Neuropsychiatric symptoms as predictors of progression to severe Alzheimer's dementia and death: The cache county dementia progression study

American Journal of Psychiatry

Volumn 172, Issue 5, 2015, Pages 460-465

  Peters, Matthew E ^a   Schwartz, Sarah ^a   Han, Dingfen ^a   Rabins, Peter V ^a   Steinberg, Martin ^a   Tschanz, Joann T ^a   Lyketsos, Constantine G ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN E4;

AGED; AGGRESSION; AGITATION; ALZHEIMER DISEASE; ARTICLE; CONTROLLED STUDY; DEMENTIA; DISEASE COURSE; DISEASE DURATION; DISEASE SEVERITY; GENOTYPE; HUMAN; INCIDENCE; KAPLAN MEIER METHOD; LONGITUDINAL STUDY; MAJOR CLINICAL STUDY; NEUROPSYCHIATRY; PATIENT EDUCATION; PREDICTION; PRIORITY JOURNAL; PSYCHOSIS; SURVIVAL; SURVIVAL TIME; VERY ELDERLY; FEMALE; MALE; MORTALITY; NEUROPSYCHOLOGICAL TEST; PREVALENCE; PROPORTIONAL HAZARDS MODEL; PSYCHOLOGY; SEVERITY OF ILLNESS INDEX; UNITED STATES;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; DEMENTIA; DISEASE PROGRESSION; FEMALE; HUMANS; KAPLAN-MEIER ESTIMATE; LONGITUDINAL STUDIES; MALE; NEUROPSYCHOLOGICAL TESTS; PREVALENCE; PROPORTIONAL HAZARDS MODELS; SEVERITY OF ILLNESS INDEX; UTAH;

EID: 84928957026     PISSN: 0002953X     EISSN: 15357228     Source Type: Journal    
DOI: 10.1176/appi.ajp.2014.14040480     Document Type: Article

References (20)

1. nd ed. New York, Oxford University Press, 2006
2. Alzheimer's Association: 2012 Alzheimer's Disease Facts and Figures. Chicago, Alzheimer's Association, 2012
3. Lopez OL, Schwam E, Cummings J, et al: Predicting cognitive decline in Alzheimer' s disease: an integrated analysis. Alzheimers Dement 2010; 6:431-439
4. Stern Y, Tang MX, Albert MS, et al: Predicting time to nursing home care and death in individuals with Alzheimer disease. JAMA 1997; 277:806-812
5. Rabins PV, Schwartz S, Black BS, et al: Predictors of progression to severe Alzheimer's disease in an incidence sample. Alzheimers Dement 2013; 9:204-207
6. Storandt M, Grant EA, Miller JP, et al: Rates of progression in mild cognitive impairment and early Alzheimer's disease. Neurology 2002; 59:1034-1041
7. Breitner JC, Wyse BW, Anthony JC, et al: APOE-epsilon4 count predicts age when prevalence of AD increases, then declines: the Cache County Study. Neurology 1999; 53:321-331
8. Lyketsos CG, Steinberg M, Tschanz JT, et al: Mental and behavioral disturbances in dementia: findings from the Cache County Study on Memory in Aging. Am J Psychiatry 2000; 157:708-714
9. Lyketsos CG, Colenda CC, Beck C, et al: Position statement of the American Association for Geriatric Psychiatry regarding principles of care for patients with dementia resulting from Alzheimer disease. Am J Geriatr Psychiatry 2006; 14:561-572
10. McKhann G, Drachman D, Folstein M, et al: Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer 's Disease. Neurology 1984; 34:939-944
11. Tschanz JT, Corcoran CD, Schwartz S, et al: Progression of cognitive, functional, and neuropsychiatric symptom domains in a population cohort with Alzheimer dementia: the Cache County Dementia Progression Study. Am J Geriatr Psychiatry 2011; 19:532-542
12. Folstein MF, Folstein SE, McHugh PR: "Mini-mental state": a practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 1975; 12:189-198
13. Hughes CP, Berg L, Danziger WL, et al: A new clinical scale for the staging of dementia. Br J Psychiatry 1982; 140:566-572
14. Cummings JL: The Neuropsychiatric Inventory: assessing psychopathology in dementia patients. Neurology 1997; 48(suppl 6):S10-S16
15. Lyketsos CG, Galik E, Steele C, et al: The General Medical Health Rating: a bedside global rating of medical comorbidity in patients with dementia. J Am Geriatr Soc 1999; 47:487-491
16. Peters ME, Rosenberg PB, Steinberg M, et al: Neuropsychiatric symptoms as risk factors for progression from CIND to dementia: the Cache County Study. Am J Geriatr Psychiatry 2013; 21:1116-1124
17. Vilalta-Franch J, Calvó-Perxas L, Garre-Olmo J, et al: Apathy syndrome in Alzheimer 's disease epidemiology: prevalence, incidence, persistence, and risk and mortality factors. J Alzheimers Dis 2013; 33:535-543
18. Steinberg M, Lyketsos CG: Atypical antipsychotic use in patients with dementia: managing safety concerns. Am J Psychiatry 2012; 169:900-906
19. Witlox J, Eurelings LS, de Jonghe JF, et al: Delirium in elderly patients and the risk of postdischarge mortality, institutionalization, and dementia: a meta-analysis. JAMA 2010; 304:443-451
20. Inouye SK, van Dyck CH, Alessi CA, et al: Clarifying confusion: the confusion assessment method: a new method for detection of delirium. Ann Intern Med 1990; 113:941-948