Angiotensin II type 1 receptor autoantibody as a novel regulator of aldosterone independent of preeclampsia

Journal of Hypertension

Volumn 33, Issue 5, 2015, Pages 1046-1056

  Yang, Jie ^a   Li, Li ^b   Shang, Jian Yu ^a   Cai, Lin ^c   Song, Li ^a   Zhang, Su Li ^a   Li, Hao ^a   Li, Xiao ^a   Lau, Wayne Bond ^d   Ma, Xin Liang ^a,d   Liu, Hui Rong ^a,b,e  

^a School of Basic Medical Sciences   (China)

^b CAPITAL MEDICAL UNIVERSITY   (China)

^c Third Hospital of Chengdu   (China)

^d THOMAS JEFFERSON UNIVERSITY   (United States)

^e Beijing Key Laboratory of Metabolic Disturbance Related Cardiovascular Disease   (China)

Author keywords

Aldosterone; Angiotensin II type 1 receptor; Autoantibodies; Preeclampsia

Indexed keywords

ALDOSTERONE; ANGIOTENSIN 1 RECEPTOR; ANGIOTENSIN II TYPE 1 RECEPTOR AUTOANTIBODY; AUTOANTIBODY; CASPASE 3; LACTATE DEHYDROGENASE; UNCLASSIFIED DRUG;

ADRENAL CORTEX; ANIMAL EXPERIMENT; ARTICLE; CELL VIABILITY; CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; HISTOPATHOLOGY; HUMAN; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MATERNAL HYPERTENSION; NONHUMAN; PREECLAMPSIA; PRIORITY JOURNAL; PROTEINURIA; RAT; ZONA GLOMERULOSA; ADULT; AGONISTS; ANIMAL; BLOOD; BLOOD PRESSURE; CASE CONTROL STUDY; IMMUNOLOGY; METABOLISM; PHYSIOLOGY; PREGNANCY; SECRETION (PROCESS); TUMOR CELL LINE;

ADRENAL CORTEX; ADULT; ALDOSTERONE; ANIMALS; AUTOANTIBODIES; BLOOD PRESSURE; CASE-CONTROL STUDIES; CELL LINE, TUMOR; FEMALE; HUMANS; HYPERTENSION, PREGNANCY-INDUCED; PRE-ECLAMPSIA; PREGNANCY; RATS; RECEPTOR, ANGIOTENSIN, TYPE 1;

EID: 84929237089     PISSN: 02636352     EISSN: 14735598     Source Type: Journal    
DOI: 10.1097/HJH.0000000000000521     Document Type: Article

References (36)

1. Kuc S, Wortelboer EJ, van Rijn BB, Franx A, Visser GH, Schielen PC. Evaluation of 7 serum biomarkers and uterine artery Doppler ultrasound for first-trimester prediction of preeclampsia: a systematic review. Obstet Gynecol Surv 2011; 66:225-239.
2. Huppertz B. Placental origins of preeclampsia: challenging the current hypothesis. Hypertension 2008; 51:970-975.
3. Xia Y, Kellems RE. Angiotensin receptor agonistic autoantibodies and hypertension: preeclampsia and beyond. Circ Res 2013; 113:78-87.
4. Zhou CC, Zhang Y, Irani RA, Zhang H, Mi T, Popek EJ, et al. Angiotensin receptor agonistic autoantibodies induce preeclampsia in pregnant mice. Nat Med 2008; 14:855-862.
5. Walther T, Wallukat G, Jank A, Bartel S, Schultheiss HP, Faber R, Stepan H. Angiotensin II type 1 receptor agonistic antibodies reflect fundamental alterations in the uteroplacental vasculature. Hypertension 2005; 46:1275-1279.
6. Hubel CA, Wallukat G, Wolf M, Herse F, Rajakumar A, Roberts JM, et al. Agonistic angiotensin II type 1 receptor autoantibodies in postpartum women with a history of preeclampsia. Hypertension 2007; 49:612-617.
7. Dragun D1, Müller DN, Bräsen JH, Fritsche L, Nieminen-Kelhä M, Dechend R, et al. Angiotensin II type 1-receptor activating antibodies in renal-allograft rejection. N Engl J Med 2005; 352:558-569.
8. Kanasaki K, Kalluri R. The biology of preeclampsia. Kidney Int 2009; 76:831-837.
9. Salas SP, Marshall G, Gutiérrez BL, Rosso P. Time course of maternal plasma volume and hormonal changes in women with preeclampsia or fetal growth restriction. Hypertension 2006; 47:203-208.
10. Yang J, Shang J, Zhang S, Li H, Liu H. The role of the renin-angiotensin-aldosterone system in preeclampsia: genetic polymorphisms and microRNA. J Mol Endocrinol 2013; 50:R53-66.
11. Siddiqui AH, Irani RA, Zhang W, Wang W, Blackwell SC, Kellems RE, Xia Y. Angiotensin receptor agonistic autoantibody-mediated soluble fms-like tyrosine kinase-1 induction contributes to impaired adrenal vasculature and decreased aldosterone production in preeclampsia. Hypertension 2013; 61:472-479.
12. Brown MA, Lindheimer MD, de Swiet M, Van Assche A, Moutquin JM. The classification and diagnosis of the hypertensive disorders of pregnancy: statement from the International Society for the Study of Hypertension in Pregnancy (ISSHP). Hypertens Pregnancy 2001; 20:ix-ix10.
13. Report of the National High Blood Pressure Education Program Working Group on high blood pressure in pregnancy. Am J Obstet Gynecol 2000; 183:S1-S22.
14. Rossitto G, Regolisti G, Rossi E, Negro A, Nicoli D, Casali B, et al. Elevation of angiotensin-II type-1-receptor autoantibodies titer in primary aldosteronism as a result of aldosterone-producing adenoma. Hypertension 2013; 61:526-533.
15. Liao YH, Wei YM, Wang M, Wang ZH, Yuan HT, Cheng LX. Autoantibodies against AT1-receptor and alpha1-adrenergic receptor in patients with hypertension. Hypertens Res 2002; 25:641-646.
16. Zhang S, Zhang X, Yang L, Yan Z, Yan L, Tian J, et al. Increased susceptibility to metabolic syndrome in adult offspring of angiotensin type 1 receptor autoantibody-positive rats. Antioxid Redox Signal 2012; 17:733-743.
17. Technical Information ELISA Data Analysis. http://www.bioreba.com/popup.php?docFile=http://www.bioreba.ch/files/Tecnical-Info/ELISA-Data-Analysis.pdf. 2011.
18. Fu ML, Leung PS, Wallukat G, Bergström G, Fu H, Schulze W, Herlitz H. Agonist-like activity of antibodies to angiotensin II receptor subtype 1 (AT1) from rats immunized with AT1 receptor peptide. Blood Press 1999; 8:317-324.
19. Zhang S, Zheng R, Yang L, Zhang X, Zuo L, Yang X, et al. Angiotensin type 1 receptor autoantibody from preeclamptic patients induces human fetoplacental vasoconstriction. J Cell Physiol 2013; 228:142-148.
20. Yang X, Wang F, Chang H, Zhang S, Yang L, Wang X, et al. Autoantibody against AT1 receptor from preeclamptic patients induces vasoconstriction through angiotensin receptor activation. J Hypertens 2008; 26:1629-1635.
21. Williams TA, Monticone S, Morello F, Liew CC, Mengozzi G, Pilon C, et al. Teratocarcinoma-derived growth factor-1 is upregulated in aldosterone-producing adenomas and increases aldosterone secretion and inhibits apoptosis in vitro. Hypertension 2010; 55:1468-1475.
22. Siddiqui AH, Irani RA, Blackwell SC, Ramin SM, Kellems RE, Xia Y. Angiotensin receptor agonistic autoantibody is highly prevalent in preeclampsia: correlation with disease severity. Hypertension 2010; 55:386-393.
23. Zhou CC, Ahmad S, Mi T, Abbasi S, Xia L, Day MC, et al. Autoantibody from women with preeclampsia induces soluble Fms-like tyrosine kinase-1 production via angiotensin type 1 receptor and calcineurin/nuclear factor of activated T-cells signaling. Hypertension 2008; 51:1010-1019.
24. Fu ML, Herlitz H, Schulze W, Wallukat G, Micke P, Eftekhari P, et al. Autoantibodies against the angiotensin receptor (AT1) in patients with hypertension. J Hypertens 2000; 18:945-953.
25. Zhu F, Sun Y, Wang M, Ma S, Chen X, Cao A, et al. Correlation between HLA-DRB1, HLA-DQB1 polymorphism and autoantibodies against angiotensin AT(1) receptors in Chinese patients with essential hypertension. Clin Cardiol 2011; 34:302-308.
26. Iwata M, Yoshikawa T, Baba A, Anzai T, Nakamura I, Wainai Y, et al. Autoimmunity against the second extracellular loop of beta(1)-adrenergic receptors induces beta-adrenergic receptor desensitization and myocardial hypertrophy in vivo. Circ Res 2001; 88:578-586.
27. Du Y, Yan L, Wang J, Zhan W, Song K, Han X, et al. Beta1-Adrenoceptor autoantibodies from DCM patients enhance the proliferation of T lymphocytes through the beta1-AR/cAMP/PKA and p38 MAPK pathways. PLoS One 2012; 7:e52911.
28. Zhang SL, Du YH, Wang J, Yang LH, Yang XL, Zheng RH, et al. Endothelial dysfunction induced by antibodies against angiotensin AT1 receptor in immunized rats. Acta Pharmacol Sin 2010; 31:1381-1388.
29. Bornholz B, Weidtkamp-Peters S, Schmitmeier S, Seidel CA, Herda LR, Felix SB, et al. Impact of human autoantibodies on b1-adrenergic receptor conformation, activity, and internalization. Cardiovasc Res 2013; 97:472-480.
30. Thway TM, Shlykov SG, Day MC, Sanborn BM, Gilstrap LC 3rd, Xia Y, Kellems RE. Antibodies from preeclamptic patients stimulate increased intracellular Ca2+ mobilization through angiotensin receptor activation. Circulation 2004; 110:1612-1619.
31. Spät A, Hunyady L. Control of aldosterone secretion: a model for convergence in cellular signaling pathways. Physiol Rev 2004; 84:489-539.
32. Williams TA, Monticone S, Crudo V, Warth R, Veglio F, Mulatero P. Visinin-like 1 is upregulated in aldosterone-producing adenomas with KCNJ5 mutations and protects from calcium-induced apoptosis. Hypertension 2012; 59:833-839.
33. Witlin G, Saade R, Mattar F, Sibai M. Predictors of neonatal outcome in women with severe preeclampsia or eclampsia between 24 and 33 weeks' gestation. Am J Obstet Gynecol 2000; 182:607-611.
34. Yia Y, Wen H, Bobst S, Day MC, Kellems RE. Maternal autoantibodies from preeclamptic patients active angiotensin receptors on human trophoblast cells. J Soc Gynecol Investig 2003; 10:82-93.
35. Irani RA, Zhang Y, Blackwell SC, Zhou CC, Ramin SM, Kellems RE, Xia Y. The detrimental role of angiotensin receptor agonistic autoantibodies in intrauterine growth restriction seen in preeclampsia. J Exp Med 2009; 206:2809-2822.
36. Herse F, Verlohren S, Wenzel K, Pape J, Muller DN, Modrow S, et al. Prevalence of agonistic autoantibodies against the angiotensin II type 1 receptor and soluble fms-like tyrosine kinase 1 in a gestational age-matched case study. Hypertension 2009; 53:393-398.