Enhancing the light-driven production of d-lactate by engineering cyanobacterium using a combinational strategy

Scientific Reports

Volumn 5, Issue , 2015, Pages

  Li, Chao ^a   Tao, Fei ^a   Ni, Jun ^a   Wang, Yu ^a   Yao, Feng ^a   Xu, Ping ^a  

^a Shanghai Jiao Tong University   (China)

Author keywords

[No Author keywords available]

Indexed keywords

LACTIC ACID; MULTIENZYME COMPLEX; RECOMBINANT PROTEIN;

BIOLOGICAL MODEL; BIOSYNTHESIS; COMBINATORIAL CHEMISTRY; COMPUTER SIMULATION; GENETIC ENHANCEMENT; GENETICS; ISOLATION AND PURIFICATION; LIGHT; PHOTOSYNTHESIS; PHYSIOLOGY; PROCEDURES; RADIATION RESPONSE; SYNECHOCOCCUS; UPREGULATION;

COMBINATORIAL CHEMISTRY TECHNIQUES; COMPUTER SIMULATION; GENETIC ENHANCEMENT; LACTIC ACID; LIGHT; MODELS, GENETIC; MULTIENZYME COMPLEXES; PHOTOSYNTHESIS; RECOMBINANT PROTEINS; SYNECHOCOCCUS; UP-REGULATION;

EID: 84929180190     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep09777     Document Type: Article

References (41)

1. Atsumi, S., Higashide, W. & Liao, J. C. Direct photosynthetic recycling of carbon dioxide to isobutyraldehyde. Nat. Biotechnol. 27, 1177-1180 (2009).
2. Groenigen, K. J., Osenberg, C. W. & Hungate, B. A. Increased soil emissions of potent greenhouse gases under increased atmospheric CO2. Nature 475, 214-216 (2011).
3. Lan, E. I. & Liao, J. C. ATP drives direct photosynthetic production of 1-butanol in cyanobacteria. Proc. Natl. Acad. Sci. USA 109, 6018-6023 (2011).
4. Li, Y. et al. Efficient production of polymer-grade d-lactate by Sporolactobacillus laevolacticus DSM442 with agricultural waste cottonseed as the sole nitrogen source. Bioresour. Technol. 142, 186-191 (2013).
5. Abdel-Rahman, M. A., Tashiro, Y. & Sonomoto, K. Lactate production from lignocellulose-derived sugars using lactate bacteria: overview and limits. J. Biotechnol. 156, 286-301 (2010).
6. Zhang, J. et al. In vitro enhancement of lactate esters on the percutaneous penetration of drugs with different lipophilicity. AAPS PharmSciTech. 11, 894-903 (2010).
7. Datta, R. & Michael, Henry. Lactic acid: recent advances in products, processes and technologies-A review. J. Chem. Technol. Biotechnol. 81, 1119-1129 (2006).
8. Okano, K. et al. Efficient production of optically pure d-lactate from raw corn starch by using a genetically modified l-lactate dehydrogenase gene-deficient and ?-Amylase-secreting Lactobacillus plantarum strain. Appl. Environ. Microbiol. 75, 462-467 (2009).
9. Yun, J. S., Wee, Y. J, Kim, J. N. & Ryu, H. W. Fermentative production of dl-lactate from amylase-treated rice and wheat brans hydrolyzate by a novel lactate bacterium, Lactobacillus sp. Biotechnol. Lett. 26, 1613-1616 (2004).
10. Tan, X. M. et al. Photosynthesis driven conversion of carbon dioxide to fatty alcohols and hydrocarbons in cyanobacteria. Metab. Eng. 13, 169-176 (2011).
11. Angermayr, S. A., Paszota, M. & Hellingwerf, K. J. Engineering a cyanobacterial cell factory for production of lactic acid. Appl. Environ. Microbiol. 78, 7098-7106 (2012).
12. Angermayr, S. A. & Hellingwerf, K. J. On the use of metabolic control analysis in the optimization of cyanobacterial biosolar cell factories. J. Phys. Chem. B 117, 11169-11175 (2013).
13. Angermayr, S. A. et al. Exploring metabolic engineerring design principles for the photosynthetic production of lactic acid by Synechocystis sp. PCC6803. Biotechnol. Biofuels 7, 99 (2014).
14. Hollinshead, W. D. et al. Boosting d-lactate production in engineered cyanobacteria using sterilized anaerobic digestion effluents. Bioresour. Technol. 169, 462-467 (2014).
15. Joseph, A. et al. Utilization of lactate bacterial genes in Synechocystis sp. PCC6803 in the production of lactate. Biosci. Biotechnol. Biochem. 77, 966-970 (2013).
16. Niederholtmeyer, H. et al. Engineering cyanobacteria to synthesize and export hydrophilic products. Appl. Environ. Microbiol. 76, 3462-3466 (2010).
17. Varman, A. M., Yu, Y., You, L. & Tang, Y. J. Photoautotrophic production of d-lactate in an engineered cyanobacterium. Microb. Cell Fact. 12, 117 (2013).
18. van der Woude, A. D. et al. Carbon sink removal: increased photosynthetic production of lactic acid by Synechocystis sp. PCC6803 in a glycogen storage mutant. J. Biotechnol. 184, 100-102 (2014).
19. Tamoi, M., Miyazaki, T., Fukamizo, T. & Shigeoka, S. The Calvin cycle in cyanobacteria is regulated by CP12 via the NAD(H)/NADP(H) ratio under light/dark conditions. Plant J. 42, 504-513 (2005).
20. Lan, E. I., Ro, S. Y. & Liao, J. C. Oxygen-tolerant coenzyme A-Acylating aldehyde dehydrogenase facilitates efficient photosynthetic n-butanol biosynthesis in cyanobacteria. Energy Environ. Sci. 6, 2672-2681 (2013).
21. Li, H. & Liao, J. C. Engineering a cyanobacterium as the catalyst for the photosynthetic conversion of CO2 to 1,2-propanediol. Microb. Cell Fact. 12, 4 (2013).
22. Oliver, J. W., Machado, I. M., Yoneda, H. & Atsumi, S. Cyanobacterial conversion of carbon dioxide to 2,3-butanediol. Proc. Natl. Acad. Sci. USA 110, 1249-1254 (2013).
23. Savakis, P. E., Angermayr, S. A. & Hellingwerf, K. J. Synthesis of 2,3-butanediol by Synechocystis sp. PCC6803 via heterologous expression of a catabolic pathway from lactate-And enterobacteria. Metab. Eng. 20, 121-130 (2013).
24. Katzberg, M., Skorupa-Parachin, N., Gorwa-Grauslund, M. F. & Bertau, M. Engineering cofactor preference of ketone reducing biocatalysts: a mutagenesis study on a ?-diketone reductase from the yeast Saccharomyces cerevisiae serving as an example. Int. J. Mol. Sci. 11, 1735-1758 (2010).
25. Watanabe, S., Kodaki, T. & Makino, K. Complete reversal of coenzyme specificity of xylitol dehydrogenase and increase of thermostability by the introduction of structural zinc. J. Biol. Chem. 280, 10340-10349 (2005).
26. Hou, J., Shen, Y., Li, X. P. & Bao, X. M. Effect of the reversal of coenzyme specificity by expression of mutated Pichia stipitis xylitol dehydrogenase in recombinant Saccharomyces cerevisiae. Lett. Appl. Microbiol. 45, 184-189 (2007).
27. Brinkmann-Chen, S. et al. General approach to reversing ketol-Acid reductoisomerase cofactor dependence from NADPH to NADH. Proc. Natl. Acad. Sci. USA 110, 10946-10951 (2013).
28. Brinkmann-Chen, S., Cahn, J. K. B. & Arnold, F. H. Uncovering rare NADH-preferring ketol-Acid reductoisomerases. Metab. Eng. 26, 17-22 (2014).
29. Opgenorth, P. H., Korman, T. P. & Bowie, J. U. A synthetic biochemistry molecular purge valve module that maintains redox balance. Nat. commun. 5, 4113 (2014).
30. Lindberg, P., Park, S. & Melis, A. Engineering a platform for photosynthetic isoprene production in cyanobacteria, using Synechocystis as the model organism. Metab. Eng. 12, 70-79 (2010).
31. Ducat, D. C., Way, J. C. & Silver, P. A. Engineering cyanobacteria to generate high-value products. Trends Biotechnol. 29, 95-103 (2011).
32. Zhou, J., Zhang, H., Meng, H., Zhang, Y. & Li, Yin. Production of optically pure d-lactate from CO2 by blocking the PHB and acetate pathways and expressing d-lactate dehydrogenase in cyanobacterium Synechocystis sp. PCC 6803. Process Biochem. 49, 2071-2077 (2014).
33. Wang, B. et al. Engineering cyanobacteria for photosynthetic production of 3-hydroxybutyrate directly from CO2. Metab. Eng. 16, 68-77 (2013).
34. Nunez, M. F. et al. Transport of l-lactate, d-lactate, and glycolate by the LldP and GlcA membrane carriers of Escherichia coli. Biochem. Bioph. Res. Commun. 290, 824-829 (2001).
35. Smith, A. J. Modes of cyanobacterial carbon metabolism. Ann. Microbiol. (Paris) 134B, 93-113 (1983).
36. Olavarria, K., Valdes, D. & Cabrera, R. The cofactor preference of glucose-6-phosphate dehydrogenase from Escherichia coli-modeling the physiological production of reduced cofactors. FEBS J. 279, 2296-2309 (2012).
37. Hagen, K. D. & Meeks, J. C. The unique cyanobacterial protein OpcA is an allosteric effector of glucose-6-phosphate dehydrogenase in Nostoc punctiforme ATCC 29133. J. Biol. Chem. 276, 11477-11486 (2001).
38. Horton, R. M. et al. Engineering hybrid genes without the use of restriction enzymes: gene splicing by overlap extension. Gene 77, 61-68 (1989).
39. Hoover, D. M. & Lubkowski, J. DNAWorks: an automated method for designing oligonucleotides for PCR-based gene synthesis. Nucleic Acids Res. 30, e43 (2002).
40. Wang, X. et al. Cloning, expression, purification, and activity assay of proteins relatd to d-lactic acid formation in Lactobacillus rhamnosus. Appl. Microbiol. Biotechnol. 87, 2117-2123 (2010).
41. Zheng, Z. J. et al. Relative catalytic efficiency of ldhL-And ldhD-encoded products is crucial for optical purity of lactate produced by Lactobacillus strains. Appl. Environ. Microbiol. 78, 3480-3483 (2012).