Reduction of pressor response to stress by centrally acting apelin in spontaneously hypertensive rats

Journal of Basic and Clinical Physiology and Pharmacology

Volumn 26, Issue 3, 2015, Pages 233-236

  Gomolka, Ryszard Stefan ^a   Cudnoch Jedrzejewska, Agnieszka ^a   Czarzasta, Katarzyna ^a   Szczepanska Sadowska, Ewa ^a  

^a MEDICAL UNIVERSITY OF WARSAW   (Poland)

Author keywords

apelin; hypertension; stress

Indexed keywords

APELIN; APELIN 13; HYPERTENSIVE FACTOR; SODIUM CHLORIDE; UNCLASSIFIED DRUG; APELIN-13 PEPTIDE; SIGNAL PEPTIDE;

ACUTE STRESS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD PRESSURE REGULATION; CARDIOVASCULAR RESPONSE; CONTROLLED STUDY; ESSENTIAL HYPERTENSION; EVOKED RESPONSE; HEART RATE; MALE; MEAN ARTERIAL PRESSURE; NONHUMAN; PRESSOR RESPONSE; RAT; SPONTANEOUSLY HYPERTENSIVE RAT; ANIMAL; ARTERIAL PRESSURE; CARDIOVASCULAR SYSTEM; DRUG EFFECTS; HYPERTENSION; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; PATHOPHYSIOLOGY; PHYSIOLOGICAL STRESS; WISTAR KYOTO RAT;

ANIMALS; ARTERIAL PRESSURE; CARDIOVASCULAR SYSTEM; HEART RATE; HYPERTENSION; INFUSIONS, INTRAVENTRICULAR; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; RATS; RATS, INBRED SHR; RATS, INBRED WKY; STRESS, PHYSIOLOGICAL;

EID: 84929086929     PISSN: 07926855     EISSN: 21910286     Source Type: Journal    
DOI: 10.1515/jbcpp-2014-0066     Document Type: Article

References (13)

1. Blumenthal JA, Sherwood A, Gullette EC, Georgiades A, Tweedy D. Biobehavioral approaches to the treatment of essential hypertension. J Consult Clin Psychol 2002;70:569-89.
2. De Mota N, Reaux-Le Goazigo A, El Messari S, Chartrel N, Roesch D, Dujardin C, et al. Apelin, a potent diuretic neuropeptide counteracting vasopressin actions through inhibition of vasopressin neuron activity and vasopressin release. Proc Natl Acad Sci USA 2004;101:10464-9.
3. O'Carroll AM, Don AL, Lolait SJ. APJ receptor mRNA expression in the rat hypothalamic paraventricular nucleus: regulation by stress and glucocorticoids. J Neuroendocrinol 2003;15:1095-101.
4. Zhang Q, Yao F, Raizada MK, O'Rourke ST, Sun C. Apelin gene transfer into the rostral ventrolateral medulla induces chronic blood pressure elevation in normotensive rats. Circ Res 2009;104:1421-8.
5. Newson MJ, Pope GR, Roberts EM, Lolait SJ, O'Carroll AM. Stress-dependent and gender-specific neuroregulatory roles of the apelin receptor in the hypothalamic-pituitary-adrenal axis response to acute stress. J Endocrinol 2013;216: 99-109.
6. Cudnoch-Jedrzejewska A, Szczepanska-Sadowska E, Dobruch J, Gomolka R, Puchalska L. Brain vasopressin V(1) receptors contribute to enhanced cardiovascular responses to acute stress in chronically stressed rats and rats with myocardial infarction. Am J Physiol Regul Integr Comp Physiol 2010;298:R672-80.
7. Szczepanska-Sadowska E, Cudnoch-Jedrzejewska A, Ufnal M, Zera T. Brain and cardiovascular diseases: common neurogenic background of cardiovascular, metabolic and inflammatory diseases. J Physiol Pharmacol 2010;61:509-21.
8. Wsol A, Szczepanska-Sadowska E, Kowalewski S, Puchalska L, Cudnoch-Jedrzejewska A. Oxytocin differently regulates pressor responses to stress in WKY and SHR rats: the role of central oxytocin and V1a receptors. Stress 2014;17:117-25.
9. Zhang F, Sun HJ, Xiong XQ, Chen Q, Li YH, Kang YM, et al. Apelin-13 and APJ in paraventricular nucleus contribute to hypertension via sympathetic activation and vasopressin release in spontaneously hypertensive rats. Acta Physiol (Oxf) 2014;212:17-27.
10. Kagiyama S, Fukuhara M, Matsumura K, Lin Y, Fujii K, Iida M. Central and peripheral cardiovascular actions of apelin in conscious rats. Regul Pept 2005;125:55-9.
11. Seyedabadi M, Goodchild AK, Pilowsky PM. Site-specific effects of apelin-13 in the rat medulla oblongata on arterial pressure and respiration. Auton Neurosci 2002;101:32-8.
12. Borowik O, Czarzasta K, Kolaszynska K, Szczepanska-Sadowska E, Cudnoch-Jedrzejewska A. The role of V1a receptors in the central blood pressure regulation by apelin in Sprague Dawley rats. J Physiol Pharmacol 2014;65(Suppl 1):76.
13. Bodineau L, Taveau C, Lê Quan Sang HH, Osterstock G, Queguiner I, Moos F, et al. Data supporting a new physiological role for brain apelin in the regulation of hypothalamic oxytocin neurons in lactating rats. Endocrinology 2011;152: 3492-503.