Dose-dependent lipid peroxidation induction on ex vivo intestine tracts exposed to chyme samples from fumonisins contaminated corn samples

Toxicology in Vitro

Volumn 29, Issue 5, 2015, Pages 1140-1145

  Garbetta, A ^a   Debellis, L ^b   De Girolamo, A ^a   Schena, R ^a   Visconti, A ^a   Minervini, F ^a  

^a INSTITUTE OF SCIENCES OF FOOD PRODUCTION   (Italy)

^b UNIVERSITY OF BARI   (Italy)

Author keywords

Fumonisins; In vitro digestion; Lipid peroxidation; Rat intestine; Ussing chamber

Indexed keywords

FUMONISIN; MALONALDEHYDE; DRUG MIXTURE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; FEMALE; FOOD CONTAMINATION; GASTROINTESTINAL TRACT; IN VITRO STUDY; INCIDENCE; LIPID PEROXIDATION; MAIZE; MEMBRANE PERMEABILITY; NONHUMAN; OXYGEN DIFFUSION; RAT; ANIMAL; DRUG EFFECTS; DRUG MIXTURE; INTESTINE; METABOLISM; TOXICITY; WISTAR RAT;

FUSARIUM; RATTUS; ZEA MAYS;

ANIMALS; COMPLEX MIXTURES; FEMALE; FOOD CONTAMINATION; FUMONISINS; INTESTINES; LIPID PEROXIDATION; MALONDIALDEHYDE; RATS, WISTAR; ZEA MAYS;

EID: 84929377768     PISSN: 08872333     EISSN: 18793177     Source Type: Journal    
DOI: 10.1016/j.tiv.2015.04.018     Document Type: Article

References (29)

1. Abado-Becognee K., Mobio T.A., Ennamany R., Fleurat-Lessard F., Shier W.T., Badria F., Creppy E.E. Cytotoxicity of fumonisin B1: implication of lipid peroxidation and inhibition of protein and DNA syntheses. Arch. Toxicol. 1998, 72:233-236.
2. Ayala A., Munoz M.F., Arguelles S. Lipid peroxidation: production, metabolism and signaling mechanisms of malondialdehyde and 4-hydroxy-2-nonenal. Oxid. Med. Cell. Lonegev. 2014, 10.1155/2014/360438.
3. Basso K., Gomes F., Loureito Bracarense A.P. Deoxynivalenol and fumonisin, alone or in combination, induce changes on intestinal junction complexes and in E-cadherin expression. Toxins 2013, 5:2341-2352.
4. Bouhet S., Oswald I.P. The intestine as a possible target for fumonisin toxicity. Mol. Nutr. Food Res. 2007, 51:925-931.
5. Bouhet S., Hourcade E., Loiseau N., Fikry A., Martinez S., Roselli M., Galtier P., Mengheri E., Oswald I.P. The mycotoxin Fumonisin B1 alters the proliferation and the barrier function of porcine intestinal epithelial cells. Toxicol. Sci. 2004, 77:165-171.
6. Commission regulation (EC), 2007. No 1126/2007 of 28 September 2007 amending regulation (EC) n.81/2006 setting maximum levels for certain contaminants in foodstuffs as regards Fusarium toxins in maize and maize products. Off. J.E.U., L255/14.
7. Debellis L., Diana A., Arcidiacono D., Fioretto R., Altomare D.F., Spirlì C., de Bernard M. The Vibrio cholerae cytolysin promotes chloride secretion from intact human intestinal mucosa. PLoS One 2009, 4:e5074-e5083.
8. Ferrante M.C., Meli R., Mattace Raso G., Esposito E., Severino L., Di Carlo G., Lucisano A. Effect of fumonisin B1 on structure and function of macrophage plasma membrane. Toxicol. Lett. 2002, 129:181-187.
9. International Programme on Chemical Safety (IPCS) Environmental Health Criteria 219. Fumonisin B1 2000, World Health Organization, Geneva.
10. Klaric M.S., Pepeljnjak S., Domjian A.M., Petrik J. Lipid peroxidation and glutathione levels in porcine kidney PK15 cells after individual and combined treatment with fumonisin B1, beauvericin and ochratoxin A. Basic Clin. Pharmacol. Toxicol. 2007, 100:157-164.
11. Kouadio J.H., Mobio T.A., Baudrimont I., Moukha S., Dano S.D., Creppy E.E. Comparative study of cytotoxicity and oxidative stress induced by deoxynivalenol, zearalenone or fumonisin B1 in human intestinal cell line Caco-2. Toxicology 2005, 213:56-65.
12. Lallès J.P., Lessard M., Oswald I.P., David J.C. Consumption of fumonisin B1 for 9 days induces stress proteins along the gastrointestinal tract of pigs. Toxicon 2010, 55:244-249.
13. Liu M., Gao R., Meng Q., Zhang Y., Bi C., Shan A. Toxic effects of maternal zearalenone exposure on intestinal oxidative stress, barrier function, immunological and morphological changes in rats. PLoS One 2014, 9:e106412.
14. Mahfoud R., Maresca M., Santelli M., Pfohl-Leszkowicz A., Puigserver A., Fantini J. PH-dependent interaction of Fumonisin B1 with cholesterol: physicochemical and molecular modeling studies at the air-water interface. J. Agric. Food Chem. 2002, 50:327-331.
15. Meca G., Ruiz M.J., Fernandez-Franzon M., Ritieni A., Manes J. Isolation, purification, LC-MS/MS characterization and reactive oxygen species induced by fumonisin B1 in VERO cells. Food Chem. Toxicol. 2010, 48:2891-2897.
16. Minervini F., Debellis L., Garbetta A., De Girolamo A., Schena R., Portincasa P., Visconti A. Influence on functional parameters of intestinal tract induced by short-term exposure to fumonisins contaminated corn chyme samples. Food Chem. Toxicol. 2014, 66:166-172.
17. Minervini F., Garbetta A., D'Antuono I., Cardinali A., Martino N., Debellis L., Visconti A. Toxic mechanisms induced by fumonisin B1 mycotoxin on human intestinal cell line. Arch. Environ. Contam. Toxicol. 2014, 67:115-123.
18. Mobio T.A., Tavan E., Baudrimont I., Anane R., Carratù M.R., Sanni A., Gbeassor M.F., Shier T.W., Narbonne J.F., Creppy E.E. Comparative study of the toxic effects of fumonisin B1 in rat C6 glioma cells and p53-null mouse embryo fibroblasts. Toxicology 2003, 183:65-75.
19. Riley R.T., Enongene E., Voss K.A., Norred K.A., Meredith F.I., Sharma R.P., Spitsbergen J., Williams D.E., Carlson D.B., Merrill A.H. Sphingolipid perturbations as mechanisms for fumonisin carcinogenesis. Environ. Health Perspect. 2001, 109:301-308.
20. Schmelz E.M., Dombrink-Kurtzman M.A., Roberts P.C., Kozutsumi Y., Kawasaki, Merril A.H. Induction of apoptosis of fumonisin B1 in HT-29 cells is mediated by the accumulation of endogenous free sphingoid bases. Toxicol. Appl. Pharmacol. 1998, 148:252-260.
21. Shephard G.S., Thiel P.G., Sydenham E.W., Savard M.E. Fate of a single dose of 14C-labelled fumonisin B1 in vervet monkeys. Nat. Toxins 1995, 3:145-150.
22. Shier W.T. The fumonisin paradox: a review of research on oral bioavailability of fumonisin B1, a mycotoxin produced by Fusarium moniliforme. J. Toxicol.-Toxin Rev. 2000, 19:161-187.
23. Soriano J.M., Gonzalez L., Catala A.I. Mechanism of action of sphingolipids and their metabolites in the toxicity of fumonisin B1. Prog. Lipid Res. 2005, 44:345-356.
24. Theumer M.G., Clop E.M., Rubinstein H.R., Perillo M.A. The lipid-mediated hypothesis of fumonisin B1 toxicodynamics tested in model membrane. Colloids Surf. Biointerfaces 2008, 64:22-33.
25. Voss K.A., Smith G.W., Haschek W.M. Fumonisins: toxicokinetics, mechanism of action and toxicity. Anim. Feed Sci. Technol. 2007, 137:299-325.
26. World Health Organization (WHO) and International Agency for Research on Cancer (IARC) Monographs on the evaluation of carcinogenic risk to humans. Some naturally occurring substances: food items and constituents, heterocyclic aromatic amines and mycotoxins 1993, IARC, Lyon, pp. 445-466.
27. Wu Q.-H., Wang X., Yang W., Nussler A.K., Xiong L.Y., Kuca K., Dohnal V., Zhang X.J., Yuan Z.H. Oxidative stress-mediated cytotoxicity and metabolism of T-2 toxin and deoxynivalenol in animals and humans: an update. Arch. Toxicol 2014, 88:1309-1326.
28. Yin J.J., Smith M.H., Eppley R.M., Page S.W., Sphon J.A. Effects of fumonisin B1 on lipid peroxidation in membranes. Biochim. Biophys. Acta 1998, 1371:134-142.
29. Yin J.J., Smith M.J., Eppley R.M., Troy A.L., Page S.W., Sphon J.A. Effects of fumonisin B1 and (hydrolyzed) fumonisin backbone AP1 on membranes: a spin-label study. Arch. Biochem. Biophys. 1996, 335:13-22.