Ultrasound assessment of carotid plaque echogenicity response to statin therapy: A systematic review and meta-analysis

International Journal of Molecular Sciences

Volumn 16, Issue 5, 2015, Pages 10734-10747

  Ibrahimi, Pranvera ^a   Jashari, Fisnik ^a   Bajraktari, Gani ^a   Wester, Per ^a   Henein, Michael Y ^a  

^a UMEÅ UNIVERSITY   (Sweden)

Author keywords

Carotid atherosclerosis; Plaque echogenicity; Statins; Ultrasound

Indexed keywords

ATORVASTATIN; C REACTIVE PROTEIN; HIGH DENSITY LIPOPROTEIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; LOW DENSITY LIPOPROTEIN; PITAVASTATIN; PRAVASTATIN; ROSUVASTATIN; SIMVASTATIN;

ARTICLE; ASSESSMENT OF HUMANS; CAROTID ATHEROSCLEROSIS; DRUG EFFECT; ECHOGRAPHY; GREY SCALE MEDIAN ANALYSIS; HUMAN; INTEGRATED BACKSCATTER ANALYSIS; META ANALYSIS; RANDOMIZED CONTROLLED TRIAL (TOPIC); SYSTEMATIC REVIEW; CAROTID STENOSIS; COMPLICATION; DIAGNOSTIC IMAGING; HYPERCHOLESTEROLEMIA; PUBLISHING; REGRESSION ANALYSIS; ULTRASOUND;

CAROTID STENOSIS; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; HYPERCHOLESTEROLEMIA; PUBLICATION BIAS; REGRESSION ANALYSIS; ULTRASONICS; ULTRASONOGRAPHY;

EID: 84929310717     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms160510734     Document Type: Article

References (35)

1. Ibrahimi, P.; Jashari, F.; Nicoll, R.; Bajraktari, G.; Wester, P.; Henein, M.Y. Coronary and carotid atherosclerosis: How useful is the imaging? Atherosclerosis 2013, 231, 323–333.
2. Amarenco, P.; Labreuche, J.; Lavallee, P.; Touboul, P.J. Statins in stroke prevention and carotid atherosclerosis: Systematic review and up-to-date meta-analysis. Stroke J. Cereb. Circ. 2004, 35, 2902–2909.
3. Martinez-Sanchez, P.; Serena, J.; Alexandrov, A.V.; Fuentes, B.; Fernandez-Dominguez, J.; Diez-Tejedor, E. Update on ultrasound techniques for the diagnosis of cerebral ischemia. Cerebrovasc. Dis. 2009, 27, 9–18.
4. Seeger, J.M.; Barratt, E.; Lawson, G.A.; Klingman, N. The relationship between carotid plaque composition and neurologic symptoms. J. Surg. Res. 1987, 43, 78–85.
5. Gronholdt, M.L.; Nordestgaard, B.G.; Bentzon, J.; Wiebe, B.M.; Zhou, J.; Falk, E.; Sillesen, H. Macrophages are associated with lipid-rich carotid artery plaques, echolucency on B-mode imaging, and elevated plasma lipid levels. J. Vasc. Surg. 2002, 35, 137–145.
6. El-Barghouty, N.M.; Levine, T.; Ladva, S.; Flanagan, A.; Nicolaides, A. Histological verification of computerised carotid plaque characterisation. Eur. J. Vasc. Endovasc. Surg. 1996, 11, 414–416.
7. Makris, G.C.; Lavida, A.; Nicolaides, A.N.; Geroulakos, G. The effect of statins on carotid plaque morphology: A LDL-associated action or one more pleiotropic effect of statins? Atherosclerosis 2010, 213, 8–20.
8. Noyes, A.M.; Thompson, P.D. A systematic review of the time course of atherosclerotic plaque regression. Atherosclerosis 2014, 234, 75–84.
9. Lind, L.P.S.; den Ruijter, H.M.; Palmer, M.K.; Grobbee, D.E.; Crouse, J.R., 3rd; O’Leary, D.H.; Evans, G.W.; Raichlen, J.S.; Bots, M.L. Effect of rosuvastatin on the echolucency of the common carotid intima-media in low-risk individuals: The METEOR trial. J. Am. Soc. Echocardiogr. 2012, 25, 1120–1127.
10. Yamagishi, T.; Kato, M.; Koiwa, Y.; Omata, K.; Hasegawa, H.; Kanai, H. Evaluation of plaque stabilization by fluvastatin with carotid intima-medial elasticity measured by a transcutaneous ultrasonic-based tissue characterization system. J. Atheroscler. Thromb. 2009, 16, 662–673.
11. Stivali, G.; Cerroni, F.; Bianco, P.; Fiaschetti, P.; Cianci, R. Images in cardiovascular medicine. Carotid plaque reduction after medical treatment. Circulation 2005, 112, e276–e277.
12. Watanabe, K.; Sugiyama, S.; Kugiyama, K.; Honda, O.; Fukushima, H.; Koga, H.; Horibata, Y.; Hirai, T.; Sakamoto, T.; Yoshimura, M, et al. Stabilization of carotid atheroma assessed by quantitative ultrasound analysis in nonhypercholesterolemic patients with coronary artery disease. J. Am. Coll. Cardiol. 2005, 46, 2022–2030.
13. Yamagami, H.; Sakaguchi, M.; Furukado, S.; Hoshi, T.; Abe, Y.; Hougaku, H.; Hori, M.; Kitagawa, K. Statin therapy increases carotid plaque echogenicity in hypercholesterolemic patients. Ultrasound Med. Biol. 2008, 34, 1353–1359.
14. Nakamura, T.; Obata, J.E.; Kitta, Y.; Takano, H.; Kobayashi, T.; Fujioka, D.; Saito, Y.; Kodama, Y.; Kawabata, K.; Mende, A, et al. Rapid stabilization of vulnerable carotid plaque within 1 month of pitavastatin treatment in patients with acute coronary syndrome. J. Cardiovasc. Pharmacol. 2008, 51, 365–371.
15. Kadoglou, N.P.; Gerasimidis, T.; Moumtzouoglou, A.; Kapelouzou, A.; Sailer, N.; Fotiadis, G.; Vitta, I.; Katinios, A.; Kougias, P.; Bandios, S, et al. Intensive lipid-lowering therapy ameliorates novel calcification markers and GSM score in patients with carotid stenosis. Eur. J. Vasc. Endovasc. Surg. 2008, 35, 661–668.
16. Yamada, K.; Yoshimura, S.; Kawasaki, M.; Enomoto, Y.; Asano, T.; Minatoguchi, S.; Iwama, T. Effects of atorvastatin on carotid atherosclerotic plaques: A randomized trial for quantitative tissue characterization of carotid atherosclerotic plaques with integrated backscatter ultrasound. Cerebrovasc. Dis. 2009, 28, 417–424.
17. Kadoglou, N.P.; Gerasimidis, T.; Kapelouzou, A.; Moumtzouoglou, A.; Avgerinos, E.D.; Kakisis, J.D.; Karayannacos, P.E.; Liapis, C.D. Beneficial changes of serum calcification markers and contralateral carotid plaques echogenicity after combined carotid artery stenting plus intensive lipid-lowering therapy in patients with bilateral carotid stenosis. Eur. J. Vasc. Endovasc. Surg. 2010, 39, 258–265.
18. Kadoglou, N.P.; Moumtzouoglou, A.; Kapelouzou, A.; Gerasimidis, T.; Liapis, C.D. Aggressive lipid-lowering is more effective than moderate lipid-lowering treatment in carotid plaque stabilization. J. Vasc. Surg. 2010, 55, 114–121.
19. Della-Morte, D.; Moussa, I.; Elkind, M.S.; Sacco, R.L.; Rundek, T. The short-term effect of atorvastatin on carotid plaque morphology assessed by computer-assisted gray-scale densitometry: A pilot study. Neurol. Res. 2011, 33, 991–994.
20. Nohara, R.; Daida, H.; Hata, M.; Kaku, K.; Kawamori, R.; Kishimoto, J.; Kurabayashi, M.; Masuda, I.; Sakuma, I.; Yamazaki, T, et al. Effect of long-term intensive lipid-lowering therapy with rosuvastatin on progression of carotid intima-media thickness—Justification for atherosclerosis regression treatment (JART) extension study. Circ. J. 2013, 77, 1526–1533.
21. Jashari, F.; Ibrahimi, P.; Nicoll, R.; Bajraktari, G.; Wester, P.; Henein, M.Y. Coronary and carotid atherosclerosis: Similarities and differences. Atherosclerosis 2013, 227, 193–200.
22. Nicolaides, A.N.; Kyriacou, E.; Griffin, M.; Sabetai, M.; Thomas, D.J.; Tegos, T.; Geroulakos, G.; Labropoulos, N.; Doré, C.J.; Morris, T.P, et al. Asymptomatic internal carotid artery stenosis and cerebrovascular risk stratification. J. Vasc. Surg. 2010, 52, 1486–1496.
23. Ibrahimi, P.; Jashari, F.; Johansson, E.; Gronlund, C.; Bajraktari, G.; Wester, P.; Henein, M.Y. Vulnerable plaques in the contralateral carotid arteries in symptomatic patients: A detailed ultrasound analysis. Atherosclerosis 2014, 235, 526–531.
24. Sztajzel, R.; Momjian-Mayor, I.; Comelli, M.; Momjian, S. Correlation of cerebrovascular symptoms and microembolic signals with the stratified gray-scale median analysis and color mapping of the carotid plaque. Stroke J. Cereb. Circ. 2006, 37, 824–829.
25. Aburahma, A.F.; Thiele, S.P.; Wulu, J.T., Jr. Prospective controlled study of the natural history of asymptomatic 60% to 69% carotid stenosis according to ultrasonic plaque morphology. J. Vasc. Surg. 2002, 36, 437–442.
26. Takemoto, M.; Liao, J.K. Pleiotropic effects of 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitors. Arterioscler. Thromb. Vasc. Biol. 2001, 21, 1712–1719.
27. Schmermund, A.A.S.; Budde, T.; Buziashvili, Y.; Förster, A.; Friedrich, G.; Henein, M.; Kerkhoff, G.; Knollmann, F.; Kukharchuk, V.; Lahiri, A, et al. Effect of intensive versus standard lipid-lowering treatment with atorvastatin on the progression of calcified coronary atherosclerosis over 12 months: A multicenter, randomized, double-blind trial. Circulation 2006, 113, 427–437.
28. Henein, M.; Granåsen, G.; Wiklund, U.; Schmermund, A.; Guerci, A.; Erbel, R.; Raggi, P. High dose and long-term statin therapy accelerate coronary artery calcification. Int. J. Cardiol. 2015, 184, 581–586.
29. Coll, B.; Feinstein, S.B. Carotid intima-media thickness measurements: Techniques and clinical relevance. Curr. Atheroscler. Rep. 2008, 10, 444–450.
30. Silva, M.A.; Swanson, A.C.; Gandhi, P.J.; Tataronis, G.R. Statin-related adverse events: A meta-analysis. Clin. Ther. 2006, 28, 26–35.
31. Jukema, J.W.; Cannon, C.P.; de Craen, A.J.; Westendorp, R.G.; Trompet, S. The controversies of statin therapy: Weighing the evidence. J. Am. Coll. Cardiol. 2012, 60, 875–881.
32. Sattar, N.; Preiss, D.; Murray, H.M.; Welsh, P.; Buckley, B.M.; de Craen, A.J.; Seshasai, S.R.; McMurray, J.J.; Freeman, D.J.; Jukema, J.W, et al. Statins and risk of incident diabetes: A collaborative meta-analysis of randomised statin trials. Lancet 2010, 375, 735–742.
33. Preiss, D.; Seshasai, S.R.; Welsh, P.; Murphy, S.A.; Ho, J.E.; Waters, D.D.; DeMicco, D.A.; Barter, P.; Cannon, C.P.; Sabatine, M.S, et al. Risk of incident diabetes with intensive-dose compared with moderate-dose statin therapy: A meta-analysis. JAMA 2011, 305, 2556–2564.
34. Liberati, A.A.D.; Tetzlaff, J.; Mulrow, C.; Gøtzsche, P.C.; Ioannidis, J.P.; Clarke, M.; Devereaux, P.J.; Kleijnen, J.; Moher, D. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: Explanation and elaboration. PLoS Med. 2009, 6, 1–28.
35. Slim, K.; Nini, E.; Forestier, D.; Kwiatkowski, F.; Panis, Y.; Chipponi, J. Methodological index for non-randomized studies (MINORS): Development and validation of a new instrument. ANZ J. Surg. 2003, 73, 712–716.