T1 and T2 values of human neonatal blood at 3 Tesla: Dependence on hematocrit, oxygenation, and temperature

Magnetic Resonance in Medicine

Volumn 75, Issue 4, 2016, Pages 1730-1735

  Liu, Peiying ^a,b   Chalak, Lina F ^b   Krishnamurthy, Lisa C ^b   Mir, Imran ^b   Peng, Shin Lei ^a,b   Huang, Hao ^b,c,d   Lu, Hanzhang ^a,b  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF TEXAS AT DALLAS   (United States)

^c CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^d UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

blood oxygenation; hematocriT; longitudinal relaxation time; neonate; transverse relaxation time; umbilical cord blood

Indexed keywords

OXYGENATION; RELAXATION TIME;

BLOOD OXYGENATION; HEMATOCRIT; LONGITUDINAL RELAXATION TIME; NEONATE; TRANSVERSE RELAXATION TIME; UMBILICAL CORD BLOOD;

BLOOD;

ADULT; ARTICLE; BLOOD OXYGENATION; CALIBRATION; HEMATOCRIT; HUMAN; IN VITRO STUDY; IN VIVO STUDY; LIMIT OF QUANTITATION; MEASUREMENT ACCURACY; NEWBORN; NORMAL HUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PROCESS OPTIMIZATION; TEMPERATURE MEASUREMENT; BLOOD; BODY TEMPERATURE; FETUS BLOOD; PHYSIOLOGY; PROCEDURES; SIGNAL PROCESSING;

OXYGEN;

BODY TEMPERATURE; FETAL BLOOD; HEMATOCRIT; HUMANS; INFANT, NEWBORN; MAGNETIC RESONANCE IMAGING; OXYGEN; SIGNAL PROCESSING, COMPUTER-ASSISTED;

EID: 84929448691     PISSN: 07403194     EISSN: 15222594     Source Type: Journal    
DOI: 10.1002/mrm.25775     Document Type: Article

References (38)

1. Wintermark P, Hansen A, Gregas MC, Soul J, Labrecque M, Robertson RL, Warfield SK., Brain perfusion in asphyxiated newborns treated with therapeutic hypothermia. AJNR Am J Neuroradiol 2011; 32: 2023-2029.
2. Pienaar R, Paldino MJ, Madan N, Krishnamoorthy KS, Alsop DC, Dehaes M, Grant PE., A quantitative method for correlating observations of decreased apparent diffusion coefficient with elevated cerebral blood perfusion in newborns presenting cerebral ischemic insults. Neuroimage 2012; 63: 1510-1518.
3. Jain V, Buckley EM, Licht DJ, et al., Cerebral oxygen metabolism in neonates with congenital heart disease quantified by MRI and optics. J Cereb Blood Flow Metab 2014; 34: 380-388.
4. De Vis JB, Petersen ET, Alderliesten T, Groenendaal F, de Vries LS, van Bel F, Benders MJ, Hendrikse J., Non-invasive MRI measurements of venous oxygenation, oxygen extraction fraction and oxygen consumption in neonates. Neuroimage 2014; 95: 185-192.
5. Varela M, Petersen ET, Golay X, Hajnal JV,. Cerebral blood flow measurements in infants using look-locker arterial spin labeling. J Magn Reson Imaging 2015; 41: 1591-1600.
6. De Vis JB, Hendrikse J, Petersen ET, de Vries LS, van Bel F, Alderliesten T, Negro S, Groenendaal F, Benders MJ., Arterial spin-labelling perfusion MRI and outcome in neonates with hypoxic-ischemic encephalopathy. Eur Radiol 2015; 25: 113-121.
7. Miranda MJ, Olofsson K, Sidaros K., Noninvasive measurements of regional cerebral perfusion in preterm and term neonates by magnetic resonance arterial spin labeling. Pediatr Res 2006; 60: 359-363.
8. Massaro AN, Bouyssi-Kobar M, Chang T, Vezina LG, du Plessis AJ, Limperopoulos C., Brain perfusion in encephalopathic newborns after therapeutic hypothermia. AJNR Am J Neuroradiol 2013; 34: 1649-1655.
9. Liu P, Huang H, Rollins N, Chalak LF, Jeon T, Halovanic C, Lu H., Quantitative assessment of global cerebral metabolic rate of oxygen (CMRO2) in neonates using MRI. NMR Biomed 2014; 27: 332-340.
10. Alsop DC, Detre JA, Golay X, et al., Recommended implementation of arterial spin-labeled perfusion MRI for clinical applications: a consensus of the ISMRM perfusion study group and the European consortium for ASL in dementia. Magn Reson Med 2015; 73: 102-116.
11. van Zijl PC, Eleff SM, Ulatowski JA, Oja JM, Ulug AM, Traystman RJ, Kauppinen RA., Quantitative assessment of blood flow, blood volume and blood oxygenation effects in functional magnetic resonance imaging. Nat Med 1998; 4: 159-167.
12. Oja JM, Gillen JS, Kauppinen RA, Kraut M, van Zijl PC., Determination of oxygen extraction ratios by magnetic resonance imaging. J Cereb Blood Flow Metab 1999; 19: 1289-1295.
13. Golay X, Silvennoinen MJ, Zhou J, Clingman CS, Kauppinen RA, Pekar JJ, van Zij PC., Measurement of tissue oxygen extraction ratios from venous blood T(2): increased precision and validation of principle. Magn Reson Med 2001; 46: 282-291.
14. Spees WM, Yablonskiy DA, Oswood MC, Ackerman JJ., Water proton MR properties of human blood at 1.5 Tesla: magnetic susceptibility, T(1), T(2), T∗(2), and non-Lorentzian signal behavior. Magn Reson Med 2001; 45: 533-542.
15. Silvennoinen MJ, Clingman CS, Golay X, Kauppinen RA, van Zijl PC., Comparison of the dependence of blood R2 and R2∗ on oxygen saturation at 1.5 and 4.7 Tesla. Magn Reson Med 2003; 49: 47-60.
16. Lu H, Clingman C, Golay X, van Zijl PC., Determining the longitudinal relaxation time (T1) of blood at 3.0 Tesla. Magn Reson Med 2004; 52: 679-682.
17. Chen JJ, Pike GB., Human whole blood T2 relaxometry at 3 Tesla. Magn Reson Med 2009; 61: 249-254.
18. Lu H, Xu F, Grgac K, Liu P, Qin Q, van Zijl P., Calibration and validation of TRUST MRI for the estimation of cerebral blood oxygenation. Magn Reson Med 2012; 67: 42-49.
19. Stanisz GJ, Odrobina EE, Pun J, Escaravage M, Graham SJ, Bronskill MJ, Henkelman RM., T1, T2 relaxation and magnetization transfer in tissue at 3T. Magn Reson Med 2005; 54: 507-512.
20. Grgac K, van Zijl PC, Qin Q., Hematocrit and oxygenation dependence of blood (1)H(2)O T(1) at 7 Tesla. Magn Reson Med 2013; 70: 1153-1159.
21. Krishnamurthy LC, Liu P, Xu F, Uh J, Dimitrov I, Lu H., Dependence of blood T(2) on oxygenation at 7 T: in vitro calibration and in vivo application. Magn Reson Med 2014; 71: 2035-2042.
22. Gardener AG, Francis ST, Prior M, Peters A, Gowland PA., Dependence of blood R2 relaxivity on CPMG echo-spacing at 2.35 and 7 T. Magn Reson Med 2010; 64: 967-974.
23. Cook CD, Brodie HR, Allen DW., Measurement of fetal hemoglobin in newborn infants; correlation with gestational age and intrauterine hypoxia. Pediatrics 1957; 20: 272-278.
24. Davis LR., Changing blood picture in sickle-cell anaemia from shortly after birth to adolescence. J Clin Pathol 1976; 29: 898-901.
25. Armstrong L, Stenson B., Effect of delayed sampling on umbilical cord arterial and venous lactate and blood gases in clamped and unclamped vessels. Arch Dis Child Fetal Neonatal Ed 2006; 91: F342-F345.
26. Lu H, Ge Y., Quantitative evaluation of oxygenation in venous vessels using T2-Relaxation-Under-Spin-Tagging MRI. Magn Reson Med 2008; 60: 357-363.
27. Jopling J, Henry E, Wiedmeier SE, Christensen RD., Reference ranges for hematocrit and blood hemoglobin concentration during the neonatal period: data from a multihospital health care system. Pediatrics 2009; 123: e333-e337.
28. Edelman RR, Chien D, Kim D., Fast selective black blood MR imaging. Radiology 1991; 181: 655-660.
29. Lu H, Golay X, Pekar JJ, Van Zijl PC., Functional magnetic resonance imaging based on changes in vascular space occupancy. Magn Reson Med 2003; 50: 263-274.
30. Petersen ET, De Vis JB, Alderliesten T, Kersbergen KJ, Benders MJ, Hendrikse J, van den Berg CAT,. Simultaneous OEF and Haematocrit assessment using T2 Prepared Blood Relaxation Imaging with Inversion Recovery. In Proceedings of the 20th Annual Meeting of ISMRM, Melbourn, Australia, 2012. Abstract 472.
31. Liu P, Xu F, Lu H., Test-retest reproducibility of a rapid method to measure brain oxygen metabolism. Magn Reson Med 2013; 69: 675-681.
32. du Plessis AJ., Cerebral blood flow and metabolism in the developing fetus. Clin Perinatol 2009; 36: 531-548.
33. Chalak LF, Sanchez PJ, Adams-Huet B, Laptook AR, Heyne RJ, Rosenfeld CR., Biomarkers for severity of neonatal hypoxic-ischemic encephalopathy and outcomes in newborns receiving hypothermia therapy. J Pediatr 2014; 164: 468-474 e461.
34. Liu P, Chalak LF, Lu H., Non-invasive assessment of neonatal brain oxygen metabolism: a review of newly available techniques. Early Hum Dev 2014; 90: 695-701.
35. Varela M, Hajnal JV, Petersen ET, Golay X, Merchant N, Larkman DJ., A method for rapid in vivo measurement of blood T1. NMR Biomed 2011; 24: 80-88.
36. Wu WC, Jain V, Li C, Giannetta M, Hurt H, Wehrli FW, Wang DJ., In vivo venous blood T1 measurement using inversion recovery true-FISP in children and adults. Magn Reson Med 2010; 64: 1140-1147.
37. Linderkamp O, Wu PY, Meiselman HJ., Geometry of neonatal and adult red blood cells. Pediatr Res 1983; 17: 250-253.
38. Zhang X, Petersen ET, Ghariq E, De Vis JB, Webb AG, Teeuwisse WM, Hendrikse J, van Osch MJ., In vivo blood T(1) measurements at 1.5 T, 3 T, and 7 T. Magn Reson Med 2013; 70: 1082-1086.