Two-sided block of a dual-topology F- channel

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 18, 2015, Pages 5697-5701

  Turman, Daniel L ^a   Nathanson, Jacob T ^a   Stockbridge, Randy B ^a   Street, Timothy O ^a   Miller, Christopher ^a  

^a BRANDEIS UNIVERSITY   (United States)

Author keywords

Block; Cooperativity; Ion channel; Monobody

Indexed keywords

F CHANNEL; ION CHANNEL; UNCLASSIFIED DRUG; 5-((2-AMINOETHYL)AMINO)NAPHTHALENE-1-SULFONIC ACID; BACTERIAL PROTEIN; CYSTEINE; EPITOPE; FLUORINE; LIPID BILAYER; MONOCLONAL ANTIBODY; NAPHTHALENESULFONIC ACID DERIVATIVE; PROTEIN BINDING;

ANISOTROPY; ARTICLE; BINDING ASSAY; CONDUCTANCE; CONTROLLED STUDY; DISSOCIATION CONSTANT; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; STATIC ELECTRICITY; BINDING SITE; CHEMISTRY; DOSE RESPONSE; FLUORESCENCE MICROSCOPY; FLUORESCENCE POLARIZATION; KINETICS; LIPID BILAYER; METABOLISM; MUTATION; THEORETICAL MODEL;

ANISOTROPY; ANTIBODIES, MONOCLONAL; BACTERIAL PROTEINS; BINDING SITES; CYSTEINE; DOSE-RESPONSE RELATIONSHIP, DRUG; EPITOPES; FLUORESCENCE POLARIZATION; FLUORINE; ION CHANNELS; KINETICS; LIPID BILAYERS; MICROSCOPY, FLUORESCENCE; MODELS, THEORETICAL; MUTATION; NAPHTHALENESULFONATES; PROTEIN BINDING; STATIC ELECTRICITY;

EID: 84928978581     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1505301112     Document Type: Article

References (6)

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2. Stockbridge RB, Koide A, Miller C, Koide S (2014) Proof of dual-topology architecture of Fluc F- channels with monobody blockers. Nat Commun 5:5120.
3. Stockbridge RB, Robertson JL, Kolmakova-Partensky L, Miller C (2013) A family of fluoride-specific ion channels with dual-topology architecture. eLife 2:e01084.
4. 10Fn3). Methods Enzymol 503:135-156.
5. Anderson CS, MacKinnon R, Smith C, Miller C (1988) Charybdotoxin block of single Ca2+-activated K+ channels. Effects of channel gating, voltage, and ionic strength. J Gen Physiol 91(3):317-333.
6. Piasta KN, Theobald DL, Miller C (2011) Potassium-selective block of barium permeation through single KcsA channels. J Gen Physiol 138(4):421-436.