A randomised controlled trial comparing duloxetine and acetyl L-carnitine in fibromyalgic patients: Preliminary data

Clinical and Experimental Rheumatology

Volumn 33, Issue , 2015, Pages S82-S85

  Leombruni, Paolo ^a   Miniotti, Marco ^a   Colonna, Fabrizio ^a   Sica, Chiara ^a   Castelli, Lorys ^a   Bruzzone, Maria ^b   Parisi, Simone ^b   Fusaro, Enrico ^b   Sarzi Puttini, Piercarlo ^c   Atzeni, Fabiola ^d   Torta, Riccardo G ^a  

^a UNIVERSITY OF TURIN   (Italy)

^b CITTÀ DELLA SALUTE E DELLA SCIENZA HOSPITAL   (Italy)

^c UNIVERSITY OF MILAN   (Italy)

^d IRCCS ISTITUTO ORTOPEDICO GALEAZZI   (Italy)

Author keywords

Acetyl L carnitine; Duloxetine; Fibromyalgia; RCT

Indexed keywords

DULOXETINE; LEVACECARNINE; ACETYLCARNITINE; ANALGESIC AGENT; ANTIDEPRESSANT AGENT; THIOPHENE DERIVATIVE;

ABSENCE OF SIDE EFFECTS; ADULT; ANXIETY; ARTICLE; CONTROLLED STUDY; DEPRESSION; DIARRHEA; DRUG EFFICACY; DRUG RESPONSE; DRUG SAFETY; FEMALE; FIBROMYALGIA; GENERAL CONDITION IMPROVEMENT; HUMAN; INSOMNIA; MAJOR CLINICAL STUDY; MIDDLE AGED; NAUSEA; PRIORITY JOURNAL; QUALITY OF LIFE; RANDOMIZED CONTROLLED TRIAL; TREATMENT OUTCOME; UNSPECIFIED SIDE EFFECT; WELLBEING; COMPARATIVE STUDY; ITALY; PAIN; PAIN MEASUREMENT; PATHOPHYSIOLOGY; PROSPECTIVE STUDY; PSYCHOLOGICAL RATING SCALE; PSYCHOLOGY; TIME;

ACETYLCARNITINE; ADULT; ANALGESICS; ANTIDEPRESSIVE AGENTS; DEPRESSION; FEMALE; FIBROMYALGIA; HUMANS; ITALY; MIDDLE AGED; PAIN; PAIN MEASUREMENT; PROSPECTIVE STUDIES; PSYCHIATRIC STATUS RATING SCALES; QUALITY OF LIFE; THIOPHENES; TIME FACTORS; TREATMENT OUTCOME;

EID: 84929289921     PISSN: 0392856X     EISSN: 1593098X     Source Type: Journal    
DOI: None     Document Type: Article

References (26)

1. WOLFE F, SMYTHE HA, YUNUS MB et al.: The American College of Rheumatology 1990 criteria for the classification of fibromyalgia. Report of the Multicenter Criteria Committee. Arthritis Rheum 1990; 33: 160-72.
2. WOLFE F, CLAUW DJ, FITZCHARLES MA et al.: The American College of Rheumatology preliminary diagnostic criteria for fibromyalgia and measurement of symptom severity. Arthritis Care Res 2010; 62: 600-10.
3. STAUD R, RODRIGUEZ ME: Mechanisms of disease: pain in fibromyalgia syndrome. Nat Clin Pract Rheumatol 2006; 2: 90-8.
4. CASSISI G, SARZI-PUTTINI P, ALCIATI A et al.: Symptoms and signs in fibromyalgia syndrome. Reumatismo 2008; (Suppl. 1): 15-24.
5. FATIMA G, DAS SK, MAHDI AA: Oxidative stress and antioxidative parameters and metal ion content in patients with fibromyalgia syndrome: implications in the pathogenesis of the disease. Clin Exp Rheumatol 2013; 31(Suppl. 79): S128-33.
6. GIACOMELLI C, SERNISSI F, SARZI-PUTTINI P, DI FRANCO M, ATZENI F, BAZZICHI L: Fibromyalgia: a critical digest of the recent literature. Clin Exp Rheumatol 2013; 31(Suppl. 79): S153-7.
7. HARBECK B, SÜFKE S, HARTEN P, HAAS CS, LEHNERT H, MÖNIG H: High prevalence of fibromyalgia-associated symptoms in patients with hypothalamic-pituitary disorders. Clin Exp Rheumatol 2013; 31 (Suppl. 79): S16-21.
8. LA RUBIA M, RUS A, MOLINA F, DEL MORAL ML: Is fibromyalgia-related oxidative stress implicated in the decline of physical and mental health status? Clin Exp Rheumatol 2013; 31 (Suppl. 79): S121-7.
9. MALIN K, LITTLEJOHN GO: Stress modulates key psychological processes and characteristic symptoms in females with fibromyalgia. Clin Exp Rheumatol 2013; 31 (Suppl. 79): S64-71.
10. PRADOS G, MIRÓ E, MARTÍNEZ MP, SÁNCHEZ AI, LÓPEZ S, SÁEZ G: Fibromyalgia: gender differences and sleep-disordered breathing. Clin Exp Rheumatol 2013; 31(Suppl. 79): S102-10.
11. PERNAMBUCO AP, SCHETINO LP, VIANA RS, CARVALHO LS, D'ÁVILA REIS D: The involvement of melatonin in the clinical status of patients with fibromyalgia syndrome. Clin Exp Rheumatol 2015; 33 (Suppl. 88): S14-19.
12. MEASE P: Fibromyalgia syndrome: review of clinical presentation, pathogenesis, outcome measures, and treatment. J Rheumatol 2005; 75: 6-21.
13. SHMERLING RH: A review of fibromyalgia. Am J Manag Care 2004; 10: 794-800.
14. SARZI-PUTTINI P, BUSKILA D, CARRABBA M et al.: Treatment strategy in fibromyalgia syndrome: where are we now? Semin Arthritis Rheum 2008; 37: 353-65.
15. CASSISI G, CECCHERELLI F, ATZENI F, SARZI-PUTTINI P: Complementary and alternative medicine in fibromyalgia: a practical clinical debate of agreements and contrasts. Clin Exp Rheumatol 2013; 31 (Suppl. 79): S134-52.
16. NISHISHINYA MB, WALITT B, URRÚTIA G et al.: Anti-depressants and centrally active agents for fibromyalgia syndrome. In The Cochrane Library 2012; Issue 4.
17. HÄUSER W, URRÚTIA G, TORT S et al.: Serotonin and noradrenaline reuptake inhibitors (SNRIs) for fibromyalgia syndrome. Cochrane Database Syst Rev 2013 Jan 31; 1: CD010292.
18. BAZZICHI L, ROSSI A, GIACOMELLI C et al.: The influence of psychiatric comorbidity on sexual satisfaction in fibromyalgia patients. Clin Exp Rheumatol 2013; 31 (Suppl. 79): S81-5.
19. NUGRAHA B, KORALLUS C, KIELSTEIN H, GUTENBRUNNER C: CD3+CD56+natural killer T cells in fibromyalgia syndrome patients: association with the intensity of depression. Clin Exp Rheumatol 2013; 31 (Suppl. 79): S9-15.
20. YENER M, ASKIN A, SOYUPEK F, AKPINAR A, DEMIRDAS A, SONMEZ S, SOYUPEK S: The evaluation of anxiety and depression status in spouses of sexually active reproductive women with fibromyalgia. Clin Exp Rheumatol 2015: 33 (Suppl. 88); S20-24.
21. MEASE PJ, DUNDON K, SARZI-PUTTINI P: Pharmacotherapy of fibromyalgia. Best Pract Res Clin Rheumatol 2011; 25: 285-97.
22. ROSSINI M, Di MUNNO O, VALENTINI G et al.: Double-blind, multicenter trial comparing acetyl l-carnitine with placebo in the treatment of fibromyalgia patients. Clin Exp Rheumatol 2007; 25: 182-8.
23. CHIECHIO S, CARICASOLE E, BARLETTA M et al.: L-Acetylcarnitine induces analgesia by selectively up-regulating mGlu2 metabotropic glutamate receptors. Mol Pharmacol 2002; 61: 989-96.
24. ZANARDI R, SMERALDI E: A double-blind, randomised, controlled clinical trial of acetyl-L-carnitine vs. amisulpride in the treatment of dysthymia. Eur Neuropsychopharmacol 2006; 16: 281-7.
25. BERSANI G, MECO G, DENARO A et al.: LAcetylcarnitine in dysthymic disorder in elderly patients: A double-blind, multicenter, controlled randomized study vs. fluoxetine. Eur Neuropsychopharmacol 2013; 23: 1219-25.
26. CASTELLI L, TESIO V, COLONNA F et al.: Alexithymia and psychological distress in fibromyalgia: prevalence and relation with quality of life. Clin Exp Rheumatol 2012; 30(Suppl. 74): S70-7.