Do we over treat mild hypertension?

Expert Opinion on Pharmacotherapy

Volumn 16, Issue 8, 2015, Pages 1121-1126

  Zanchetti, Alberto ^a  

^a UNIVERSITY OF MILAN   (Italy)

Author keywords

Antihypertensive treatment; Cardiovascular risk; Grade 1 hypertension; Meta analysis; Mild hypertension; Randomized controlled trial

Indexed keywords

ANTIHYPERTENSIVE AGENT;

ANTIHYPERTENSIVE THERAPY; BORDERLINE HYPERTENSION; CARDIOVASCULAR MORTALITY; CARDIOVASCULAR RISK; DIASTOLIC BLOOD PRESSURE; FOLLOW UP; HUMAN; PRACTICE GUIDELINE; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; RISK REDUCTION; SYSTOLIC BLOOD PRESSURE; BLOOD PRESSURE; CARDIOVASCULAR DISEASES; DIASTOLE; DRUG EFFECTS; HYPERTENSION; META ANALYSIS (TOPIC); PATHOPHYSIOLOGY; RISK; SYSTOLE;

ANTIHYPERTENSIVE AGENTS; BLOOD PRESSURE; CARDIOVASCULAR DISEASES; DIASTOLE; HUMANS; HYPERTENSION; META-ANALYSIS AS TOPIC; RANDOMIZED CONTROLLED TRIALS AS TOPIC; RISK; SYSTOLE;

EID: 84929179674     PISSN: 14656566     EISSN: 17447666     Source Type: Journal    
DOI: 10.1517/14656566.2015.1040761     Document Type: Review

References (22)

1. Smith WM. Treatment of mild hypertension: results of a ten-year intervention trial. Circ Res 1977;40:I98-105
2. Perry HM Jr, Goldman AI, Lavin MA, et al. Evaluation of drug treatment in mild hypertension: VA-NHLBI feasibility trial. Plan and preliminary results of a two-year feasibility trial for a multicenter intervention study to evaluate the benefits versus the disadvantages of treating mild hypertension. Prepared for the Veterans Administration-National Heart, Lung, and Blood Institute study group for evaluating treatment in mild hypertension. Ann N Y Acad Sci 1978;304:267-92
3. Hypertension Detection and Follow-up Program Cooperative Group. Five-year findings of the hypertension detection and follow-up program. I. Reduction in mortality of persons with high blood pressure, including mild hypertension. JAMA 1979;242:2562-71
4. Management Committee. The Australian therapeutic trial in mild hypertension. Lancet 1980;315:1261-7
5. Helgeland A. Treatment of mild hypertension: a five year controlled drug trial. The Oslo study. Am J Med 1980;69:725-32
6. Medical Research Council Working Party. MRC trial on treatment of mild hypertension: principal results. Br Med J 1985;291:97-104
7. Neaton JD, Grimm RH Jr, Prineas RJ, et al. Treatment of mild hypertension study. Final results. Treatment of mild hypertension study research group. JAMA 1993;270:713-24
8. Mancia G, Fagard R, Narkiewicz K, et al. The task force for the management of arterial hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). 2013 ESH/ESC Guidelines for the management of arterial hypertension. J Hypertens 2013;31:1281-357
9. Chobanian AV, Bakris GL, Black HR, et al. Seventh report of the Joint National Committee on Prevention, Detection, Evaluation and Treatment of High Blood Pressure. Hypertension 2003;42:1206-52
10. Zanchetti A, Grassi G, Mancia G. When should antihypertensive drug treatment be initiated and to what levels should systolic blood pressure be lowered? A critical re-appraisal. J Hypertens 2009;27:923-34
11. National Institute for Health and Clinical Excellence. Hypertension (CG127): clinical management of primary hypertension in adults. Available from: http://www.nice.org.uk/guidance/ CG127
12. James PA, Oparil S, Carter BL, et al. 2014 Evidence-based guideline for the management of high blood pressure in adults. Report from the panel members appointed to the Eighth Joint National Committee (JNC 8). JAMA 2014;311:507-20
13. Weber MA, Schiffrin EL, White B, et al. Clinical practice guidelines for the management of hypertension in the community: A statement by the American Society of Hypertension and the International Society of Hypertension. J Hypertens 2014;32:3-15
14. Czernichow S, Zanchetti A, Turnbull F, et al. The effects of blood pressure reduction and of different blood pressure-lowering regimens on major cardiovascular events according to baseline blood pressure: meta-analysis of randomized trials. J Hypertens 2011;29:4-16
15. Law MR, Morris JK, Wald NJ. Use of blood pressure lowering drugs in the prevention of cardiovascular disease: meta-analysis of 147 randomised trials in the context of expectations from prospective epidemiological studies. Br Med J 2009;338:b1665
16. Thompson AM, Hu T, Eshelbrenner CL, et al. Antihypertensive treatment and secondary prevention of cardiovascular disease events among persons without hypertension: a meta-analysis. JAMA 2011;305:913-22
17. Diao D, Wright JM, Cundiff DK, et al. Pharmacotherapy for mild hypertension. Cochrane Database Syst Rev 2012;8:CD006742
18. Sundstrom J, Arima H, Jackson R, et al. Effects of blood pressure reduction in mild hypertension. A systematic review and meta-analysis. Ann Intern Med 2015;162:184-91
19. Thomopoulos C, Parati G, Zanchetti A. Effects of blood pressure lowering on outcome incidence in hypertension. 2. Effects at different baseline and achieved blood pressure levels. Overview and meta-analyses of randomized trials. J Hypertens 2014;32:2296-304
20. Thomopoulos C, Parati G, Zanchetti A. Effects of blood pressure lowering on outcome incidence in hypertension. 3. Effects in patients at different levels of cardiovascular risk. Overview and metaanalyses of randomized trials. J Hypertens 2014;32:2305-14
21. Zanchetti A. Bottom blood pressure or bottom cardiovascular risk? How far can cardiovascular risk be reduced? J Hypertens 2009;27:1509-20
22. Zanchetti A. Hypertension: Cardiac hypertrophy as a target of antihypertensive therapy. Nat Rev Cardiol 2010;7:66-7