FASTKD2 and human memory: Functional pathways and prospects for novel therapeutic target development for Alzheimer's disease and age-associated memory decline

Pharmacogenomics

Volumn 16, Issue 5, 2015, Pages 429-432

  Ramanan, Vijay K ^a   Saykin, Andrew J ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Alzheimer's disease; Apoptosis; Cognitive aging; Drug target; Fas associated serine threonine kinase domains 2; FASTKD2; Functional genomics; Inflammation; Memory; microRNA; Mitochondria

Indexed keywords

AGING; ALZHEIMER DISEASE; APOPTOSIS; ASTROCYTE; BRAIN FUNCTION; BRAIN SIZE; COGNITIVE DEFECT; DRUG TARGETING; EPISODIC MEMORY; FASTKD2 GENE; GENE; GENE EXPRESSION; GENE MUTATION; GRAY MATTER; HIPPOCAMPUS; HUMAN; INFLAMMATION; MEMORY; MITOCHONDRION; PROTEIN FAMILY; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN STRUCTURE; REVIEW; SINGLE NUCLEOTIDE POLYMORPHISM; DRUG EFFECTS; GENETICS; MEMORY DISORDERS; PHYSIOLOGY; SIGNAL TRANSDUCTION;

FASTKD2 PROTEIN, HUMAN; PROTEIN SERINE THREONINE KINASE;

AGING; ALZHEIMER DISEASE; APOPTOSIS; HUMANS; MEMORY; MEMORY DISORDERS; PROTEIN-SERINE-THREONINE KINASES; SIGNAL TRANSDUCTION;

EID: 84929070242     PISSN: 14622416     EISSN: 17448042     Source Type: Journal    
DOI: 10.2217/pgs.15.8     Document Type: Review

References (21)

1. Ramanan VK, Nho K, Shen L et al. FASTKD2 is associated with memory and hippocampal structure in older adults. Mol. Psychiatry doi:10.1038/mp.2014.142. (2014) (Epub ahead of print)
2. Sekar S, Mcdonald J, Cuyugan L et al. Alzheimer's disease is associated with altered expression of genes involved in immune response and mitochondrial processes in astrocytes. Neurobiol. Aging 36(2), 583-591 (2014)
3. Simarro M, Gimenez-Cassina A, Kedersha N et al. Fast kinase domain-containing protein 3 is a mitochondrial protein essential for cellular respiration. Biochem. Biophys. Res. Commun. 401(3), 440-446 (2010)
4. Li W, Simarro M, Kedersha N, Anderson P. FAST is a survival protein that senses mitochondrial stress and modulates TIA-1-regulated changes in protein expression. Mol. Cell. Biol. 24(24), 10718-10732 (2004)
5. Phillips K, Kedersha N, Shen L, Blackshear PJ, Anderson P. Arthritis suppressor genes TIA-1 and TTP dampen the expression of tumor necrosis factor alpha, cyclooxygenase 2, and inflammatory arthritis. Proc. Natl Acad. Sci. USA 101(7), 2011-2016 (2004)
6. Ghezzi D, Saada A, D'Adamo P et al. FASTKD2 nonsense mutation in an infantile mitochondrial encephalomyopathy associated with cytochrome c oxidase deficiency. Am. J. Hum. Genet. 83(3), 415-423 (2008)
7. Das S, Yeung K, Mahajan M, Samuels H. Fas activated serine-threonine kinase domains 2 (FASTKD2) mediates apoptosis of breast and prostate cancer cells through its novel FAST2 domain. BMC Cancer 14(1), 852 (2014)
8. Yeung KT, Das S, Zhang J et al. A novel transcription complex that selectively modulates apoptosis of breast cancer cells through regulation of FASTKD2. Mol. Cell. Biol. 31(11), 2287-2298 (2011)
9. Ewing RM, Chu P, Elisma F et al. Large-scale mapping of human protein-protein interactions by mass spectrometry. Mol. Syst. Biol. 3, 89 (2007)
10. Kang HJ, Kawasawa YI, Cheng F et al. Spatio-temporal transcriptome of the human brain. Nature 478(7370), 483-489 (2011)
11. Ruhoy IS, Saneto RP. The genetics of Leigh syndrome and its implications for clinical practice and risk management. Appl. Clin. Genet. 7, 221-234 (2014)
12. Pyle A, Smertenko T, Bargiela D et al. Exome sequencing in undiagnosed inherited and sporadic ataxias. Brain 138(Pt 2), 276-283 (2014)
13. Ramanan VK, Saykin AJ. Pathways to neurodegeneration: mechanistic insights from GWAS in Alzheimer's disease, Parkinson's disease, and related disorders. Am. J. Neurodegener. Dis. 2(3), 145-175 (2013)
14. Lin MT, Beal MF. Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases. Nature 443(7113), 787-795 (2006)
15. Simarro M, Giannattasio G, De La Fuente MA et al. Fas-activated serine/threonine phosphoprotein promotes immune-mediated pulmonary inflammation. J. Immunol. 184(9), 5325-5332 (2010)
16. Piecyk M, Wax S, Beck AR et al. TIA-1 is a translational silencer that selectively regulates the expression of TNFalpha. EMBO J. 19(15), 4154-4163 (2000)
17. Bird L. Inflammation Travelling Fast. Nat. Rev. Immunol. 10(4), 219 (2010)
18. Prinz M, Priller J, Sisodia SS, Ransohoff RM. Heterogeneity of CNS myeloid cells and their roles in neurodegeneration. Nat. Neurosci. 14(10), 1227-1235 (2011)
19. Lucin KM, Wyss-Coray T. Immune activation in brain aging and neurodegeneration: too much or too little? Neuron 64(1), 110-122 (2009)
20. Castello A, Fischer B, Eichelbaum K et al. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Cell 149(6), 1393-1406 (2012)
21. Ramanan VK, Shen L, Moore JH, Saykin AJ. Pathway analysis of genomic data: concepts, methods, and prospects for future development. Trends Genet. 28(7), 323-332 (2012).