Social rejection following neonatal inflammation is mediated by olfactory scent cues

Brain, Behavior, and Immunity

Volumn 49, Issue , 2015, Pages 43-48

  MacRae, M ^a   Kenkel, W M ^b   Kentner, A C ^a  

^a MASSACHUSETTS COLLEGE OF PHARMACY AND HEALTH SCIENCES   (United States)

^b NORTHEASTERN UNIVERSITY   (United States)

Author keywords

Anosmia; Anxiety; Inflammation; Olfaction; Social interaction; Ultrasonic vocalizations

Indexed keywords

DIAZEPAM; LIPOPOLYSACCHARIDE; ZINC SULFIDE; ANXIOLYTIC AGENT; ZINC SULFATE;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUDITORY THRESHOLD; CONTROLLED STUDY; FEMALE; JUVENILE ANIMAL; MALE; MOTOR CONTROL; NEWBORN; NONHUMAN; PRIORITY JOURNAL; RAT; SOCIAL BEHAVIOR; SOCIAL INTERACTION; SOCIAL REJECTION; SPRAGUE DAWLEY RAT; ULTRASONIC VOCALIZATION; VOCALIZATION; ANIMAL; ASSOCIATION; CHEMICALLY INDUCED; DRUG EFFECTS; INFLAMMATION; INTRANASAL DRUG ADMINISTRATION; ODOR; PATHOPHYSIOLOGY; PHYSIOLOGY; PSYCHOLOGY; SMELLING DISORDER; SOCIAL DISTANCE;

ADMINISTRATION, INTRANASAL; ANIMALS; ANIMALS, NEWBORN; ANTI-ANXIETY AGENTS; BEHAVIOR, ANIMAL; CUES; DIAZEPAM; FEMALE; INFLAMMATION; LIPOPOLYSACCHARIDES; MALE; OLFACTION DISORDERS; RATS; RATS, SPRAGUE-DAWLEY; SMELL; SOCIAL DISTANCE; VOCALIZATION, ANIMAL; ZINC SULFATE;

EID: 84928918109     PISSN: 08891591     EISSN: 10902139     Source Type: Journal    
DOI: 10.1016/j.bbi.2015.02.026     Document Type: Article

References (22)

1. Alberts J.R., Galef B.G. Acute anosmia in the rat: a behavioural test of a peripherally-induced olfactory deficit. Physiol. Behav. 1973, 6:619-621.
2. Arakawa H., Arakawa K., Deak T. Sickness-related odor communication signals as determinants of social behavior in rat: a role for inflammatory processes. Horm. Behav. 2010, 330-341.
3. Arakawa H., Cruz S., Deak T. From models to mechanisms: odorant communication as a key determinant of social behavior in rodents during illness-associated states. Neurosci. Biobehav. Rev. 2011, 35:1911-1928.
4. Boissé L., Mouihate A., Ellis S., Pittman Q.J. Long-term alterations in neuroimmune responses after neonatal exposure to lipopolysaccharide. J. Neurosci. 2004, 24:4928-4934.
5. Borrell J., Vela J.M., Arevalo-Martin A., Molina-Holgado M., Guaza C. Prenatal immune challenge disrupts sensorimotor gating in adult rats: implications for the etiopathogenesis of schizophrenia. Neuropsychopharmacology 2002, 26:204-215.
6. Christenson T., Wallen K., Brown B.A., Glickman S.E. Effects of castration, blindness and anosmia on social reactivity in the male Mongolian gerbil (Meriones unguiculatus). Physiol. Behav. 1973, 10:989-994.
7. Connors E.J., Shaik A.N., Migliore M.M., Kentner A.C. Environmental enrichment mitigates the sex-specific effects of gestational inflammation on social engagement and the hypothalamic pituitary adrenal axis-feedback system. Brain Behav. Immun. 2014, 42:178-190.
8. De Theije C.G.M., Koelink P.J., Korte-Bouws G.A.H., Lopes da Silva S., Korte S.M., Olivier B., et al. Intestinal inflammation in a murine model of autism spectrum disorders. Brain Behav. Immun. 2014, 37:240-247.
9. Dean M., Kasari C., Shih W., Frankel F., Whitney R., Landa R., et al. The peer relationships of girls with ASD at school: comparison to boys and girls with and without ASD. J. Child Psychol. Psychiatry 2014, 55:1218-1225.
10. Ducray A., Bondier J.R., Michel G., Bon K., Propper A., Kastner A. Recovery following peripheral destruction of olfactory neurons in young and adult mice. Eur. J. Neurosci. 2002, 15:1907-1917.
11. Hacquemand R., Jacquot L., Brand G. Comparative fear-related behaviors to predator odors (TMT and natural fox feces) before and after intranasal ZnSO(4) treatment in mice. Front. Behav. Neurosci. 2010, 4:188.
12. Kimball B.A., Opiekun M., Yamazaki K., Beauchamp G.K. Immunization alters body odor. Physiol. Behav. 2014, 128:80-85.
13. Lieblein-Boff J.C., McKim D.B., Shea D.T., Wei P., Deng Z., Sawicki C., et al. Neonatal E. coli infection causes neuro-behavioral deficits associated with hypomyelination and neuronal sequestration of iron. J. Neurosci. 2013, 33:16334-16345.
14. Masuda A., Narikiyo K., Someya N., Aou S. Multisensory interaction mediates the social transmission of avoidance in rats: dissociation from social transmission of fear. Behav. Brain Res. 2013, 252:334-338.
15. Mychasiuk R., Hehar H., Farran A., Esser M.J. Mean girls: sex differences in the effects of mild traumatic brain injury on the social dynamics of juvenile rat play behavior. Behav. Brain Res. 2014, 259:284-291.
16. Patterson P.H. Immune involvement in schizophrenia and autism: etiology, pathology and animal models. Behav. Brain Res. 2009, 204:313-321.
17. Sieck M.H., Baumbach H.D. Differential effects of peripheral and central anosmia producing techniques on spontaneous behavior patterns. Physiol. Behav. 1974, 13:407-425.
18. Sominsky L., Fuller E.A., Bondarenko E., Ong L.K., Averell L., Nalivaiko E., et al. Functional programming of the autonomic nervous system by early life immune exposure: implications for anxiety. PLoS One 2013, 8:e57700.
19. Taylor P.V., Veenema A.H., Paul M.J., Bredewold R., Isaacs S., de Vries G.J. Sexually dimorphic effects of a prenatal immune challenge on social play and vasopressin expression in juvenile rats. Biol. Sex Differ. 2012, 3:15.
20. Tenk C.M., Foley K.A., Kavaliers M., Ossenkopp K.-P. Neonatal treatment with lipopolysaccharide differentially affects adult anxiety responses in the light-dark test and taste neophobia test in male and female rats. Int. J. Dev. Neurosci. 2013, 31:171-180.
21. Walker M.C., Tong X., Brown S., Shorvon S.D., Patsalos P.N. Comparison of single- and repeated-dose pharmacokinetics of diazepam. Epilepsia 1998, 39:283-289.
22. Webber E.S., Harmon K.M., Beckwith T.J., Pena S., Burgdorf J., Panksepp J., Cromwell H.C. Selective breeding for 50kHz ultrasonic vocalization emission produces alternations in the ontogeny and regulation of rough-and-tumble play. Behav. Brain Res. 2012, 229:138-144.