Porous gelatin/tricalcium phosphate/genipin composites containing lumbrokinase for bone repair

Bone

Volumn 78, Issue , 2015, Pages 15-22

  Fu, Yuan Tsung ^a,b   Sheu, Shi Yuan ^a,c,d   Chen, Yueh Sheng ^a   Chen, Kuo Yu ^e   Yao, Chun Hsu ^a,f  

^a CHINA MEDICAL UNIVERSITY   (Taiwan)

^b Taichung Tzu Chi Hospital   (Taiwan)

^c CHUNG SHAN MEDICAL UNIVERSITY   (Taiwan)

^d CHUNG SHAN MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^e NATIONAL YUNLIN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Taiwan)

^f ASIA UNIVERSITY   (Taiwan)

Author keywords

Bone tissue regeneration; Gelatin; Genipin; Lumbrokinase; Tricalcium phosphate

Indexed keywords

ACID PHOSPHATASE TARTRATE RESISTANT ISOENZYME; ALKALINE PHOSPHATASE; BONE DENSITY CONSERVATION AGENT; CALCIUM PHOSPHATE; GELATIN; GENIPIN; LUMBROKINASE; OSTEOCALCIN; OSTEOPONTIN; UNCLASSIFIED DRUG; BETA-TRICALCIUM PHOSPHATE; BIOMATERIAL; BONE PROSTHESIS; DRUG CARRIER; IRIDOID; PROTEINASE;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE REMODELING; CELL ACTIVITY; CELL DIFFERENTIATION; CELL MIGRATION; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DRUG MECHANISM; DRUG RELEASE; ENZYME ACTIVITY; EXCIPIENT COMPATIBILITY; FRACTURE HEALING; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; OSSIFICATION; OSTEOBLAST; OSTEOCLAST; PROTEIN EXPRESSION; RAT; SKULL DEFECT; ADMINISTRATION AND DOSAGE; ANIMAL; BONE PROSTHESIS; BONE REGENERATION; CELL LINE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; HUMAN; METABOLISM; MICRO-COMPUTED TOMOGRAPHY; MOUSE; POROSITY; RAW 264.7 CELL LINE; SKULL; SPRAGUE DAWLEY RAT; WOUND HEALING;

ANIMALS; BIOCOMPATIBLE MATERIALS; BONE REGENERATION; BONE SUBSTITUTES; CALCIUM PHOSPHATES; CELL LINE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG CARRIERS; ENDOPEPTIDASES; GELATIN; HUMANS; IRIDOIDS; MICE; OSTEOBLASTS; OSTEOCLASTS; POROSITY; RATS; RATS, SPRAGUE-DAWLEY; RAW 264.7 CELLS; SKULL; WOUND HEALING; X-RAY MICROTOMOGRAPHY;

EID: 84928953890     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bone.2015.04.034     Document Type: Article

References (22)

1. Carano R.A.D., Filvaroff E.H. Angiogenesis and bone repair. Drug Discov Today 2003, 8:980-989.
2. Wong R.W.K., Rabie A.B.M. Traditional Chinese medicines and bone formation-a review. J Oral Maxillofac Surg 2006, 64:828-837.
3. Peng L.H., Ko C.H., Siu S.W., Koon C.M., Yue G.L., Cheng W.H., et al. In vitro & in vivo assessment of a herbal formula used topically for bone fracture treatment. J Ethnopharmacol 2010, 131:282-289.
4. Liu C.H., Lin Y.W., Tang N.Y., Liu H.J., Huang C.Y., Hsieh C.L. Effect of oral administration of Pheretima aspergillum (earthworm) in rats with cerebral infarction induced by middle-cerebral artery occlusion. Afr J Tradit Complement Altern Med 2013, 10:66-82.
5. Hrženjak T., Popović M., Božić T., Grdiša M., Kobrehel D., Tiška-Rudman L. Fibrinolytic and anticoagulative activities from the earthworm Eisenia foetida. Comp Biochem Physiol B 1998, 119:825-832.
6. Cooper E.L., Hrzenjak T.M., Grdiša M. Alternative sources of fibrinolytic, anticoagulative, antimicrobial and anticancer molecules. Int J Immunopathol Pharmacol 2004, 17:237-244.
7. Chen H., Takahashi S., Imamura M., Okutani E., Zhang Z.G., Kazuaki C., et al. Earthworm fibrinolytic enzyme: anti-tumor activity on human hepatoma cells in vitro and in vivo. Chin Med J 2007, 120:898-904.
8. Jin L., Jin H., Zhang G., Xu G. Changes in coagulation and tissue plasminogen activator after the treatment of cerebral infarction with lumbrokinase. Clin Hemorheol Microcirc 2000, 23:213-218.
9. Li W., Wang C., Sun Z. Vermipharmaceuticals and active proteins isolated from earthworms. Pedobiologia 2011, 54S:S49-S56.
10. Cho I.H., Choi E.S., Lim H.G., Lee H.H. Purification and characterization of six fibrinolytic serine-proteases from earthworm Lumbricus rubellus. J Biochem Mol Biol 2004, 37:199-205.
11. Huang C.Y., Kuo W.W., Liao H.E., Lin Y.M., Kuo C.H., Tsai F.J., et al. Lumbrokinase attenuates side-stream-smoke-induced apoptosis and autophagy in young hamster hippocampus: correlated with eNOS induction and NFκB/iNOS/COX-2 signaling suppression. Chem Res Toxicol 2013, 26:654-661.
12. Sun H., Ge N., Shao M., Cheng X., Li Y., Li S., et al. Lumbrokinase attenuates diabetic nephropathy through regulating extracellular matrix degradation in streptozotocin-induced diabetic rats. Diabetes Res Clin Pract 2013, 100:85-95.
13. Ji H., Wang L., Bi H., Sun L., Cai B., Wang Y., et al. Mechanisms of lumbrokinase in protection of cerebral ischemia. Eur J Pharmacol 2008, 590:281-289.
14. Lin C.Y., Sun J.S., Sheu S.Y., Lin F.H., Wang Y.J., Chen L.T. The effect of Chinese medicine on bone cell activities. Am J Chin Med 2002, 30:271-285.
15. Cheng C.P., Sheu M.J., Sytwu H.K., Chang D.M. Decoy receptor 3 suppresses RANKL-induced osteoclastogenesis via down-regulating NFATc1 and enhancing cell apoptosis. Rheumatol 2013, 52:609-622.
16. Yao C.H., Liu B.S., Hsu S.H., Chen Y.S., Tsai C.C. Biocompatibility and biodegradation of a bone composite containing tricalcium phosphate and genipin crosslinked gelatin. J Biomed Mater Res A 2004, 69:709-717.
17. Mihara H., Maruyama M., Sumi H. Novel thrombolytic therapy discovered from traditional oriental medicine using the earthworm. Southeast Asian J Trop Med Public Health 1992, 23:131-140.
18. Grdiša M., Popović M., Hrženjak T. Glycolipoprotein extract (G-90) from earthworm Eisenia foetida exerts some antioxidative activity. Comp Biochem Physiol 2001, 128A:821-825.
19. Chen C.T., Lin J.G., Lu T.W., Tsai F.J., Huang C.Y., Yao C.H., et al. Earthworm extracts facilitate PC12 cell differentiation and promote axonal sprouting in peripheral nerve injury. Am J Chin Med 2010, 38:547-560.
20. Chang Y.M., Shih Y.T., Chen Y.S., Liu C.L., Fang W.K., Tsai C.H., et al. Schwann cell migration induced by earthworm extract via activation of PAs and MMP2/9 mediated through ERK1/2 and p38 Evid Based Complement. Alter Med 2011, 2011:395458.
21. Liu B.S., Yao C.H., Chen Y.S., Hsu S.H. In vitro evaluation of degradation and cytotoxicity of a novel composite as a bone substitute. J Biomed Mater Res A 2003, 67:1163-1169.
22. Yao C.H., Liu B.S., Hsu S.H., Chen Y.S. Calvarial bone response to a tricalcium phosphate-genipin crosslinked gelatin composite. Biomaterials 2005, 26:3065-3074.