Evaluation of the Xpert MTB/RIF test for the diagnosis of childhood pulmonary tuberculosis in Uganda: A cross-sectional diagnostic study

BMC Infectious Diseases

Volumn 13, Issue 1, 2013, Pages

  Sekadde, Moorine Penninah ^a   Wobudeya, Eric ^a,b   Joloba, Moses L ^a   Ssengooba, Willy ^a   Kisembo, Harriet ^b   Bakeera Kitaka, Sabrina ^a   Musoke, Philippa ^a  

^a MAKERERE UNIVERSITY   (Uganda)

^b MULAGO NATIONAL REFERRAL HOSPITAL   (Uganda)

Author keywords

Children; Pulmonary tuberculosis; Sensitivity; Specificity; Xpert MTB RIF

Indexed keywords

ARTICLE; CHILD; CLINICAL FEATURE; CROSS-SECTIONAL STUDY; DIAGNOSTIC KIT; DIAGNOSTIC PROCEDURE; DIAGNOSTIC TEST; DIAGNOSTIC TEST ACCURACY STUDY; FEMALE; HEALTH CARE FACILITY; HUMAN; INFANT; INTERMETHOD COMPARISON; LUNG TUBERCULOSIS; MAJOR CLINICAL STUDY; MALE; MEDICAL HISTORY; MICROSCOPY; MYCOBACTERIUM TUBERCULOSIS; PRESCHOOL CHILD; SCHOOL CHILD; SENSITIVITY AND SPECIFICITY; SMEAR; SPUTUM ANALYSIS; TERTIARY HEALTH CARE; TUBERCULIN TEST; UGANDA; MICROBIOLOGICAL EXAMINATION; MICROBIOLOGY; PROCEDURES; SPUTUM; THORAX RADIOGRAPHY; TUBERCULOSIS, PULMONARY;

DIAGNOSTIC KIT;

BACTERIOLOGICAL TECHNIQUES; CHILD; CHILD, PRESCHOOL; CROSS-SECTIONAL STUDIES; FEMALE; HUMANS; INFANT; MALE; RADIOGRAPHY, THORACIC; REAGENT KITS, DIAGNOSTIC; SENSITIVITY AND SPECIFICITY; SPUTUM; TUBERCULIN TEST; TUBERCULOSIS, PULMONARY; UGANDA;

EID: 84874766224     PISSN: None     EISSN: 14712334     Source Type: Journal    
DOI: 10.1186/1471-2334-13-133     Document Type: Article

References (21)

1. Eamranond P, Jaramillo E. Tuberculosis in children: reassessing the need for improved diagnosis in global control strategies. Int J Tuberc Lung Dis 2001, 5(7):594-603.
2. Newton SM, Brent AJ, Anderson S, Whittaker E, Kampmann B. Paediatric tuberculosis. Lancet Infect Dis 2008, 8:498-510. 10.1016/S1473-3099(08)70182-8, 2804291, 18652996.
3. Shingadia D, Novelli V. Diagnosis and treatment of tuberculosis in children. Lancet Infect Dis 2003, 3:624-632. 10.1016/S1473-3099(03)00771-0, 14522261.
4. Lighter J, Riguaud M. Diagnosing childhood tuberculosis: traditional and innovative modalities. Curr Probl Pediatr Adolesc Health Care 2009, 39:61-88. 10.1016/j.cppeds.2008.12.003, 19215860.
5. Iriso R, Mudido PM, Karamagi C, Whalen C. The diagnosis of childhood tuberculosis in an HIV-endemic setting and the use of induced sputum. Int J Tuberc Lung Dis 2005, 9(7):716-726.
6. Oberhelman RA, Soto-Castellares G, Gilman RH, Caviedes L, Castillo ME, Kolevic L. Diagnostic approaches for paediatric tuberculosis by use of diff erent specimen types, culture methods, and PCR: a prospective case-control study. Lancet Infect Dis 2010, 10:612-620. 10.1016/S1473-3099(10)70141-9, 2975578, 20656559.
7. Cepheid GeneXpert System [cited 2012 October 1st]; Available from: http://www.cepheid.com/systems-and-software/genexpert-system, Cepheid.
8. World Health Organization Automated Real-time Nucleic Acid Amplification Technology for Rapid and Simultaneous Detection of Tuberculosis and Rifampicin Resistance: Xpert MTB/RIF System2011 2011, Contract No.: WHO/HTM/TB/2011.4. http://whqlibdoc.who.int/publications/2011/9789241501545_eng.pdf, World Health Organization.
9. Boehme CC, Nabeta P, Hillemann D, Nicol MP, Shenai S, Krapp F. Rapid molecular detection of tuberculosis and rifampin resistance. N Engl J Med 2010, 363(11):1005-1015. 10.1056/NEJMoa0907847, 2947799, 20825313.
10. Helb D, Jones M, Story E, Boehme C, Wallace E, Ho K. Rapid detection of Mycobacterium tuberculosis and rifampin-resistance 1 using on-demand, near patient technology. Clin Microbiol 2010, 48(1):229-237.
11. Nicol MP, Workman L, Isaacs W, Munro J, Black F, Eley B. Accuracy of the Xpert MTB/RIF test for the diagnosis of pulmonary tuberculosis in children admitted to hospital in Cape Town, South Africa: a descriptive study. Lancet 2011, 11:70167.
12. Rachow APC, Saathoff E, Mtafya B, Michael E, Ntinginya EN. Increased and expedited case detection by xpert MTB/RIF assay in childhood tuberculosis:a prospective cohort study. Clin Infect Dis 2012, 54(10):1388-1396. 10.1093/cid/cis190, 22474220.
13. World Health Organization Guidance for national tuberculosis programmes on the management of tuberculosis in children 2006, Contract No.: WHO/HTM/TB/2006.371. http://whqlibdoc.who.int/hq/2006/WHO_HTM_TB_2006.371_eng.pdf, World Health Organization.
14. World Health Organization Treatment of Tuberculosis Guidelines 2009, Contract No.: WHO/HTM/TB/2009.420. http://whqlibdoc.who.int/publications/2010/9789241547833_eng.pdf, World Health Organization.
15. World Health Organization The WHO Child Growth Standards 2013, http://www.who.int/childgrowth/en/index.html, World Health Organization.
16. Marais BJ, Gie RP, Schaaf HS, Starke JR, Hesseling AC, Donald PR. A proposed radiological classification of childhood intra-thoracic tuberculosis. Pediatr Radiol 2004, 34(11):886-894. 10.1007/s00247-004-1238-0, 15300340.
17. Carley S, Dosman S, Jones SR, Harrison M. Simple nomograms to calculate sample size in diagnostic studies. Emerg Med J 2005, 22:180-181. 10.1136/emj.2003.011148, 1726700, 15735264.
18. Fagan TJ. Normogram for Bayes's theorem. N Engl J Med 1975, 293(5):257.
19. Boehme CC, Nicol MP, Nabeta P, Michael JS, Gotuzzo E, Tahirli R. Feasibility, diagnostic accuracy, and effectiveness of decentralised use of the Xpert MTB/RIF test for diagnosis of tuberculosis and multidrug resistance: a multicentre implementation study. Lancet Infect Dis 2011, 377(9776):1495-1505.
20. Marais BJ, Gie RP, Schaaf HS, Hesseling AC, Obihara CC, Starke JJ. The natural history of childhood inta-thoracic tuberculosis:a critical review of literature from the pre-chemotherapy era. Int J Tuberc Lung Dis 2004, 8(4):392-402.
21. Theron G, Peter J, van Zyl-Smit R, Mishra H, Streicher E, Murray S. Evaluation of the Xpert MTB/RIF assay for the diagnosis of pulmonary tuberculosis in a high HIV prevalence setting. Am J Respir Crit Care Med 2011, 184(1):132-140. 10.1164/rccm.201101-0056OC, 21493734.