Reproducible matrix deposition for MALDI MSI based on open-source software and hardware

Journal of the American Society for Mass Spectrometry

Volumn 26, Issue 6, 2015, Pages 911-914

  Stoeckli, Markus ^a   Staab, Dieter ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

Author keywords

Imaging; iMatrixSpray; MALDI MSI; Matrix; Open source; Spray

Indexed keywords

COATINGS; COMPUTER SOFTWARE; DEPOSITION; HARDWARE; IMAGING TECHNIQUES; MATRIX ALGEBRA; OPEN SYSTEMS; SOFTWARE ENGINEERING; SPRAYING;

CONSTANT QUALITY; IMAGING EXPERIMENTS; IMATRIXSPRAY; MALDI MSI; MATRIX DEPOSITION; OPEN SOURCES; REPRODUCIBILITIES; SAMPLE PREPARATION;

OPEN SOURCE SOFTWARE;

AIRFLOW; ARTICLE; ARTIFACT; COMPUTER; COMPUTER PROGRAM; CRYSTALLIZATION; DRY DEPOSITION; HUMIDITY; MASS SPECTROMETRY; MATRIX ASSISTED LASER DESORPTION IONIZATION MASS SPECTROMETRY IMAGING; MOLECULAR IMAGING; MOLECULAR WEIGHT; REPRODUCIBILITY; TEMPERATURE; ANIMAL; DEVICES; EQUIPMENT DESIGN; INFORMATION DISSEMINATION; MATRIX-ASSISTED LASER DESORPTION-IONIZATION MASS SPECTROMETRY; PHARMACOKINETICS; PROCEDURES; RAT; SOFTWARE; SPECIMEN HANDLING;

ANIMALS; EQUIPMENT DESIGN; INFORMATION DISSEMINATION; PHARMACOKINETICS; RATS; REPRODUCIBILITY OF RESULTS; SOFTWARE; SPECIMEN HANDLING; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION;

EID: 84929083876     PISSN: 10440305     EISSN: 18791123     Source Type: Journal    
DOI: 10.1007/s13361-015-1099-9     Document Type: Article

References (14)

1. Caprioli, R.M., Farmer, T.B., Gile, J.: Molecular imaging of biological samples: localization of peptides and proteins using MALDI-TOF MS. Anal. Chem. 69, 4751-4760 (1997)
2. Stoeckli, M., Chaurand, P., Hallahan, D.E., Caprioli, R.M.: Imaging mass spectrometry: a new technology for the analysis of protein expression in mammalian tissues. Nat. Med. 7, 493-496 (2001)
3. Aerni, H.-R., Cornett, D.S., Caprioli, R.M.: Automated acoustic matrix deposition for MALDI sample preparation. Anal. Chem. 78, 827-834 (2006)
4. Moon, H., Wheeler, A.R., Garrell, R.L., Loo, J.A, Kim, C.J.: An integrated digital microfluidic chip for multiplexed proteomic sample preparation and analysis by MALDI-MS. Lab Chip 6, 1213-1219 (2006)
5. Baluya, D.L., Garrett, T.J., Yost, R.A.: Automated MALDI matrix deposition method with inkjet printing for imaging mass spectrometry. Anal. Chem. 79, 6862-6867 (2007)
6. Mounfield, W.P., Garrett, T.J.: Automated MALDI matrix coating system for multiple tissue samples for imaging mass spectrometry. J. Am. Soc. Mass Spectrom. 23, 563-569 (2012)
7. MacAleese, L.: Imaging MS: Sample preparation and instrumentation for high spatial resolution and sensitivity. SMAP - Jt. Conference SFSM SFEAP (2007)
8. Shariatgorji, M., Nilsson, A., Goodwin, R.J.A., Svenningsson, P., Schintu, N., Banka, Z., Kladni, L., Hasko, T., Szabo, A., Andren P. E.: Deuterated matrix-assisted laser desorption ionization matrix uncovers masked mass spectrometry imaging signals of small molecules. Anal. Chem. 84, 7152-7157 (2012)
9. Chen, Y., Liu, Y., Allegood, J., Wang, E., Cachón-González, B., Cox, T.M., Merrill, A.H., Sullards, M.C.: Imaging MALDI mass spectrometry of sphingolipids using an oscillating capillary nebulizer matrix application system. Methods Mol. Biol. 656, 1-14 (2010)
10. Yang, J., Caprioli, R.: Matrix sublimation/recrystallization for imaging proteins by mass spectrometry at high spatial resolution. Anal. Chem. 83, 5728-5734 (2011)
11. Hankin, J.A., Barkley, R.M., Murphy, R.C.: Sublimation as a method of matrix application for mass spectrometric imaging. J. Am. Soc. Mass Spectrom. 18, 1646-1652 (2007)
12. Murphy, R.C., Hankin, J.A., Barkley, R.M., Zemski Berry, K.A.: MALDI imaging of lipids after matrix sublimation/deposition. Biochim. Biophys. Acta Mol. Cell. Biol. Lipids 1811, 970-975 (2011)
13. Bouschen, W., Schulz, O., Eikely, D., Spengler, B.: Matrix vapor deposition/recrystallization and dedicated spray preparation for high-resolution scanning microprobe matrix-assisted laser desorption/ionization imaging mass spectrometry (SMALDI-MS) of tissue and single cells. Rapid Commun. Mass Spectrom. 24, 355-364 (2010)
14. Stoeckli, M., Staab, D., Wetzel, M., Brechbuehl, M.: iMatrixSpray: A Free and Open Source Sample Preparation Device for Mass Spectrometric Imaging. Chim. Int. J. Chem. 68, 146-149 (2014)