Vitamin D and liver fibrosis: Let's start soon before it's too late

Gut

Volumn 64, Issue 5, 2015, Pages 698-699

  Nobili, Valerio ^a   Reif, Shimon ^b,c  

^a BAMBINO GESÙ CHILDREN S HOSPITAL   (Italy)

^b HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

^c HEBREW UNIVERSITY OF JERUSALEM   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; CALCITRIOL; COLLAGEN TYPE 1; COLLAGEN TYPE 3; FIBRONECTIN; NEUTROPHIL COLLAGENASE; OSTEOGENIC PROTEIN 1; PARICALCITOL; SMAD PROTEIN; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1; VITAMIN D; VITAMIN D RECEPTOR; CALCITRIOL RECEPTOR;

ANTIPROLIFERATIVE ACTIVITY; CELL PROLIFERATION; DRUG EFFICACY; FATTY LIVER; FIBROBLAST; HUMAN; KIDNEY FIBROSIS; LIVER FIBROSIS; MULTIPOTENT STEM CELL; NONALCOHOLIC FATTY LIVER; NONHUMAN; NOTE; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; STELLATE CELL; VITAMIN SUPPLEMENTATION; ANTAGONISTS AND INHIBITORS; DRUG EFFECTS; FEMALE; MALE; METABOLISM; PHYSIOLOGY;

FEMALE; HEPATIC STELLATE CELLS; HUMANS; MALE; NON-ALCOHOLIC FATTY LIVER DISEASE; RECEPTORS, CALCITRIOL; TRANSFORMING GROWTH FACTOR BETA; VITAMIN D;

EID: 84929462486     PISSN: 00175749     EISSN: 14683288     Source Type: Journal    
DOI: 10.1136/gutjnl-2014-308175     Document Type: Note

References (14)

1. Plum LA, Deluca HF. The functional metabolism and molecular biology of vitamin D action. In: Holick MF, ed. Vitamin D: physiology, molecular biology and clinical applications. 2nd edn. Totowa, NJ: The Humana Press, 2009.
2. Ramirez AM, Wongtrakool C, Welch T, et al. Vitamin D inhibition of pro-fibrotic effects of transformation growth factor β1 in lung fibroblasts and epithelial cells. J Steroid Biochem Mol Biol 2010;118:142-50.
3. Artaza JN, Sirad F, Ferrini MG, et al. 1,25(OH) 2vitamin D3 inhibits cell proliferation by promoting cell cycle arrest without inducing apoptosis and modifies cell morphology of mesenchymal multipotent cells. J Steroid Biochem Mol Biol 2010;119:73-83.
4. Artaza JN, Norris KC. Vitamin D reduces the expression of collagen and key profibrotic factors by inducing an antifibrotic phenotype in mesenchymal multipotent cells. J Endocrinol 2009;200:207-21.
5. Tan X, Li Y, Liu Y. Paricalcitol attenuates renal interstitial fibrosis in obstructive nephropathy. J Am Soc Nephrol 2006;7:3382-93.
6. Friedman SL. Liver fibrosis-from bench to bedside. J Hepatol 2003;38(Suppl. 1):S38-53.
7. Beilfuss A, Sowa JP, Sydor S, et al. Vitamin D counteracts fibrogenic TGF-beta signaling in human hepatic stellate cells both receptor-dependently and independently. Gut 2015;64:791-9.
8. Abramovitch S, Dahan-Bachar L, Sharvit E, et al. Vitamin D inhibits proliferation and profibrotic marker expression in hepatic stellate cells and decreases thioacetamide-induced liver fibrosis in rats. Gut 2011;60:1728-37.
9. Abramovitch S, Sharvit E, Weisman Y, et al. Vitamin D inhibits development of liver fibrosis in animal model but cannot ameliorate established cirrhosis. Am J Physiology. In press.
10. Ding N, Yu RT, Subramaniam N, et al. A vitamin D receptor/SMAD genomic circuit gates hepatic fibrotic response. Cell 2013;153:601-13.
11. Yin Y, Yu Z, Xia M, et al. Vitamin D attenuates high fat diet-induced hepatic steatosis in rats by modulating lipid metabolism. Eur J Clin Invest 2012;42:1189-96.
12. Skoien R, Richardson MM, Jonsson JR, et al. Heterogeneity of fibrosis patterns in non-alcoholic fatty liver disease supports the presence of multiple fibrogenic pathways. Liver Int 2013;33:624-32.
13. Nobili V, Giorgio V, Liccardo D, et al. Vitamin D levels and liver histological alterations in children with nonalcoholic fatty liver disease. Eur J Endocrinol 2014;170:547-53.
14. Nobili V, Svegliati-Baroni G, Alisi A, et al. A 360-degree overview of paediatric NAFLD: recent insights. J Hepatol 2013;58:1218-29.