Dendrimer-inspired nanomaterials for the in vivo delivery of siRNA to lung vasculature

Nano Letters

Volumn 15, Issue 5, 2015, Pages 3008-3016

  Khan, Omar F ^a   Zaia, Edmond W ^a   Jhunjhunwala, Siddharth ^a   Xue, Wen ^a   Cai, Wenxin ^a   Yun, Dong Soo ^a   Barnes, Carmen M ^c   Dahlman, James E ^a,d   Dong, Yizhou ^a,b   Pelet, Jeisa M ^a   Webber, Matthew J ^a   Tsosie, Jonathan K ^a   Jacks, Tyler E ^a   Langer, Robert ^a,d,e   Anderson, Daniel G ^a,d,e  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^b BOSTON CHILDREN S HOSPITAL   (United States)

^c ALNYLAM PHARMACEUTICALS   (United States)

^d HARVARD MIT DIVISION OF HEALTH SCIENCES AND TECHNOLOGY   (United States)

^e Massachusetts Institute of Technology Cambridge   (United States)

Author keywords

in vivo; modified dendrimer nanoparticles; nanomaterial; siRNA; target lung endothelial cells

Indexed keywords

BIOLOGICAL ORGANS; DENDRIMERS; DISEASES; NANOSTRUCTURED MATERIALS; RNA;

CHEMICALLY MODIFIED; COMBINATORIAL APPROACH; IN-VIVO; NANOMATERIAL; PRO-INFLAMMATORY CYTOKINES; PULMONARY DELIVERY; SIRNA; SMALL INTERFERING RNA (SIRNA);

ENDOTHELIAL CELLS;

DENDRIMER; NANOMATERIAL; SMALL INTERFERING RNA;

ANIMAL; CHEMISTRY; DRUG EFFECTS; ENDOTHELIUM CELL; GENE TRANSFER; GENETICS; HUMAN; LUNG; PATHOLOGY; RNA INTERFERENCE;

ANIMALS; DENDRIMERS; ENDOTHELIAL CELLS; GENE TRANSFER TECHNIQUES; HUMANS; LUNG; NANOSTRUCTURES; RNA INTERFERENCE; RNA, SMALL INTERFERING;

EID: 84929180252     PISSN: 15306984     EISSN: 15306992     Source Type: Journal    
DOI: 10.1021/nl5048972     Document Type: Article

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