Length polymorphism in the Period 3 gene is associated with sleepiness and maladaptive circadian phase in night-shift workers

Journal of Sleep Research

Volumn 24, Issue 3, 2015, Pages 254-261

  Drake, Christopher L ^a   Belcher, Ren ^a,c   Howard, Ryan ^a,d   Roth, Thomas ^a   Levin, Albert M ^a   Gumenyuk, Valentina ^a,b  

^a HENRY FORD HOSPITAL   (United States)

^b Meadowlands Hospital   (United States)

^c UNIVERSITY OF CHICAGO   (United States)

^d UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

Circadian rhythms; DLMO; Fatigue; MSLT; PER 3; Shift work disorder

Indexed keywords

MELATONIN; CIRCADIAN RHYTHM SIGNALING PROTEIN; PER3 PROTEIN, HUMAN;

ADULT; ALLELE; ARTICLE; CIRCADIAN RHYTHM; CIRCADIAN RHYTHM SLEEP DISORDER; DNA POLYMORPHISM; EPWORTH SLEEPINESS SCALE; FEMALE; GENE; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPE; HETEROZYGOTE; HOMOZYGOTE; HUMAN; LIGHT; MAJOR CLINICAL STUDY; MALE; NIGHT WORK; OBSERVATIONAL STUDY; PERIOD 3 GENE; PRIORITY JOURNAL; SALIVA ANALYSIS; SHIFT WORKER; SLEEP; SLEEP DEPRIVATION; SOMNOLENCE; WORKING TIME; CASE CONTROL STUDY; CHEMISTRY; GENETIC POLYMORPHISM; GENETICS; PATHOPHYSIOLOGY; POLYSOMNOGRAPHY; RADIATION RESPONSE; SALIVA; SLEEP STAGE; TIME;

ADULT; ALLELES; CASE-CONTROL STUDIES; CIRCADIAN RHYTHM; FEMALE; HUMANS; LIGHT; MALE; MELATONIN; PERIOD CIRCADIAN PROTEINS; POLYMORPHISM, GENETIC; POLYSOMNOGRAPHY; SALIVA; SLEEP; SLEEP DEPRIVATION; SLEEP DISORDERS, CIRCADIAN RHYTHM; SLEEP STAGES; TIME FACTORS;

EID: 84929454948     PISSN: 09621105     EISSN: 13652869     Source Type: Journal    
DOI: 10.1111/jsr.12264     Document Type: Article

References (43)

1. Akerstedt, T. and Knutsson, A. Cardiovascular disease and shift work. Scand. J. Work Environ. Health, 1997, 23: 241-242.
2. Archer, S. N., Robilliard, D. L., Skene, D. J. et al. A length polymorphism in the circadian clock gene Per3 is linked to delayed sleep phase syndrome and extreme diurnal preference. Sleep, 2003, 26: 413-415.
3. Archer, S. N., Viola, A. U., Kyriakopoulou, V., Von Schantz, M. and Dijk, D. J. Inter-individual differences in habitual sleep timing and entrained phase of endogenous circadian rhythms of BMAL1, PER2 and PER3 mRNA in human leukocytes. Sleep, 2008, 31: 608-617.
4. Burgess, H. J. and Fogg, L. F. Individual differences in the amount and timing of salivary melatonin secretion. PLoS One, 2008, 3: e3055.
5. Chellappa, S. L., Viola, A. U., Schmidt, C. et al. Human melatonin and alerting response to blue-enriched light depend on a polymorphism in the clock gene PER3. J. Clin. Endocrinol. Metab., 2012, 97: E433-E437.
6. Ciarleglio, C. M., Ryckman, K. K., Servick, S. V. et al. Genetic differences in human circadian clock genes among worldwide populations. J. Biol. Rhythms, 2008, 23: 330-340.
7. Conlon, M., Lightfoot, N. and Kreiger, N. Rotating shift work and risk of prostate cancer. Epidemiology, 2007, 18: 182-183.
8. Czeisler, C. A. Medical and genetic differences in the adverse impact of sleep loss on performance: ethical considerations for the medical profession. Trans. Am. Clin. Climatol. Assoc., 2009, 120: 249-285.
9. Czeisler, C. A., Walsh, J. K., Wesnes, K. A., Arora, S. and Roth, T. Armodafinil for treatment of excessive sleepiness associated with shift work disorder: a randomized controlled study. Mayo Clin. Proc., 2009, 84: 958-972.
10. Davis, S., Mirick, D. K. and Stevens, R. G. Night shift work, light at night, and risk of breast cancer. J. Natl Cancer Inst., 2001, 93: 1557-1562.
11. Dijk, D. J. and Archer, S. N. PERIOD3, circadian phenotypes, and sleep homeostasis. Sleep Med. Rev., 2010, 14: 151-160.
12. Drake, C. L. Shift work, Shift-work disorder, and jet lag. In: T. R. Meir, H. Kryger and W. C. Dement (Eds) Principles and Practice of Sleep Medicine. Elsevier, St Louis, 2011: 784-798.
13. Drake, C. L., Roehrs, T., Richardson, G., Walsh, J. K. and Roth, T. Shift work sleep disorder: prevalence and consequences beyond that of symptomatic day workers. Sleep, 2004, 27: 1453-1462.
14. Erren, T. C., Gross, J. V. and Pinger, A. Counter-clockwise shift-work and prostate cancer: putting pieces in the puzzle. Int. J. Urol., 2011, 18: 612-613; author reply 613.
15. Folkard, S. Do permanent night workers show circadian adjustment? A review based on the endogenous melatonin rhythm. Chronobiol. Int., 2008, 25: 215-224.
16. Gamble, K. L., Motsinger-Reif, A. A., Hida, A. et al. Shift work in nurses: contribution of phenotypes and genotypes to adaptation. PLoS One, 2011, 6: e18395.
17. Goel, N., Banks, S., Mignot, E. and Dinges, D. F. PER3 polymorphism predicts cumulative sleep homeostatic but not neurobehavioral changes to chronic partial sleep deprivation. PLoS One, 2009, 4: e5874.
18. Groeger, J. A., Viola, A. U., Lo, J. C., Von Schantz, M., Archer, S. N. and Dijk, D. J. Early morning executive functioning during sleep deprivation is compromised by a PERIOD3 polymorphism. Sleep, 2008, 31: 1159-1167.
19. Gumenyuk, V., Roth, T. and Drake, C. L. Circadian phase, sleepiness, and light exposure assessment in night workers with and without shift work disorder. Chronobiol. Int., 2012, 29: 928-936.
20. Gumenyuk, V., Howard, R., Roth, T., Korzyukov, O. and Drake, C. L. Sleep loss, circadian mismatch, and abnormalities in reorienting of attention in night workers with shift work disorder. Sleep, 2014, 37: 545-556.
21. Hamilton, M. A rating scale for depression. J. Neurol. Neurosurg. Psychiatr., 1960, 23: 56-62.
22. Juda, M., Vetter, C. and Roenneberg, T. Chronotype modulates sleep duration, sleep quality, and social jet lag in shift-workers. J. Biol. Rhythms, 2013, 28: 141-151.
23. Kamdar, B. B., Tergas, A. I., Mateen, F. J., Bhayani, N. H. and Oh, J. Night-shift work and risk of breast cancer: a systematic review and meta-analysis. Breast Cancer Res. Treat., 2013, 138: 291-301.
24. Leclerc, A. Shift-work and cardiovascular disease. Eur. J. Epidemiol., 2010, 25: 285-286.
25. Lee, C., Smith, M. R. and Eastman, C. I. A compromise phase position for permanent night shift workers: circadian phase after two night shifts with scheduled sleep and light/dark exposure. Chronobiol. Int., 2006, 23: 859-875.
26. Lewy, A. J. and Sack, R. L. The dim light melatonin onset as a marker for circadian phase position. Chronobiol. Int., 1989, 6: 93-102.
27. Lo, J. C., Groeger, J. A., Santhi, N. et al. Effects of partial and acute total sleep deprivation on performance across cognitive domains, individuals and circadian phase. PLoS One, 2012, 7: e45987.
28. Maire, M., Reichert, C. F., Gabel, V. et al. Sleep ability mediates individual differences in the vulnerability to sleep loss: evidence from a PER3 polymorphism. Cortex, 2014, 52: 47-59.
29. Minors, D. S., Waterhouse, J. M. and Wirz-Justice, A. A human phase-response curve to light. Neurosci. Lett., 1991, 133: 36-40.
30. Murata, K., Yano, E. and Shinozaki, T. Impact of shift work on cardiovascular functions in a 10-year follow-up study. Scand. J. Work Environ. Health, 1999, 25: 272-277.
31. Netzer, N. C., Stoohs, R. A., Netzer, C. M., Clark, K. and Strohl, K. P. Using the Berlin Questionnaire to identify patients at risk for the sleep apnea syndrome. Ann. Intern. Med., 1999, 131: 485-491.
32. Ostberg, O. Interindividual differences in circadian fatigue patterns of shift workers. Br. J. Ind. Med., 1973, 30: 341-351.
33. Pijpe, A., Slottje, P., Van Pelt, C. et al. The Nightingale study: rationale, study design and baseline characteristics of a prospective cohort study on shift work and breast cancer risk among nurses. BMC Cancer, 2014, 14: 47.
34. Puttonen, S., Kivimaki, M., Elovainio, M. et al. Shift work in young adults and carotid artery intima-media thickness: the Cardiovascular Risk in Young Finns study. Atherosclerosis, 2009, 205: 608-613.
35. Reinberg, A., Vieux, N., Ghata, J., Chaumont, A. J. and Laporte, A. Circadian rhythm amplitude and individual ability to adjust to shift work. Ergonomics, 1978, 21: 763-766.
36. Revell, V. L., Kim, H., Tseng, C. Y., Crowley, S. J. and Eastman, C. I. Circadian phase determined from melatonin profiles is reproducible after 1 wk in subjects who sleep later on weekends. J. Pineal Res., 2005, 39: 195-200.
37. Rupp, T. L., Wesensten, N. J., Newman, R. and Balkin, T. J. PER3 and ADORA2A polymorphisms impact neurobehavioral performance during sleep restriction. J. Sleep Res., 2013, 22: 160-165.
38. Smith, M. R., Fogg, L. F. and Eastman, C. I. Practical interventions to promote circadian adaptation to permanent night shift work: study 4. J. Biol. Rhythms, 2009, 24: 161-172.
39. Vener, K. J., Szabo, S. and Moore, J. G. The effect of shift work on gastrointestinal (GI) function: a review. Chronobiologia, 1989, 16: 421-439.
40. Viola, A. U., Archer, S. N., James, L. M. et al. PER3 polymorphism predicts sleep structure and waking performance. Curr. Biol., 2007, 17: 613-618.
41. Viola, A. U., Chellappa, S. L., Archer, S. N. et al. Interindividual differences in circadian rhythmicity and sleep homeostasis in older people: effect of a PER3 polymorphism. Neurobiol. Aging, 2012, 33: e17-e27.
42. Wagstaff, A. S. and Sigstad Lie, J. A. Shift and night work and long working hours - a systematic review of safety implications. Scand. J. Work Environ. Health, 2011, 37: 173-185.
43. Wang, F., Yeung, K. L., Chan, W. C. et al. A meta-analysis on dose-response relationship between night shift work and the risk of breast cancer. Ann. Oncol., 2013, 24: 2724-2732.