Depression in Gulf War veterans: A systematic review and meta-analysis

Psychological Medicine

Volumn 45, Issue 8, 2015, Pages 1565-1580

  Blore, J D ^a,b   Sim, M R ^a   Forbes, A B ^a   Creamer, M C ^c   Kelsall, H L ^a  

^a MONASH UNIVERSITY   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

^c UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

Depression; Gulf War; meta analysis; systematic review; veterans

Indexed keywords

DEPRESSIVE DISORDER; HUMAN; META ANALYSIS; ODDS RATIO; PREVALENCE; PSYCHOLOGY; STATISTICS AND NUMERICAL DATA; UNITED STATES; VETERAN; WAR;

DEPRESSIVE DISORDER; GULF WAR; HUMANS; ODDS RATIO; PREVALENCE; UNITED STATES; VETERANS;

EID: 84929129614     PISSN: 00332917     EISSN: 14698978     Source Type: Journal    
DOI: 10.1017/S0033291714001913     Document Type: Review

References (38)

1. Barendregt JJ, Doi SA (n.d.). MetaXL User Guide, Version 1.1 (www.epigear.com). Accessed 2 November 2012
2. Beck AT, Steer RA, Carbin MG. (1988). Psychometric properties of the Beck Depression Inventory: twenty-five years of evaluation. Clinical Psychology Review 8, 77-100
3. Carlson K, Kehle S, Meis L, Greer N, MacDonald R, Rutks I, Wilt TJ. (2009). The Assessment and Treatment of Individuals with History of Traumatic Brain Injury and Post-Traumatic Stress Disorder: A Systematic Review of the Evidence. Department of Veterans Affairs (US): Washington, DC (www.ncbi.nlm.nih.gov/books/NBK49144/). Accessed 10 April 2013
4. Derogatis LR, Savitz KL. (1999). The SCL-90-R, Brief Symptom Inventory, and matching clinical rating scales. In The Use of Psychological Testing for Treatment Planning and Outcomes Assessment (ed. M. E. Maruish), pp. 679-724. Erlbaum: Mahwah, NJ.
5. Fiedler N, Ozakinci G, Hallman W, Wartenberg D, Brewer NT, Barrett DH, Kipen HM. (2006). Military deployment to the Gulf War as a risk factor for psychiatric illness among US troops. British Journal of Psychiatry 188, 453-459
6. Gadermann AM, Engel CC, Naifeh JA, Nock MK, Petukhova M, Santiago PN, Wu B, Zaslavsky AM, Kessler RC. (2012). Prevalence of DSM-IV major depression among U.S. military personnel: meta-Analysis and simulation. Military Medicine 177, 47-59
7. Gilbody S, Richards D, Brealey S, Hewitt C. (2007). Screening for depression in medical settings with the Patient Health Questionnaire (PHQ): a diagnostic meta-Analysis. Journal of General Internal Medicine 22, 1596-1602
8. Glass DC, Sim MR, Kelsall HL, Ikin JF, McKenzie D, Forbes A, Ittak P. (2006). What was different about exposures reported by male Australian Gulf War veterans during the 1991 Gulf War compared with exposures reported for other deployments? Military Medicine 171, 632-638
9. Goss Gilroy Inc. (1998). Health Study of Canadian Forces Personnel Involved in the 1991 Conflict in the Persian Gulf. Gulf War Illness Advisory Committee: Ottawa
10. Gray GC, Reed RJ, Kaiser KS, Smith TC, Gastanaga VM. (2002). Self-reported symptoms and medical conditions among 11, 868 Gulf War-era veterans: the Seabee Health Study. American Journal of Epidemiology 155, 1033-1044
11. Higgins JPT, Altman DG, GOh;tzsche PC, Jüni P, Moher D, Oxman AD, Savovic J, Schulz KF, Weeks L, Sterne JA; Cochrane Bias Methods Group; Cochrane Statistical Methods Group. (2011). The Cochrane Collaboration's tool for assessing risk of bias in randomised trials. British Medical Journal 343, d5928
12. Higgins JPT, Green S (eds). (2011). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. The Cochrane Collaboration (www. cochrane-handbook.org). Accessed 1 November 2012
13. Higgins JPT, Thompson SG, Deeks JJ, Altman DG. (2003). Measuring inconsistency in meta-Analyses. British Medical Journal 327, 557-560
14. Hoy D, Brooks P, Woolf A, Blyth F, March L, Bain C, Baker P, Smith E, Buchbinder R. (2012). Assessing risk of bias in prevalence studies: modification of an existing tool and evidence of interrater agreement. Journal of Clinical Epidemiology 65, 934-939
15. Ikin JF, McKenzie DP, Creamer MC, McFarlane AC, Kelsall HL, Glass DC, Forbes AB, Horsley KWA, Harrex WK, Sim MR (2005). War zone stress without direct combat: the Australian naval experience of the Gulf War. Journal of Traumatic Stress 18, 193-204
16. Ikin JF, Sim M, Creamer M, Forbes A, Mckenzie D, Kelsall H, Glass DC, McFarlane AC, Abramson MJ, Ittak P, Dwyer T, Blizzard L, Delaney KR, Horsley KW, Harrex WK, Schwarz H. (2004). War-related psychological stressors and risk of psychological disorders in Australian veterans of the 1991 Gulf War. British Journal of Psychiatry 185, 116-126
17. Iowa Persian Gulf Study Group. (1997). Self-reported illness and health status among Gulf War veterans: a population-based study. Journal of the American Medical Association 277, 238-245
18. Ishoy T, Knop J, Suadicani P, Guldager B, Appleyard M, Gyntelberg F. (2004). Increased psychological distress among Danish Gulf War veterans - without evidence for a neurotoxic background. The Danish Gulf War Study. Danish Medical Bulletin 51, 108-113
19. Kang HK, Li B, Mahan CM, Eisen SA, Engel CC. (2009). Health of US veterans of 1991 Gulf War: a follow-up survey in 10 years. Journal of Occupational and Environmental Medicine 51, 401-410
20. Kang HK, Mahan CM, Lee KY, Magee CA, Murphy FM. (2000). Illnesses among United States veterans of the Gulf War: a population-based survey of 30, 000 veterans. Journal of Occupational and Environmental Medicine 42, 491-501
21. Kroenke K, Spitzer RL. (2002). The PHQ-9: a new depression diagnostic and severity measure. Psychiatric Annals 32, 509-515
22. Magruder KM, Yeager DE. (2009). The prevalence of PTSD across war eras and the effect of deployment on PTSD: a systematic review and meta-Analysis. Psychiatric Annals 39, 778-788
23. McCauley LA, Lasarev M, Sticker D, Rischitelli DG, Spencer PS. (2002). Illness experience of Gulf War veterans possibly exposed to chemical warfare agents. American Journal of Preventative Medicine 23, 200-206
24. McKenzie DP, Ikin J, McFarlane A, Creamer M, Forbes A, Kelsall H, Glass DC, Ittak P, Sim MR. (2004). Psychological health of Australian veterans of the 1991 Gulf War: an assessment using the SF-12, GHQ-12 and PCL-S. Psychological Medicine 34, 1419-1430
25. Mitchell AJ, Vaze A, Rao S. (2009). Clinical diagnosis of depression in primary care: a meta-Analysis. Lancet 374, 609-619
26. Moher D, Liberati A, Tetzlaff J, Altman DG; PRISMA Group. (2009). Preferred reporting items for systematic reviews and meta-Analyses: the PRISMA statement. PLoS Medicine 6, e1000097
27. Perconte ST, Wilson AT, Pontius EB, Dietrick AL, Spiro KJ. (1993). Psychological and war stress symptoms among deployed and non-deployed reservists following the Persian Gulf War. Military Medicine 158, 516-521
28. Ramchand R, Karney BR, Osilla KC, Burns RM, Caldarone LB. (2008). Prevalence of PTSD, depression, and TBI among returning service members. In Invisible Wounds of War: Psychological and Cognitive Injuries, Their Consequences, and Services to Assist Recovery (ed. T. L. Tanielian and L. H. Jaycox), pp. 35-85. RAND Corporation: Santa Monica, CA.
29. Robins LN, Wing J, Wittchen HU, Helzer JE, Babor TF, Burke J, Farmer A, Jablenski A, Pickens R, Regier DA, Sartorius N, Towle LH. (1988). The Composite International Diagnostic Interview: an epidemiologic instrument suitable for use in conjunction with different diagnostic systems and in different cultures. Archives of General Psychiatry 45, 1069-1077
30. Spitzer RL, Williams JB, Kroenke K, Linzer M, Hahn SR, Brody D, Johnson JG. (1994). Utility of a new procedure for diagnosing mental disorders in primary care. Journal of the American Medical Association 272, 1749-1756
31. Steele L. (2000). Prevalence and patterns of Gulf War illness in Kansas veterans: association of symptoms with characteristics of person, place, and time of military service. American Journal of Epidemiology 152, 992-1002
32. Stimpson NJ, Thomas HV, Weightman AL, Dunstan F, Lewis G. (2003). Psychiatric disorder in veterans of the Persian Gulf War of 1991. Systematic review. British Journal of Psychiatry 182, 391-403
33. Sutker PB, Uddo M, Brailey K, Allain AN. (1993). War-zone trauma and stress-related symptoms in Operation Desert Shield/Storm (ODS) returnees. Journal of Social Issues 49, 33-50
34. Sutker PB, Davis JM, Uddo M, Ditta SR. (1995). Assessment of psychological distress in Persian Gulf troops: ethnicity and gender comparisons. Journal of Personality Assessment 64, 415-427
35. Toomey R, Kang HK, Karlinsky J, Baker DG, Vasterling JJ, Alpern R, Reda DJ, Henderson WG, Murphy FM, Eisen SA. (2007). Mental health of US Gulf War veterans 10 years after the war. British Journal of Psychiatry 190, 385-393
36. Vos T, Flaxman AD, Naghavi M, Lozano R, Michaud C, Ezzati M, Shibuya K, Salomon JA, Abdalla S, Aboyans V, Abraham J, Ackerman I, Aggarwal R, Ahn SY, Ali MK, Alvarado M, Anderson HR, Anderson LM, Andrews KG, Atkinson C, Baddour LM, Bahalim AN, Barker-Collo S, Barrero LH, Bartels DH, Basáñez MG, Baxter A, Bell ML, Benjamin EJ, Bennett D, Bernabé E, Bhalla K, Bhandari B, Bikbov B, Bin Abdulhak A, Birbeck G, Black JA, Blencowe H, Blore JD, Blyth F, Bolliger I, Bonaventure A, Boufous S, Bourne R, Boussinesq M, Braithwaite T, Brayne C, Bridgett L, Brooker S, Brooks P, Brugha TS, Bryan-Hancock C, Bucello C, Buchbinder R, Buckle G, Budke CM, Burch M, Burney P, Burstein R, Calabria B, Campbell B, Canter CE, Carabin H, Carapetis J, Carmona L, Cella C, Charlson F, Chen H, Cheng AT, Chou D, Chugh SS, Coffeng LE, Colan SD, Colquhoun S, Colson KE, Condon J, Connor MD, Cooper LT, Corriere M, Cortinovis M, de Vaccaro KC, Couser W, Cowie BC, Criqui MH, Cross M, Dabhadkar KC, Dahiya M, Dahodwala N, Damsere-Derry J, Danaei G, D vis A, De Leo D, Degenhardt L, Dellavalle R, Delossantos A, Denenberg J, Derrett S, Des Jarlais DC, Dharmaratne SD, Dherani M, Diaz-Torne C, Dolk H, Dorsey ER, Driscoll T, Duber H, Ebel B, Edmond K, Elbaz A, Ali SE, Erskine H, Erwin PJ, Espindola P, Ewoigbokhan SE, Farzadfar F, Feigin V, Felson DT, Ferrari A, Ferri CP, Fèvre EM, Finucane MM, Flaxman S, Flood L, Foreman K, Forouzanfar MH, Fowkes FG, Franklin R, Fransen M, Freeman MK, Gabbe BJ, Gabriel SE, Gakidou E, Ganatra HA, Garcia B, Gaspari F, Gillum RF, Gmel G, Gosselin R, Grainger R, Groeger J, Guillemin F, Gunnell D, Gupta R, Haagsma J, Hagan H, Halasa YA, Hall W, Haring D, Haro JM, Harrison JE, Havmoeller R, Hay RJ, Higashi H, Hill C, Hoen B, Hoffman H, Hotez PJ, Hoy D, Huang JJ, Ibeanusi SE, Jacobsen KH, James SL, Jarvis D, Jasrasaria R, Jayaraman S, Johns N, Jonas JB, Karthikeyan G, Kassebaum N, Kawakami N, Keren A, Khoo JP, King CH, Knowlton LM, Kobusingye O, Koranteng A, Krishnamurthi R, Lalloo R, Laslett LL, Lathlean T, Leasher JL, Lee YY, Leigh J, Lim SS, Limb E, Lin JK, Lipnick M, Lipshultz SE, Liu W, Loane M, Ohno SL, Lyons R, Ma J, Mabweijano J, MacIntyre MF, Malekzadeh R, Mallinger L, Manivannan S, Marcenes W, March L, Margolis DJ, Marks GB, Marks R, Matsumori A, Matzopoulos R, Mayosi BM, McAnulty JH, McDermott MM, McGill N, McGrath J, Medina-Mora ME, Meltzer M, Mensah GA, Merriman TR, Meyer AC, Miglioli V, Miller M, Miller TR, Mitchell PB, Mocumbi AO, Moffitt TE, Mokdad AA, Monasta L, Montico M, Moradi-Lakeh M, Moran A, Morawska L, Mori R, Murdoch ME, Mwaniki MK, Naidoo K, Nair MN, Naldi L, Narayan KM, Nelson PK, Nelson RG, Nevitt MC, Newton CR, Nolte S, Norman P, Norman R, O'Donnell M, O'Hanlon S, Olives C, Omer SB, Ortblad K, Osborne R, Ozgediz D, Page A, Pahari B, Pandian JD, Rivero AP, Patten SB, Pearce N, Padilla RP, Perez-Ruiz F, Perico N, Pesudovs K, Phillips D, Phillips MR, Pierce K, Pion S, Polanczyk GV, Polinder S, Pope CA III, Popova S, Porrini E, Pourmalek F, Prince M, Pullan RL, Ramaiah KD, Ranganathan D, Razavi H, Regan M, Rehm JT, Rein DB, Remuzzi G, Richardson K, Rivara FP, Roberts T, Robinson C, De Lepn FR, Ronfani L, Room R, Rosenfeld LC, Rushton L, Sacco RL, Saha S, Sampson U, Sanchez-Riera L, Sanman E, Schwebel DC, Scott JG, Segui-Gomez M, Shahraz S, Shepard DS, Shin H, Shivakoti R, Singh D, Singh GM, Singh JA, Singleton J, Sleet DA, Sliwa K, Smith E, Smith JL, Stapelberg NJ, Steer A, Steiner T, Stolk WA, Stovner LJ, Sudfeld C, Syed S, Tamburlini G, Tavakkoli M, Taylor HR, Taylor JA, Taylor WJ, Thomas B, Thomson WM, Thurston GD, Tleyjeh IM, Tonelli M, Towbin JA, Truelsen T, Tsilimbaris MK, Ubeda C, Undurraga EA, van der Werf MJ, van Os J, Vavilala MS, Venketasubramanian N, Wang M, Wang W, Watt K, Weatherall DJ, Weinstock MA, Weintraub R, Weisskopf MG, Weissman MM, White RA, Whiteford H, Wiersma ST, Wilkinson JD, Williams HC, Williams SR, Witt E, Wolfe F, Woolf AD, Wulf S, Yeh PH, Zaidi AK, Zheng ZJ, Zonies D, Lopez AD, Murray CJ, AlMazroa MA, Memish ZA. (2012). Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet 380, 2163-2196
37. Wells TS, Miller SC, Adler AB, Engel CC, Smith TC, Fairbank JA. (2011). Mental health impact of the Iraq and Afghanistan conflicts: a review of US research, service provision, and programmatic responses. International Review of Psychiatry 23, 144-152
38. Wolfe J, Proctor SP, Erickson DJ, Heeren T, Friedman MJ, Huang MT, Sutker PB, Vasterling JJ, White RF. (1999). Relationship of psychiatric status to Gulf War veterans' health problems. Psychosomatic Medicine 61, 532-540