Lysosomal dysfunction in Parkinson's disease

Brain

Volumn 138, Issue 4, 2015, Pages e339-

  McNeill, Alisdair ^a  

^a UNIVERSITY OF SHEFFIELD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SYNUCLEIN; BETA N ACETYLHEXOSAMINIDASE; CARBOXYPEPTIDASE C; CATHEPSIN D; GLUCOSYLCERAMIDASE; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 2;

BRAIN REGION; BRAIN TISSUE; CELL FUNCTION; DEGENERATIVE DISEASE; DIFFUSE LEWY BODY DISEASE; DISEASE COURSE; ENZYME ACTIVITY; FUNCTIONAL DISEASE; HUMAN; LETTER; LYSOSOME; PARKINSON DISEASE; PATHOGENESIS; PRIORITY JOURNAL; SPHINGOLIPID METABOLISM; UPREGULATION; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; FEMALE; MALE; METABOLISM; PHYSIOLOGY;

ALPHA-SYNUCLEIN; FEMALE; GLUCOSYLCERAMIDASE; HUMANS; MALE; PARKINSON DISEASE; UP-REGULATION;

EID: 84929086724     PISSN: 00068950     EISSN: 14602156     Source Type: Journal    
DOI: 10.1093/brain/awu266     Document Type: Letter

References (11)

1. Dehay B, Martinez-Vicente M, Caldwell GA, Caldwell KA, Yue Z, Cookson MR, et al. Lysosomal impairment in Parkinson's disease. Mov Disord 2013; 28: 725-32.
2. Ebrahimi-Fakhari D, Wahlster L, McLean PJ. Protein degradation pathways in Parkinson's disease: curse or blessing. Acta Neuropathol 2012; 124: 153-72.
3. Gegg ME, Burke D, Heales SJ, Cooper JM, Hardy J, Wood NW, et al. Glucocerebrosidase deficiency in substantia nigra of Parkinson disease brains. Ann Neurol 2012; 72: 455-63.
4. Ho MW, Seck J, Schmidt D, Veath ML, Johnson W, Brady RO, et al. Adult Gaucher's disease: kindred studies and demonstration of a deficiency of acid beta-glucosidase in cultured fibroblasts. Am J Hum Genet 1972; 24: 37-45.
5. Houlden H, Singleton AB. The genetics and neuropathology of Parkinson's disease. Acta Neuropathol 2012; 124: 325-38.
6. Kurzawa-Akanbi M, Hanson PS, Blain PG, Lett DJ, McKeith IG, Chinnery PF, et al. Glucocerebrosidase mutations alter the endoplas-mic reticulum and lysosomes in Lewy body disease. J Neurochem 2012; 123: 298-309.
7. McNeill A, Duran R, Hughes DA, Mehta A, Schapira AH. A clinical and family history study of Parkinson's disease in glucocerebrosidase mutation carriers. J Neurol Neurosurg Psych 2012; 83: 853-4.
8. McNeill A, Magalhaes J, Shen C, Chau K-Y, Hughes D, Mehta A, et al. Ambroxol improves lysosomal biochemistry in glucocerebrosidase mutation-linked Parkinson disease cells. Brain 2014; 137: 1481-95.
9. Murphy KE, Gysbers AM, Abbott SK, Tayebi N, Kim WS, Sidransky E, et al. Reduced glucocerebrosidase is associated with increased a-synuclein in sporadic Parkinson's disease. Brain 2014; 137: 834-48.
10. Parnetti L, Chiasserini D, Persichetti E, Eusebi P, Varghese S, Qureshi MM, et al. Cerebrospinal fluid lysosomal enzymes and alpha-synuclein in Parkinson's disease. Mov Disord 2014; 8: 1019-27.
11. Shachar T, Lo Bianco C, Recchia A, Wiessner C, Raas-Rothschild A, Futerman AH. Lysosomal storage disorders and Parkinson's disease: Gaucher disease and beyond. Mov Disord 2011; 9: 1593-604.