Economic burden of opioid-induced constipation among long-term Opioid users with non cancer pain

American Health and Drug Benefits

Volumn 8, Issue 2, 2015, Pages 93-101

  Wan, Yin ^a   Corman, Shelby ^a   Gao, Xin ^a   Liu, Sizhu ^a   Patel, Haridarshan ^b,c   Mody, Reema ^b  

^a PHARMERIT INTERNATIONAL   (United States)

^b Takeda Pharmaceuticals International Inc   (United States)

^c Immensity Consulting   (United States)

Author keywords

Constipation; Economic burden; Elderly; Healthcare resource utilization; Long term care; Long term opioid use; Opioid induced constipation; Pain management

Indexed keywords

OPIATE;

ADULT; AGED; ARTICLE; CHARLSON COMORBIDITY INDEX; COHORT ANALYSIS; CONSTIPATION; CONTROLLED STUDY; DEPRESSION; DRUG INDUCED DISEASE; ECONOMIC ASPECT; FEMALE; HEALTH CARE COST; HEALTH CARE UTILIZATION; HUMAN; LENGTH OF STAY; MAJOR CLINICAL STUDY; MALE; MULTIPLE SCLEROSIS; NAUSEA AND VOMITING; OBESITY; OUTCOME ASSESSMENT; PAIN; PARKINSON DISEASE; RETROSPECTIVE STUDY;

EID: 84929169429     PISSN: 19422962     EISSN: 19422970     Source Type: Journal    
DOI: None     Document Type: Article

References (21)

1. Trescot A, Glaser SE, Hansen H. Effectiveness of opioids in the treatment of chronic non-cancer pain. Pain Physician. 2008;11:S181-S200
2. Dorn SD, Meek PD, Shah ND. Increasing frequency of opioid prescriptions for chronic abdominal pain in US outpatient clinics. Clin Gastroenterol Hepatol. 2011;9:1078-1085.e1. Erratum in: Clin Gastroenterol Hepatol. 2012;10:332
3. Moore RA, McQuay HJ. Prevalence of opioid adverse events in chronic non-malignant pain: systematic review of randomised trials of oral opioids. Arthritis Res Ther. 2005;7:R1046-R1051
4. Bell T, Milanova T, Grove G, et al. OBD symptoms impair quality of life and daily activities, regardless of frequency and duration of opioid treatment: results of a US patient survey (PROBE survey). J Pain. 2007;8(4 suppl 1). Abstract 882
5. Singh G, Kahler K, Bharathi V, et al. Constipation in adults: complications and comorbidities. Gastroenterology. 2005;128(4 suppl 2). Abstract S960
6. Bell T, Annunziata K, Freedman D, et al. Opioid-induced constipation increases healthcare resource use and impairs work productivity: comparison with other patient groups with and without constipation. J Pain. 2007;8(4 suppl 1). Abstract 897
7. Candrilli SD, Davis KL, Iyer S. Impact of constipation on opioid use patterns, health care resource utilization, and costs in cancer patients on opioid therapy. J Pain Palliat Care Pharmacother. 2009;23:231-241
8. Iyer S, Davis KL, Candrilli S. Opioid use patterns and health care resource utilization in patients prescribed opioid therapy with and without constipation. Manag Care. 2010;19:44-51
9. Caudill-Slosberg MA, Schwartz LM, Woloshin S. Office visits and analgesic prescriptions for musculoskeletal pain in US: 1980 vs. 2000. Pain. 2004; 109:514-519
10. Sullivan MD, Edlund MJ, Fan M-Y, et al. Trends in use of opioids for non-cancer pain conditions 2000-2005 in commercial and Medicaid insurance plans: the TROUP study. Pain. 2008;138:440-449
11. Kwong WJ, Diels J, Kavanagh S. Costs of gastrointestinal events after outpatient opioid treatment for non-cancer pain. Ann Pharmacother. 2010;44:630-640
12. Max EK, Hernandez JJ, Sturpe DA, Zuckerman IH. Prophylaxis for opioid-induced constipation in elderly long-term care residents: a cross-sectional study of Medicare beneficiaries. Am J Geriatr Pharmacother. 2007;5:129-136
13. McMillan SC. Assessing and managing opiate-induced constipation in adults with cancer. Cancer Control. 2004;11(3 suppl 1):3-9
14. Staats PS, Markowitz J, Schein J. Incidence of constipation associated with long-acting opioid therapy: a comparative study. South Med J. 2004;97:129-134
15. National Center for Health Statistics. Health, United States, 2010: with special feature on death and dying. February 2011. www.cdc.gov/nchs/data/hus/hus10.pdf#specialfeature. Accessed March 10, 2015
16. Kessler ER, Shah M, Gruschkus SK, Raju A. Cost and quality implications of opioid-based postsurgical pain control using administrative claims data from a large health system: opioid-related adverse events and their impact on clinical and economic outcomes. Pharmacotherapy. 2013;33:383-391
17. Takemoto MLS, Fernandes RA, Almeida GR, et al. Health care resource use and costs in opioid-treated patients with and without constipation in Brazil. Value Health. 2011;14(5 suppl 1):S78-S81
18. Hjalte F, Berggren A-C, Bergendahl H, Hjortsberg C. The direct and indirect costs of opioid-induced constipation. J Pain Symptom Manage. 2010;40:696-703
19. Goodheart CR, Leavitt SB. Managing opioid-induced constipation in ambulatory- care patients. Pain Treatment Topics. August 2006. http://paincommu nity.org/blog/wp-content/uploads/Managing_Opioid-Induced_Constipation. pdf. Accessed March 2, 2015
20. Bell TJ, Panchal SJ, Miaskowski C, et al. The prevalence, severity, and impact of opioid-induced bowel dysfunction: results of a US and European Patient Survey (PROBE 1). Pain Med. 2009;10:35-42
21. Panchal SJ, Müller-Schwefe P, Wurzelmann JI. Opioid-induced bowel dysfunction: prevalence, pathophysiology and burden. Int J Clin Pract. 2007;61: 1181-1187.