Molecular diagnosis of TB in the HIV positive population

Annals of Global Health

Volumn 80, Issue 6, 2014, Pages 476-485

  Vittor, Amy Y ^a   Garland, Joseph M ^b   Gilman, Robert H ^c  

^a UNIVERSITY OF FLORIDA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

Drug susceptibility testing; HIV; Molecular diagnostics; RNA transcription signatures; Tuberculosis; Xpert MTB RIF

Indexed keywords

DIAGNOSTIC TEST; DRUG SENSITIVITY; GENE EXPRESSION; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; LOOP MEDIATED ISOTHERMAL AMPLIFICATION; LUNG TUBERCULOSIS; MIXED INFECTION; MOLECULAR DIAGNOSIS; NUCLEIC ACID AMPLIFICATION; POLYMERASE CHAIN REACTION; PREVALENCE; REVIEW; RNA TRANSCRIPTION; SENSITIVITY AND SPECIFICITY; TUBERCULOSIS; WORLD HEALTH ORGANIZATION; AIDS RELATED COMPLEX; BLOOD; CHEMISTRY; COMPLICATION; DRUG EFFECTS; GENETICS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; ISOLATION AND PURIFICATION; MICROBIAL SENSITIVITY TEST; MYCOBACTERIUM TUBERCULOSIS; SPUTUM; TUBERCULOSIS, PULMONARY; URINE;

BACTERIAL DNA; BACTERIAL RNA; RIFAMPICIN; TUBERCULOSTATIC AGENT;

AIDS-RELATED OPPORTUNISTIC INFECTIONS; ANTIBIOTICS, ANTITUBERCULAR; COINFECTION; DNA, BACTERIAL; HIV SEROPOSITIVITY; HUMANS; MICROBIAL SENSITIVITY TESTS; MOLECULAR DIAGNOSTIC TECHNIQUES; MYCOBACTERIUM TUBERCULOSIS; NUCLEIC ACID AMPLIFICATION TECHNIQUES; RIFAMPIN; RNA, BACTERIAL; SPUTUM; TUBERCULOSIS, PULMONARY; URINE;

EID: 84929168770     PISSN: None     EISSN: 22149996     Source Type: Journal    
DOI: 10.1016/j.aogh.2015.01.001     Document Type: Review

References (88)

1. Global Tuberculosis Control: Report 2013. Geneva, World Health Organization, 2011 (WHO/HTM/TB/2013.11).
2. Global Plan to Stop TB 2011-2015: transforming the fight towards elimination of tuberculosis 2010 World Health Organization Geneva
3. L. Aaron, D. Saadoun, and I. Calatroni Tuberculosis in HIV-infected patients: a comprehensive review Clin Microbiol Infect 10 2004 388 398
4. P. Monkongdee, K.D. McCarthy, and K.P. Cain Yield of acid-fast smear and mycobacterial culture for tuberculosis diagnosis in people with human immunodeficiency virus Am J Respir Crit Care Med 180 2009 903 908
5. A.M. Elliot, K. Namaambo, and B.W. Allen Negative sputum smear results in HIV-positive patients with pulmonary tuberculosis in Lusaka, Zambia Tub Lung Dis 74 1993 191 194
6. A. Palmieri, E. Girardi, and A.M. Pellicelli Pulmonary tuberculosis in HIV-infected patients presenting with normal chest radiograph and negative sputum smear Infection 30 2002 68 74
7. H. Getahun, M. Harrington, and R. O'Brien Diagnosis of smear-negative pulmonary tuberculosis in people with HIV infection of AIDS in resource-constrained settings: informing urgent policy changes Lancet 369 2007 2042 2049
8. C.T. Kang'ombe, A.D. Harries, and K. Ito Long-term outcome in patients registered with tuberculosis in Zomba, Malawi: mortality at 7 years according to initial HIV status and type of TB Int J Tuberc Lung Dis 8 2004 829 836
9. R. Wood, K. Middelkoop, and L. Myer Undiagnosed tuberculosis in a community with high HIV prevalence: implications for tuberculosis control Am J Respir Crit Care Med 175 2007 87 93
10. M.E. Ramirez-Cardich, V. Kawai, and R.A. Oberhelman Clinical correlates of tuberculosis co-infection in HIV-infected children hospitalized in Peru Int J Infect Dis 10 2006 278 281
11. C.F. Gilks, R.J. Brindle, and L.S. Otieno Extrapulmonary and disseminated tuberculosis in HIV-1-seropositive patients presenting to the acute medical services in Nairobi AIDS 4 1990 981 985
12. B.E. Jones, S.M. Young, and D. Antoniskis Relationship of the manifestations of tuberculosis to CD4 cell counts in patients with human immunodeficiency virus infection Am Rev Respir Dis 148 1993 292 297
13. I.L. Leeds, M.J. Magee, and E.V. Kurbatova Site of extrapulmonary tuberculosis is associated with HIV infection Clin Infect Dis 55 2012 75 81
14. J.A. Cox, R.L. Lukande, and S. Lucas Autopsy causes of death in HIV-positive individuals in sub-Saharan Africa and correlation with clinical diagnoses AIDS Rev 12 2010 183 194
15. J. Cox, R.L. Lukande, and A.M. Nelson An autopsy study describing causes of death and comparing clinico-pathological findings among hospitalized patients in Kampala, Uganda PLoS One 7 2012 e33685
16. P.M. Pronyk, K. Kahn, and J.R. Hargreaves Undiagnosed pulmonary tuberculosis deaths in rural South Africa Int J Tuberc Lung Dis 8 2004 796 799
17. S.B. Lucas, A. Hounnou, and C. Peacock The mortality and pathology of HIV infection in a west African city AIDS 7 1993 1569 1579
18. N.A. Ansari, A.H. Kombe, and T.A. Kenyon Pathology and causes of death in a group of 128 predominantly HIV-positive patients in Botswana, 1997-1998 Int J Tuberc Lung Dis 6 2002 55 63
19. A.M. Nelson, J.H. Perriens, and B. Kapita A clinical and pathological comparison of the WHO and CDC case definitions for AIDS in Kinshasa, Zaire: is passive surveillance valid? AIDS 7 1993 1241 1245
20. F.S. Rana, M.P. Hawken, and C. Mwachari Autopsy study of HIV-1-positive and HIV-1-negative adult medical patients in Nairobi, Kenya J Acquir Immune Defic Syndr 24 2000 23 29
21. D.N. Lanjewar, and R. Duggal Pulmonary pathology in patients with AIDS: an autopsy study from Mumbai HIV Med 2 2001 266 271
22. N.J. Hargreaves, O. Kadzakumanja, and C.J. Whitty "Smear-negative" pulmonary tuberculosis in a DOTS programme: poor outcomes in an area of high HIV seroprevalence Int J Tuerc Lung Dis 5 2001 847 854
23. E. Pukenyte, F.X. Lescure, and D. Rey Incidence of and risk factors for severe liver toxicity in HIV-infected patients on anti-tuberculosis treatment Int J Tuberc Lung Dis 11 2007 78 84
24. Multidrug-resistant tuberculosis (MDR-TB): October 2013 update 2013 WHO Geneva
25. Multidrug and extensively drug-resistant TB (M/XDR-TB): 2010 global report on surveillance and response 2010 WHO Geneva
26. P.E. Campos, P.G. Suarez, and J. Sanchez Multidrug-resistant Mycobacterium tuberculosis in HIV-infected persons Peru. Emerg Infect Dis 9 2003 1571 1578
27. C.D. Wells Global impact of multidrug-resistant pulmonary tuberculosis among HIV-infected and other immunocompromised hosts: epidemiology, diagnosis, and strategies for management Curr Infect Dis Rep 12 2010 192 197
28. V. Kawai, G. Soto, and R.H. Gilman Tuberculosis mortality, drug resistance, and infectiousness in patients with and without HIV infection in Peru Am J Trop Med Hyg 75 2006 1027 1033
29. S. Greco, E. Girardi, and A. Navarra Current evidence on diagnostic accuracy of commercially based nucleic acid amplification tests for the diagnosis of pulmonary tuberculosis Thorax 61 2006 783 790
30. D.I. Ling, L.L. Flores, and L.W. Riley Commercial nucleic-acid amplification tests for diagnosis of pulmonary tuberculosis in respiratory specimens: meta-analysis and meta-regression PLoS One 3 2008 e1536
31. J. Dinnes, J. Deeks, and H. Kunst A systematic review of rapid diagnostic tests for the detection of tuberculosis infection Health Technol Assess 11 2007 1 196
32. L. Kivihya-Ndugga, M. van Cleeff, and E. Juma Comparison of PCR with the routine procedure for diagnosis of tuberculosis in a population with high prevalences of tuberculosis and human immunodeficiency virus J Clin Microbiol 42 2004 1012 1015
33. J.L. Davis, L. Huang, and W. Worodria Nucleic acid amplification tests for diagnosis of smear-negative TB in a high HIV-prevalence setting: a prospective cohort study PLoS One 6 2011 e16321
34. L.E. Scott, K. McCarthy, and N. Gous Comparison of Xpert MTB/RIF with other nucleic acid technologies for diagnosing pulmonary tuberculosis in a high HIV prevalence setting: a prospective study PLoS Med 8 2011 e1001061
35. J.L. Davis, L. Huang, and J.A. Kovacs Polymerase chain reaction of secA1 on sputum or oral wash samples for the diagnosis of pulmonary tuberculosis Clin Infect Dis 48 2009 725 732
36. X. Chen, Q. Yang, H. Kong, and Y. Chen Real-time PCR and Amplified MTD for rapid detection of Mycobacterium tuberculosis in pulmonary specimens Int J Tuberc Lung Dis 16 2012 235 239
37. S. Hofmann-Thiel, L. Turaev, and H. Hoffmann Evaluation of the hyplex TBC PCR test for detection of Mycobacterium tuberculosis complex in clinical samples BMC Microbiol 10 2010 95
38. H. Tanaka, H. Hirose, and Y. Kato Clinical evaluation of TRCRapid M.TB for detection of Mycobacterium tuberculosis complex in respiratory and nonrespiratory specimens J Clin Microbiol 48 2010 1536 1541
39. F. Laraque, A. Griggs, and M. Slopen Performance of nucleic acid amplification tests for diagnosis of tuberculosis in a large urban setting Clin Infect Dis 49 2009 46 54
40. R.L. Guerra, N.M. Hooper, and J.F. Baker Use of the amplified mycobacterium tuberculosis direct test in a public health laboratory: test performance and impact on clinical care Chest 132 2007 946 951
41. L.L. Flores, M. Pai, and J.M. Colford Jr. In-house nucleic acid amplification tests for the detection of Mycobacterium tuberculosis in sputum specimens: meta-analysis and meta-regression BMC Microbiol 5 2005 55
42. P.P. Banada, S.K. Sivasubramani, and R. Blakemore Containment of bioaerosol infection risk by the Xpert MTB/RIF assay and its applicability to point-of-care settings J Clin Microbiol 48 2010 3551 3557
43. C.C. Boehme, P. Nabeta, and D. Hillemann Rapid molecular detection of tuberculosis and rifampin resistance N Engl J Med 363 2011 1005 1015
44. TB diagnostics and laboratory strengthening. Available at: http://who.int/tb/laboratory/mtbrifrollout/en/. Accessed October 1, 2014.
45. G. Theron, J. Peter, and R. van Zyl-Smit Evaluation of the Xpert MTB/RIF assay for the diagnosis of pulmonary tuberuclosis in a high HIV prevalence setting Am J Respir Crit Care Med 184 2011 132 140
46. K.R. Steingart, I. Schiller, and D.J. Horne Xpert® MTB/RIF assay for pulmonary tuberculosis and rifampicin resistance in adults Cochrane Database Syst Rev 1 2014 CD009593
47. R. Moure, R. Martin, and F. Alcaide Effectiveness of an integrated real-time PCR method for detection of the Mycobacterium tuberculosis complex in smear-negative extrapulmonary samples in an area of low tuberculosis prevalence J Clin Microbiol 50 2012 513 515
48. E. Tortoli, C. Russo, and C. Piersimoni Clinical validation of Xpert MTB/RIF for the diagnosis of extrapulmonary tuberculosis Eur Resp J 40 2012 442 447
49. V. Vadwai, C. Boehme, and P. Nabeta Xpert MTB/RIF: a new pillar in diagnosis of extrapulmonary tuberculosis? J Clin Microbiol 49 2011 2540 2545
50. Automated real-time nucleic acid amplification technology for rapid and simultaneous detection of tuberculosis and rifampin resistance: Xpert MTB/RIF assay for the diagnosis of pulmonary and extrapulmonary TB in adults and children. Policy update 2013 WHO Geneva
51. FIND. FIND-negotiated prices for Xpert MTB/RIF and country list. Available at: http://www.finddiagnostics.org/about/what-we-do/successes/find-negotiated-prices/xpert-mtb-rif.html. Accessed October 1, 2014.
52. A. Trebucq, D.A. Enarson, and C.Y. Chiang Xpert MTB/RIF for national tuberculosis programmes in low-income countries: when, where and how? Int J Tuberc Lung Dis 15 2011 1567 1572
53. A. Vassal, S. van Kampen, and H. Sohn Rapid diagnosis of tuberculosis with the Xpert MTB/RIF assay in high burden countries: a cost-effectiveness analysis PLoS Med 8 2011 e1001120
54. J.R. Andrews, S.D. Lawn, and C. Rusu The cost-effectiveness of routine tuberculosis screening with Xpert MTB/RIF prior to initiation of antiretroviral therapy: a model-based analysis AIDS 26 2012 987 995
55. I.V. Bassett, B. Wang, and S. Chetty Intensive tuberculosis screening for HIV-infected patients starting antiretroviral therapy in Durban, South Africa Clin Infect Dis 51 2010 823 829
56. S.D. Lawn, K. Kranzer, and D.J. Edwards Tuberculosis during the first year of antiretroviral therapy in a South African cohort using an intensive pretreatment screening strategy AIDS 24 2010 1323 1328
57. H. Getahun, W. Kittikraisak, and C.M. Heilig Development of a standardized screening rule for tuberculosis in people living with HIV in resource-constrained settings: individual participant data meta-analysis of observational studies PLoS Med 8 2011 e1000391
58. S.D. Lawn, and R. Wood Tuberculosis in antiretroviral treatment services in resource-limited settings: addressing the challenges of screening and diagnosis J Infect Dis 204 2011 S1159 S1167
59. C.C. Boehme, P. Nabeta, and G. Henostroza Operational feasibility of using loop-mediated isothermal amplification for diagnosis of pulmonary tuberculosis in microscopy centers of developing countries J Clin Microbiol 45 2007 1936 1940
60. S. Mitarai, M. Okumura, and E. Toyota Evaluation of a simple loop-mediated isothermal amplification test kit for the diagnosis of tuberculosis Int J Tuberc Lung Dis 15 2011 1211 1217
61. The use of a commercial loop-mediated isothermal amplification assay (TB-LAMP) for the detection of tuberculosis. Expert Group Meeting Report 2013 WHO Geneva
62. H.J. Zar, D. Hanslo, and P. Apolles Induced sputum versus gastric lavage for microbiological confirmation of pulmonary tuberculosis in infants and young children: a prospective study Lancet 365 2005 130 134
63. C. Green, J.F. Huggett, and E. Talbot Rapid diagnosis of tuberculosis through the detection of mycobacterial DNA in urine by nucleic acid amplification methods Lancet Infect Dis 9 2009 505 511
64. J.G. Peter, G. Theron, and T.E. Muchinga The diagnostic accuracy of urine-based Xpert MTB/RIF in HIV-infected hospitalized patients who are smear-negative or sputum scarce PLoS One 7 2012 e39966
65. S.D. Lawn, A.D. Kerkhoff, and M. Vogt High diagnostic yield of tuberculosis from screening urine samples from HIV-infected patients with advanced immunodeficiency using the Xpert MTB/RIF assay J Acquir Immune Defic Syndr 60 2012 289 294
66. J. Cordova, R. Shiloh, and R.H. Gilman Evaluation of molecular tools for detection and drug susceptibility testing of Mycobacterium tuberculosis in stool specimens from patients with pulmonary tuberculosis J Clin Microbiol 48 2009 1820 1826
67. G.E. Oramasionwu, C.M. Heilig, and N. Udomsantisuk The utility of stool cultures for diagnosing tuberculosis in people living with the human immunodeficiency virus Int J Tuberc Lung Dis 17 2013 1023 1028
68. M.P. Nicol, K. Spiers, and L. Workman Xpert MTB/RIF testing of stool samples for the diagnosis of pulmonary tuberculosis in children Clin Infect Dis 57 2013 e18 21
69. E. Walters, R.P. Gie, and A.C. Hesseling Rapid diagnosis of pediatric intrathoracic tuberculosis from stool samples using the Xpert MTB/RIF assay: a pilot study Ped Infect Dis J 31 2012 1316
70. M. Kaforou, V.J. Wright, and T. Oni Detection of tuberculosis in HIV-infected and -uninfected African adults using whole blood RNA expression signatures: a case-control study PLoS Med 10 2013 e1001538
71. S.T. Anderson, M. Kaforou, and A.J. Brent Diagnosis of childhood tuberculosis and host RNA expression in Africa N Eng J Med 370 2014 1712 1723
72. C.M. Perez-Velez, and B.J. Marais Tuberculosis in children N Eng J Med 367 2012 348 361
73. H.J. Zar, T.G. Connell, and M. Nicol Diagnosis of pulmonary tuberculosis in children: new advances Expert Rev Anti Infect Ther 8 2010 277 288
74. J. Makinen, H.R. Marttila, and M. Marjamaki Comparison of two commercially available DNA line probe assays for detection of multidrug-resistant Mycobacterium tuberculosis J Clin Microbiol 44 2006 350 352
75. G. Skenders, T.H. Holtz, and V. Riekstina Implementation of the INNO-LiPA Rif. TB line-probe assay in rapid detection of multidrug-resistant tuberculosis in Latvia Int J Tuberc Lung Dis 15 2011 1546 1552
76. S. Ogwang, B.B. Asiimwe, and H. Traore Comparison of rapid tests for detection of rifampin-resistant Mycobacterium tuberculosis in Kampala, Uganda BMC Infect Dis 9 2009 139
77. Molecular line probe assays for rapid screening of patients at risk of multi-drug resistant tuberculosis (MDR-TB) 2008 WHO Geneva Available at: http://www.who.int/tb/features-archive/expert-group-report-june08.pdf Accessed October 1, 2014
78. FIND. FIND negotiated prices and country list for Line Probe Assay and associated instrumentation. Available at: http://www.finddiagnostics.org/about/what-we-do/successes/find-negotiated-prices/mtbdrplus.html. Accessed October 1, 2014.
79. st line drugs). Available at: http://www.finddiagnostics.org/programs/tb/find-activities/line-probe-assay-1.html. Accessed October 1, 2014.
80. M. Barnard, H. Albert, and G. Coetzee Rapid molecular screening for multidrug-resistant tuberculosis in a high-volume public health laboratory in South Africa Am J Respir Crit Care Med 177 2008 787 792
81. R. Anek-Vorapong, C. Sinthuwattanawibool, and L.J. Podewils Validation of the Genotype MTBDRplus assay for detection of MDR-TB in a public health laboratory in Thailand BMC Infect Dis 10 2010 123
82. F. Brossier, N. Veziris, and A. Aubry Detection by Genotype MTBDRsl test of complex mechanisms of resistance to second-line drugs and ethambutol in multidrug-resistant Mycobacterium tuberculosis complex isolates J Clin Microbiol 48 2010 1683 1689
83. D. Hillemann, S. Rusch-Gerdes, and E. Richter Feasibility of the GenoType MTBDRsl assay for fluoroquinolone, amikacin-capreomycin, and ethambutol resistance testing of Mycobacterium tuberculosis strains and clinical specimens J Clin Microbiol 47 2009 1767 1772
84. O. Ignatyeva, I. Kontsevaya, and A. Kovalyov Detection of resistance to second-line antituberculosis drugs by use of the Genotype MTBDRsl assay: a multicenter evaluation and feasibility study J Clin Microbiol 50 2012 1593
85. G.F. Araj, R.S. Talhouk, and L.Y. Itani Comparative performance of PCR-based assay versus microscopy and culture for the direct detection of Mycobacterium tuberculosis in clinical respiratory specimens in Lebanon Int J Tuberc Lung Dis 4 2000 877 881
86. C.C. Boehme, M.P. Nikol, and P. Nabeta Feasibility, diagnostic accuracy, and effectiveness of decentralised use of the Xpert MTB/RIF test for diagnosis of tuberculosis and multidrug resistance: a multicentre implementation study Lancet 377 2011 1495 1505
87. G. George, P. Mony, and J. Kenneth Comparison of the efficacies of loop-mediated isothermal amplification, fluorescence smear microscopy and culture for the diagnosis of tuberculosis PLoS One 6 2011 e21007
88. H. Albert, F. Bwanga, and S. Mukkada Rapid screening of MDR-TB using molecular line probe assay is feasible in Uganda BMC Infect Dis 10 2010 41