Frequent nightmares are associated with blunted cortisol awakening response in women

Physiology and Behavior

Volumn 147, Issue , 2015, Pages 233-237

  Nagy, Tamás ^a   Salavecz, Gyöngyvér ^b   Simor, Péter ^c,d   Purebl, György ^b   Bódizs, Róbert ^b   Dockray, Samantha ^e   Steptoe, Andrew ^f  

^a EÖTVÖS LORÁND UNIVERSITY   (Hungary)

^b SEMMELWEIS UNIVERSITY   (Hungary)

^c BUDAPEST UNIVERSITY OF TECHNOLOGY AND ECONOMICS   (Hungary)

^d NATIONAL INSTITUTE OF PSYCHIATRY AND NEUROLOGY   (Hungary)

^e UNIVERSITY COLLEGE CORK   (Ireland)

^f UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Cortisol awakening response; Hypothalamus pituitary adrenal axis; Nightmare; Sleep

Indexed keywords

HYDROCORTISONE;

ADULT; ALCOHOL CONSUMPTION; AROUSAL; ARTICLE; CROSS-SECTIONAL STUDY; EXPERIENCE; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; MENTAL DISEASE; NIGHTMARE; PRIORITY JOURNAL; QUESTIONNAIRE; SLOW WAVE SLEEP; CIRCADIAN RHYTHM; CONTROLLED STUDY; DREAM; METABOLISM; MIDDLE AGED; PHYSIOLOGY; RANDOMIZED CONTROLLED TRIAL; SALIVA; WAKEFULNESS;

ADULT; CIRCADIAN RHYTHM; CROSS-SECTIONAL STUDIES; DREAMS; FEMALE; HUMANS; HYDROCORTISONE; MIDDLE AGED; SALIVA; WAKEFULNESS;

EID: 84929008244     PISSN: 00319384     EISSN: 1873507X     Source Type: Journal    
DOI: 10.1016/j.physbeh.2015.05.001     Document Type: Article

References (30)

1. Spoormaker V.I., Schredl M., van den Bout J. Nightmares: from anxiety symptom to sleep disorder. Sleep Med. Rev. 2006, 10:19-31. 10.1016/j.smrv.2005.06.001.
2. Levin R., Nielsen T.A. Disturbed dreaming, posttraumatic stress disorder, and affect distress: a review and neurocognitive model. Psychol. Bull. 2007, 133:482-528. 10.1037/0033-2909.133.3.482.
3. Schredl M. Effects of state and trait factors on nightmare frequency. Eur. Arch. Psychiatry Clin. Neurosci. 2003, 253:241-247. 10.1007/s00406-003-0438-1.
4. Schredl M. Nightmares as a paradigm for studying the effects of stressors. Sleep 2013, 36:969-970. 10.5665/sleep.2784.
5. Van Liempt S., Van Zuiden M., Westenberg H., Super A., Vermetten E. Impact of impaired sleep on the development of PTSD symptoms in combat veterans: a prospective longitudinal cohort study. Depress. Anxiety. 2013, 30:469-474. 10.1002/da.22054.
6. Coolidge F.L., Segal D.L., Coolidge C.M., Spinath F.M., Gottschling J. Do nightmares and generalized anxiety disorder in childhood and adolescence have a common genetic origin?. Behav. Genet. 2010, 40:349-356. 10.1007/s10519-009-9310-z.
7. Simor P., Pajkossy P., Horváth K., Bódizs R. Impaired executive functions in subjects with frequent nightmares as reflected by performance in different neuropsychological tasks. Brain Cogn. 2012, 78:274-283. 10.1016/j.bandc.2012.01.006.
8. Nielsen T., Levin R. Nightmares: a new neurocognitive model. Sleep Med. Rev. 2007, 11:295-310. 10.1016/j.smrv.2007.03.004.
9. Herman J.P., Ostrander M.M., Mueller N.K., Figueiredo H. Limbic system mechanisms of stress regulation: hypothalamo-pituitary-adrenocortical axis. Prog. Neuro-Psychopharmacol. Biol. Psychiatry 2005, 29:1201-1213. 10.1016/j.pnpbp.2005.08.006.
10. Backhaus J., Junghanns K., Hohagen F. Sleep disturbances are correlated with decreased morning awakening salivary cortisol. Psychoneuroendocrinology 2004, 29:1184-1191. 10.1016/j.psyneuen.2004.01.010.
11. Simor P., Horváth K., Gombos F., Takács K.P., Bódizs R. Disturbed dreaming and sleep quality: altered sleep architecture in subjects with frequent nightmares. Eur. Arch. Psychiatry Clin. Neurosci. 2012, 262:687-696. 10.1007/s00406-012-0318-7.
12. Rohleder N., Joksimovic L., Wolf J.M., Kirschbaum C. Hypocortisolism and increased glucocorticoid sensitivity of pro-inflammatory cytokine production in Bosnian war refugees with posttraumatic stress disorder. Biol. Psychiatry 2004, 55:745-751. 10.1016/j.biopsych.2003.11.018.
13. de Kloet C.S., Vermetten E., Heijnen C.J., Geuze E., Lentjes E.G.W.M., Westenberg H.G.M. Enhanced cortisol suppression in response to dexamethasone administration in traumatized veterans with and without posttraumatic stress disorder. Psychoneuroendocrinology 2007, 32:215-226. 10.1016/j.psyneuen.2006.12.009.
14. Wessa M., Rohleder N., Kirschbaum C., Flor H. Altered cortisol awakening response in posttraumatic stress disorder. Psychoneuroendocrinology 2006, 31:209-215. 10.1016/j.psyneuen.2005.06.010.
15. Steptoe A., Wardle J., Stone A., Kahneman D., Marmot M. International Study of Biology and Positive Well-being: Full Research Report ESRC End of Award Report, RES-177-25-0005 2009, ESRC, Swindon. 10.5255/UKDA-SN-6692-1.
16. Chida Y., Steptoe A. Cortisol awakening response and psychosocial factors: a systematic review and meta-analysis. Biol. Psychol. 2009, 80:265-278. 10.1016/j.biopsycho.2008.10.004.
17. Haraszti R.Á., Purebl G., Salavecz G., Poole L., Dockray S., Steptoe A. Morningness-eveningness interferes with perceived health, physical activity, diet and stress levels in working women: a cross-sectional study. Chronobiol. Int. 2014, 1-9. 10.3109/07420528.2014.911188.
18. Shiffman S., Stone A., Hufford M.R. Ecological momentary assessment. Annu. Rev. Clin. Psychol. 2008, 4:1-32. 10.1146/annurev.clinpsy.3.022806.091415.
19. R Core Team R: A Language and Environment for Statistical Computing 2014.
20. Nielsen T. Nightmares associated with the eveningness chronotype. J. Biol. Rhythm. 2010, 25:53-62. 10.1177/0748730409351677.
21. Fries E., Dettenborn L., Kirschbaum C. The cortisol awakening response (CAR): facts and future directions. Int. J. Psychophysiol. 2009, 72:67-73. 10.1016/j.ijpsycho.2008.03.014.
22. Kunz-Ebrecht S.R., Kirschbaum C., Marmot M., Steptoe A. Differences in cortisol awakening response on work days and weekends in women and men from the Whitehall II cohort. Psychoneuroendocrinology 2004, 29:516-528. 10.1016/S0306-4530(03)00072-6.
23. Simor P., Bódizs R., Horváth K., Ferri R. Disturbed dreaming and the instability of sleep: altered nonrapid eye movement sleep microstructure in individuals with frequent nightmares as revealed by the cyclic alternating pattern. Sleep 2013, 36:413-419. 10.5665/sleep.2462.
24. Simor P., Körmendi J., Horváth K., Gombos F., Ujma P.P., Bódizs R. Electroencephalographic and autonomic alterations in subjects with frequent nightmares during pre- and post-REM periods. Brain Cogn. 2014, 91:62-70. 10.1016/j.bandc.2014.08.004.
25. Steiger A. Sleep and the hypothalamo-pituitary-adrenocortical system. Sleep Med. Rev. 2002, 6:125-138. 10.1053/smrv.2001.0159.
26. Wilhelm I., Born J., Kudielka B.M., Schlotz W., Wüst S. Is the cortisol awakening rise a response to awakening?. Psychoneuroendocrinology 2007, 32:358-366. 10.1016/j.psyneuen.2007.01.008.
27. Dettenborn L., Rosenloecher F., Kirschbaum C. No effects of repeated forced wakings during three consecutive nights on morning cortisol awakening responses (CAR): a preliminary study. Psychoneuroendocrinology 2007, 32:915-921. 10.1016/j.psyneuen.2007.06.011.
28. Villarreal G., Hamilton D.A., Petropoulos H., Driscoll I., Rowland L.M., Griego J.A., et al. Reduced hippocampal volume and total white matter volume in posttraumatic stress disorder. Biol. Psychiatry 2002, 52:119-125. 10.1016/S0006-3223(02)01359-8.
29. Germain A., Buysse D.J., Nofzinger E. Sleep-specific mechanisms underlying posttraumatic stress disorder: integrative review and neurobiological hypotheses. Sleep Med. Rev. 2008, 12:185-195. 10.1016/j.smrv.2007.09.003.
30. Ahmadpanah M., Sabzeiee P., Hosseini S.M., Torabian S., Haghighi M., Jahangard L., et al. Comparing the effect of prazosin and hydroxyzine on sleep quality in patients suffering from posttraumatic stress disorder. Neuropsychobiology 2014, 69:235-242. 10.1159/000362243.