In vitro evaluation of degradation and cytotoxicity of a novel composite as a bone substitute

Journal of Biomedical Materials Research - Part A

Volumn 67, Issue 4, 2003, Pages 1163-1169

  Liu, Bai Shuan ^a,b   Yao, Chun Hsu ^a   Chen, Yueh Sheng ^c   Hsu, Shan Hui ^b  

^a CHUNGTAI INST HLTH SCI TECHNOL   (Taiwan)

^b NATIONAL CHUNG HSING UNIVERSITY   (Taiwan)

^c CHINA MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Bone substitute; Gelatin; Genipin; Osteoblast; Tricalcium phosphate

Indexed keywords

BIOCOMPATIBILITY; BIODEGRADATION; BONE; CELLS; CERAMIC MATERIALS; COMPOSITE MATERIALS; CROSSLINKING; ENZYMES; TOXICITY; ULTRAVIOLET SPECTROPHOTOMETERS;

GELATIN;

BIOMATERIALS;

ALKALINE PHOSPHATASE; CALCIUM PHOSPHATE; GELATIN; GENIPIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BIOCOMPATIBILITY; BIODEGRADATION; BONE CELL; BONE TISSUE; CALCIUM TRANSPORT; CELL DIFFERENTIATION; CELL GROWTH; CELL PROLIFERATION; CERAMICS; COMPOSITE MATERIAL; CONCENTRATION RESPONSE; CYTOTOXICITY; DEGRADATION; IN VITRO STUDY; NEWBORN; NONHUMAN; OSTEOBLAST; PARTICLE SIZE; RAT; REACTION ANALYSIS; ULTRAVIOLET SPECTROPHOTOMETRY;

EID: 0346123063     PISSN: 00219304     EISSN: None     Source Type: Journal    
DOI: 10.1002/jbm.a.20017     Document Type: Article

References (24)

1. Burwell RG. History of bone grafts and bone substitutes. In: Urist MR, O'Connor BT, Burwell RG, editors. Bone graft, derivatives and substitute. Cambridge, Great Britain: University Press; 1994. p 3-102.
2. Damien JC, Parson JR. Bone graft and bone graft substitutes: A review of current technology and applications. J Appl Biomater 1991;2:187-208.
3. Kocialkowski A, Wallace WA, Burwell RG. Collagraft combined with autogeneic bone marrow: Experimental and clinical results. In: Urist MR, O'Connor BT, Burwell RG, editors. Bone grafts, derivatives and substitutes. London: Butterworth-Heinemann Ltd.; 1994. p 271-290.
4. Grynpas MD, Pilliar RM, Kandel RA, Renlund R, Filiaggi M, Dumitriu M. Porous calcium polyphosphate scaffolds for bone substitute applications in vivo studies. Biomaterials 2002;23: 2063-2070.
5. Lee JY, Nam SH, Im SY, Park YJ, Lee YM, Seol YJ, Chung CP, Lee SJ. Enhanced bone formation by controlled growth factor delivery from chitosan-based biomaterials. J Controlled Release 2002;78:187-197.
6. Holmes R, Bucholz R, Mooney V. Porous hydroxyapatite as a bone-graft substitute in metaphyseal defects: A histometric study. J Bone Joint Surg 1986;68A:904-909.
7. 5 system. J Biomed Eng 1991;133:328-334.
8. Yao CH, Sun JS, Lin FH, Liao JR, Huang CW. Biological effects and cytotoxicity of tricalcium phosphate and formaldehyde crosslinked gelatin composite. Mater Chem Phys 1996;45:6-14.
9. Saito N, Takaoka T. New synthetic biodegradable polymers as BMP carriers for bone tissue engineering. Biomaterials 2003;24: 2287-2293.
10. Laurencin CT, Attawia MA, Lu LQ, Borden MD, Lu HH, Gorum WJ, Lieberman JR. Poly(lactide-co-glycolide)/hydroxyapatite delivery of BMP-2-producing cells: A regional gene therapy approach to bone regeneration. Biomaterials 2001;22: 1271-1277.
11. Nimni ME, Cheung D, Strates B, Kodama M, Sheikh K. Bioprosthesis derived from crosslinked and chemically modified collagenous tissues. In: Nimni ME, editor. Collagen, Vol. III. Boca Raton, Florida: CRC Press; 1988. p 1-38.
12. Lin FH, Yao CH, Sun JS, Liu HC, Huang CW. Biological effects and cytotoxicity of the composite composed by tricalcium phosphate and glutaraldehyde crosslinked gelatin. Biomaterials 1998;19:905-917.
13. Sung HW, Huang RN, Huang Lynn LH, Tsai CC. In vitro evaluation of cytotoxicity of a naturally occurring crosslinking reagent for biological tissue fixation. J Biomater Sci, Polym Edn 1999;10:63-78.
14. Huang LL, Sung HW, Tsai CC, Huang DM. Biocompatibility study of a biological tissue fixed with a naturally occurring crosslinking reagent. J Biomed Mater Res 1998;42:568-576.
15. Akao T, Kobashi K, Aburada M. Enzymatic studies on the animal and intestinal bacterial metabolism of geniposide. Biol Pharm Bull 1994;17:1573-1576.
16. Touyama R, Takeda Y, Inoue K, Kawamura I, Yatsuzuka M, Ikumoto T, Shingu T, Yokoi T, Inouye H. Studies on the blue pigments produced from genipin and methylamine. I. Structures of the brownish-red pigments, intermediates leading to the blue pigments. Chem Pharm Bull 1994;42:668-673.
17. Hollinger JO, Battistone GC. Biodegradable bone repair materials. Clin Orthop Rel Res 1986;207:290-305.
18. Tsai TR, Tseng TY, Chen CF, Tsai TH. Determination and identification of geniposide contained in Gardenia jasminoides, and in two preparations of mixed traditional Chinese medicines. J Chromatogr 2002;961:83-88.
19. Yao CH, Chang YL, Lin FH. Preparation and evaluation of β-TCP powder and cross-linked gelatin composite as bone substitute. Chinese J Biomed Eng 1994;14:47-51.
20. Koehlein HE, Lemperle G. Studies of gelatin-resorcin-formaldehyde glue. Surgery 1969;66:377-383.
21. Vrouwenvelder WCA, Groot GG, De Grook K. Behaviour of fetal rat osteoblasts cultured in vitro on bioactive glass and nonreactive glasses. Biomaterials 1992;13:382-392.
22. Zhang H, Ahmad M, Gronowicz G. Effect of transforming growth factor-beta 1 (TGF-β1) on in vitro mineralization of human osteoblasts on implant materials. Biomaterials 2003;24: 2013-2020.
23. Goldstein AS, Juarez TM, Helmke CD, Gustin MC, Mikos AG. Effect of convection on osteoblastic cell growth and function in biodegradable polymer foam scaffolds. Biomaterials 2001;22: 1279-1288.
24. Lin FH, Liu CC, Huang YY, Wang CY, Lu CM. Sintered porous DP-bioactive glass and hydroxyapatite as bone substitute. Biomaterials 1994;15:1087-1097.