TGF-β mediates CTLA-4 suppression of cellular immunity in murine kalaazar

Journal of Immunology

Volumn 164, Issue 4, 2000, Pages 2001-2008

  Gomes, Nitza A ^a   Gattass, Cerli R ^a   Barreto De Souza, Victor ^a   Wilson, Mary E ^b   DosReis, George A ^a  

^a FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^b UNIVERSITY OF IOWA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; GAMMA INTERFERON; OKT 4; RECOMBINANT TRANSFORMING GROWTH FACTOR BETA1; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELLULAR IMMUNITY; CONTROLLED STUDY; CROSS LINKING; CYTOKINE PRODUCTION; FEMALE; HOST RESISTANCE; IMMUNOPATHOGENESIS; INTERFERON PRODUCTION; LEISHMANIA CHAGASI; LEISHMANIASIS; MACROPHAGE; MALE; MOUSE; NONHUMAN; PARASITE DEVELOPMENT; PRIORITY JOURNAL; SPLEEN CELL; T LYMPHOCYTE ACTIVATION;

EID: 0034651999     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.164.4.2001     Document Type: Article

References (37)

1. Sperling, A. I., and J. L. Bluestone. 1996. The complexities of T-cell costimulation: CD28 and beyond. Immunol. Rev. 153:155.
2. Thompson, C. B., and J. P. Allison. 1997. The emerging role of CTLA-4 as an immune attenuator. Immunity. 7:445.
3. Waterhouse, P., J. M. Penning, E. Timms, A. Wakeham, A. Shahinian, K. Lee, C. B. Thompson, H. Griesser, and T. W. Mak. 1995. Lymphoproliferative disorders with early lethality in mice deficient in CTLA-4. Science 270:985.
4. Tivol, E. A., F. Borriello, A. N. Schweitzer, W. P. Lynch, J. A. Bluestone, and A. H. Sharpe. 1995. Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4. Immunity 3:541.
5. + T cells. J. Exp. Med. 188:1849.
6. Bright, J. J., L. D. Kerr, and S. Sriram. 1997. TGF-β inhibits IL-2-induced tyrosine phosphorylation and activation of Jak-1 and Stat 5 in T lymphocytes. J. Immunol. 159:175.
7. Kehrl, J. H., L. M. Wakefield, A. Roberts, B. Jakowlew, S.M. Alvarez-Mon, R. Derynck, M. B. Sporn, and A. S. Fauci. 1986. Production of TGF-β by human T lymphocytes and its potential role in the regulation of T cell growth. J. Exp. Med. 163:1037.
8. Barral-Netto, M., A. Barral, C. E. Brownell, Y. A. Skeiky, L. R. Ellingsworth, D. R. Twardzik, and S. G. Reed. 1992. Transforming growth factor-β in leishmanial infection: a parasite escape mechanism. Science 257:545.
9. Brandes, M. E., Allen, J. B., Ogawa, Y., and Wahl, S. M. 1991. Transforming growth factor β1 suppresses acute and chronic arthritis in experimental animals. J. Clin. Invest. 87:1108.
10. Shull, M. M., I. Ormsby, A. B. Kier, S. Pawlowski, R. J. Diebold, M. Yin, R. Allen, C. Sidman, G. Proetzel, D. Calvin, N. Annunziata, and T. Doetschmann. 1992. Targeted disruption of the mouse transforming growth factor-β1 gene results in multifocal inflammatory disease. Nature 359:693.
11. Carvalho E. M., R. Badaró, S. G. Reed, T. C. Jones, and W. D. Johnson. 1985. Absence of γ-interferon and interleukin 2 production during active visceral leishmaniasis. J. Clin. Invest. 76:2066.
12. Murphy, M. L., S. E. J. Cotterell, P. M. A. Gorak, C. R. Engwerda, and P. M. Kaye. 1998. Blockade of CTLA-4 enhances host resistance to the intracellular pathogen, Leishmania donovani. J. Immunol. 161:4153.
13. + T lymphocytes from Leishmania chagasi-infected mice increase cytokine production and mediate parasite killing after blockade of B7-1/ CTLA-4 molecular pathway. J. Infect. Dis. 178:1847.
14. Barral, A., M. Barral-Netto, E. C. Yong, C. E. Brownell, D. R. Twardzik, and S. G. Reed. 1993. Transforming growth factor β as a virulence mechanism for Leishmania braziliensis. Proc. Natl. Acad. Sci. USA 90:3442.
15. Li, J., C. A. Hunter, and J. P. Farrell. 1999. Anti-TGF-β treatment promotes rapid healing of Leishmania major infection in mice by enhancing in vivo nitric oxide production. J. Immunol. 162:974.
16. Wilson, M. E., B. M. Young, B. L. Davidson, K. A. Mente, and S. E. McGowan. 1998. The importance of TGF-β in murine visceral leishmaniasis. J. Immunol. 161:6148.
17. Rodrigues, V. Jr., J. Santana da Silva, and A. Campos-Neto. 1998. Transforming growth factor β and immunosuppression in experimental visceral leishmaniasis. Infect. Immun. 66:1233.
18. Laurenti, M. D., C. E. P. Corbett, M. N. Sotto, I. L. Sinhorini, and H. Goto. 1996. The role of complement in the acute inflammatory process in the skin and in host-parasite interaction in hamsters inoculated with Leishmania (Leishmania) chagasi. Int. J. Exp. Pathol. 77:15.
19. Kaye, P. M., A. J. Curry, and J. M. Blackwell. 1991. Differential production of Th1-and Th2-derived cytokines does not determine the genetically controlled or vaccine-induced rate of cure in murine visceral leishmaniasis. J. Immunol. 146: 2763.
20. + T lymphocytes from infected hosts. J. Immunol. 160:1313.
21. Krummel, M. F., and J. P. Allison. 1995. CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation. J. Exp. Med. 182:459.
22. Wilson, M. E., B. M. Young, K. Paetz Andersen, J. V. Weinstock, A. Metwali, K. M. Ali, and J. E. Donelson. 1995. A recombinant Leishmania chagasi antigen that stimulates cellular immune responses in infected mice. Infect. Immun. 63: 2062.
23. Lima, H. C., J. A. Bleyenberg, and R. G. Titus. 1997. A simple method for quantifying Leishmania in tissues of infected animals. Parasitol. Today 13:80.
24. Alegre, M. L., H. Shiels, C. B. Thompson, and T. F. Gajewski. 1998. Expression and function of CTLA-4 in Th1 and Th2 cells. J. Immunol. 161:3347.
25. Fox, F. E., R. J. Capocasale, H. C. Ford, R. J. Lamb, J. S. Moore, and P. C. Nowell. 1992. Transforming growth factor-β inhibits human T cell proliferation through multiple targets. Lymphokine Cytokine Res. 11:299.
26. + T cells requires the coordinate action of interleukin-12 and IFN-γ and is inhibited by TGF-β. Eur. J. Immunol. 24:793.
27. Bright, J. J., and S. Sriram. 1998. TGF-β inhibits IL-12-induced activation of Jak-STAT pathway in T lymphocytes. J. Immunol. 161:1772.
28. Murphy, M. L., C. R. Engwerda, P. M. Gorak, and P. M. Kaye. 1997. B7-2 blockade enhances T cell responses to Leishmania donovani. J. Immunol. 159: 4460.
29. Karandikar, N. J., C. L. Vanderlugt, T. Eagar, L. Tan, J. A. Bluestone, and S. D. Miller. 1998. Tissue specific up-regulation of B7-1 expression and function during the course of murine relapsing experimental autoimmune encephalomyelitis. J. Immunol. 161:192.
30. Brown, J. A., R. G. Titus, N. Nabavi, and L. H. Glimcher. 1996. Blockade of CD86 ameliorates Leishmania major infection by down-regulating the Th2 response. J. Infect. Dis. 174:1303.
31. Elloso, M. M., and P. Scott. 1999. Expression and contribution of B7-1 (CD80) and B7-2 (CD86) in the early immune response to Leishmania major infection. J. Immunol. 162:6708.
32. Corry, D. B., S. L. Reiner, P. S. Linsley, and R. M. Locksley. 1994. Differential effects of blockade of CD28-B7 on the development of Th1 or Th2 effector cells in experimental leishmaniasis. J. Immunol. 153:4142.
33. Metz, D. P., D. L. Farber, T. Taylor, and K. Bottomly. 1998. Differential role of CTLA-4 in regulation of resting memory versus naive CD4 T cell activation. J. Immunol. 161:5855.
34. + T cells: IL-4 and IFN-γ have opposing effects, while TGF-β positively regulates its own production. J. Immunol. 160:5719.
35. Saha, B., G. Das, H. Vohra, N. K. Ganguly, and G. C. Mishra. 1995. Macrophage-T cell interaction in experimental visceral leishmaniasis: failure to express costimulatory molecules on Leishmania-infected macrophages and its implication in the suppression of cell-mediated immunity. Eur. J. Immunol. 25:2492.
36. Perez, V. L., L. Van Parijs, A. Biuckians, X. X. Zheng, T. B. Strom, and A. K. Abbas. 1997. Induction of peripheral T cell tolerance in vivo requires CTLA-4 engagement. Immunity 6:411.
37. Genestier, L., S. Kasibhatla, T. Brunner, and D. R. Green. 1999. Transforming growth factor β1 inhibits Fas ligand expression and subsequent activation-induced cell death in T cells via downregulation of c-Myc. J. Exp. Med. 189:231.