Multi-contrast imaging and digital refocusing on a mobile microscope with a domed LED array

PLoS ONE

Volumn 10, Issue 5, 2015, Pages

  Phillips, Zachary F ^a   D'Ambrosio, Michael V ^c   Tian, Lei ^b   Rulison, Jared J ^b   Patel, Hurshal S ^b   Sadras, Nitin ^b   Gande, Aditya V ^b   Switz, Neil A ^c   Fletcher, Daniel A ^c   Waller, Laura ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c University of California   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CLINICAL EFFECTIVENESS; CONTRAST ENHANCEMENT; CONTROLLED STUDY; DIGITAL REFOCUSING; ILLUMINATION; IMAGING AND DISPLAY; IMAGING SOFTWARE; LED ARRAY ILLUMINATOR; LIGHT EMITTING DIODE; MAGNIFICATION; MATHEMATICAL ANALYSIS; MEASUREMENT PRECISION; MICROSCOPE; MOBILE PHONE; MULTI CONTRAST IMAGING; DEVICES; EQUIPMENT DESIGN; FOURIER ANALYSIS; HUMAN; IMAGE PROCESSING; MICROSCOPY; POINT OF CARE SYSTEM; PROCEDURES; SMARTPHONE; SOFTWARE; STATISTICS AND NUMERICAL DATA; THREE DIMENSIONAL IMAGING;

EQUIPMENT DESIGN; FOURIER ANALYSIS; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; IMAGING, THREE-DIMENSIONAL; MICROSCOPY; POINT-OF-CARE SYSTEMS; SMARTPHONE; SOFTWARE;

EID: 84929377822     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0124938     Document Type: Article

References (38)

1. Zhu H, Yaglidere O, Su TW, Tseng D, Ozcan A. Cost-effective and compact wide-field fluorescent imaging on a cell-phone. Lab on a Chip. 2011; 11:315-322. doi: 10.1039/c0lc00358a PMID: 21063582
2. Switz NA, D'Ambrosio MV, Fletcher DA. Low-Cost Mobile Phone Microscopy with a Reversed Mobile Phone Camera Lens. PLOS ONE. 2014; 9(5):e95330. doi: 10.1371/journal.pone.0095330 PMID: 24854188
3. Smith ZJ, Chu K, Espenson AR, Rahimzadeh M, Gryshuk A, Molinaro M, et al. Cell-phone-based platform for biomedical device development and education applications. PLOS ONE. 2011; 6(3):e17150. doi: 10.1371/journal.pone.0017150 PMID: 21399693
4. Maamari RN, Keenan JD, Fletcher DA, Margolis TP. A mobile phone-based retinal camera for portable wide field imaging. British Journal of Ophthalmology. 2013; 98(4):438-441. doi: 10.1136/bjophthalmol-2013-303797 PMID: 24344230
5. Ozcan A. Mobile phones democratize and cultivate next-generation imaging, diagnos tics and measurement tools. Lab on a Chip. 2014; 14:3187-3194. doi: 10.1039/c4lc00010b PMID: 24647550
6. Vashist S, Mudanyali O, Schneider EM, Zengerle R, Ozcan A. Cellphone-based devices for bioanalytical sciences. Analytical and Bioanalytical Chemistry. 2014; 406(14):3263-3277. doi: 10.1007/s00216-013-7473-1 PMID: 24287630
7. Steenblik RA, Steenblik PH. Lenses and uses, including microscopes. Google Patents; 2005. US Patent 6,847,480.
8. Cybulski JS, Clements J, Prakash M. Foldscope: Origami-Based Paper Microscope. PLOS ONE. 2014 06; 9(6):e98781. doi: 10.1371/journal.pone.0098781 PMID: 24940755
9. Boppart SA, Richards-Kortum R. Point-of-care and point-of-procedure optical imaging technolo gies for primary care and global health. Science Translational Medicine. 2014; 6(253):253rv2-253rv2. doi: 10.1126/scitranslmed.3009725 PMID: 25210062
10. Greenbaum A, Zhang Y, Feizi A, Chung PL, Luo W, Kandukuri SR, et al. Wide-field computational imaging of pathology slides using lens-free on-chip microscopy. Science Translational Medicine. 2014; 6 (267):267ra175. Available from: http://stm.sciencemag.org/content/6/267/267ra175.abstract. doi: 10.1126/scitranslmed.3009850 PMID: 25520396
11. Mudanyali O, Tseng D, Oh C, Isikman SO, Sencan I, Bishara W, et al. Compact, light-weight and cost-effective microscope based on lensless incoherent holography for telemedicine applications. Lab on a Chip. 2010; 10(11):1417-1428. doi: 10.1039/c000453g PMID: 20401422
12. Tseng D, Mudanyali O, Oztoprak C, Isikman SO, Sencan I, Yaglidere O, et al. Lensfree microscopy on a cellphone. Lab on a Chip. 2010; 10(14):1787-1792. doi: 10.1039/c003477k PMID: 20445943
13. Breslauer DN, Maamari RN, Switz NA, Lam WA, Fletcher DA. Mobile Phone Based Clinical Microscopy for Global Health Applications. PLOS ONE. 2009; 4(7):e6320. doi: 10.1371/journal.pone.0006320 PMID: 19623251
14. Skandarajah A, Reber CD, Switz NA, Fletcher DA. Quantitative Imaging with a Mobile Phone Microscope. PLOS ONE. 2014; 9(5):e96906. doi: 10.1371/journal.pone.0096906 PMID: 24824072
15. Oncescu V, Mancuso M, Erickson D. Cholesterol testing on a smartphone. Lab on a Chip. 2015; 14 (4):759-763. doi: 10.1039/C3LC51194D
16. Pamplona VF, Mohan A, Oliveira MM, Raskar R. NETRA: interactive display for estimating refractive errors and focal range. ACM Transactions on Graphics (TOG). 2010; 29(4):77. doi: 10.1145/1778765. 1778814
17. Welch Allyn;. Available from: http://www.welchallyn.com/en/microsites/iexaminer.html.
18. Peek Vision;. Available from: http://www.peekvision.org/.
19. Zheng G, Kolner C, Yang C. Microscopy refocusing and dark-field imaging by using a simple LED array. Optics Letters. 2011; 36(20):3987-3989. doi: 10.1364/OL.36.003987 PMID: 22002361
20. Tian L, Wang J, Waller L. 3D differential phase-contrast microscopy with computational illumination using an LED array. Optics Letters. 2014; 39(5):1326-1329. doi: 10.1364/OL.39.001326 PMID: 24690738
21. Liu Z, Tian L, Liu S, Waller L. Real-time brightfield, darkfield, and phase contrast imaging in a light-emitting diode array microscope. Journal of Biomedical Optics. 2014; 19(10):106002. doi: 10.1117/1.JBO.19.10.106002 PMID: 25271540
22. Amos W, Reichelt S, Cattermole D, Laufer J. Re-evaluation of differential phase contrast (DPC) in a scanning laser microscope using a split detector as an alternative to differential interference contrast (DIC) optics. Journal of Microscopy. 2003; 210(2):166-175. doi: 10.1046/j.1365-2818.2003.01189.x PMID: 12753099
23. Mehta SB, Sheppard CJ. Quantitative phase-gradient imaging at high resolution with asymmetric illumination-based differential phase contrast. Optics Letters. 2009; 34(13):1924-1926. doi: 10.1364/OL.34.001924 PMID: 19571953
24. Ford TN, Chu KK, Mertz J. Phase-gradient microscopy in thick tissue with oblique backillumination. Nature Methods. 2012; 9(12):1195-1197. doi: 10.1038/nmeth.2219 PMID: 23103879
25. Popescu G, Park Y, Lue N, Best-Popescu C, Deflores L, Dasari RR, et al. Optical imaging of cell mass and growth dynamics. American Journal of Physiology-Cell Physiology. 2008; 295(2):C538-C544. doi: 10.1152/ajpcell.00121.2008 PMID: 18562484
26. Popescu G, Park Y, Choi W, Dasari RR, Feld MS, Badizadegan K. Imaging red blood cell dynamics by quantitative phase microscopy. Blood Cells, Molecules, and Diseases. 2008; 41(1):10-16. doi: 10.1016/j.bcmd.2008.01.010 PMID: 18387320
27. Curl C, Harris T, Harris P, Allman B, Bellair C, Stewart A, et al. Quantitative phase microscopy: a new tool for measurement of cell culture growth and confluency in situ. Pflgers Archiv. 2004; 448(4):462-468. doi: 10.1007/s00424-004-1248-7
28. Ng R, Levoy M, Bredif M, Duval G, Horowitz M, Hanrahan P. Light Field Photography with a Hand-held Plenoptic Camera. Stanford; 2005. CTSR 2005-02.
29. Tian L, Waller L. 3D intensity and phase imaging from light field measurements in an LED array microscope. Optica. 2015; 2(2):104-111. doi: 10.1364/OPTICA.2.000104
30. Dominguez D, Molina L, Desai DB, O'Loughlin T, Bernussi AA, de Peralta LG. Hemispherical digital optical condensers with no lenses, mirrors, or moving parts. Optics Express. 2014; 22(6):6948-6957. doi: 10.1364/OE.22.006948 PMID: 24664043
31. Brady D, Gehm M, Stack R, Marks D, Kittle D, Golish D, et al. Multiscale gigapixel photography. Nature. 2012; 486(7403):386-389. doi: 10.1038/nature11150 PMID: 22722199
32. Kachar B. Asymmetric illumination contrast: a method of image formation for video light microscopy. Science. 1985; 227(4688):766-768. doi: 10.1126/science.3969565 PMID: 3969565
33. Dodt HU, Eder M, Frick A, Zieglgnsberger W. Precisely Localized LTD in the Neocortex Revealed by Infrared-Guided Laser Stimulation. Science. 1999; 286(5437):110-113. doi: 10.1126/science.286.5437.110 PMID: 10506556
34. Hamilton D, Sheppard C. Differential phase contrast in scanning optical microscopy. Journal of Microscopy. 1984; 133(1):27-39. doi: 10.1111/j.1365-2818.1984.tb00460.x
35. Kak AC, Slaney M. Principle of Computerized Tomographic Imaging. Society for Industrial and Applied Mathematics; 2001.
36. Zheng G, Horstmeyer R, Yang C. Wide-field, high-resolution Fourier Ptychographic microscopy. Nature Photonics. 2013; 7(9):739-745. doi: 10.1038/nphoton.2013.187 PMID: 25243016
37. Dong S, Guo K, Nanda P, Shiradkar R, Zheng G. FPscope: a field-portable high-resolution microscope using a cellphone lens. Biomed Opt Express. 2014; 5(10):3305-3310. doi: 10.1364/BOE.5.003305 PMID: 25360351
38. Tian L, Li X, Ramchandran K, Waller L. Multiplexed coded illumination for Fourier Ptychography with an LED array microscope. Biomed Opt Express. 2014; 5(7):2376-2389. doi: 10.1364/BOE.5.002376 PMID: 25071971