Enhancing TB case detection: Experience in offering upfront Xpert MTB/RIF testing to pediatric presumptive TB and DR TB cases for early rapid diagnosis of drug sensitive and drug resistant TB

PLoS ONE

Volumn 9, Issue 8, 2014, Pages

  Raizada, Neeraj ^a   Sachdeva, Kuldeep Singh ^a   Nair, Sreenivas Achuthan ^b   Kulsange, Shubhangi ^a   Gupta, Radhey Shayam ^a   Thakur, Rahul ^a   Parmar, Malik ^b   Gray, Christen ^c   Ramachandran, Ranjani ^b   Vadera, Bhavin ^a   Ekka, Shobha ^a   Dhawan, Shikha ^a   Babre, Ameet ^a   Ghedia, Mayank ^b   Alavadi, Umesh ^a   Dewan, Puneet ^b   Khetrapal, Mini ^a   Khanna, Ashwini ^a   Boehme, Catharina ^c   Paramsivan, Chinnambedu Nainarappan ^a  

^a Foundation for Innovative New Diagnostics ^*  (India)

^b WORLD HEALTH ORGANIZATION   (Switzerland)

^c FOUNDATION FOR INNOVATIVE NEW DIAGNOSTICS   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

RIFAMPICIN; TUBERCULOSTATIC AGENT;

ADOLESCENT; ALGORITHM; ARTICLE; CHILD; DIAGNOSTIC TEST; DRUG RESISTANT TUBERCULOSIS; FEMALE; HEALTH CARE FACILITY; HUMAN; HUMAN TISSUE; INDIA; INFANT; LUNG TUBERCULOSIS; MAJOR CLINICAL STUDY; MALE; PREDICTIVE VALUE; PROSPECTIVE STUDY; PUBLIC HEALTH; SPUTUM SMEAR; XPERT MTB RIF TEST; ANTIBIOTIC RESISTANCE; CROSS-SECTIONAL STUDY; DRUG EFFECTS; GENETICS; MICROBIOLOGY; MOLECULAR DIAGNOSIS; MYCOBACTERIUM TUBERCULOSIS; NEWBORN; PRESCHOOL CHILD; SPUTUM; STANDARDS; TOTAL QUALITY MANAGEMENT; TUBERCULOSIS, PULMONARY;

ADOLESCENT; ANTIBIOTICS, ANTITUBERCULAR; CHILD; CHILD, PRESCHOOL; CROSS-SECTIONAL STUDIES; DRUG RESISTANCE, BACTERIAL; HUMANS; INFANT; INFANT, NEWBORN; MOLECULAR DIAGNOSTIC TECHNIQUES; MYCOBACTERIUM TUBERCULOSIS; QUALITY IMPROVEMENT; RIFAMPIN; SPUTUM; TUBERCULOSIS, PULMONARY;

EID: 84928994611     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0105346     Document Type: Article

References (28)

1. Newton S, Brent A, Anderson S (2008) Paediatric tuberculosis. Lancet Infectious Disease: Volume 8, Issue 8, Pages 457-524 (August 2008) Available: http://www.sciencedirect.com/science/article/pii/S1473309908701828. Accessed: 2014 Apr 1.
2. Kabra S, Lodha R, Seth V (2004) Some current concepts on childhood tuberculosis. Indian J Med Res. 120, 387-397PMID: 15520488, Available: http://www.ncbi.nlm.nih.gov/pubmed/15520488. Accessed: 2014 Apr 1.
3. Centre for Disease Control (2014) TB in Children (Global Perspective): 1-4. Available: http://www.cdc.gov/tb/topic/populations/TBinChildren/global.htm. Accessed: 2014 Apr 1.
4. Jain S, Ordonez A, Kinikar A, Gupte N, Thakar M, et al. (2013) Pediatric tuberculosis in young children in India: a prospective study. Biomed Res Int. 2013: 783698. doi: 10.1155/2013/783698, Available: http://www.pubmedcentral.nih. gov/articlerender.fcgiartid=3872373&tool=pmcentrez&rendertype=abstract.
5. Revised National Tuberculosis Control Program (2013) TB India 2013, RNTCP Annual Status Report Available: http://www.tbcindia.nic.in/pdfs/ tb%20india%202013.pdf.
6. Marais B, Hesseling A, Gie R, Schaaf H, Beyers N (2006) The burden of childhood tuberculosis and the accuracy of community-based surveillance data. International Journal of Tuberculosis and Lung Disease 10: 259-263PMID: 16562704, Available: http://www.ncbi.nlm.nih.gov/pubmed/16562704.
7. Kumar A, Gupta D, Nagaraja S, Singh V, Prasad J (2014) Updated National Guidelines for Pediatric Tuberculosis in India, 2012. Indian Pediatr 50: 301-306. Available: http://www.indianpediatrics.net/mar2013/mar-301-306.htm.
8. Avalos G (2012) Classic and New Diagnostic Approaches to Childhood Tuberculosis. Journal of Tropical Medicine Volume 2012 (2012), Article ID 818219, 12 pages. Doi:10.1155/2012/818219, Available: http://dx.doi.org/10.1155/ 2012/818219.
9. Swaminathan S, Rekha B (2010) Pediatric tuberculosis: global overview and challenges. Clin Infect Dis 50 Suppl 3: S184-94. doi: 10.1086/651490, Available: http://www.ncbi.nlm.nih.gov/pubmed/20397947. Accessed: 2014 March 24.
10. Nicol M, Zar H (2011) New Specimens and laboratory diagnostics for childhood pulmonary TB: progress and prospects. 2011 March; 12(1): 16-21. doi:10.1016/j.prrv.2010.09.008 Available: http://www.ncbi.nlm.nih.gov/pmc/ articles/PMC3052970/pdf/nihms-238505.pdf.
11. Acosta CD, Rusovich V, Harries AD, Ahmedov S, van den Boom M, et al. (2014) A new roadmap for childhood tuberculosis. Lancet Glob Heal 2: e15-e17. doi:10.1016/S2214-109X(13)70153-0, Available: http://linkinghub.elsevier.com/ retrieve/pii/S2214109X13701530.
12. Central TB Division Ministry of Health and Family Welfare, Managing the RNTCP in your area - A training course (Module 1-4). Available: http://tbcindia.nic.in/pdfs/Module%201%20to%204.zip.
13. Amdekar Y (2010) Consensus statement on childhood tuberculosis Indian Pediatrics, vol. 47, no. 1, pp. 41-55, 2010. Available: http://www.ncbi.nlm.nih. gov/pubmed/20139477
14. Central TB Division Ministry of Health and Family Welfare,New Delhi, India, Revised National TB Control Programme (2012) Guidelines on Programmatic Management of Drug Resitant TB (PMDT) in India. Available: http://tbcindia.nic. in/pdfs/Guidelines%20for%20PMDT%20in%20India%20-%20May%202012.pdf
15. World Health Organization. Geneva (2013) Definitions and reporting framework for tuberculosis -2013 revision. S.n.p.3. Available: http://apps.who.int/iris/bitstream/10665/79199/1/9789241505345-eng.pdf.
16. Central TB Division Ministry of Health and Family Welfare, National guidelines on diagnosis and treatment of Pediatric Tuberculosis (2012), Available: http://tbcindia.nic.in/Paediatric%20guidelines-New.pdf.
17. Nicol MP, Workman L, Isaacs W, Munro J, Black F, et al. (2011) Accuracy of the Xpert MTB/RIF test for the diagnosis of pulmonary tuberculosis in children admitted to hospital in Cape Town, South Africa: a descriptive study. 3099: 1-6. doi:10.1016/S1473-3099(11)70167-0. Available: http://www.ncbi.nlm. nih.gov/pubmed/21764384.
18. Sekadde M, Wobudeya E, Joloba M L, Sengooba W, Harriet K, at el (2013) Evaluation of the Xpert MTB/RIF Test for the Diagnosis of Childhood Pulmonary Tuberculosis in Uganda: a cross sectional diagnostic study, BMC Infectious Diseases 2013, 13:133. Available: http://www.biomedcentral.com/content/pdf/1471- 2334-13-133.pdf.
19. Rachow A, Clowes P, Saathoff E, Mtafya B, Michael E, et al. (2012) Increased and expedited case detection by Xpert MTB/RIF assay in childhood tuberculosis: a prospective cohort study. Clin Infect Dis 54: 1388-1396. doi: 10.1093/cid/cis190. Epub 2012 Apr 3. Available: http://www.ncbi.nlm.nih.gov/ pubmed/22474220. Accessed: 2014 Apr 1.
20. Nhu NT, Ha DT, Anh ND, Thu do DA, Duong TN, et al. (2011) Evaluation of Xpert MTB/RIF and MODS assay for the diagnosis of pediatric tuberculosis. Lancet Infect Dis 2011 Nov; 11(11):819-24. doi: 10.1016/S1473-3099(11)70167-0. Epub 2011 Jul 19. Available: http://www.pubmedcentral.nih.gov/articlerender. fcgiartid=3562258&tool=pmcentrez&rendertype=abstract. Accessed 1 April 2014. Accessed: 2014 Apr 1.
21. Shah I, Chilkar S (2012) Clinical profile of drug resistant tuberculosis in children. Indian Pediatric 2012 Sep; 49(9):741-4. Epub 2012 Jun 10, Available: http://www.ncbi.nlm.nih.gov/pubmed/22728624.
22. Shah I (2012) DRUG RESISTANT TUBERCULOSIS IN CHILDREN IN INDIA. Pediatric Oncall [serial online] 2012[cited 2012 January 1]; 9. Art #27, DOI: 10.7199/ped.oncall.2012.27, Available: http://www.pediatriconcall.com/Journal/ Article/FullText.aspxartid=490amp;type=J&tid=&imgid=&reportid= 365&tbltype=
23. World Health Organisation-Policy statement (2011) Automated Real-time Nucleic Acid Amplification Technology for Rapid and Simultaneous Detection of Tuberculosis and Rifampicin Resistance: Xpert MTB/RIF System Available: http://whqlibdoc.who.int/publications/2011/9789241501545-eng.pdf.
24. Central TB Division Ministry of Health and Family Welfare-Revised National Tuberculosis program (2012) National Strategic Plan for Tuberculosis Control 2012-2017. pp. 100-105,
25. Satyanarayana S, Shivashankar R, Vashist R, Chauhan L, Chadha S, et al. (2010) Characteristics and programme-defined treatment outcomes among childhood tuberculosis (TB) patients under the national TB programme in Delhi. PLoS One 5: e13338. doi: 10.1371/journal.pone.0013338, Available: http://www.pubmedcentral. nih.gov/articlerender.fcgiartid=2953513&tool=pmcentrez&rendertype= abstract. Accessed: 2014 Apr 1.
26. Thakur R (2014) Characteristics of childhood tuberculosis patients registered under RNTCP in Varanasi, Uttar Pradesh- Indian J Public Health: 2-5; 57:36-9, DOI: 10.4103/0019-557X.111367, Available: http://www.ijph.in/article. aspissn=0019557X;year=2013;volume=57;issue=1;spage=36;epage=39;aulast=Ruchi, Accessed: 2014 Jan 22.
27. Arora V, Agarwal S (2005) Chapter 12-Paediatric Tuberculosis: An Experience from LRS Institute of Tuberculosis and Respiratory Diseases. Tuberculosis Control In India. Vol. 330. pp. 115-118. Available: http://tbcindia.nic.in/pdfs/Tuberculosis%20Control%20in%20India12.pdf.
28. Nelliyanil M, Sharada MP, Joseph N, Basagoudar SS, Jayaram S, et al. (2014) A study of the socio-demographic profile and treatment outcome of paediatric tuberculosis patients in Bangalore Mahanagar Palike area. Indian J Tuberc 2012 Oct; 59(4):207-13. Available: http://www.ncbi.nlm.nih.gov/pubmed/ 23342540 29. http://www.finddiagnostics.org/media/press/140430.html, Accessed: 2014 May 3.