Anti-ganglioside antibodies induce nodal and axonal injury via Fcγ receptor-mediated inflammation

Journal of Neuroscience

Volumn 35, Issue 17, 2015, Pages 6770-6785

  He, Lan ^a   Zhang, Gang ^a   Liu, Weiqiang ^a   Gao, Tong ^a   Sheikh, Kazim A ^a  

^a UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

Author keywords

Anti ganglioside antibody; Blood nerve barrier; Fcgammareceptors; Guillain Barr syndrome; Macrophage; Nodal and axonal injury

Indexed keywords

FC RECEPTOR; GANGLIOSIDE ANTIBODY; (N-ACETYLNEURAMINYL)-GALACTOSYLGLUCOSYLCERAMIDE N-ACETYLGALACTOSAMINYLTRANSFERASE; COLONY STIMULATING FACTOR 1; COMPLEMENT COMPONENT C5; FCGR1 PROTEIN, MOUSE; FCGR2B PROTEIN, MOUSE; GANGLIOSIDE; MONOCLONAL ANTIBODY; N ACETYLGALACTOSAMINYLTRANSFERASE;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AXONAL INJURY; BRAIN ELECTROPHYSIOLOGY; EXPERIMENTAL BEHAVIORAL TEST; FEMALE; FLUORESCENCE MICROSCOPY; GUILLAIN BARRE SYNDROME; HUMAN; IMAGE ANALYSIS; IMMUNOCYTOCHEMISTRY; IMMUNOHISTOCHEMISTRY; INFLAMMATION; MORPHOMETRICS; MOUSE; NERVE DEGENERATION; NERVE TRANSECTION; NERVOUS SYSTEM INJURY; NODAL INJURY; NONHUMAN; PRIORITY JOURNAL; WESTERN BLOTTING; ACTION POTENTIAL; ANIMAL; BLOOD; C57BL MOUSE; COMPLICATION; DISEASE MODEL; DRUG EFFECTS; GENETICS; HYPERALGESIA; IMMUNOLOGY; METABOLISM; NERVE CONDUCTION; NEUROGENIC INFLAMMATION; PAIN THRESHOLD; PATHOLOGY; PATHOPHYSIOLOGY; PERIPHERAL NERVE INJURIES; PHYSIOLOGY; SCIATIC NERVE; SPINAL NERVE; TRANSGENIC MOUSE;

ACTION POTENTIALS; ANIMALS; ANTIBODIES, MONOCLONAL; COMPLEMENT C5; DISEASE MODELS, ANIMAL; FEMALE; GANGLIOSIDES; HUMANS; HYPERALGESIA; MACROPHAGE COLONY-STIMULATING FACTOR; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; N-ACETYLGALACTOSAMINYLTRANSFERASES; NEURAL CONDUCTION; NEUROGENIC INFLAMMATION; PAIN THRESHOLD; PERIPHERAL NERVE INJURIES; RECEPTORS, IGG; SCIATIC NERVE; SPINAL NERVES;

EID: 84929347113     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.4926-14.2015     Document Type: Article

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