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Volumn , Issue , 2015, Pages 251-267

Inhibitors of mitotic kinesins for cancer treatment: Consequences for neurons

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EID: 84929218351     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-94-017-9732-0_14     Document Type: Chapter
Times cited : (1)

References (103)
  • 1
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • S0092-8674(11)00127-9
    • Hanahan D, Weinberg RA (2011) Hallmarks of cancer: the next generation. Cell 144:646–674. doi:10.1016/j.cell.2011.02.013, S0092-8674(11)00127-9
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 2
    • 0022919318 scopus 로고
    • Beyond self-assembly: From microtubules to morphogenesis
    • Kirschner M, Mitchison T (1986) Beyond self-assembly: from microtubules to morphogenesis. Cell 45:329–342. doi:10.1016/0092-8674(86)90318-1
    • (1986) Cell , vol.45 , pp. 329-342
    • Kirschner, M.1    Mitchison, T.2
  • 4
    • 84155167955 scopus 로고    scopus 로고
    • Mechanisms in cancer-chemotherapeutic drugs-induced peripheral neuropathy
    • S0300-483X(11)00458-6[pii]
    • Jaggi AS, Singh N (2012) Mechanisms in cancer-chemotherapeutic drugs-induced peripheral neuropathy. Toxicology 291:1–9. doi:10.1016/j.tox.2011.10.019, S0300-483X(11)00458-6[pii]
    • (2012) Toxicology , vol.291 , pp. 1-9
    • Jaggi, A.S.1    Singh, N.2
  • 5
    • 0033102385 scopus 로고    scopus 로고
    • How taxol stabilises microtubule structure
    • S1074-5521(99)89002-4
    • Amos LA, Lowe J (1999) How taxol stabilises microtubule structure. Chem Biol 6:R65–R69. doi:S1074-5521(99)89002-4
    • (1999) Chem Biol , vol.6
    • Amos, L.A.1    Lowe, J.2
  • 6
    • 84873090491 scopus 로고    scopus 로고
    • Molecular mechanism of action of microtubule-stabilizing anticancer agents
    • science.1230582
    • Prota AE et al (2013) Molecular mechanism of action of microtubule-stabilizing anticancer agents. Science 339:587–590. doi:10.1126/science.1230582, science.1230582[pii]
    • (2013) Science , vol.339 , pp. 587-590
    • Prota, A.E.1
  • 7
    • 79951814364 scopus 로고    scopus 로고
    • The characterization of microtubule-stabilizing drugs as possible therapeutic agents for alzheimer’s disease and related tauopathies
    • S1043-6618(10)00227-6
    • Brunden KR et al (2011) The characterization of microtubule-stabilizing drugs as possible therapeutic agents for Alzheimer’s disease and related tauopathies. Pharmacol Res 63:341– 351. doi:10.1016/j.phrs.2010.12.002, S1043-6618(10)00227-6[pii]
    • (2011) Pharmacol Res , vol.63
    • Brunden, K.R.1
  • 8
    • 84863230105 scopus 로고    scopus 로고
    • The microtubule-stabilizing agent, epothilone d, reduces axonal dysfunction, neurotoxicity, cognitive defi cits, and alzheimer-like pathology in an interventional study with aged tau transgenic mice
    • 32/11/3601
    • Zhang B et al (2012) The microtubule-stabilizing agent, epothilone D, reduces axonal dysfunction, neurotoxicity, cognitive defi cits, and Alzheimer-like pathology in an interventional study with aged tau transgenic mice. J Neurosci 32:3601–3611. doi:10.1523/JNEUROSCI.4922-11.2012, 32/11/3601[pii]
    • (2012) J Neurosci , vol.32 , pp. 3601-3611
    • Zhang, B.1
  • 9
    • 84884835990 scopus 로고    scopus 로고
    • Beyond taxol: Microtubule-based treatment of disease and injury of the nervous system
    • awt153
    • Baas PW, Ahmad FJ (2013) Beyond taxol: microtubule-based treatment of disease and injury of the nervous system. Brain. doi:10.1093/brain/awt153, awt153[pii]
    • (2013) Brain
    • Baas, P.W.1    Ahmad, F.J.2
  • 10
    • 0344254845 scopus 로고    scopus 로고
    • Expression of the mitotic kinesin kif15 in postmitotic neurons: Implications for neuronal migration and development
    • Buster DW et al (2003) Expression of the mitotic kinesin Kif15 in postmitotic neurons: implications for neuronal migration and development. J Neurocytol 32:79–96. doi:5146300[pii]
    • (2003) J Neurocytol , vol.32 , pp. 79-96
    • Buster, D.W.1
  • 11
    • 2342618971 scopus 로고    scopus 로고
    • Monastrol, a prototype anti-cancer drug that inhibits a mitotic kinesin, induces rapid bursts of axonal outgrowth from cultured postmitotic neurons
    • Haque SA, Hasaka TP, Brooks AD, Lobanov PV, Baas PW (2004) Monastrol, a prototype anti-cancer drug that inhibits a mitotic kinesin, induces rapid bursts of axonal outgrowth from cultured postmitotic neurons. Cell Motil Cytoskeleton 58:10–16. doi:10.1002/cm.10176
    • (2004) Cell Motil Cytoskeleton , vol.58 , pp. 10-16
    • Haque, S.A.1    Hasaka, T.P.2    Brooks, A.D.3    Lobanov, P.V.4    Baas, P.W.5
  • 12
    • 34548833602 scopus 로고    scopus 로고
    • Kinesin-5 regulates the growth of the axon by acting as a brake on its microtubule array
    • Myers KA, Baas PW (2007) Kinesin-5 regulates the growth of the axon by acting as a brake on its microtubule array. J Cell Biol 178:1081–1091. doi:10.1083/jcb.200702074, jcb.200702074[pii]
    • (2007) J Cell Biol , vol.178 , pp. 1081-1091
    • Myers, K.A.1    Baas, P.W.2
  • 13
    • 57649188646 scopus 로고    scopus 로고
    • Kinesin-5 is essential for growth-cone turning
    • S0960-9822(08)01501-7
    • Nadar VC, Ketschek A, Myers KA, Gallo G, Baas PW (2008) Kinesin-5 is essential for growth-cone turning. Curr Biol 18:1972–1977. doi:10.1016/j.cub.2008.11.021, S0960-9822(08)01501-7[pii]
    • (2008) Curr Biol , vol.18 , pp. 1972-1977
    • Nadar, V.C.1    Ketschek, A.2    Myers, K.A.3    Gallo, G.4    Baas, P.W.5
  • 14
    • 78049514886 scopus 로고    scopus 로고
    • Kinesin-12, a mitotic microtubule-associated motor protein, impacts axonal growth, navigation, and branching
    • 30/44/14896
    • Liu M et al (2010) Kinesin-12, a mitotic microtubule-associated motor protein, impacts axonal growth, navigation, and branching. J Neurosci 30:14896–14906. doi:10.1523/JNEUROSCI.3739-10.2010, 30/44/14896[pii]
    • (2010) J Neurosci , vol.30 , pp. 14896-14906
    • Liu, M.1
  • 15
    • 79955490607 scopus 로고    scopus 로고
    • Kinesin-5, a mitotic microtubule-associated motor protein, modulates neuronal migration
    • mbc.E10-11-0905
    • Falnikar A, Tole S, Baas PW (2011) Kinesin-5, a mitotic microtubule-associated motor protein, modulates neuronal migration. Mol Biol Cell 22:1561–1574. doi:10.1091/mbc.E10-11-0905, mbc.E10-11-0905[pii]
    • (2011) Mol Biol Cell , vol.22 , pp. 1561-1574
    • Falnikar, A.1    Tole, S.2    Baas, P.W.3
  • 16
    • 84866990769 scopus 로고    scopus 로고
    • Mitotic motors coregulate microtubule patterns in axons and dendrites
    • 32/40/14033
    • Lin S, Liu M, Mozgova OI, Yu W, Baas PW (2012) Mitotic motors coregulate microtubule patterns in axons and dendrites. J Neurosci 32:14033–14049. doi:10.1523/JNEUROSCI. 3070-12.2012, 32/40/14033[pii]
    • (2012) J Neurosci , vol.32 , pp. 14033-14049
    • Lin, S.1    Liu, M.2    Mozgova, O.I.3    Yu, W.4    Baas, P.W.5
  • 17
    • 80255127361 scopus 로고    scopus 로고
    • Neurogenesis, cellular plasticity and cognition: The impact of stem cells in the adult and aging brain–a mini-review
    • 000323481
    • Couillard-Despres S, Iglseder B, Aigner L (2011) Neurogenesis, cellular plasticity and cognition: the impact of stem cells in the adult and aging brain–a mini-review. Gerontology 57:559–564. doi:10.1159/000323481, 000323481[pii]
    • (2011) Gerontology , vol.57 , pp. 559-564
    • Couillard-Despres, S.1    Iglseder, B.2    Aigner, L.3
  • 18
    • 84888299106 scopus 로고    scopus 로고
    • Mutations of the synapse genes and intellectual disability syndromes
    • S0014-2999(13)00545-1
    • Verpelli C, Montani C, Vicidomini C, Heise C, Sala C (2013) Mutations of the synapse genes and intellectual disability syndromes. Eur J Pharmacol. doi:10.1016/j.ejphar.2013.07.023, S0014-2999(13)00545-1[pii]
    • (2013) Eur J Pharmacol
    • Verpelli, C.1    Montani, C.2    Vicidomini, C.3    Heise, C.4    Sala, C.5
  • 19
    • 84888290134 scopus 로고    scopus 로고
    • Optical imaging of structural and functional synaptic plasticity in vivo
    • S0014-2999(13)00542-6
    • Holtmaat A, Randall J, Cane M (2013) Optical imaging of structural and functional synaptic plasticity in vivo. Eur J Pharmacol. doi:10.1016/j.ejphar.2013.07.020, S0014-2999(13)00542-6[pii]
    • (2013) Eur J Pharmacol
    • Holtmaat, A.1    Randall, J.2    Cane, M.3
  • 20
    • 84879978794 scopus 로고    scopus 로고
    • Actin fi laments and microtubules in dendritic spines
    • Shirao T, Gonzalez-Billault C (2013) Actin fi laments and microtubules in dendritic spines. J Neurochem 126:155–164. doi:10.1111/jnc.12313
    • (2013) J Neurochem , vol.126 , pp. 155-164
    • Shirao, T.1    Gonzalez-Billault, C.2
  • 21
    • 84881412677 scopus 로고    scopus 로고
    • Letrozole potentiates mitochondrial and dendritic spine impairments induced by beta amyloid
    • Chang PK, Boridy S, McKinney RA, Maysinger D (2013) Letrozole potentiates mitochondrial and dendritic spine impairments induced by beta amyloid. J Aging Res 2013:538-979. doi:10.1155/2013/538979
    • (2013) J Aging Res , pp. 538-979
    • Chang, P.K.1    Boridy, S.2    McKinney, R.A.3    Maysinger, D.4
  • 22
    • 84881498826 scopus 로고    scopus 로고
    • Low-level laser therapy rescues dendrite atrophy via upregulating bdnf expression: Implications for alzheimer’s disease
    • 33/33/13505
    • Meng C, He Z, Xing D (2013) Low-level laser therapy rescues dendrite atrophy via upregulating BDNF expression: implications for Alzheimer’s disease. J Neurosci 33:13505–13517. doi:10.1523/JNEUROSCI. 0918-13.2013, 33/33/13505[pii]
    • (2013) J Neurosci , vol.33 , pp. 13505-13517
    • Meng, C.1    He, Z.2    Xing, D.3
  • 23
    • 84881148047 scopus 로고    scopus 로고
    • Dendritic spine instability leads to progressive neocortical spine loss in a mouse model of huntington’s disease
    • 33/32/12997
    • Murmu RP, Li W, Holtmaat A, Li JY (2013) Dendritic spine instability leads to progressive neocortical spine loss in a mouse model of Huntington’s disease. J Neurosci 33:12997– 13009. doi:10.1523/JNEUROSCI. 5284-12.2013, 33/32/12997[pii]
    • (2013) J Neurosci , vol.33
    • Murmu, R.P.1    Li, W.2    Holtmaat, A.3    Li, J.Y.4
  • 24
    • 65249107203 scopus 로고    scopus 로고
    • Microtubule assembly, organization and dynamics in axons and dendrites
    • nrn2631
    • Conde C, Caceres A (2009) Microtubule assembly, organization and dynamics in axons and dendrites. Nat Rev Neurosci 10:319–332. doi:10.1038/nrn2631, nrn2631[pii]
    • (2009) Nat Rev Neurosci , vol.10 , pp. 319-332
    • Conde, C.1    Caceres, A.2
  • 25
    • 0033748308 scopus 로고    scopus 로고
    • Establishment of neuronal polarity: Lessons from cultured hippocampal neurons
    • S0959-4388(00)00124-0
    • Bradke F, Dotti CG (2000) Establishment of neuronal polarity: lessons from cultured hippocampal neurons. Curr Opin Neurobiol 10:574–581. doi:S0959-4388(00)00124-0[pii]
    • (2000) Curr Opin Neurobiol , vol.10 , pp. 574-581
    • Bradke, F.1    Dotti, C.G.2
  • 27
    • 0342419162 scopus 로고
    • Polarity orientation of microtubules in hippocampal neurons: Uniformity in the axon and nonuniformity in the dendrite
    • Baas PW, Deitch JS, Black MM, Banker GA (1988) Polarity orientation of microtubules in hippocampal neurons: uniformity in the axon and nonuniformity in the dendrite. Proc Natl Acad Sci U S A 85:8335–8339
    • (1988) Proc Natl Acad Sci U S A , vol.85 , pp. 8335-8339
    • Baas, P.W.1    Deitch, J.S.2    Black, M.M.3    Banker, G.A.4
  • 28
    • 79955724181 scopus 로고    scopus 로고
    • Hooks and comets: The story of microtubule polarity orientation in the neuron
    • Baas PW, Lin S (2011) Hooks and comets: the story of microtubule polarity orientation in the neuron. Dev Neurobiol 71:403–418. doi:10.1002/dneu.20818
    • (2011) Dev Neurobiol , vol.71 , pp. 403-418
    • Baas, P.W.1    Lin, S.2
  • 29
    • 0038382300 scopus 로고    scopus 로고
    • Dual modes of endoplasmic reticulum-to-golgi transport in dendrites revealed by live-cell imaging
    • 23/15/6188
    • Horton AC, Ehlers MD (2003) Dual modes of endoplasmic reticulum-to-Golgi transport in dendrites revealed by live-cell imaging. J Neurosci 23:6188–6199. doi:23/15/6188[pii]
    • (2003) J Neurosci , vol.23 , pp. 6188-6199
    • Horton, A.C.1    Ehlers, M.D.2
  • 30
    • 0346120162 scopus 로고    scopus 로고
    • Slow axonal transport and the genesis of neuronal morphology
    • Baas PW, Buster DW (2004) Slow axonal transport and the genesis of neuronal morphology. J Neurobiol 58:3–17. doi:10.1002/neu.10281
    • (2004) J Neurobiol , vol.58 , pp. 3-17
    • Baas, P.W.1    Buster, D.W.2
  • 31
    • 80051969901 scopus 로고    scopus 로고
    • Microtubule-actin interactions during neuronal development
    • Myers KA, Baas PW (2011) Microtubule-actin interactions during neuronal development. Adv Neurobiol 5:73–96
    • (2011) Adv Neurobiol , vol.5 , pp. 73-96
    • Myers, K.A.1    Baas, P.W.2
  • 32
    • 33745868372 scopus 로고    scopus 로고
    • Axonal transport of microtubules: The long and short of it
    • TRA392
    • Baas PW, Vidya Nadar C, Myers KA (2006) Axonal transport of microtubules: the long and short of it. Traffic 7:490–498. doi:10.1111/j.1600-0854.2006.00392.x, TRA392[pii]
    • (2006) Traffic , vol.7 , pp. 490-498
    • Baas, P.W.1    Vidya Nadar, C.2    Myers, K.A.3
  • 33
    • 0026051594 scopus 로고
    • Microtubule dynamics in axons and dendrites
    • Baas PW, Slaughter T, Brown A, Black MM (1991) Microtubule dynamics in axons and dendrites. J Neurosci Res 30:134–153. doi:10.1002/jnr.490300115
    • (1991) J Neurosci Res , vol.30 , pp. 134-153
    • Baas, P.W.1    Slaughter, T.2    Brown, A.3    Black, M.M.4
  • 34
    • 0030898065 scopus 로고    scopus 로고
    • Dynamic microtubule ends are required for growth cone turning to avoid an inhibitory guidance cue
    • Challacombe JF, Snow DM, Letourneau PC (1997) Dynamic microtubule ends are required for growth cone turning to avoid an inhibitory guidance cue. J Neurosci 17:3085–3095
    • (1997) J Neurosci , vol.17 , pp. 3085-3095
    • Challacombe, J.F.1    Snow, D.M.2    Letourneau, P.C.3
  • 35
    • 70350417339 scopus 로고    scopus 로고
    • Cytoskeletal dynamics in growth-cone steering
    • 122/20/3595
    • Geraldo S, Gordon-Weeks PR (2009) Cytoskeletal dynamics in growth-cone steering. J Cell Sci 122:3595–3604. doi:10.1242/jcs.042309, 122/20/3595[pii]
    • (2009) J Cell Sci , vol.122 , pp. 3595-3604
    • Geraldo, S.1    Gordon-Weeks, P.R.2
  • 36
    • 0025313509 scopus 로고
    • Individual microtubules in the axon consist of domains that differ in both composition and stability
    • Baas PW, Black MM (1990) Individual microtubules in the axon consist of domains that differ in both composition and stability. J Cell Biol 111:495–509
    • (1990) J Cell Biol , vol.111 , pp. 495-509
    • Baas, P.W.1    Black, M.M.2
  • 37
    • 0027537548 scopus 로고
    • Composite microtubules of the axon: Quantitative analysis of tyrosinated and acetylated tubulin along individual axonal microtubules
    • Brown A, Li Y, Slaughter T, Black MM (1993) Composite microtubules of the axon: quantitative analysis of tyrosinated and acetylated tubulin along individual axonal microtubules. J Cell Sci 104(Pt 2):339–352
    • (1993) J Cell Sci , vol.104 , pp. 339-352
    • Brown, A.1    Li, Y.2    Slaughter, T.3    Black, M.M.4
  • 38
    • 0026561904 scopus 로고
    • The plus ends of stable microtubules are the exclusive nucleating structures for microtubules in the axon
    • Baas PW, Ahmad FJ (1992) The plus ends of stable microtubules are the exclusive nucleating structures for microtubules in the axon. J Cell Biol 116:1231–1241
    • (1992) J Cell Biol , vol.116 , pp. 1231-1241
    • Baas, P.W.1    Ahmad, F.J.2
  • 39
    • 0024805885 scopus 로고
    • Changes in microtubule polarity orientation during the development of hippocampal neurons in culture
    • Baas PW, Black MM, Banker GA (1989) Changes in microtubule polarity orientation during the development of hippocampal neurons in culture. J Cell Biol 109:3085–3094
    • (1989) J Cell Biol , vol.109 , pp. 3085-3094
    • Baas, P.W.1    Black, M.M.2    Banker, G.A.3
  • 40
    • 77449107515 scopus 로고    scopus 로고
    • Paclitaxel induces axonal microtubules polar reconfi guration and impaired organelle transport: Implications for the pathogenesis of paclitaxel-induced polyneuropathy
    • Shemesh OA, Spira ME (2010) Paclitaxel induces axonal microtubules polar reconfi guration and impaired organelle transport: implications for the pathogenesis of paclitaxel-induced polyneuropathy. Acta Neuropathol 119:235–248. doi:10.1007/s00401-009-0586-0
    • (2010) Acta Neuropathol , vol.119 , pp. 235-248
    • Shemesh, O.A.1    Spira, M.E.2
  • 41
    • 77956058557 scopus 로고    scopus 로고
    • Effect of the degree of polar mismatching on traffi c jam formation in fast axonal transport
    • 920291996
    • Kuznetsov AV (2010) Effect of the degree of polar mismatching on traffi c jam formation in fast axonal transport. Comput Methods Biomech Biomed Engin 13:711–722. doi:10.1080/10255840903505154, 920291996[pii]
    • (2010) Comput Methods Biomech Biomed Engin , vol.13 , pp. 711-722
    • Kuznetsov, A.V.1
  • 42
    • 84863782833 scopus 로고    scopus 로고
    • A novel role for retrograde transport of microtubules in the axon
    • Baas PW, Mozgova OI (2012) A novel role for retrograde transport of microtubules in the axon. Cytoskeleton (Hoboken) 69:416–425. doi:10.1002/cm.21013
    • (2012) Cytoskeleton (Hoboken) , vol.69 , pp. 416-425
    • Baas, P.W.1    Mozgova, O.I.2
  • 43
    • 77955272733 scopus 로고    scopus 로고
    • Tubulin post-translational modifi cations: Encoding functions on the neuronal microtubule cytoskeleton
    • S0166-2236(10)00065-2
    • Janke C, Kneussel M (2010) Tubulin post-translational modifi cations: encoding functions on the neuronal microtubule cytoskeleton. Trends Neurosci 33:362–372. doi:10.1016/j. tins.2010.05.001, S0166-2236(10)00065-2[pii]
    • (2010) Trends Neurosci , vol.33 , pp. 362-372
    • Janke, C.1    Kneussel, M.2
  • 44
    • 81855196008 scopus 로고    scopus 로고
    • Post-translational regulation of the microtubule cytoskeleton: Mechanisms and functions
    • nrm3227
    • Janke C, Bulinski JC (2011) Post-translational regulation of the microtubule cytoskeleton: mechanisms and functions. Nat Rev Mol Cell Biol 12:773–786. doi:10.1038/nrm3227, nrm3227[pii]
    • (2011) Nat Rev Mol Cell Biol , vol.12 , pp. 773-786
    • Janke, C.1    Bulinski, J.C.2
  • 45
    • 77957868249 scopus 로고    scopus 로고
    • Post-translational modifi cations of microtubules
    • 123/20/3447
    • Wloga D, Gaertig J (2010) Post-translational modifi cations of microtubules. J Cell Sci 123:3447–3455. doi:10.1242/jcs.063727, 123/20/3447[pii]
    • (2010) J Cell Sci , vol.123 , pp. 3447-3455
    • Wloga, D.1    Gaertig, J.2
  • 46
    • 75649140874 scopus 로고    scopus 로고
    • Hyperglutamylation of tubulin can either stabilize or destabilize microtubules in the same cell
    • EC.00176-09
    • Wloga D et al (2010) Hyperglutamylation of tubulin can either stabilize or destabilize microtubules in the same cell. Eukaryot Cell 9:184–193. doi:10.1128/EC.00176-09, EC.00176-09[pii]
    • (2010) Eukaryot Cell , vol.9 , pp. 184-193
    • Wloga, D.1
  • 47
    • 84863774430 scopus 로고    scopus 로고
    • The chemical complexity of cellular microtubules: Tubulin post-translational modifi cation enzymes and their roles in tuning microtubule functions
    • Garnham CP, Roll-Mecak A (2012) The chemical complexity of cellular microtubules: tubulin post-translational modifi cation enzymes and their roles in tuning microtubule functions. Cytoskeleton (Hoboken) 69:442–463. doi:10.1002/cm.21027
    • (2012) Cytoskeleton (Hoboken) , vol.69 , pp. 442-463
    • Garnham, C.P.1    Roll-Mecak, A.2
  • 48
    • 0345169048 scopus 로고    scopus 로고
    • Post-translational modifi cations regulate microtubule function
    • nrm1260
    • Westermann S, Weber K (2003) Post-translational modifi cations regulate microtubule function. Nat Rev Mol Cell Biol 4:938–947. doi:10.1038/nrm1260, nrm1260[pii]
    • (2003) Nat Rev Mol Cell Biol , vol.4 , pp. 938-947
    • Westermann, S.1    Weber, K.2
  • 49
    • 67649580185 scopus 로고    scopus 로고
    • Motor-dependent microtubule disassembly driven by tubulin tyrosination
    • jcb.200902142
    • Peris L et al (2009) Motor-dependent microtubule disassembly driven by tubulin tyrosination. J Cell Biol 185:1159–1166. doi:10.1083/jcb.200902142, jcb.200902142[pii]
    • (2009) J Cell Biol , vol.185 , pp. 1159-1166
    • Peris, L.1
  • 50
    • 43149106461 scopus 로고    scopus 로고
    • Differential traffi cking of kif5c on tyrosinated and detyrosinated microtubules in live cells
    • jcs.026492
    • Dunn S et al (2008) Differential traffi cking of Kif5c on tyrosinated and detyrosinated microtubules in live cells. J Cell Sci 121:1085–1095. doi:10.1242/jcs.026492, jcs.026492[pii]
    • (2008) J Cell Sci , vol.121 , pp. 1085-1095
    • Dunn, S.1
  • 51
    • 67349200776 scopus 로고    scopus 로고
    • Tubulin tyrosination navigates the kinesin-1 motor domain to axons
    • nn.2314
    • Konishi Y, Setou M (2009) Tubulin tyrosination navigates the kinesin-1 motor domain to axons. Nat Neurosci 12:559–567. doi:10.1038/nn.2314, nn.2314[pii]
    • (2009) Nat Neurosci , vol.12 , pp. 559-567
    • Konishi, Y.1    Setou, M.2
  • 52
    • 76649143069 scopus 로고    scopus 로고
    • Posttranslational modifi cations of tubulin and the polarized transport of kinesin-1 in neurons
    • E09-01-0044
    • Hammond JW et al (2010) Posttranslational modifi cations of tubulin and the polarized transport of kinesin-1 in neurons. Mol Biol Cell 21:572–583. doi:10.1091/mbc.E09-01-0044, E09-01-0044[pii]
    • (2010) Mol Biol Cell , vol.21 , pp. 572-583
    • Hammond, J.W.1
  • 53
    • 70350446761 scopus 로고    scopus 로고
    • Traffi c control: Regulation of kinesin motors
    • Verhey KJ, Hammond JW (2009) Traffi c control: regulation of kinesin motors. Nat Rev Mol Cell Biol 10:765–777. doi:10.1038/nrm2782, nrm2782[pii]
    • (2009) Nat Rev Mol Cell Biol , vol.10 , pp. 765-777
    • Verhey, K.J.1    Hammond, J.W.2
  • 54
    • 0034618565 scopus 로고    scopus 로고
    • Microtubule motors in mitosis
    • Sharp DJ, Rogers GC, Scholey JM (2000) Microtubule motors in mitosis. Nature 407:41–47. doi:10.1038/35024000
    • (2000) Nature , vol.407 , pp. 41-47
    • Sharp, D.J.1    Rogers, G.C.2    Scholey, J.M.3
  • 55
    • 0029947691 scopus 로고    scopus 로고
    • Expression of a kinesin-related motor protein induces sf9 cells to form dendrite-like processes with nonuniform microtubule polarity orientation
    • Sharp DJ, Kuriyama R, Baas PW (1996) Expression of a kinesin-related motor protein induces Sf9 cells to form dendrite-like processes with nonuniform microtubule polarity orientation. J Neurosci 16:4370–4375
    • (1996) J Neurosci , vol.16 , pp. 4370-4375
    • Sharp, D.J.1    Kuriyama, R.2    Baas, P.W.3
  • 56
    • 0007675625 scopus 로고    scopus 로고
    • Expression of a minus-end-directed motor protein induces sf9 cells to form axon-like processes with uniform microtubule polarity orientation
    • Sharp DJ, Kuriyama R, Essner R, Baas PW (1997) Expression of a minus-end-directed motor protein induces Sf9 cells to form axon-like processes with uniform microtubule polarity orientation. J Cell Sci 110(Pt 19):2373–2380
    • (1997) J Cell Sci , vol.110 , pp. 2373-2380
    • Sharp, D.J.1    Kuriyama, R.2    Essner, R.3    Baas, P.W.4
  • 57
    • 0030857398 scopus 로고    scopus 로고
    • Identifi cation of a microtubule-associated motor protein essential for dendritic differentiation
    • Sharp DJ et al (1997) Identifi cation of a microtubule-associated motor protein essential for dendritic differentiation. J Cell Biol 138:833–843
    • (1997) J Cell Biol , vol.138 , pp. 833-843
    • Sharp, D.J.1
  • 58
    • 84863772449 scopus 로고    scopus 로고
    • Kar3vik1, a member of the kinesin-14 superfamily, shows a novel kinesin microtubule binding pattern
    • Rank KC et al (2012) Kar3Vik1, a member of the kinesin-14 superfamily, shows a novel kinesin microtubule binding pattern. J Cell Biol 197:957–970. doi:10.1083/jcb.201201132, jcb.201201132[pii]
    • (2012) J Cell Biol , vol.197 , pp. 957-970
    • Rank, K.C.1
  • 59
    • 77949655621 scopus 로고    scopus 로고
    • Mitotic functions of kinesin-5
    • S1084-9521(10)00020-0
    • Ferenz NP, Gable A, Wadsworth P (2010) Mitotic functions of kinesin-5. Semin Cell Dev Biol 21:255–259. doi:10.1016/j.semcdb.2010.01.019, S1084-9521(10)00020-0[pii]
    • (2010) Semin Cell Dev Biol , vol.21 , pp. 255-259
    • Ferenz, N.P.1    Gable, A.2    Wadsworth, P.3
  • 60
    • 34250183789 scopus 로고    scopus 로고
    • Kinesin-5 acts as a brake in anaphase spindle elongation
    • S0960-9822(07)01333-4
    • Saunders AM, Powers J, Strome S, Saxton WM (2007) Kinesin-5 acts as a brake in anaphase spindle elongation. Curr Biol 17:R453–R454. doi:10.1016/j.cub.2007.05.001, S0960-9822(07)01333-4[pii]
    • (2007) Curr Biol , vol.17
    • Saunders, A.M.1    Powers, J.2    Strome, S.3    Saxton, W.M.4
  • 61
    • 0030025443 scopus 로고    scopus 로고
    • A bipolar kinesin
    • Kashina AS et al (1996) A bipolar kinesin. Nature 379:270–272. doi:10.1038/379270a0
    • (1996) Nature , vol.379 , pp. 270-272
    • Kashina, A.S.1
  • 62
    • 0032476724 scopus 로고    scopus 로고
    • Localization of the kinesin-like protein xklp2 to spindle poles requires a leucine zipper, a microtubule-associated protein, and dynein
    • Wittmann T, Boleti H, Antony C, Karsenti E, Vernos I (1998) Localization of the kinesin-like protein Xklp2 to spindle poles requires a leucine zipper, a microtubule-associated protein, and dynein. J Cell Biol 143:673–685
    • (1998) J Cell Biol , vol.143 , pp. 673-685
    • Wittmann, T.1    Boleti, H.2    Antony, C.3    Karsenti, E.4    Vernos, I.5
  • 63
    • 0034618133 scopus 로고    scopus 로고
    • A kinesin-related protein, krp(180), positions prometaphase spindle poles during early sea urchin embryonic cell division
    • Rogers GC et al (2000) A kinesin-related protein, KRP(180), positions prometaphase spindle poles during early sea urchin embryonic cell division. J Cell Biol 150:499–512
    • (2000) J Cell Biol , vol.150 , pp. 499-512
    • Rogers, G.C.1
  • 64
    • 84880703330 scopus 로고    scopus 로고
    • Kinesin-12 differentially affects spindle assembly depending on its microtubule substrate
    • S0960-9822(13)00638-6
    • Sturgill EG, Ohi R (2013) Kinesin-12 differentially affects spindle assembly depending on its microtubule substrate. Curr Biol 23:1280–1290. doi:10.1016/j.cub.2013.05.043, S0960-9822(13)00638-6[pii]
    • (2013) Curr Biol , vol.23 , pp. 1280-1290
    • Sturgill, E.G.1    Ohi, R.2
  • 65
    • 69949155962 scopus 로고    scopus 로고
    • Dynamics of myosin, microtubules, and kinesin-6 at the cortex during cytokinesis in drosophila s2 cells
    • jcb.200902083
    • Vale RD, Spudich JA, Griffi s ER (2009) Dynamics of myosin, microtubules, and Kinesin-6 at the cortex during cytokinesis in Drosophila S2 cells. J Cell Biol 186:727–738. doi:10.1083/jcb.200902083, jcb.200902083[pii]
    • (2009) J Cell Biol , vol.186 , pp. 727-738
    • Vale, R.D.1    Spudich, J.A.2    Griffi S, E.R.3
  • 66
    • 84880069821 scopus 로고    scopus 로고
    • Binding of the cyk-4 subunit of the centralspindlin complex induces a large scale conformational change in the kinesin subunit
    • M113.463695
    • White EA, Raghuraman H, Perozo E, Glotzer M (2013) Binding of the CYK-4 subunit of the centralspindlin complex induces a large scale conformational change in the kinesin subunit. J Biol Chem 288:19785–19795. doi:10.1074/jbc.M113.463695, M113.463695[pii]
    • (2013) J Biol Chem , vol.288 , pp. 19785-19795
    • White, E.A.1    Raghuraman, H.2    Perozo, E.3    Glotzer, M.4
  • 67
    • 77953137954 scopus 로고    scopus 로고
    • Aurora b and 14-3-3 coordinately regulate clustering of centralspindlin during cytokinesis
    • S0960-9822(10)00381-7
    • Douglas ME, Davies T, Joseph N, Mishima M (2010) Aurora B and 14-3-3 coordinately regulate clustering of centralspindlin during cytokinesis. Curr Biol 20:927–933. doi:10.1016/j. cub.2010.03.055, S0960-9822(10)00381-7[pii]
    • (2010) Curr Biol , vol.20 , pp. 927-933
    • Douglas, M.E.1    Davies, T.2    Joseph, N.3    Mishima, M.4
  • 68
    • 84860174849 scopus 로고    scopus 로고
    • Microtubule redistribution in growth cones elicited by focal inactivation of kinesin-5
    • 32/17/5783
    • Nadar VC, Lin S, Baas PW (2012) Microtubule redistribution in growth cones elicited by focal inactivation of kinesin-5. J Neurosci 32:5783–5794. doi:10.1523/JNEUROSCI.0144-12.2012, 32/17/5783[pii]
    • (2012) J Neurosci , vol.32 , pp. 5783-5794
    • Nadar, V.C.1    Lin, S.2    Baas, P.W.3
  • 69
    • 84920501033 scopus 로고    scopus 로고
    • Effects of kinesin-5 inhibition on dendritic architecture and microtubule organization
    • 1091/mbc.E14-08-1313
    • Kahn OI, Sharma V, González-Billault C, Baas PW (2015) Effects of kinesin-5 inhibition on dendritic architecture and microtubule organization. Mol Biol Cell 26(1):66–77. doi:1091/mbc.E14-08-1313
    • (2015) Mol Biol Cell , vol.26 , Issue.1 , pp. 66-77
    • Kahn, O.I.1    Sharma, V.2    González-Billault, C.3    Baas, P.W.4
  • 70
    • 84879906973 scopus 로고    scopus 로고
    • Polarity in migrating neurons is related to a mechanism analogous to cytokinesis
    • S0960-9822(13)00622-2
    • Falnikar A, Tole S, Liu M, Liu JS, Baas PW (2013) Polarity in migrating neurons is related to a mechanism analogous to cytokinesis. Curr Biol 23:1215–1220. doi:10.1091/mbc.E14-08-1313, S0960-9822(13)00622-2[pii]
    • (2013) Curr Biol , vol.23 , pp. 1215-1220
    • Falnikar, A.1    Tole, S.2    Liu, M.3    Liu, J.S.4    Baas, P.W.5
  • 71
    • 0031870960 scopus 로고    scopus 로고
    • Expression of the mitotic motor protein cho1/mklp1 in postmitotic neurons
    • Ferhat L, Kuriyama R, Lyons GE, Micales B, Baas PW (1998) Expression of the mitotic motor protein CHO1/MKLP1 in postmitotic neurons. Eur J Neurosci 10:1383–1393
    • (1998) Eur J Neurosci , vol.10 , pp. 1383-1393
    • Ferhat, L.1    Kuriyama, R.2    Lyons, G.E.3    Micales, B.4    Baas, P.W.5
  • 72
    • 0032190094 scopus 로고    scopus 로고
    • Expression of the mitotic motor protein eg5 in postmitotic neurons: Implications for neuronal development
    • Ferhat L et al (1998) Expression of the mitotic motor protein Eg5 in postmitotic neurons: implications for neuronal development. J Neurosci 18:7822–7835
    • (1998) J Neurosci , vol.18 , pp. 7822-7835
    • Ferhat, L.1
  • 73
    • 78649600795 scopus 로고    scopus 로고
    • Expression of kinesin superfamily genes in cultured hippocampal neurons
    • Silverman MA et al (2010) Expression of kinesin superfamily genes in cultured hippocampal neurons. Cytoskeleton (Hoboken) 67:784–795. doi:10.1002/cm.20487
    • (2010) Cytoskeleton (Hoboken) , vol.67 , pp. 784-795
    • Silverman, M.A.1
  • 74
    • 79751469568 scopus 로고    scopus 로고
    • Inhibition of kinesin-5, a microtubule-based motor protein, as a strategy for enhancingregenerationofadultaxons
    • Lin S et al (2011) Inhibition of kinesin-5, a microtubule-based motor protein, as a strategy for enhancingregenerationofadultaxons. Traffi c12:269–286. doi:10.1111/j.1600-0854.2010.01152.x
    • (2011) Traffi , vol.12 , pp. 269-286
    • Lin, S.1
  • 75
    • 0033363319 scopus 로고    scopus 로고
    • Learning enhances adult neurogenesis in the hippocampal formation
    • Gould E, Beylin A, Tanapat P, Reeves A, Shors TJ (1999) Learning enhances adult neurogenesis in the hippocampal formation. Nat Neurosci 2:260–265. doi:10.1038/6365
    • (1999) Nat Neurosci , vol.2 , pp. 260-265
    • Gould, E.1    Beylin, A.2    Tanapat, P.3    Reeves, A.4    Shors, T.J.5
  • 76
    • 33645098296 scopus 로고    scopus 로고
    • Is there a link between adult neurogenesis and learning?
    • Leuner B, Gould E, Shors TJ (2006) Is there a link between adult neurogenesis and learning? Hippocampus 16:216–224. doi:10.1002/hipo.20153
    • (2006) Hippocampus , vol.16 , pp. 216-224
    • Leuner, B.1    Gould, E.2    Shors, T.J.3
  • 77
    • 84855945935 scopus 로고    scopus 로고
    • Cognitive side effects of cancer therapy demonstrate a functional role for adult neurogenesis
    • S0166-4328(11)00401-3
    • Monje M, Dietrich J (2012) Cognitive side effects of cancer therapy demonstrate a functional role for adult neurogenesis. Behav Brain Res 227:376–379. doi:10.1016/j.bbr.2011.05.012, S0166-4328(11)00401-3[pii]
    • (2012) Behav Brain Res , vol.227 , pp. 376-379
    • Monje, M.1    Dietrich, J.2
  • 78
    • 84860668053 scopus 로고    scopus 로고
    • Inhibition of adult neurogenesis by inducible and targeted deletion of erk5 mitogen-activated protein kinase specifi cally in adult neurogenic regions impairs contextual fear extinction and remote fear memory
    • 32/19/6444
    • Pan YW, Chan GC, Kuo CT, Storm DR, Xia Z (2012) Inhibition of adult neurogenesis by inducible and targeted deletion of ERK5 mitogen-activated protein kinase specifi cally in adult neurogenic regions impairs contextual fear extinction and remote fear memory. J Neurosci 32:6444–6455. doi:10.1523/JNEUROSCI. 6076-11.2012, 32/19/6444[pii]
    • (2012) J Neurosci , vol.32 , pp. 6444-6455
    • Pan, Y.W.1    Chan, G.C.2    Kuo, C.T.3    Storm, D.R.4    Xia, Z.5
  • 79
    • 34447122079 scopus 로고    scopus 로고
    • Sleep deprivation inhibits adult neurogenesis in the hippocampus by elevating glucocorticoids
    • 0608644103
    • Mirescu C, Peters JD, Noiman L, Gould E (2006) Sleep deprivation inhibits adult neurogenesis in the hippocampus by elevating glucocorticoids. Proc Natl Acad Sci U S A 103:19170– 19175. doi:10.1073/pnas.0608644103, 0608644103[pii]
    • (2006) Proc Natl Acad Sci , vol.103
    • Mirescu, C.1    Peters, J.D.2    Noiman, L.3    Gould, E.4
  • 80
    • 79957503202 scopus 로고    scopus 로고
    • Kif4 regulates midzone length during cytokinesis
    • S0960-9822(11)00435-0
    • Hu CK, Coughlin M, Field CM, Mitchison TJ (2011) KIF4 regulates midzone length during cytokinesis. Curr Biol 21:815–824. doi:10.1016/j.cub.2011.04.019, S0960-9822(11)00435-0[pii]
    • (2011) Curr Biol , vol.21 , pp. 815-824
    • Hu, C.K.1    Coughlin, M.2    Field, C.M.3    Mitchison, T.J.4
  • 81
    • 21844473254 scopus 로고    scopus 로고
    • Functional analysis of human microtubule-based motor proteins, the kinesins and dyneins, in mitosis/cytokinesis using rna interference
    • E05-02-0167
    • Zhu C et al (2005) Functional analysis of human microtubule-based motor proteins, the kinesins and dyneins, in mitosis/cytokinesis using RNA interference. Mol Biol Cell 16:3187– 3199. doi:10.1091/mbc.E05-02-0167, E05-02-0167[pii]
    • (2005) Mol Biol Cell , vol.16
    • Zhu, C.1
  • 82
    • 21744452482 scopus 로고    scopus 로고
    • Chromokinesins: Multitalented players in mitosis
    • S0962-8924(05)00131-5
    • Mazumdar M, Misteli T (2005) Chromokinesins: multitalented players in mitosis. Trends Cell Biol 15:349–355. doi:10.1016/j.tcb.2005.05.006, S0962-8924(05)00131-5[pii]
    • (2005) Trends Cell Biol , vol.15 , pp. 349-355
    • Mazumdar, M.1    Misteli, T.2
  • 83
    • 33746533757 scopus 로고    scopus 로고
    • Tumor formation via loss of a molecular motor protein
    • S0960-9822(06)01755-6
    • Mazumdar M et al (2006) Tumor formation via loss of a molecular motor protein. Curr Biol 16:1559–1564. doi:10.1016/j.cub.2006.06.029, S0960-9822(06)01755-6[pii]
    • (2006) Curr Biol , vol.16 , pp. 1559-1564
    • Mazumdar, M.1
  • 84
    • 36749076543 scopus 로고    scopus 로고
    • Activation of kif4a as a prognostic biomarker and therapeutic target lung cancer
    • 13/22/6624
    • Taniwaki M et al (2007) Activation of KIF4A as a prognostic biomarker and therapeutic target lung cancer. Clin Cancer Res 13(6624–6631):2007. doi:10.1158/1078-0432.CCR-07-1328, 13/22/6624[pii]
    • (2007) Clin Cancer Res , vol.13 , pp. 6624-6631
    • Taniwaki, M.1
  • 85
    • 33947101323 scopus 로고    scopus 로고
    • Gene dosage alterations revealed by cdna microarray analysis in cervical cancer: Identifi cation of candidate amplifi ed and overexpressed genes
    • Narayan G et al (2007) Gene dosage alterations revealed by cDNA microarray analysis in cervical cancer: identifi cation of candidate amplifi ed and overexpressed genes. Genes Chromosomes Cancer 46:373–384. doi:10.1002/gcc.20418
    • (2007) Genes Chromosomes Cancer , vol.46 , pp. 373-384
    • Narayan, G.1
  • 86
    • 66149144750 scopus 로고    scopus 로고
    • Kif4 mediates anterograde translocation and positioning of ribosomal constituents to axons
    • M808586200
    • Bisbal M et al (2009) KIF4 mediates anterograde translocation and positioning of ribosomal constituents to axons. J Biol Chem 284:9489–9497. doi:10.1074/jbc.M808586200, M808586200[pii]
    • (2009) J Biol Chem , vol.284 , pp. 9489-9497
    • Bisbal, M.1
  • 87
    • 33646039322 scopus 로고    scopus 로고
    • When a motor goes bad: A kinesin regulates neuronal survival
    • S0092-8674(06)00432-6
    • Kaplan DR, Miller FD (2006) When a motor goes bad: a kinesin regulates neuronal survival. Cell 125:224–226. doi:10.1016/j.cell.2006.03.031, S0092-8674(06)00432-6[pii]
    • (2006) Cell , vol.125 , pp. 224-226
    • Kaplan, D.R.1    Miller, F.D.2
  • 88
    • 33750456123 scopus 로고    scopus 로고
    • Lucky 13-microtubule depolymerisation by kinesin-13 motors
    • 119/19/3905
    • Moores CA, Milligan RA (2006) Lucky 13-microtubule depolymerisation by kinesin-13 motors. J Cell Sci 119:3905–3913. doi:10.1242/jcs.03224, 119/19/3905[pii]
    • (2006) J Cell Sci , vol.119 , pp. 3905-3913
    • Moores, C.A.1    Milligan, R.A.2
  • 89
    • 37549037135 scopus 로고    scopus 로고
    • Kinesin-13 regulates fl agellar, interphase, and mitotic microtubule dynamics in giardia intestinalis
    • EC.00128-07
    • Dawson SC et al (2007) Kinesin-13 regulates fl agellar, interphase, and mitotic microtubule dynamics in Giardia intestinalis. Eukaryot Cell 6:2354–2364. doi:10.1128/EC.00128-07, EC.00128-07[pii]
    • (2007) Eukaryot Cell , vol.6 , pp. 2354-2364
    • Dawson, S.C.1
  • 90
    • 77949489741 scopus 로고    scopus 로고
    • Kinesin-13 s in mitosis: Key players in the spatial and temporal organization of spindle microtubules
    • S1084-9521(10)00017-0
    • Ems-McClung SC, Walczak CE (2010) Kinesin-13 s in mitosis: key players in the spatial and temporal organization of spindle microtubules. Semin Cell Dev Biol 21:276–282. doi:10.1016/j.semcdb.2010.01.016, S1084-9521(10)00017-0[pii]
    • (2010) Semin Cell Dev Biol , vol.21 , pp. 276-282
    • Ems-McClung, S.C.1    Walczak, C.E.2
  • 91
    • 84862538643 scopus 로고    scopus 로고
    • Plk1 regulates the kinesin-13 protein kif2b to promote faithful chromosome segregation
    • mbc.E11-12-1013
    • Hood EA, Kettenbach AN, Gerber SA, Compton DA (2012) Plk1 regulates the kinesin-13 protein Kif2b to promote faithful chromosome segregation. Mol Biol Cell 23:2264–2274. doi:10.1091/mbc.E11-12-1013, mbc.E11-12-1013[pii]
    • (2012) Mol Biol Cell , vol.23 , pp. 2264-2274
    • Hood, E.A.1    Kettenbach, A.N.2    Gerber, S.A.3    Compton, D.A.4
  • 92
    • 72149125306 scopus 로고    scopus 로고
    • Overexpression of kif2a promotes the progression and metastasis of squamous cell carcinoma of the oral tongue
    • S1368-8375(09)00967-1
    • Wang CQ et al (2010) Overexpression of Kif2a promotes the progression and metastasis of squamous cell carcinoma of the oral tongue. Oral Oncol 46:65–69. doi:10.1016/j.oraloncology.2009.11.003, S1368-8375(09)00967-1[pii]
    • (2010) Oral Oncol , vol.46 , pp. 65-69
    • Wang, C.Q.1
  • 93
    • 80052608464 scopus 로고    scopus 로고
    • Evaluation of associations between common variation in mitotic regulatory pathways and risk of overall and high grade breast cancer
    • Stevens KN et al (2011) Evaluation of associations between common variation in mitotic regulatory pathways and risk of overall and high grade breast cancer. Breast Cancer Res Treat 129:617–622. doi:10.1007/s10549-011-1587-y
    • (2011) Breast Cancer Res Treat , vol.129 , pp. 617-622
    • Stevens, K.N.1
  • 94
    • 0043199576 scopus 로고    scopus 로고
    • Kinesin superfamily protein 2a (Kif2a) functions in suppression of collateral branch extension
    • Homma N et al (2003) Kinesin superfamily protein 2A (KIF2A) functions in suppression of collateral branch extension. Cell 114:229–239. doi:S0092867403005221[pii]
    • (2003) Cell , vol.114 , pp. 229-239
    • Homma, N.1
  • 95
    • 84878717611 scopus 로고    scopus 로고
    • Mutations in tubg1, dync1h1, kif5c and kif2a cause malformations of cortical development and microcephaly
    • ng0813-962b
    • Poirier K et al (2013) Mutations in TUBG1, DYNC1H1, KIF5C and KIF2A cause malformations of cortical development and microcephaly. Nat Genet 45:962. doi:10.1038/ng0813-962b, ng0813-962b[pii]
    • (2013) Nat Genet , vol.45
    • Poirier, K.1
  • 96
    • 77952759760 scopus 로고    scopus 로고
    • Ectopic expression of the microtubule-dependent motor protein eg5 promotes pancreatic tumourigenesis
    • Liu M et al (2010) Ectopic expression of the microtubule-dependent motor protein Eg5 promotes pancreatic tumourigenesis. J Pathol 221:221–228. doi:10.1002/path.2706
    • (2010) J Pathol , vol.221 , pp. 221-228
    • Liu, M.1
  • 97
    • 35948946506 scopus 로고    scopus 로고
    • Overexpression of eg5 causes genomic instability and tumor formation in mice
    • 67/21/10138
    • Castillo A, Morse HC 3rd, Godfrey VL, Naeem R, Justice MJ (2007) Overexpression of Eg5 causes genomic instability and tumor formation in mice. Cancer Res 67:10138–10147. doi:10.1158/0008-5472.CAN-07-0326, 67/21/10138[pii]
    • (2007) Cancer Res , vol.67 , pp. 10138-10147
    • Castillo, A.1    Morse, H.C.2    Godfrey, V.L.3    Naeem, R.4    Justice, M.J.5
  • 98
    • 79958725353 scopus 로고    scopus 로고
    • Overexpression of mitotic centromere-associated kinesin stimulates microtubule detachment and confers resistance to paclitaxel
    • 1535-7163.MCT-10-1109
    • Ganguly A, Yang H, Cabral F (2011) Overexpression of mitotic centromere-associated Kinesin stimulates microtubule detachment and confers resistance to paclitaxel. Mol Cancer Ther 10:929–937. doi:10.1158/1535-7163.MCT-10-1109, 1535-7163.MCT-10-1109[pii]
    • (2011) Mol Cancer Ther , vol.10 , pp. 929-937
    • Ganguly, A.1    Yang, H.2    Cabral, F.3
  • 99
    • 84867152057 scopus 로고    scopus 로고
    • Kinesin spindle protein sirna slows tumor progression
    • Marra E, Palombo F, Ciliberto G, Aurisicchio L (2013) Kinesin spindle protein SiRNA slows tumor progression. J Cell Physiol 228:58–64. doi:10.1002/jcp.24103
    • (2013) J Cell Physiol , vol.228 , pp. 58-64
    • Marra, E.1    Palombo, F.2    Ciliberto, G.3    Aurisicchio, L.4
  • 100
    • 84877120847 scopus 로고    scopus 로고
    • First-in-humans trial of an rna interference therapeutic targeting vegf and ksp in cancer patients with liver involvement
    • 2159-8290.CD-12-0429
    • Tabernero J et al (2013) First-in-humans trial of an RNA interference therapeutic targeting VEGF and KSP in cancer patients with liver involvement. Cancer Discov 3:406–417. doi:10.1158/2159-8290.CD-12-0429, 2159-8290.CD-12-0429[pii]
    • (2013) Cancer Discov , vol.3 , pp. 406-417
    • Tabernero, J.1
  • 101
    • 84858277073 scopus 로고    scopus 로고
    • Phase i dose-escalation and pharmacokinetic study of ispinesib, a kinesin spindle protein inhibitor, administered on days 1 and 15 of a 28-day schedule in patients with no prior treatment for advanced breast cancer
    • Gomez HL et al (2012) Phase I dose-escalation and pharmacokinetic study of ispinesib, a kinesin spindle protein inhibitor, administered on days 1 and 15 of a 28-day schedule in patients with no prior treatment for advanced breast cancer. Anticancer Drugs 23:335–341. doi:10.1097/CAD.0b013e32834e74d6
    • (2012) Anticancer Drugs , vol.23 , pp. 335-341
    • Gomez, H.L.1
  • 102
    • 84863335493 scopus 로고    scopus 로고
    • A phase 1 dose-escalation study of arry-520, a kinesin spindle protein inhibitor, in patients with advanced myeloid leukemias
    • Khoury HJ et al (2012) A phase 1 dose-escalation study of ARRY-520, a kinesin spindle protein inhibitor, in patients with advanced myeloid leukemias. Cancer 118:3556–3564. doi:10.1002/cncr.26664
    • (2012) Cancer , vol.118 , pp. 3556-3564
    • Khoury, H.J.1
  • 103
    • 75149121482 scopus 로고    scopus 로고
    • Arry-520, a novel ksp inhibitor with potent activity in hematological and taxane-resistant tumor models
    • Woessner R et al (2009) ARRY-520, a novel KSP inhibitor with potent activity in hematological and taxane-resistant tumor models. Anticancer Res 29:4373–4380. doi:29/11/4373[pii]
    • (2009) Anticancer Res , vol.29 , pp. 4373-4380
    • Woessner, R.1


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