Molecular mechanism underlying chemoprotective effects of Ganoderma atrum polysaccharide in cyclophosphamide-induced immunosuppressed mice

Journal of Functional Foods

Volumn 15, Issue , 2015, Pages 52-60

  Yu, Qiang ^a   Nie, Shao Ping ^a   Wang, Jun Qiao ^a   Huang, Dan Fei ^a   Li, Wen Juan ^a   Xie, Ming Yong ^a  

^a NANCHANG UNIVERSITY   (China)

Author keywords

Cyclophosphamide; Ganoderma atrum polysaccharide; Immunosuppression; Peritoneal macrophages; Spleen lymphocytes

Indexed keywords

GANODERMA; MUS;

EID: 84929234125     PISSN: 17564646     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jff.2015.03.015     Document Type: Article

References (37)

1. Adams D.O., Hamilton T.A. The cell biology of macrophage activation. Annual Review of Immunology 1984, 2:283-318.
2. Aderem A., Underhill D.M. Mechanisms of phagocytosis in macrophages. Annual Review of Immunology 1999, 17:593-623.
3. Baeuerle P.A., Henkel T. Function and activation of NF-kappaB in the immune system. Annual Review of Immunology 1994, 12:141-179.
4. Brüne B., Zhou J., Von Knethen A. Nitric oxide, oxidative stress, and apoptosis. Kidney International 2003, 63:S22-S24.
5. Chen Y., Xie M.Y., Nie S.P., Li C., Wang Y.X. Purification, composition analysis and antioxidant activity of a polysaccharide from the fruiting bodies of Ganoderma atrum. Food Chemistry 2008, 107:231-241.
6. Clapham D.E. Calcium signaling. Cell 2007, 131:1047-1058.
7. Dunn D.L., Barke R.A., Ewald D.C., Simmons R.L. Macrophages and translymphatic absorption represent the first line of host defense of the peritoneal cavity. Archives of Surgery 1987, 122:105-110.
8. Ehrke M.J. Immunomodulation in cancer therapeutics. International Immunopharmacology 2003, 3:1105-1119.
9. Feske S. Calcium signalling in lymphocyte activation and disease. Nature Reviews Immunology 2007, 7:690-702.
10. Friedman D.L. Role of cyclic nucleotides in cell growth and differentiation. Physiological Reviews 1976, 56:652-708.
11. Fruman D.A., Cantley L.C. Phosphoinositide 3-kinase in immunological systems. Seminars in Immunology 2002, 14:7-18.
12. Fruman D.A., Meyers R.E., Cantley L.C. Phosphoinositide kinases. Annual Review of Biochemistry 1998, 67:481-507.
13. Katsiari C.G., Liossis S.-N.C., Sfikakis P.P. The pathophysiologic role of monocytes and macrophages in systemic lupus erythematosus: A reappraisal. Seminars in Arthritis and Rheumatism 2010, 39:491-503.
14. Kim H.S., Kim Y.J., Lee H.K., Ryu H.S., Kim J.S., Yoon M.J., Kang J.S., Hong J.T., Kim Y., Han S.-B. Activation of macrophages by polysaccharide isolated from Paecilomyces cicadae through toll-like receptor 4. Food and Chemical Toxicology 2012, 50:3190-3197.
15. Li J.E., Nie S.P., Xie M.Y., Li C. Isolation and partial characterization of a neutral polysaccharide from Mosla chinensis Maxim. cv. Jiangxiangru and its antioxidant and immunomodulatory activities. Journal of Functional Foods 2014, 6:410-418.
16. Meng L.Z., Feng K., Wang L.Y., Cheong K.L., Nie H., Zhao J., Li S.P. Activation of mouse macrophages and dendritic cells induced by polysaccharides from a novel Cordyceps sinensis fungus UM01. Journal of Functional Foods 2014, 9:242-253.
17. Newton A.C. Protein kinase C: Structure, function, and regulation. The Journal of Biological Chemistry 1995, 270:28495-28498.
18. Nie S.P., Zhang H., Li W.J., Xie M.Y. Current development of polysaccharides from Ganoderma: Isolation, structure and bioactivities. Bioactive Carbohydrates and Dietary Fibre 2013, 1:10-20.
19. Nishizuka Y. Studies and perspectives of protein kinase C. Science 1986, 233:305-312.
20. Oh-hora M., Rao A. Calcium signaling in lymphocytes. Current Opinion in Immunology 2008, 20:250-258.
21. Pass G.J., Carrie D., Boylan M., Lorimore S., Wright E., Houston B., Henderson C.J., Wolf C.R. Role of hepatic cytochrome p450s in the pharmacokinetics and toxicity of cyclophosphamide: Studies with the hepatic cytochrome p450 reductase null mouse. Cancer Research 2005, 65:4211-4217.
22. Quakyi E., Carter P., Tsai C.-M., Marti G. Immunization with meningococcal membrane-bound lipooligosaccharide accelerates granulocyte recovery and enhances lymphocyte proliferation in myelosuppressed mice. Pathobiology: Journal of Immunopathology, Molecular and Cellular Biology 1997, 65:26-38.
23. Ramioul H., Zutterman R. Chemotherapy with cyclophosphamide. Acta Clinica Belgica 1961, 16:271.
24. Rao K.M.K. MAP kinase activation in macrophages. Journal of Leukocyte Biology 2001, 69:3-10.
25. Serezani C.H., Ballinger M.N., Aronoff D.M., Peters-Golden M. Cyclic AMP: Master regulator of innate immune cell function. American Journal of Respiratory Cell and Molecular Biology 2008, 39:127-132.
26. Skalhegg B., Tasken K. Specificity in the cAMP/PKA signaling pathway. Differential expression, regulation, andsubcellular localization of subunits of PKA. Frontiers in Bioscience 2000, 5:D678-D693.
27. Walsh D.A., Van Patten S.M. Multiple pathway signal transduction by the cAMP-dependent protein kinase. The FASEB Journal 1994, 8:1227-1236.
28. Weiss A., Cambier J.C. Lymphocyte activation. Current Opinion in Immunology 2004, 16:285-287.
29. Xia L., Liu X., Guo H., Zhang H., Zhu J., Ren F. Partial characterization and immunomodulatory activity of polysaccharides from the stem of Dendrobium officinale (Tiepishihu) in vitro. Journal of Functional Foods 2012, 4:294-301.
30. Yu Q., Nie S.P., Li W.J., Zheng W.Y., Yin P.F., Gong D.M., Xie M.Y. Macrophage immunomodulatory activity of a purified polysaccharide isolated from Ganoderma atrum. Phytotherapy Research 2013, 27:186-191.
31. Yu Q., Nie S.P., Wang J.Q., Liu X.Z., Yin P.F., Huang D.F., Li W.J., Gong D.M., Xie M.Y. Chemoprotective effects of Ganoderma atrum polysaccharide in cyclophosphamide-induced mice. International Journal of Biological Macromolecules 2014, 64:395-401.
32. Yu Q., Nie S.P., Wang J.Q., Yin P.F., Huang D.F., Li W.J., Xie M.Y. Toll-like receptor 4-mediated ROS signaling pathway involved in Ganoderma atrum polysaccharide-induced tumor necrosis factor-α secretion during macrophage activation. Food and Chemical Toxicology 2014, 66:14-22.
33. Yu Q., Nie S.P., Wang J.Q., Yin P.F., Li W.J., Xie M.Y. Polysaccharide from Ganoderma atrum induces tumor necrosis factor-α secretion via phosphoinositide 3-kinase/Akt, mitogen-activated protein kinase and nuclear factor-κB signaling pathways in RAW264.7 cells. International Immunopharmacology 2012, 14:362-368.
34. Zhang D., Wu H., Xia Z., Wang C., Cai J., Huang Z., Du L., Sun P., Xie J. Partial characterization, antioxidant and antitumor activities of three sulfated polysaccharides purified from Bullacta exarata. Journal of Functional Foods 2012, 4:784-792.
35. Zhang H., Li W.J., Nie S.P., Chen Y., Wang Y.X., Xie M.Y. Structural characterisation of a novel bioactive polysaccharide from Ganoderma atrum. Carbohydrate Polymers 2012, 88:1047-1054.
36. Zhang H., Nie S.P., Yin J.Y., Wang Y.X., Xie M.Y. Structural characterization of a heterogalactan purified from fruiting bodies of Ganoderma atrum. Food Hydrocolloids 2014, 36:339-347.
37. Zhao T., Feng Y., Li J., Mao R., Zou Y., Feng W., Zheng D., Wang W., Chen Y., Yang L. Schisandra polysaccharide evokes immunomodulatory activity through TLR 4-mediated activation of macrophages. International Journal of Biological Macromolecules 2014, 65:33-40.