Molecular and genetic analyses of collagen type IV mutant mouse models of spontaneous intracerebral hemorrhage identify mechanisms for stroke prevention

Circulation

Volumn 131, Issue 18, 2015, Pages 1555-1565

  Jeanne, Marion ^a   Jorgensen, Jeff ^a   Gould, Douglas B ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Cerebrovascular disorders; Collagen; Genetics; Hemorrhage; Stroke

Indexed keywords

4 PHENYLBUTYRIC ACID; COLLAGEN TYPE 4; COLLAGEN TYPE 4 ALPHA1; COLLAGEN TYPE 4 ALPHA2; CRE RECOMBINASE; HEMOSIDERIN; TAMOXIFEN; UNCLASSIFIED DRUG; WARFARIN; COL4A2 PROTEIN, MOUSE; COLLAGEN; PEPTIDE FRAGMENT;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTICOAGULATION; ARTICLE; BLOOD CLOTTING; BRAIN HEMATOMA; BRAIN HEMORRHAGE; BRAIN HISTOLOGY; CEREBROVASCULAR ACCIDENT; CONTROLLED STUDY; DISEASE SEVERITY; DNA MODIFICATION; EMBRYO; EMBRYO DEVELOPMENT; ENVIRONMENTAL FACTOR; EXERCISE; FEMALE; FIBROBLAST; GENE MUTATION; GENETIC ANALYSIS; GENETIC HETEROGENEITY; IN VIVO STUDY; LOXP SITE; MISSENSE MUTATION; MOUSE; NONHUMAN; PHENOTYPE; PORENCEPHALY; PRIORITY JOURNAL; PROTEIN FOLDING; ANIMAL; BLOOD BRAIN BARRIER; BLOOD VESSEL; BRAIN; C57BL MOUSE; CEREBRAL HEMORRHAGE; CONGENITAL MALFORMATION; DEFICIENCY; DISEASE MODEL; EMBRYOLOGY; ENDOTHELIUM CELL; GENETICS; GENOTYPE ENVIRONMENT INTERACTION; MALE; METABOLISM; MUTANT MOUSE STRAIN; MUTATION; PERICYTE; PHYSIOLOGY; RETINA BLOOD VESSEL; VASCULARIZATION;

ANIMALS; BLOOD VESSELS; BLOOD-BRAIN BARRIER; BRAIN; CEREBRAL HEMORRHAGE; COLLAGEN; COLLAGEN TYPE IV; DISEASE MODELS, ANIMAL; ENDOTHELIAL CELLS; FEMALE; GENE-ENVIRONMENT INTERACTION; GENETIC HETEROGENEITY; MALE; MICE; MICE, INBRED C57BL; MICE, MUTANT STRAINS; MUTATION; NEOVASCULARIZATION, PHYSIOLOGIC; PEPTIDE FRAGMENTS; PERICYTES; PHENOTYPE; PHYSICAL CONDITIONING, ANIMAL; PORENCEPHALY; RETINAL VESSELS;

EID: 84929359436     PISSN: 00097322     EISSN: 15244539     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.114.013395     Document Type: Article

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