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Volumn 125, Issue 19, 2015, Pages 2915-2922

The Bruton tyrosine kinase inhibitor ibrutinib with chemoimmunotherapy in patients with chronic lymphocytic leukemia

Author keywords

[No Author keywords available]

Indexed keywords

BENDAMUSTINE; CYCLOPHOSPHAMIDE; FLUDARABINE; IBRUTINIB; RITUXIMAB; AGAMMAGLOBULINAEMIA TYROSINE KINASE; PROTEIN TYROSINE KINASE; PYRAZOLE DERIVATIVE; PYRIMIDINE DERIVATIVE;

EID: 84929154536     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2014-09-585869     Document Type: Article
Times cited : (104)

References (42)
  • 1
    • 84859410688 scopus 로고    scopus 로고
    • The treatment of relapsed refractory chronic lymphocytic leukemia
    • Brown JR. The treatment of relapsed refractory chronic lymphocytic leukemia. Hematology Am Soc Hematol Educ Program. 2011;2011:110-118.
    • (2011) Hematology Am Soc Hematol Educ Program , vol.2011 , pp. 10-118
    • Brown, J.R.1
  • 2
    • 79952093131 scopus 로고    scopus 로고
    • Update on therapy of chronic lymphocytic leukemia
    • Gribben JG, O'Brien S. Update on therapy of chronic lymphocytic leukemia. J Clin Oncol. 2011; 29(5):544-550.
    • (2011) J Clin Oncol , vol.29 , Issue.5 , pp. 544-550
    • Gribben, J.G.1    O'Brien, S.2
  • 3
    • 0034649696 scopus 로고    scopus 로고
    • Fludarabine compared with chlorambucil as primary therapy for chronic lymphocytic leukemia
    • Rai KR, Peterson BL, Appelbaum FR, et al. Fludarabine compared with chlorambucil as primary therapy for chronic lymphocytic leukemia. N Engl J Med. 2000;343(24):1750-1757.
    • (2000) N Engl J Med , vol.343 , Issue.24 , pp. 1750-1757
    • Rai, K.R.1    Peterson, B.L.2    Appelbaum, F.R.3
  • 4
    • 34447530283 scopus 로고    scopus 로고
    • Assessment of fludarabine plus cyclophosphamide for patients with chronic lymphocytic leukaemia (the LRF CLL4 Trial): A randomised controlled trial
    • Catovsky D, Richards S, Matutes E, et al UK National Cancer Research Institute (NCRI) Haematological Oncology Clinical Studies Group; NCRI Chronic Lymphocytic Leukaemia Working Group. Assessment of fludarabine plus cyclophosphamide for patients with chronic lymphocytic leukaemia (the LRF CLL4 Trial): a randomised controlled trial. Lancet. 2007;370(9583):230-239.
    • (2007) Lancet , vol.370 , Issue.9583 , pp. 230-239
    • Catovsky, D.1    Richards, S.2    Matutes, E.3
  • 5
    • 31544434508 scopus 로고    scopus 로고
    • Fludarabine plus cyclophosphamide versus fludarabine alone in first-line therapy of younger patients with chronic lymphocytic leukemia
    • Eichhorst BF, Busch R, Hopfinger G, et al German CLL Study Group. Fludarabine plus cyclophosphamide versus fludarabine alone in first-line therapy of younger patients with chronic lymphocytic leukemia. Blood. 2006;107(3):885-891.
    • (2006) Blood , vol.107 , Issue.3 , pp. 885-891
    • Eichhorst, B.F.1    Busch, R.2    Hopfinger, G.3
  • 6
    • 33947541773 scopus 로고    scopus 로고
    • Phase III trial of fludarabine plus cyclophosphamide compared with fludarabine for patients with previously untreated chronic lymphocytic leukemia: US Intergroup Trial E2997
    • Flinn IW, Neuberg DS, Grever MR, et al. Phase III trial of fludarabine plus cyclophosphamide compared with fludarabine for patients with previously untreated chronic lymphocytic leukemia: US Intergroup Trial E2997. J Clin Oncol. 2007;25(7):793-798.
    • (2007) J Clin Oncol , vol.25 , Issue.7 , pp. 793-798
    • Flinn, I.W.1    Neuberg, D.S.2    Grever, M.R.3
  • 7
    • 70349330220 scopus 로고    scopus 로고
    • Phase III randomized study of bendamustine compared with chlorambucil in previously untreated patients with chronic lymphocytic leukemia
    • Knauf WU, Lissichkov T, Aldaoud A, et al. Phase III randomized study of bendamustine compared with chlorambucil in previously untreated patients with chronic lymphocytic leukemia. J Clin Oncol. 2009;27(26):4378-4384.
    • (2009) J Clin Oncol , vol.27 , Issue.26 , pp. 4378-4384
    • Knauf, W.U.1    Lissichkov, T.2    Aldaoud, A.3
  • 8
    • 79953072637 scopus 로고    scopus 로고
    • Fludarabine, cyclophosphamide, and rituximab chemoimmunotherapy is highly effective treatment for relapsed patients with CLL
    • Badoux XC, Keating MJ, Wang X, et al. Fludarabine, cyclophosphamide, and rituximab chemoimmunotherapy is highly effective treatment for relapsed patients with CLL. Blood. 2011;117(11):3016-3024.
    • (2011) Blood , vol.117 , Issue.11 , pp. 3016-3024
    • Badoux, X.C.1    Keating, M.J.2    Wang, X.3
  • 9
    • 77957664665 scopus 로고    scopus 로고
    • Addition of rituximab to fludarabine and cyclophosphamide in patients with chronic lymphocytic leukaemia: A randomised, open-label, phase 3 trial
    • Hallek M, Fischer K, Fingerle-Rowson G, et al International Group of Investigators; German Chronic Lymphocytic Leukaemia Study Group. Addition of rituximab to fludarabine and cyclophosphamide in patients with chronic lymphocytic leukaemia: a randomised, open-label, phase 3 trial. Lancet. 2010;376(9747):1164-1174.
    • (2010) Lancet , vol.376 , Issue.9747 , pp. 1164-1174
    • Hallek, M.1    Fischer, K.2    Fingerle-Rowson, G.3
  • 10
    • 23044510136 scopus 로고    scopus 로고
    • Early results of a chemoimmunotherapy regimen of fludarabine, cyclophosphamide, and rituximab as initial therapy for chronic lymphocytic leukemia
    • Keating MJ, O'Brien S, Albitar M, et al. Early results of a chemoimmunotherapy regimen of fludarabine, cyclophosphamide, and rituximab as initial therapy for chronic lymphocytic leukemia. J Clin Oncol. 2005;23(18):4079-4088.
    • (2005) J Clin Oncol , vol.23 , Issue.18 , pp. 4079-4088
    • Keating, M.J.1    O'Brien, S.2    Albitar, M.3
  • 11
    • 77950478885 scopus 로고    scopus 로고
    • Rituximab plus fludarabine and cyclophosphamide prolongs progression-free survival compared with fludarabine and cyclophosphamide alone in previously treated chronic lymphocytic leukemia
    • Robak T, Dmoszynska A, Solal-Céligny P, et al. Rituximab plus fludarabine and cyclophosphamide prolongs progression-free survival compared with fludarabine and cyclophosphamide alone in previously treated chronic lymphocytic leukemia. J Clin Oncol. 2010; 28(10):1756-1765.
    • (2010) J Clin Oncol , vol.28 , Issue.10 , pp. 1756-1765
    • Robak, T.1    Dmoszynska, A.2    Solal-Céligny, P.3
  • 12
    • 23044501404 scopus 로고    scopus 로고
    • Chemoimmunotherapy with fludarabine, cyclophosphamide, and rituximab for relapsed and refractory chronic lymphocytic leukemia
    • Wierda W, O'Brien S, Wen S, et al. Chemoimmunotherapy with fludarabine, cyclophosphamide, and rituximab for relapsed and refractory chronic lymphocytic leukemia. J Clin Oncol. 2005;23(18):4070-4078.
    • (2005) J Clin Oncol , vol.23 , Issue.18 , pp. 4070-4078
    • Wierda, W.1    O'Brien, S.2    Wen, S.3
  • 13
    • 80053020928 scopus 로고    scopus 로고
    • Bendamustine combined with rituximab in patients with relapsed and/or refractory chronic lymphocytic leukemia: A multicenter phase II trial of the German Chronic Lymphocytic Leukemia Study Group
    • Fischer K, Cramer P, Busch R, et al. Bendamustine combined with rituximab in patients with relapsed and/or refractory chronic lymphocytic leukemia: a multicenter phase II trial of the German Chronic Lymphocytic Leukemia Study Group. J Clin Oncol. 2011;29(26): 3559-3566.
    • (2011) J Clin Oncol , vol.29 , Issue.26 , pp. 3559-3566
    • Fischer, K.1    Cramer, P.2    Busch, R.3
  • 14
    • 0035892106 scopus 로고    scopus 로고
    • Survival of leukemic B cells promoted by engagement of the antigen receptor
    • Bernal A, Pastore RD, Asgary Z, et al. Survival of leukemic B cells promoted by engagement of the antigen receptor. Blood. 2001;98(10):3050-3057.
    • (2001) Blood , vol.98 , Issue.10 , pp. 3050-3057
    • Bernal, A.1    Pastore, R.D.2    Asgary, Z.3
  • 15
    • 84859256604 scopus 로고    scopus 로고
    • Inhibiting B-cell receptor signaling pathways in chronic lymphocytic leukemia
    • Burger JA. Inhibiting B-cell receptor signaling pathways in chronic lymphocytic leukemia. Curr Hematol Malig Rep. 2012;7(1):26-33.
    • (2012) Curr Hematol Malig Rep , vol.7 , Issue.1 , pp. 26-33
    • Burger, J.A.1
  • 16
    • 0037114744 scopus 로고    scopus 로고
    • Expression of ZAP-70 is associated with increased B-cell receptor signaling in chronic lymphocytic leukemia
    • Chen L, Widhopf G, Huynh L, et al. Expression of ZAP-70 is associated with increased B-cell receptor signaling in chronic lymphocytic leukemia. Blood. 2002;100(13):4609-4614.
    • (2002) Blood , vol.100 , Issue.13 , pp. 4609-4614
    • Chen, L.1    Widhopf, G.2    Huynh, L.3
  • 17
    • 41949140313 scopus 로고    scopus 로고
    • ZAP-70 enhances IgM signaling independent of its kinase activity in chronic lymphocytic leukemia
    • Chen L, Huynh L, Apgar J, et al. ZAP-70 enhances IgM signaling independent of its kinase activity in chronic lymphocytic leukemia. Blood. 2008;111(5):2685-2692.
    • (2008) Blood , vol.111 , Issue.5 , pp. 2685-2692
    • Chen, L.1    Huynh, L.2    Apgar, J.3
  • 18
    • 33847412872 scopus 로고    scopus 로고
    • ZAP-70 enhances B-cellreceptor signaling despite absent or inefficient tyrosine kinase activation in chronic lymphocytic leukemia and lymphoma B cells
    • Gobessi S, Laurenti L, Longo PG, Sica S, Leone G, Efremov DG. ZAP-70 enhances B-cellreceptor signaling despite absent or inefficient tyrosine kinase activation in chronic lymphocytic leukemia and lymphoma B cells. Blood. 2007;109(5):2032-2039.
    • (2007) Blood , vol.109 , Issue.5 , pp. 2032-2039
    • Gobessi, S.1    Laurenti, L.2    Longo, P.G.3    Sica, S.4    Leone, G.5    Efremov, D.G.6
  • 19
    • 78751549662 scopus 로고    scopus 로고
    • The lymph node microenvironment promotes B-cell receptor signaling, NF-kappaB activation, and tumor proliferation in chronic lymphocytic leukemia
    • Herishanu Y, Pérez-Galán P, Liu D, et al. The lymph node microenvironment promotes B-cell receptor signaling, NF-kappaB activation, and tumor proliferation in chronic lymphocytic leukemia. Blood. 2011;117(2):563-574.
    • (2011) Blood , vol.117 , Issue.2 , pp. 563-574
    • Herishanu, Y.1    Pérez-Galán, P.2    Liu, D.3
  • 20
    • 77957201023 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase-d inhibitor CAL-101 shows promising preclinical activity in chronic lymphocytic leukemia by antagonizing intrinsic and extrinsic cellular survival signals
    • Herman SE, Gordon AL, Wagner AJ, et al. Phosphatidylinositol 3-kinase-d inhibitor CAL-101 shows promising preclinical activity in chronic lymphocytic leukemia by antagonizing intrinsic and extrinsic cellular survival signals. Blood. 2010;116(12):2078-2088.
    • (2010) Blood , vol.116 , Issue.12 , pp. 2078-2088
    • Herman, S.E.1    Gordon, A.L.2    Wagner, A.J.3
  • 21
    • 0037111661 scopus 로고    scopus 로고
    • Constitutively activated phosphatidylinositol-3 kinase (PI-3K) is involved in the defect of apoptosis in B-CLL: Association with protein kinase Cdelta
    • Ringshausen I, Schneller F, Bogner C, et al. Constitutively activated phosphatidylinositol-3 kinase (PI-3K) is involved in the defect of apoptosis in B-CLL: association with protein kinase Cdelta. Blood. 2002;100(10):3741-3748.
    • (2002) Blood , vol.100 , Issue.10 , pp. 3741-3748
    • Ringshausen, I.1    Schneller, F.2    Bogner, C.3
  • 22
    • 0034657307 scopus 로고    scopus 로고
    • Bruton's tyrosine kinase is required for activation of IkappaB kinase and nuclear factor kappaB in response to B cell receptor engagement
    • Petro JB, Rahman SM, Ballard DW, Khan WN. Bruton's tyrosine kinase is required for activation of IkappaB kinase and nuclear factor kappaB in response to B cell receptor engagement. J Exp Med. 2000;191(10):1745-1754.
    • (2000) J Exp Med , vol.191 , Issue.10 , pp. 1745-1754
    • Petro, J.B.1    Rahman, S.M.2    Ballard, D.W.3    Khan, W.N.4
  • 23
    • 0035910580 scopus 로고    scopus 로고
    • Phospholipase C-gamma 2 couples Bruton's tyrosine kinase to the NF-kappaB signaling pathway in B lymphocytes
    • Petro JB, Khan WN. Phospholipase C-gamma 2 couples Bruton's tyrosine kinase to the NF-kappaB signaling pathway in B lymphocytes. J Biol Chem. 2001;276(3):1715-1719.
    • (2001) J Biol Chem , vol.276 , Issue.3 , pp. 1715-1719
    • Petro, J.B.1    Khan, W.N.2
  • 24
    • 0032748581 scopus 로고    scopus 로고
    • Syk and Bruton's tyrosine kinase are required for B cell antigen receptor-mediated activation of the kinase Akt
    • Craxton A, Jiang A, Kurosaki T, Clark EA. Syk and Bruton's tyrosine kinase are required for B cell antigen receptor-mediated activation of the kinase Akt. J Biol Chem. 1999;274(43): 30644-30650.
    • (1999) J Biol Chem , vol.274 , Issue.43 , pp. 30644-30650
    • Craxton, A.1    Jiang, A.2    Kurosaki, T.3    Clark, E.A.4
  • 25
    • 0028847329 scopus 로고
    • Defective B cell development and function in Btk-deficient mice
    • Khan WN, Alt FW, Gerstein RM, et al. Defective B cell development and function in Btk-deficient mice. Immunity. 1995;3(3):283-299.
    • (1995) Immunity , vol.3 , Issue.3 , pp. 283-299
    • Khan, W.N.1    Alt, F.W.2    Gerstein, R.M.3
  • 26
    • 0345016875 scopus 로고    scopus 로고
    • The B cell antigen receptor controls integrin activity through Btk and PLCgamma2
    • Spaargaren M, Beuling EA, Rurup ML, et al. The B cell antigen receptor controls integrin activity through Btk and PLCgamma2. J Exp Med. 2003; 198(10):1539-1550.
    • (2003) J Exp Med , vol.198 , Issue.10 , pp. 1539-1550
    • Spaargaren, M.1    Beuling, E.A.2    Rurup, M.L.3
  • 27
    • 2542443772 scopus 로고    scopus 로고
    • A conditional form of Bruton's tyrosine kinase is sufficient to activate multiple downstream signaling pathways via PLC Gamma 2 in B cells
    • Tomlinson MG, Woods DB, McMahon M, et al. A conditional form of Bruton's tyrosine kinase is sufficient to activate multiple downstream signaling pathways via PLC Gamma 2 in B cells. BMC Immunol. 2001;2:4.
    • (2001) BMC Immunol , vol.2 , pp. 4
    • Tomlinson, M.G.1    Woods, D.B.2    McMahon, M.3
  • 28
    • 79959404661 scopus 로고    scopus 로고
    • Bruton tyrosine kinase represents a promising therapeutic target for treatment of chronic lymphocytic leukemia and is effectively targeted by PCI-32765
    • Herman SE, Gordon AL, Hertlein E, et al. Bruton tyrosine kinase represents a promising therapeutic target for treatment of chronic lymphocytic leukemia and is effectively targeted by PCI-32765. Blood. 2011;117(23):6287-6296.
    • (2011) Blood , vol.117 , Issue.23 , pp. 6287-6296
    • Herman, S.E.1    Gordon, A.L.2    Hertlein, E.3
  • 29
    • 84863011553 scopus 로고    scopus 로고
    • The Bruton tyrosine kinase inhibitor PCI-32765 thwarts chronic lymphocytic leukemia cell survival and tissue homing in vitro and in vivo
    • Ponader S, Chen SS, Buggy JJ, et al. The Bruton tyrosine kinase inhibitor PCI-32765 thwarts chronic lymphocytic leukemia cell survival and tissue homing in vitro and in vivo. Blood. 2012; 119(5):1182-1189.
    • (2012) Blood , vol.119 , Issue.5 , pp. 1182-1189
    • Ponader, S.1    Chen, S.S.2    Buggy, J.J.3
  • 30
    • 77955625479 scopus 로고    scopus 로고
    • The Bruton tyrosine kinase inhibitor PCI-32765 blocks B-cell activation and is efficacious in models of autoimmune disease and B-cell malignancy
    • Honigberg LA, Smith AM, Sirisawad M, et al. The Bruton tyrosine kinase inhibitor PCI-32765 blocks B-cell activation and is efficacious in models of autoimmune disease and B-cell malignancy. Proc Natl Acad Sci USA. 2010;107(29):13075-13080.
    • (2010) Proc Natl Acad Sci USA , vol.107 , Issue.29 , pp. 13075-13080
    • Honigberg, L.A.1    Smith, A.M.2    Sirisawad, M.3
  • 31
    • 38049084406 scopus 로고    scopus 로고
    • Discovery of selective irreversible inhibitors for Bruton's tyrosine kinase
    • Pan Z, Scheerens H, Li SJ, et al. Discovery of selective irreversible inhibitors for Bruton's tyrosine kinase. ChemMedChem. 2007;2(1): 58-61.
    • (2007) ChemMedChem , vol.2 , Issue.1 , pp. 58-61
    • Pan, Z.1    Scheerens, H.2    Li, S.J.3
  • 32
    • 84871806385 scopus 로고    scopus 로고
    • Bruton tyrosine kinase inhibitor ibrutinib (PCI-32765) has significant activity in patients with relapsed/refractory B-cell malignancies
    • Advani RH, Buggy JJ, Sharman JP, et al. Bruton tyrosine kinase inhibitor ibrutinib (PCI-32765) has significant activity in patients with relapsed/refractory B-cell malignancies. J Clin Oncol. 2013; 31(1):88-94.
    • (2013) J Clin Oncol , vol.31 , Issue.1 , pp. 88-94
    • Advani, R.H.1    Buggy, J.J.2    Sharman, J.P.3
  • 33
    • 84879748062 scopus 로고    scopus 로고
    • Targeting BTK with ibrutinib in relapsed chronic lymphocytic leukemia
    • Byrd JC, Furman RR, Coutre SE, et al. Targeting BTK with ibrutinib in relapsed chronic lymphocytic leukemia. N Engl J Med. 2013;369(1):32-42.
    • (2013) N Engl J Med , vol.369 , Issue.1 , pp. 32-42
    • Byrd, J.C.1    Furman, R.R.2    Coutre, S.E.3
  • 34
    • 84891373281 scopus 로고    scopus 로고
    • Ibrutinib as initial therapy for elderly patients with chronic lymphocytic leukaemia or small lymphocytic lymphoma: An open-label, multicentre, phase 1b/2 trial
    • O'Brien S, Furman RR, Coutre SE, et al. Ibrutinib as initial therapy for elderly patients with chronic lymphocytic leukaemia or small lymphocytic lymphoma: an open-label, multicentre, phase 1b/2 trial. Lancet Oncol. 2014;15(1):48-58.
    • (2014) Lancet Oncol , vol.15 , Issue.1 , pp. 48-58
    • O'Brien, S.1    Furman, R.R.2    Coutre, S.E.3
  • 35
    • 84929203514 scopus 로고    scopus 로고
    • Imbruvica prescribing information
    • Accessed February 20, 2015
    • Pharmacyclics and Janssen Biotech. Imbruvica prescribing information. US Food and Drug Administration. http://www.accessdata.fda.gov/drugsatfda-docs/label/2015/205552s002lbl.pdf. Accessed February 20, 2015.
    • US Food and Drug Administration
    • Pharmacyclics and Janssen Biotech1
  • 36
    • 45149100665 scopus 로고    scopus 로고
    • Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia: A report from the International Workshop on Chronic Lymphocytic Leukemia updating the National Cancer Institute-Working Group 1996 guidelines
    • Hallek M, Cheson BD, Catovsky D, et al International Workshop on Chronic Lymphocytic Leukemia. Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia: a report from the International Workshop on Chronic Lymphocytic Leukemia updating the National Cancer Institute-Working Group 1996 guidelines. Blood. 2008;111(12):5446-5456.
    • (2008) Blood , vol.111 , Issue.12 , pp. 5446-5456
    • Hallek, M.1    Cheson, B.D.2    Catovsky, D.3
  • 37
    • 84902183019 scopus 로고    scopus 로고
    • Resistance mechanisms for the Bruton's tyrosine kinase inhibitor ibrutinib
    • Woyach JA, Furman RR, Liu TM, et al. Resistance mechanisms for the Bruton's tyrosine kinase inhibitor ibrutinib. N Engl J Med. 2014; 370(24):2286-2294.
    • (2014) N Engl J Med , vol.370 , Issue.24 , pp. 2286-2294
    • Woyach, J.A.1    Furman, R.R.2    Liu, T.M.3
  • 38
    • 84903201129 scopus 로고    scopus 로고
    • Chemoimmunotherapy with Fludarabine (F), Cyclophosphamide (C), and Rituximab (R) (FCR) versus bendamustine and rituximab (BR) in previously untreated and physically fit patients (pts) with advanced chronic lymphocytic leukemia (CLL): Results of a planned interim analysis of the CLL10 trial, an international, randomized study of the German CLL study group (GCLLSG)
    • [abstract]
    • Eichhorst B, Fink AM, Busch R, et al. Chemoimmunotherapy with Fludarabine (F), Cyclophosphamide (C), and Rituximab (R) (FCR) versus bendamustine and rituximab (BR) in previously untreated and physically fit patients (pts) with advanced chronic lymphocytic leukemia (CLL): results of a planned interim analysis of the CLL10 trial, an international, randomized study of the German CLL study group (GCLLSG) [abstract]. Blood. 2013;122(21). Abstract 526.
    • (2013) Blood , vol.122 , Issue.21
    • Eichhorst, B.1    Fink, A.M.2    Busch, R.3
  • 39
    • 60949087189 scopus 로고    scopus 로고
    • Other malignancies in chronic lymphocytic leukemia/small lymphocytic lymphoma
    • Tsimberidou AM, Wen S, McLaughlin P, et al. Other malignancies in chronic lymphocytic leukemia/small lymphocytic lymphoma. J Clin Oncol. 2009;27(6):904-910.
    • (2009) J Clin Oncol , vol.27 , Issue.6 , pp. 904-910
    • Tsimberidou, A.M.1    Wen, S.2    McLaughlin, P.3
  • 40
    • 84878898569 scopus 로고    scopus 로고
    • Extended follow up of the CLL8 protocol, a randomized phase-III trial of the German CLL Study Group (GCLLSG) comparing fludarabine and cyclophosphamide (FC) to FC plus rituximab (FCR) for previously untreated patients with chronic lymphocytic leukemia (CLL): Results on survival, progression-free survival, delayed neutropenias and secondary malignancies confirm superiority of the FCR regimen
    • [abstract]
    • Fischer K, Bahlo J, Fink AM, et al. Extended follow up of the CLL8 protocol, a randomized phase-III trial of the German CLL Study Group (GCLLSG) comparing fludarabine and cyclophosphamide (FC) to FC plus rituximab (FCR) for previously untreated patients with chronic lymphocytic leukemia (CLL): results on survival, progression-free survival, delayed neutropenias and secondary malignancies confirm superiority of the FCR regimen [abstract]. Blood. 2012;120(21). Abstract 435.
    • (2012) Blood , vol.120 , Issue.21
    • Fischer, K.1    Bahlo, J.2    Fink, A.M.3
  • 41
    • 80054853285 scopus 로고    scopus 로고
    • B-cell receptor signaling in chronic lymphocytic leukemia
    • Stevenson FK, Krysov S, Davies AJ, Steele AJ, Packham G. B-cell receptor signaling in chronic lymphocytic leukemia. Blood. 2011;118(16): 4313-4320.
    • (2011) Blood , vol.118 , Issue.16 , pp. 4313-4320
    • Stevenson, F.K.1    Krysov, S.2    Davies, A.J.3    Steele, A.J.4    Packham, G.5
  • 42
    • 84897069190 scopus 로고    scopus 로고
    • Prolonged lymphocytosis during ibrutinib therapy is associated with distinct molecular characteristics and does not indicate a suboptimal response to therapy
    • Woyach JA, Smucker K, Smith LL, et al. Prolonged lymphocytosis during ibrutinib therapy is associated with distinct molecular characteristics and does not indicate a suboptimal response to therapy. Blood. 2014;123(12): 1810-1817.
    • (2014) Blood , vol.123 , Issue.12 , pp. 1810-1817
    • Woyach, J.A.1    Smucker, K.2    Smith, L.L.3


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