Computed Tomography Assessment of Airways Throughout Bronchial Tree Demonstrates Airway Narrowing in Severe Asthma

Academic Radiology

Volumn 22, Issue 6, 2015, Pages 734-742

  Brillet, Pierre Yves ^a,b   Debray, Marie Pierre ^c   Golmard, Jean Louis ^d   Ould Hmeidi, Yahya ^b   Fetita, Catalin ^e   Taillé, Camille ^c,f,g   Aubier, Michel ^c,f,g   Grenier, Philippe A ^d,h  

^a UNIVERSITÉ PARIS 13   (France)

^b AVICENNE HOSPITAL   (France)

^c BICHAT HOSPITAL   (France)

^d ASSISTANCE PUBLIQUE HÔPITAUX DE PARIS   (France)

^e UNIVERSITÉ PARIS DESCARTES   (France)

^f UNIVERSITÉ PARIS DESCARTES   (France)

^g INSERM   (France)

^h SORBONNE UNIVERSITÉ   (France)

Author keywords

Airway remodeling; Asthma; Imaging; Multidetector computed tomography; Three dimensional

Indexed keywords

ADULT; ARTICLE; ASTHMA; BRONCHUS STENOSIS; CLINICAL ARTICLE; COMPUTED TOMOGRAPHY SCANNER; CONTROLLED STUDY; FEMALE; FORCED EXPIRATORY VOLUME; FORCED VITAL CAPACITY; HUMAN; MALE; MULTIDETECTOR COMPUTED TOMOGRAPHY; PRIORITY JOURNAL; TRACHEOBRONCHIAL TREE; BRONCHOGRAPHY; BRONCHUS; CROSS-SECTIONAL STUDY; MIDDLE AGED; RADIOGRAPHY; SEVERITY OF ILLNESS INDEX; THREE DIMENSIONAL IMAGING;

ADULT; ASTHMA; BRONCHI; BRONCHOGRAPHY; CROSS-SECTIONAL STUDIES; FEMALE; HUMANS; IMAGING, THREE-DIMENSIONAL; MALE; MIDDLE AGED; MULTIDETECTOR COMPUTED TOMOGRAPHY; SEVERITY OF ILLNESS INDEX;

EID: 84929048645     PISSN: 10766332     EISSN: 18784046     Source Type: Journal    
DOI: 10.1016/j.acra.2014.12.026     Document Type: Article

References (40)

1. Wenzel S. Severe asthma: from characteristics to phenotypes to endotypes. Clin Exp Allergy 2012, 42:650-658.
2. Chung K.F., Wenzel S.E., Brozek J.L., et al. International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma. Eur Respir J 2014, 43:343-373.
3. Holgate S.T., Polosa R. The mechanisms, diagnosis, and management of severe asthma in adults. Lancet 2006, 368:780-793.
4. Bergeron C., Al-Ramli W., Hamid Q. Remodeling in asthma. Proc Am Thorac Soc 2009, 6:301-305.
5. Bara I., Ozier A., Tunon de Lara J.M., et al. Pathophysiology of bronchial smooth muscle remodelling in asthma. Eur Respir J 2010, 36:1174-1184.
6. Benayoun L., Druilhe A., Dombret M.C., et al. Airway structural alterations selectively associated with severe asthma. Am J Respir Crit Care Med 2003, 167:1360-1368.
7. Moore W.C., Meyers D.A., Wenzel S.E., et al. Identification of asthma phenotypes using cluster analysis in the Severe Asthma Research Program. Am J Respir Crit Care Med 2010, 181:315-323.
8. Hsia C.C., Hyde D.M., Ochs M., et al. An official research policy statement of the American Thoracic Society/European Respiratory Society: standards for quantitative assessment of lung structure. Am J Respir Crit Care Med 2010, 181:394-418.
9. Boser S.R., Park H., Perry S.F., et al. Fractal geometry of airway remodeling in human asthma. Am J Respir Crit Care Med 2005, 172:817-823.
10. Siddiqui S., Redhu N.S., Ojo O.O., et al. Emerging airway smooth muscle targets to treat asthma. Pulm Pharmacol Ther 2013, 26:132-144.
11. Walker C., Gupta S., Hartley R., et al. Computed tomography scans in severe asthma: utility and clinical implications. Curr Opin Pulm Med 2012, 18:42-47.
12. Szefler S.J., Wenzel S., Brown R., et al. Asthma outcomes: biomarkers. J Allergy Clin Immunol 2012, 129:S9-S23.
13. Niimi A., Matsumoto H., Amitani R., et al. Airway wall thickness in asthma assessed by computed tomography. Relation to clinical indices. Am J Respir Crit Care Med 2000, 162:1518-1523.
14. Niimi A., Matsumoto H., Amitani R., et al. Effect of short-term treatment with inhaled corticosteroid on airway wall thickening in asthma. Am J Med 2004, 116:725-731.
15. Aysola R.S., Hoffman E.A., Gierada D., et al. Airway remodeling measured by multidetector CT is increased in severe asthma and correlates with pathology. Chest 2008, 134:1183-1191.
16. Gupta S., Siddiqui S., Haldar P., et al. Quantitative analysis of high-resolution computed tomography scans in severe asthma subphenotypes. Thorax 2010, 65:775-781.
17. Brightling C.E., Gupta S., Gonem S., et al. Lung damage and airway remodelling in severe asthma. Clin Exp Allergy 2012, 42:638-649.
18. Hackx M., Bankier A.A., Gevenois P.A. Chronic obstructive pulmonary disease: CT quantification of airways disease. Radiology 2012, 265:34-48.
19. Gupta S., Hartley R., Khan U.T., et al. Quantitative computed tomography-derived clusters: redefining airway remodeling in asthmatic patients. J Allergy Clin Immunol 2014, 133:729-738.
20. Wahidi M.M., Kraft M. Bronchial thermoplasty for severe asthma. Am J Respir Crit Care Med 2012, 185:709-714.
21. Bousquet J., Mantzouranis E., Cruz A.A., et al. Uniform definition of asthma severity, control, and exacerbations: document presented for the World Health Organization Consultation on Severe Asthma. J Allergy Clin Immunol 2010, 126:926-938.
22. Lo P., van Ginneken B., Reinhardt J.M., et al. Extraction of airways from CT (EXACT'09). IEEE Trans Med Imaging 2012, 31:2093-2107.
23. Fetita C., Ortner M., Brillet P.Y., et al. A morphological-aggregative approach for 3D segmentation of pulmonary airways from generic MSCT acquisitions. Second International Workshop on Pulmonary Image Analysis in conjunction with MICCAI'09 2009, 215-226. United Kingdom.
24. Brillet P.Y., Fetita C.I., Beigelman-Aubry C., et al. Quantification of bronchial dimensions at MDCT using dedicated software. Eur Radiol 2007, 17:1483-1489.
25. Fetita C.I., Ortner M., Brillet P.Y., et al. Airway shape assessment with visual feed-back in asthma and obstructive diseases. Proceedings of the SPIE: Medical Imaging 2010: Visualization, Image-Guided Procedures, and Modeling 2010, 76251.
26. Hosmer D.W., Lemeshow S. Applied logistic regression 2000, John Wiley & Sons Inc., Hoboken, NJ.
27. Anderberg M.R. Cluster Analysis for Applications 1973, Academic Press, New York.
28. Viegi G., Pedreschi M., Pistelli F., et al. Prevalence of airways obstruction in a general population: European Respiratory Society vs American Thoracic Society definition. Chest 2000, 117:339S-345S.
29. James A.L., Wenzel S. Clinical relevance of airway remodelling in airway diseases. Eur Respir J 2007, 30:134-155.
30. Gupta S.S. Effectiveness and safety of bronchial thermoplasty in the treatment of severe asthma. Am J Respir Crit Care Med 2010, 182:1565. author reply 1567.
31. Matsuoka S., Kurihara Y., Nakajima Y., et al. Serial change in airway lumen and wall thickness at thin-section CT in asymptomatic subjects. Radiology 2005, 234:595-603.
32. de Lange E.E., Altes T.A., Patrie J.T., et al. Evaluation of asthma with hyperpolarized helium-3 MRI: correlation with clinical severity and spirometry. Chest 2006, 130:1055-1062.
33. 3He MR imaging. Radiology 2009, 250:567-575.
34. de Backer J.W., Vos W.G., Vinchurkar S.C., et al. Validation of computational fluid dynamics in CT-based airway models with SPECT/CT. Radiology 2010, 257:854-862.
35. Hoshino M., Matsuoka S., Handa H., et al. Correlation between airflow limitation and airway dimensions assessed by multidetector CT in asthma. Respir Med 2010, 104:794-800.
36. Montaudon M., Lederlin M., Reich S., et al. Bronchial measurements in patients with asthma: comparison of quantitative thin-section CT findings with those in healthy subjects and correlation with pathologic findings. Radiology 2009, 253:844-853.
37. Shimizu K., Hasegawa M., Makita H., et al. Airflow limitation and airway dimensions assessed per bronchial generation in older asthmatics. Respir Med 2010, 104:1809-1816.
38. Brillet P.Y., Attali V., Nachbaur G., et al. Multidetector row computed tomography to assess changes in airways linked to asthma control. Respiration 2011, 81:461-468.
39. Barnes P.J. Severe asthma: advances in current management and future therapy. J Allergy Clin Immunol 2012, 129:48-59.
40. Boyden E. The nomenclature of the bronchopulmonary segments and their blood supply. Dis Chest 1961, 39:1-6.