2010, 54(4): 1580-1589.
13. Bao G, Clifton M, Hoette TM, et al. Iron traffics in circulation bound to a siderocalin (Ngal)-catechol complex. Nat Chem Biol, 2010, 6(8): 602-609.