A decades-long investigation of acute metabolism-based hepatotoxicity by herbal constituents: A case study of pennyroyal oil

Drug Metabolism Reviews

Volumn 47, Issue 1, 2015, Pages 12-20

  Gordon, Perry ^a   Khojasteh, S Cyrus ^b  

^a Genomics Institute of Novartis Research Foundation (GNF)   (United States)

^b GENENTECH INC   (United States)

Author keywords

Bioactivation; in vivo models; Mechanistic studies; Metabolites; P450; Reactive metabolites

Indexed keywords

CYTOCHROME P450; GLUCURONIDE; MENTHOFURAN; PENNYROYAL OIL; PULEGONE; UNCLASSIFIED DRUG; VEGETABLE OIL; CYCLOHEXANONE DERIVATIVE; ESSENTIAL OIL; PLANT MEDICINAL PRODUCT;

CHEMICAL STRUCTURE; CYCLIZATION; DRUG CONJUGATION; DRUG HALF LIFE; DRUG METABOLISM; DRUG OXIDATION; GAS CHROMATOGRAPHY; GERMANDER; HUMAN; IN VITRO STUDY; LIQUID CHROMATOGRAPHY; LIVER FAILURE; LIVER INJURY; LIVER MICROSOME; LIVER TOXICITY; MENTHA PULEGIUM; NONHUMAN; REDUCTION; REVIEW; ANIMAL; DRUG EFFECTS; LIVER; METABOLISM; PATHOLOGY; TIME FACTOR; TOXIC HEPATITIS;

ANIMALS; CYCLOHEXANONES; DRUG-INDUCED LIVER INJURY; HUMANS; LIVER; OILS, VOLATILE; PLANT PREPARATIONS; TIME FACTORS;

EID: 84929457538     PISSN: 03602532     EISSN: 10979883     Source Type: Journal    
DOI: 10.3109/03602532.2014.990032     Document Type: Review

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