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Volumn 33, Issue 6, 2015, Pages 2889-2898

MiR-128-3p suppresses hepatocellular carcinoma proliferation by regulating PIK3R1 and is correlated with the prognosis of HCC patients

Author keywords

HCC; MiR 128 3p; PIK3R1; Prognosis; Proliferation

Indexed keywords

MESSENGER RNA; MICRORNA; MICRORNA 128 3P; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN P85; PROTEIN P85ALPHA; UNCLASSIFIED DRUG; MIRN128 MICRORNA, HUMAN; ONCOPROTEIN; PIK3R1 PROTEIN, HUMAN; TUMOR MARKER;

EID: 84928905894     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.2015.3936     Document Type: Article
Times cited : (75)

References (44)
  • 2
    • 84859212951 scopus 로고    scopus 로고
    • Hepatocellular carcinoma
    • Forner A, Llovet JM and Bruix J: Hepatocellular carcinoma. Lancet 379: 1245-1255, 2012.
    • (2012) Lancet , vol.379 , pp. 1245-1255
    • Forner, A.1    Llovet, J.M.2    Bruix, J.3
  • 4
    • 84898767802 scopus 로고    scopus 로고
    • Hepatocellular carcinoma: Clinical frontiers and perspectives
    • Bruix J, Gores GJ and Mazzaferro V: Hepatocellular carcinoma: Clinical frontiers and perspectives. Gut 63: 844-855, 2014.
    • (2014) Gut , vol.63 , pp. 844-855
    • Bruix, J.1    Gores, G.J.2    Mazzaferro, V.3
  • 6
    • 84873726893 scopus 로고    scopus 로고
    • Cellular and molecular mechanisms of hepatocellular carcinoma: An update
    • Aravalli RN, Cressman EN and Steer CJ: Cellular and molecular mechanisms of hepatocellular carcinoma: An update. Arch Toxicol 87: 227-247, 2013.
    • (2013) Arch Toxicol , vol.87 , pp. 227-247
    • Aravalli, R.N.1    Cressman, E.N.2    Steer, C.J.3
  • 7
    • 84879579860 scopus 로고    scopus 로고
    • Emerging signaling pathways in hepatocellular carcinoma
    • Moeini A, Cornellà H and Villanueva A: Emerging signaling pathways in hepatocellular carcinoma. Liver Cancer 1: 83-93, 2012.
    • (2012) Liver Cancer , vol.1 , pp. 83-93
    • Moeini, A.1    Cornellà, H.2    Villanueva, A.3
  • 8
    • 58149376548 scopus 로고    scopus 로고
    • Molecular mechanisms of hepatocellular carcinoma
    • Aravalli RN, Steer CJ and Cressman EN: Molecular mechanisms of hepatocellular carcinoma. Hepatology 48: 2047-2063, 2008.
    • (2008) Hepatology , vol.48 , pp. 2047-2063
    • Aravalli, R.N.1    Steer, C.J.2    Cressman, E.N.3
  • 9
    • 4644309196 scopus 로고    scopus 로고
    • The functions of animal microRNAs
    • Ambros V: The functions of animal microRNAs. Nature 431: 350-355, 2004.
    • (2004) Nature , vol.431 , pp. 350-355
    • Ambros, V.1
  • 10
    • 60149084560 scopus 로고    scopus 로고
    • MicroRNAs and cancer: Short RNAs go a long way
    • Ventura A and Jacks T: MicroRNAs and cancer: Short RNAs go a long way. Cell 136: 586-591, 2009.
    • (2009) Cell , vol.136 , pp. 586-591
    • Ventura, A.1    Jacks, T.2
  • 12
    • 67651154718 scopus 로고    scopus 로고
    • MicroRNA-195 suppresses tumorigenicity and regulates G1/S transition of human hepatocellular carcinoma cells
    • Xu T, Zhu Y, Xiong Y, Ge YY, Yun JP and Zhuang SM: MicroRNA-195 suppresses tumorigenicity and regulates G1/S transition of human hepatocellular carcinoma cells. Hepatology 50: 113-121, 2009.
    • (2009) Hepatology , vol.50 , pp. 113-121
    • Xu, T.1    Zhu, Y.2    Xiong, Y.3    Ge, Y.Y.4    Yun, J.P.5    Zhuang, S.M.6
  • 13
    • 79751484450 scopus 로고    scopus 로고
    • Identification of miRNomes in human liver and hepatocellular carcinoma reveals miR-199a/b-3p as therapeutic target for hepatocellular carcinoma
    • Hou J, Lin L, Zhou W, Wang Z, Ding G, Dong Q, Qin L, Wu X, Zheng Y, Yang Y, et al: Identification of miRNomes in human liver and hepatocellular carcinoma reveals miR-199a/b-3p as therapeutic target for hepatocellular carcinoma. Cancer Cell 19: 232-243, 2011.
    • (2011) Cancer Cell , vol.19 , pp. 232-243
    • Hou, J.1    Lin, L.2    Zhou, W.3    Wang, Z.4    Ding, G.5    Dong, Q.6    Qin, L.7    Wu, X.8    Zheng, Y.9    Yang, Y.10
  • 14
    • 80054694898 scopus 로고    scopus 로고
    • MicroRNA-99a inhibits hepatocellular carcinoma growth and correlates with prognosis of patients with hepatocellular carcinoma
    • Li D, Liu X, Lin L, Hou J, Li N, Wang C, Wang P, Zhang Q, Zhang P, Zhou W, et al: MicroRNA-99a inhibits hepatocellular carcinoma growth and correlates with prognosis of patients with hepatocellular carcinoma. J Biol Chem 286: 36677-36685, 2011.
    • (2011) J Biol Chem , vol.286 , pp. 36677-36685
    • Li, D.1    Liu, X.2    Lin, L.3    Hou, J.4    Li, N.5    Wang, C.6    Wang, P.7    Zhang, Q.8    Zhang, P.9    Zhou, W.10
  • 15
    • 84895914554 scopus 로고    scopus 로고
    • miR-625 suppresses tumour migration and invasion by targeting IGF2BP1 in hepatocellular carcinoma
    • Zhou X, Zhang CZ, Lu SX, Chen GG, Li LZ, Liu LL, Yi C, Fu J, Hu W, Wen JM, et al: miR-625 suppresses tumour migration and invasion by targeting IGF2BP1 in hepatocellular carcinoma. Oncogene 34: 965-977, 2015.
    • (2015) Oncogene , vol.34 , pp. 965-977
    • Zhou, X.1    Zhang, C.Z.2    Lu, S.X.3    Chen, G.G.4    Li, L.Z.5    Liu, L.L.6    Yi, C.7    Fu, J.8    Hu, W.9    Wen, J.M.10
  • 16
    • 78751513089 scopus 로고    scopus 로고
    • PI-103 and sorafenib inhibit hepatocellular carcinoma cell proliferation by blocking Ras/Raf/MAPK and PI3K-AKT-mTOR pathways
    • Gedaly R, Angulo P, Hundley J, Daily MF, Chen C, Koch A and Evers BM: PI-103 and sorafenib inhibit hepatocellular carcinoma cell proliferation by blocking Ras/Raf/MAPK and PI3K-AKT-mTOR pathways. Anticancer Res 30: 4951-4958, 2010.
    • (2010) Anticancer Res , vol.30 , pp. 4951-4958
    • Gedaly, R.1    Angulo, P.2    Hundley, J.3    Daily, M.F.4    Chen, C.5    Koch, A.6    Evers, B.M.7
  • 18
    • 77956627711 scopus 로고    scopus 로고
    • The role of signaling pathways in the development and treatment of hepatocellular carcinoma
    • Whittaker S, Marais R and Zhu AX: The role of signaling pathways in the development and treatment of hepatocellular carcinoma. Oncogene 29: 4989-5005, 2010.
    • (2010) Oncogene , vol.29 , pp. 4989-5005
    • Whittaker, S.1    Marais, R.2    Zhu, A.X.3
  • 19
    • 51849128358 scopus 로고    scopus 로고
    • Class I PI3K in oncogenic cellular transformation
    • Zhao L and Vogt PK: Class I PI3K in oncogenic cellular transformation. Oncogene 27: 5486-5496, 2008.
    • (2008) Oncogene , vol.27 , pp. 5486-5496
    • Zhao, L.1    Vogt, P.K.2
  • 23
    • 81255138201 scopus 로고    scopus 로고
    • Reduced miR-128 in breast tumor-initiating cells induces chemotherapeutic resistance via Bmi-1 and ABCC5
    • Zhu Y, Yu F, Jiao Y, Feng J, Tang W, Yao H, Gong C, Chen J, Su F, Zhang Y, et al: Reduced miR-128 in breast tumor-initiating cells induces chemotherapeutic resistance via Bmi-1 and ABCC5. Clin Cancer Res 17: 7105-7115, 2011.
    • (2011) Clin Cancer Res , vol.17 , pp. 7105-7115
    • Zhu, Y.1    Yu, F.2    Jiao, Y.3    Feng, J.4    Tang, W.5    Yao, H.6    Gong, C.7    Chen, J.8    Su, F.9    Zhang, Y.10
  • 24
    • 84887139031 scopus 로고    scopus 로고
    • miR-128 and its target genes in tumorigenesis and metastasis
    • Li M, Fu W, Wo L, Shu X, Liu F and Li C: miR-128 and its target genes in tumorigenesis and metastasis. Exp Cell Res 319: 3059-3064, 2013.
    • (2013) Exp Cell Res , vol.319 , pp. 3059-3064
    • Li, M.1    Fu, W.2    Wo, L.3    Shu, X.4    Liu, F.5    Li, C.6
  • 25
    • 84925615729 scopus 로고    scopus 로고
    • Deregulation of miR-128 in ovarian cancer promotes cisplatin resistance
    • Li B, Chen H, Wu N, Zhang WJ and Shang LX: Deregulation of miR-128 in ovarian cancer promotes cisplatin resistance. Int J Gynecol Cancer 24: 1381-1388, 2014.
    • (2014) Int J Gynecol Cancer , vol.24 , pp. 1381-1388
    • Li, B.1    Chen, H.2    Wu, N.3    Zhang, W.J.4    Shang, L.X.5
  • 26
    • 84905559842 scopus 로고    scopus 로고
    • microRNA-128 plays a critical role in human non-small cell lung cancer tumourigenesis, angiogenesis and lymphangiogenesis by directly targeting vascular endothelial growth factor-C
    • Hu J, Cheng Y, Li Y, Jin Z, Pan Y, Liu G, Fu S, Zhang Y, Feng K and Feng Y: microRNA-128 plays a critical role in human non-small cell lung cancer tumourigenesis, angiogenesis and lymphangiogenesis by directly targeting vascular endothelial growth factor-C. Eur J Cancer 50: 2336-2350, 2014.
    • (2014) Eur J Cancer , vol.50 , pp. 2336-2350
    • Hu, J.1    Cheng, Y.2    Li, Y.3    Jin, Z.4    Pan, Y.5    Liu, G.6    Fu, S.7    Zhang, Y.8    Feng, K.9    Feng, Y.10
  • 32
    • 84872485839 scopus 로고    scopus 로고
    • Loss of heterozygosity and methylation of multiple tumor suppressor genes on chromosome 3 in hepatocellular carcinoma
    • Zhang X, Li HM, Liu Z, Zhou G, Zhang Q, Zhang T, Zhang J and Zhang C: Loss of heterozygosity and methylation of multiple tumor suppressor genes on chromosome 3 in hepatocellular carcinoma. J Gastroenterol 48: 132-143, 2013.
    • (2013) J Gastroenterol , vol.48 , pp. 132-143
    • Zhang, X.1    Li, H.M.2    Liu, Z.3    Zhou, G.4    Zhang, Q.5    Zhang, T.6    Zhang, J.7    Zhang, C.8
  • 33
    • 84895833353 scopus 로고    scopus 로고
    • Chromosome 3p loss of heterozygosity is associated with a unique metabolic network in clear cell renal carcinoma
    • Gatto F, Nookaew I and Nielsen J: Chromosome 3p loss of heterozygosity is associated with a unique metabolic network in clear cell renal carcinoma. Proc Natl Acad Sci USA 111: E866-E875, 2014.
    • (2014) Proc Natl Acad Sci USA , vol.111 , pp. E866-E875
    • Gatto, F.1    Nookaew, I.2    Nielsen, J.3
  • 34
    • 64249110057 scopus 로고    scopus 로고
    • Role of air pollution Particulate Matter (PM(2.5)) in the occurrence of loss of heterozygosity in multiple critical regions of 3p chromosome in human epithelial lung cells (L132)
    • Saint-Georges F, Garçon G, Escande F, Abbas I, Verdin A, Gosset P, Mulliez P and Shirali P: Role of air pollution Particulate Matter (PM(2.5)) in the occurrence of loss of heterozygosity in multiple critical regions of 3p chromosome in human epithelial lung cells (L132). Toxicol Lett 187: 172-179, 2009.
    • (2009) Toxicol Lett , vol.187 , pp. 172-179
    • Saint-Georges, F.1    Garçon, G.2    Escande, F.3    Abbas, I.4    Verdin, A.5    Gosset, P.6    Mulliez, P.7    Shirali, P.8
  • 35
    • 38049123402 scopus 로고    scopus 로고
    • MicroRNA expression signatures accurately discriminate acute lymphoblastic leukemia from acute myeloid leukemia
    • Mi S, Lu J, Sun M, Li Z, Zhang H, Neilly MB, Wang Y, Qian Z, Jin J, Zhang Y, et al: MicroRNA expression signatures accurately discriminate acute lymphoblastic leukemia from acute myeloid leukemia. Proc Natl Acad Sci USA 104: 19971-19976, 2007.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 19971-19976
    • Mi, S.1    Lu, J.2    Sun, M.3    Li, Z.4    Zhang, H.5    Neilly, M.B.6    Wang, Y.7    Qian, Z.8    Jin, J.9    Zhang, Y.10
  • 36
    • 84919871646 scopus 로고    scopus 로고
    • Loss of SNAIL inhibits cellular growth and metabolism through the miR-128-mediated RPS6KB1/HIF-1α/PKM2 signaling pathway in prostate cancer cells
    • Tao T, Li G, Dong Q, Liu D, Liu C, Han D, Huang Y, Chen S, Xu B and Chen M: Loss of SNAIL inhibits cellular growth and metabolism through the miR-128-mediated RPS6KB1/HIF-1α/PKM2 signaling pathway in prostate cancer cells. Tumour Biol 35: 8543-8550, 2014.
    • (2014) Tumour Biol , vol.35 , pp. 8543-8550
    • Tao, T.1    Li, G.2    Dong, Q.3    Liu, D.4    Liu, C.5    Han, D.6    Huang, Y.7    Chen, S.8    Xu, B.9    Chen, M.10
  • 37
    • 84875904750 scopus 로고    scopus 로고
    • miR-128 exerts pro-apoptotic effect in a p53 transcription-dependent and -independent manner via PUMA-Bak axis
    • Adlakha YK and Saini N: miR-128 exerts pro-apoptotic effect in a p53 transcription-dependent and -independent manner via PUMA-Bak axis. Cell Death Dis 4: e542, 2013.
    • (2013) Cell Death Dis , vol.4 , pp. e542
    • Adlakha, Y.K.1    Saini, N.2
  • 38
    • 80054778946 scopus 로고    scopus 로고
    • High frequency of PIK3R1 and PIK3R2 mutations in endometrial cancer elucidates a novel mechanism for regulation of PTEN protein stability
    • Cheung LW, Hennessy BT, Li J, Yu S, Myers AP, Djordjevic B, Lu Y, Stemke-Hale K, Dyer MD, Zhang F, et al: High frequency of PIK3R1 and PIK3R2 mutations in endometrial cancer elucidates a novel mechanism for regulation of PTEN protein stability. Cancer Discov 1: 170-185, 2011.
    • (2011) Cancer Discov , vol.1 , pp. 170-185
    • Cheung, L.W.1    Hennessy, B.T.2    Li, J.3    Yu, S.4    Myers, A.P.5    Djordjevic, B.6    Lu, Y.7    Stemke-Hale, K.8    Dyer, M.D.9    Zhang, F.10
  • 40
    • 77957258073 scopus 로고    scopus 로고
    • Cancer-derived mutations in the regulatory subunit p85α of phosphoinositide 3-kinase function through the catalytic subunit p110α
    • Sun M, Hillmann P, Hofmann BT, Hart JR and Vogt PK: Cancer-derived mutations in the regulatory subunit p85α of phosphoinositide 3-kinase function through the catalytic subunit p110α. Proc Natl Acad Sci USA 107: 15547-15552, 2010.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 15547-15552
    • Sun, M.1    Hillmann, P.2    Hofmann, B.T.3    Hart, J.R.4    Vogt, P.K.5
  • 41
    • 79958820962 scopus 로고    scopus 로고
    • PIK3R1 (p85α) is somatically mutated at high frequency in primary endometrial cancer
    • Urick ME, Rudd ML, Godwin AK, Sgroi D, Merino M and Bell DW: PIK3R1 (p85α) is somatically mutated at high frequency in primary endometrial cancer. Cancer Res 71: 4061-4067, 2011.
    • (2011) Cancer Res , vol.71 , pp. 4061-4067
    • Urick, M.E.1    Rudd, M.L.2    Godwin, A.K.3    Sgroi, D.4    Merino, M.5    Bell, D.W.6
  • 42
    • 70449363850 scopus 로고    scopus 로고
    • Depletion of PI3K p85α induces cell cycle arrest and apoptosis in colorectal cancer cells
    • Sun Y, Zhao S, Tian H, Xie X, Xiao F, Li K and Song Y: Depletion of PI3K p85α induces cell cycle arrest and apoptosis in colorectal cancer cells. Oncol Rep 22: 1435-1441, 2009.
    • (2009) Oncol Rep , vol.22 , pp. 1435-1441
    • Sun, Y.1    Zhao, S.2    Tian, H.3    Xie, X.4    Xiao, F.5    Li, K.6    Song, Y.7
  • 43
    • 79955944293 scopus 로고    scopus 로고
    • Non-Smad transforming growth factor-β signaling regulated by focal adhesion kinase binding the p85 subunit of phosphatidylinositol 3-kinase
    • Hong M, Wilkes MC, Penheiter SG, Gupta SK, Edens M and Leof EB: Non-Smad transforming growth factor-β signaling regulated by focal adhesion kinase binding the p85 subunit of phosphatidylinositol 3-kinase. J Biol Chem 286: 17841-17850, 2011.
    • (2011) J Biol Chem , vol.286 , pp. 17841-17850
    • Hong, M.1    Wilkes, M.C.2    Penheiter, S.G.3    Gupta, S.K.4    Edens, M.5    Leof, E.B.6


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