Imaging MALDI mass spectrometry of sphingolipids using an oscillating capillary nebulizer matrix application system

Methods in Molecular Biology

Volumn 656, Issue , 2010, Pages 131-146

  Chen, Yanfeng ^a   Liu, Ying ^a   Allegood, Jeremy ^a   Wang, Elaine ^a   Cachón González, Begoña ^b   Cox, Timothy M ^b   Merrill Jr , Alfred H ^a   Sullards, M Cameron ^a  

^a GEORGIA INSTITUTE OF TECHNOLOGY   (United States)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Imaging MALDI mass spectrometry; matrix application; oscillating capillary nebulizer; sphingolipids

Indexed keywords

SPHINGOLIPID;

ANIMAL; ARTICLE; CHEMISTRY; DIAGNOSTIC IMAGING; ELECTROSPRAY MASS SPECTROMETRY; MASS SPECTROMETRY; METHODOLOGY; MOUSE; MOUSE MUTANT; SCANNING ELECTRON MICROSCOPY; TANDEM MASS SPECTROMETRY;

ANIMALS; DIAGNOSTIC IMAGING; MICE; MICE, MUTANT STRAINS; MICROSCOPY, ELECTRON, SCANNING; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; SPHINGOLIPIDS; TANDEM MASS SPECTROMETRY;

EID: 84155169002     PISSN: 10643745     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-60761-746-4_7     Document Type: Article

References (17)

1. Caprioli, R. M., Farmer, T. B., Gile, J. (1997) Molecular imaging of biological samples: Localization of peptides and proteins using MALDI-TOF MS. Anal Chem, 69, 4751-4760.
2. Chaurand, P., Schwartz, S. A., Caprioli, R. M. (2004) Profiling and imaging proteins in tissue sections by MS. Anal Chem, 76, 86A-93A.
3. Rubakhin, S. S., Greenough,W. T., Sweedler, J. V. (2003) Spatial profiling with MALDI MS: Distribution of neuropeptides within single neurons. Anal Chem, 75, 5374-5380.
4. McDonnell, L. A., Heeren, R. M. A. (2007) Imaging mass spectrometry. Mass Spectrom Rev, 26, 606-643.
5. Wang, L., May, S. W., Browner, R. F. (1996) Low-flow interface for liquid chromatography-inductively coupled plasma mass spectrometry speciation using an oscillating capillary nebulizer. J Anal Atomic Spectrom, 11, 1137-1146.
6. Reyderman, L., Stavchansky, S. (1996) Novel methods of microparticulate production: Application to drug delivery. Pharm Dev Technol, 1, 223-229.
7. Perez, J., Petzold, C. J., Watkins, M. A., Vaughn, W. E., Kenttamaa, H. I. (1999) Laser desorption in transmission geometry inside a Fourier-transform ion cyclotron resonance mass spectrometer. J Am Soc Mass Spectrom, 10, 1105-1110.
8. Lake, D. A., Johnson, M. V., McEwen, C. N., Larsen, B. S. (2000) Sample preparation for high throughput accurate mass analysis by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Rapid Commun Mass Spectrom, 14, 1008-1013.
9. Basile, F., Kassalainen, G. E., Williams, S. K. R. (2005) Interface for direct and continuous sample-matrix deposition onto a MALDI probe for polymer analysis by thermal field flow fractionation and off-line MALDI-MS. Anal Chem, 77, 3008-3012.
10. Fung, K. Y. C., Askovic, S., Basile, F., Duncan, M. W. (2004) A simple and inexpensive approach to interfacing highperformance liquid chromatography and matrix-assisted laser desorption/ionizationtime of flight-mass spectrometry. Proteomics, 4, 3121-3127.
11. Kirlew, P. W., Caruso, J. A. (1998) Investigation of a modified oscillating capillary nebulizer design as an interface for CE-ICP-MS. Appl Spectrosc, 52, 770-772.
12. Chen, Y., Allegood, J., Liu, Y., Wang, E., Cachon-Gonzalez, B., Cox, T. M., Merrill, A. H., Jr., Sullards, M. C. (2008) Imaging MALDI mass spectrometry using an oscillating capillary nebulizer matrix coating system and its application to analysis of lipids in brain from a mouse model of Tay-Sachs/Sandhoff disease. Anal Chem, 80, 2780-2788.
13. Cachon-Gonzalez, M. B., Wang, S. Z., Lynch, A., Ziegler, R., Cheng, S. H., Cox, T. M. (2006) Effective gene therapy in an authentic model of Tay-Sachs-related diseases. Proc Natl Acad Sci U S A, 103, 10373-10378.
14. van Echten-Deckert, G. (2000) Sphingolipid Metabolism and Cell Signaling, Pt B, Vol. 312, Academic Press Inc, San Diego, CA, 64-79.
15. Hankin, J. A., Barkley, R. M., Murphy, R. C. (2007) Sublimation as a method of matrix application for mass spectrometric imaging. J Am Soc Mass Spectrom, 18, 1646-1652.
16. Conzelmann, E., Sandhoff, K. (1978) Abvariant of infantile Gm2 gangliosidosis - deficiency of a factor necessary for stimulation of hexosaminidase a-catalyzed degradation of ganglioside Gm2 and glycolipid Ga2. Proc Natl Acad Sci U S A, 75, 3979-3983.
17. Merrill, A. H., Sullards, M. C., Allegood, J. C., Kelly, S., Wang, E. (2005) Sphingolipidomics: High-throughput, structurespecific, and quantitative analysis of sphingolipids by liquid chromatography tandem mass spectrometry. Methods, 36, 207-224.