Impact of constipation on opioid use patterns, health care resource utilization, and costs in cancer patients on opioid therapy

Journal of Pain and Palliative Care Pharmacotherapy

Volumn 23, Issue 3, 2009, Pages 231-241

  Candrilli, Sean D ^a   Davis, Keith L ^a   Iyer, Shrividya ^b  

^a RTI HEALTH SOLUTIONS   (United States)

^b PFIZER INC   (United States)

Author keywords

Cancer; Claims data; Constipation; Costs; Opioid use

Indexed keywords

BUPRENORPHINE; CODEINE; DEXTROPROPOXYPHENE; DEZOCINE; FENTANYL; HYDROCODONE; HYDROMORPHONE; LEVORPHANOL; METHADONE; MORPHINE; NALBUPHINE; OPIATE; OXYCODONE; OXYMORPHONE; PENTAZOCINE; PETHIDINE; TRAMADOL;

ADULT; AGED; ANALGESIA; ARTICLE; BILLING AND CLAIMS; CANCER PAIN; CANCER PATIENT; CONSTIPATION; CONTROLLED STUDY; DELIRIUM; DISORIENTATION; DRUG SUBSTITUTION; DRUG UTILIZATION; DRUG WITHDRAWAL; DYSPNEA; EMERGENCY CARE; FEMALE; FOLLOW UP; HEALTH CARE COST; HEALTH CARE UTILIZATION; HEALTH INSURANCE; HOME CARE; HOSPICE CARE; HOSPITAL CARE; HUMAN; INTERNATIONAL CLASSIFICATION OF DISEASES; INTESTINE OBSTRUCTION; LABORATORY TEST; MAJOR CLINICAL STUDY; MALE; MYOCLONUS; NAUSEA; NAUSEA AND VOMITING; NURSING HOME; OPIOID INDUCED EMESIS; OUTPATIENT; PRURITUS; RESPIRATION DEPRESSION; RETROSPECTIVE STUDY; URINE RETENTION;

ADOLESCENT; ADULT; AGED; ANALGESICS, OPIOID; CONSTIPATION; FEMALE; FOLLOW-UP STUDIES; HEALTH CARE COSTS; HEALTH SERVICES; HUMANS; MALE; MIDDLE AGED; NEOPLASMS; PAIN; REGRESSION ANALYSIS; RETROSPECTIVE STUDIES; YOUNG ADULT;

EID: 70849111560     PISSN: 15360288     EISSN: 15360539     Source Type: Journal    
DOI: 10.1080/15360280903098440     Document Type: Article

References (24)

1. Pharo GH, Zhou L. Pharmacologic management of cancer pain. J Am Osteopath Assoc. 2005;105(11 Suppl 5):S21-S28.
2. Gershell L, Goater JJ. Making gains in pain. Nat Rev Drug Discovery. 2006;5:889-890.
3. Bernabei R, Gambassi G, Lapane K et al. Management of pain in elderly patients with cancer. SAGE Study Group. Systematic assessment of geriatric drug use via epidemiology. JAMA. 1998;279:1877-1882.
4. Choi YS, Billings JA. Opioid antagonists: a review of their role in palliative care, focusing on use in opioid-related constipation. J Pain Symptom Manage. 2002;24:71-90.
5. Thorpe DM. Management of opioid-induced constipation. Curr Pain Headache Rep. 2001;5:237-240.
6. Portenoy RK. Management of common opioid side effects during long-term therapy of cancer pain. Ann Acad Med Singapore. 1994;23:160-170.
7. Moore RA, McQuay HJ. Prevalence of opioid adverse events in chronic non-malignant pain: systematic reviewof randomized trials of oral opioids. Arthritis Res Ther. 2005;7:R1046-R1051.
8. Staats PS, Markowitz J, Schein J. Prevalence of constipation associated with long-acting opioid therapy: a comparative study. South Med J. 2004;97:129-134.
9. Charlson ME, Pompei P, Ales KL, McKenzie CR. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis. 1987;40:373-383.
10. Duan N. Smearing estimate: a nonparametric retransformation method. J Am Stat Assoc. 1983;78:605-610.
11. Buntin MB, Zaslavsky AM. Too much ado about two-part models and transformation? Comparing methods of modeling Medicare expenditures. J Health Econ. 2004;23:525-542.
12. Dennison C, Prasad M, Lloyd A, Bhattacharyya SK, Dhawan R, Coyne K. The health-related quality of life and economic burden of constipation. Pharmacoeconomics. 2005;23:461-476.
13. Martin BC, Barghout V, Cerulli A. Direct medical costs of constipation in the United States. Manag Care Interface. 2006;19:43-49.
14. Singh G, Lingala V, Wang H et al. Use of health care resources and cost of care for adults with constipation. Clin Gastroenterol Hepatol. 2007;5:1053-1058.
15. Bloodworth D. Opioids in the treatment of chronic pain: legal framework and therapeutic indications and limitations. Phys Med Rehabil Clin N Am. 2006;17:355-379.
16. Nicholson B, Passik SD. Management of chronic noncancer pain in the primary care setting. South Med J. 2007;100:1028-1036.
17. Indelicato RA, Portenoy RK. Opioid rotation in the management of ractory cancer pain. J Clin Oncol. 2002;20:348-352.
18. Quigley C. Opioid switching to improve pain relief and drug tolerability. Cochrane Database Syst Rev. 2004;(3):CD004847.
19. Pharmacology and pharmacotherapy of opioid switching in cancer patients. Oncologist. 2006;11:765-773.
20. Berger A, Hoffman DL, Goodman S, Delea TE, Seifeldin R, Oster G. Therapy switching in patients receiving long-acting opioids. Ann Pharmacother. 2004;38:389-395.
21. Mercadante S, Bruera E. Opioid switching: a systematic and critical review. Cancer Treat Rev. 2006;32:304-315.
22. Mancini I, Bruera E. Constipation in advanced cancer patients. Support Care Cancer. 1998;6: 356-364.
23. Losina E, Barrett J, Baron JA, Katz JN. Accuracy of Medicare claims data for rheumatologic diagnoses in total hip replacement recipients. J Clin Epidemiol. 2003;56:515-519.
24. Newcomer R, Clay T, Luxenberg JS, Miller RH. Misclassification and selection bias when identifying Alzheimer's disease solely from Medicare claims records. J Am Geriatr Soc. 1999;47:215-219.