Simultaneous determination of seven anthraquinones in rat plasma by Ultra High Performance Liquid Chromatography-tandem Mass Spectrometry and pharmacokinetic study after oral administration of Semen Cassiae extract

Journal of Ethnopharmacology

Volumn 169, Issue , 2015, Pages 305-313

  Yang, Chunjuan ^a   Wang, Shuhong ^a   Guo, Xiaowei ^a   Sun, Jiahui ^a   Liu, Lu ^a   Wu, Lijun ^a  

^a HARBIN MEDICAL UNIVERSITY   (China)

Author keywords

Anthraquinones; Pharmacokinetics; Rat plasma; Semen Cassiae; UHPLC MS MS

Indexed keywords

ALOE EMODIN; ANTHRAQUINONE DERIVATIVE; AURANTIO OBTUSIN; BUTYL PARABEN; CASSIA EXTRACT; CHRYSOPHANIC ACID; EMODIN; OBTUSIFOLIN; PHYSCION; RHEIN; SEMEN CASSIAE EXTRACT; UNCLASSIFIED DRUG; PLANT EXTRACT;

ANALYTIC METHOD; ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG ELIMINATION; DRUG HALF LIFE; DRUG ISOLATION; DRUG STABILITY; DRUG STRUCTURE; ELECTROSPRAY; IONIZATION; LIMIT OF QUANTITATION; MALE; MAXIMUM PLASMA CONCENTRATION; MULTIPLE REACTION MONITORING; NONHUMAN; PHARMACOKINETICS; PLASMA CONCENTRATION-TIME CURVE; RAT; TANDEM MASS SPECTROMETRY; TIME TO MAXIMUM PLASMA CONCENTRATION; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; ANIMAL; BLOOD; CASSIA; CHEMISTRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ORAL DRUG ADMINISTRATION; PLANT SEED;

ALOE; FABACEAE; RATTUS; SENNA OBTUSIFOLIA;

ADMINISTRATION, ORAL; ANIMALS; ANTHRAQUINONES; CASSIA; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; MALE; PLANT EXTRACTS; RATS; SEEDS; TANDEM MASS SPECTROMETRY;

EID: 84929333622     PISSN: 03788741     EISSN: 18727573     Source Type: Journal    
DOI: 10.1016/j.jep.2015.04.008     Document Type: Article

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