Echinacoside induces rat pulmonary artery vasorelaxation by opening the NO-cGMP-PKG-BKCa channels and reducing intracellular Ca2+ levels

Acta Pharmacologica Sinica

Volumn 36, Issue 5, 2015, Pages 587-596

  Gai, Xiang Yun ^a,b   Wei, Yu Hai ^c   Zhang, Wei ^b   Wuren, Ta Na ^b   Wang, Ya Ping ^b   Li, Zhan Qiang ^b   Liu, Shou ^b   Ma, Lan ^b   Lu, Dian Xiang ^b   Zhou, Yi ^a,b   Ge, Ri Li ^a,b  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^b QINGHAI UNIVERSITY   (China)

^c Qinghai Entry Exit Inspection and Quarantine Bureau   (China)

Author keywords

artery ring; BKCa; echinacoside; high altitude; KIR; NO; pulmonary arterial smooth muscle cells; pulmonary hypertension; Tibetan herb; vasorelaxation

Indexed keywords

BARIUM CHLORIDE; CALCIUM ION; CYCLIC GMP; CYCLIC GMP DEPENDENT PROTEIN KINASE; ECHINACOSIDE; FAMPRIDINE; GLIBENCLAMIDE; INDOMETACIN; LARGE CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; TETRYLAMMONIUM CHLORIDE; GLYCOSIDE; KCNMA1 PROTEIN, RAT; LARGE CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL ALPHA SUBUNIT; NORADRENALIN; VASOCONSTRICTOR AGENT; VASODILATOR AGENT;

ALTITUDE; ANIMAL CELL; ANIMAL TISSUE; ARTERY CONSTRICTION; ARTERY DILATATION; ARTICLE; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CONCENTRATION RESPONSE; CONTROLLED STUDY; EC50; EXTRACELLULAR CALCIUM; IN VITRO STUDY; MALE; NONHUMAN; PULMONARY ARTERIAL SMOOTH MUSCLE CELL; PULMONARY ARTERY; PULMONARY HYPERTENSION; RAT; SMOOTH MUSCLE FIBER; VASCULAR ENDOTHELIUM; AGONISTS; ANIMAL; CALCIUM SIGNALING; CELL CULTURE; CHANNEL GATING; DOSE RESPONSE; DRUG EFFECTS; ENDOTHELIUM CELL; ENZYMOLOGY; METABOLISM; VASCULAR SMOOTH MUSCLE; VASODILATATION; WISTAR RAT;

ANIMALS; CALCIUM SIGNALING; CELLS, CULTURED; CYCLIC GMP; CYCLIC GMP-DEPENDENT PROTEIN KINASES; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIAL CELLS; GLYCOSIDES; IN VITRO TECHNIQUES; ION CHANNEL GATING; LARGE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNEL ALPHA SUBUNITS; MALE; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; NITRIC OXIDE; NOREPINEPHRINE; PULMONARY ARTERY; RATS, WISTAR; VASOCONSTRICTOR AGENTS; VASODILATION; VASODILATOR AGENTS;

EID: 84929152130     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1038/aps.2014.126     Document Type: Article

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