Pre-transplant donor-specific T-cell alloreactivity is strongly associated with early acute cellular rejection in kidney transplant recipients not receiving T-cell depleting induction therapy

PLoS ONE

Volumn 10, Issue 2, 2015, Pages

  Crespo, Elena ^a   Lucia, Marc ^a   Cruzado, Josep M ^a,b   Luque, Sergio ^a   Melilli, Edoardo ^b   Manonelles, Anna ^a,b   Lloberas, Nuria ^a   Torras, Joan ^a,b   Grinyó, Josep M ^a,b   Bestard, Oriol ^a,b  

^a BELLVITGE BIOMEDICAL RESEARCH INSTITUTE IDIBELL   (Spain)

^b HOSPITAL UNIVERSITARI DE BELLVITGE   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

HLA ANTIGEN CLASS 1; IMMUNOSUPPRESSIVE AGENT;

ACUTE GRAFT REJECTION; ADULT; ALLOIMMUNITY; ARTICLE; CELLULAR IMMUNITY; CONTROLLED STUDY; ENZYME LINKED IMMUNOSPOT ASSAY; FEMALE; GRAFT RECIPIENT; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOSUPPRESSIVE TREATMENT; KIDNEY BIOPSY; KIDNEY GRAFT REJECTION; MAJOR CLINICAL STUDY; MALE; OUTCOME ASSESSMENT; T CELL DEPLETION; AGED; GRAFT REJECTION; IMMUNOLOGY; KIDNEY TRANSPLANTATION; LYMPHOCYTE DEPLETION; MIDDLE AGED; PROCEDURES; RETROSPECTIVE STUDY; T LYMPHOCYTE;

ADULT; AGED; FEMALE; GRAFT REJECTION; HUMANS; IMMUNOSUPPRESSION; IMMUNOSUPPRESSIVE AGENTS; KIDNEY TRANSPLANTATION; LYMPHOCYTE DEPLETION; MALE; MIDDLE AGED; RETROSPECTIVE STUDIES; T-LYMPHOCYTES;

EID: 84928901962     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0117618     Document Type: Article

References (33)

1. Heeger PS (2003) T-cell allorecognition and transplant rejection: a summary and update. Am J Transplant 3:525-533. PMID: 12752308
2. Issa F, Schiopu A, Wood KJ (2010) Role of T cells in graft rejection and transplantation tolerance. Expert Rev Clin Immunol 6:155-169. PMID: 20383898
3. Valujskikh A (2007) Memory T cells in allograft rejection. Adv Exp Med Biol 601:247-256. PMID: 17713012
4. Pearl JP, Parris J, Hale DA, Hoffmann SC, Bernstein WB, et al. (2005) Immunocompetent T-cells with a memory-like phenotype are the dominant cell type following antibody-mediated T-cell depletion. Am J Transplant 5:465-474. PMID: 15707400
5. Zeevi A, Husain S, Spichty KJ, Raza K, Woodcock JB, et al. (2007) Recovery of functional memory T cells in lung transplant recipients following induction therapy with alemtuzumab. Am J Transplant 7:471-475. PMID: 17283491
6. Trzonkowski P, Zilvetti M, Chapman S, Wieckiewicz J, Sutherland A, et al. (2008) Homeostatic repopulation by CD28-CD8+ T cells in alemtuzumab-depleted kidney transplant recipients treated with reduced immunosuppression. Am J Transplant 8:338-347. doi: 10.1111/j.1600-6143.2007.02078.x PMID: 18211507
7. Bestard O, Cassis L, Cruzado JM, Torras J, Franquesa M, et al. (2011) Costimulatory blockade with mTor inhibition abrogates effector T-cell responses allowing regulatory T-cell survival in renal transplantation. Transpl Int 24:451-460. doi: 10.1111/j.1432-2277.2011.01223.x PMID: 21294788
8. Adams AB, Williams MA, Jones TR, Shirasugi N, Durham MM, et al. (2003) Heterologous immunity provides a potent barrier. J Clin Invest 111:1887-1895. PMID: 12813024
9. Brook MO, Wood KJ, Jones ND (2006) The impact of memory T cells on rejection and the induction of tolerance. Transplantation 82:1-9. PMID: 16861933
10. Kim S-K, Brehm M A., Welsh RM, Selin LK (2002) Dynamics of memory T cell proliferation under conditions of heterologous immunity and bystander stimulation. J Immunol 169:90-98. PMID: 12077233
11. Gamadia LE, Remmerswaal EB, Surachno S, Lardy NM, Wertheim-Van Dillen PM, et al. (2004) Crossreactivity of cytomegalovirus-specific CD8+ T-cells to allo-major histocompatibility complex class I molecules. Transplantation 77:1879-1885. PMID: 15223907
12. Nickel P, Presber F, Bold G, Biti D, Schonemann C, et al. (2004) Enzyme-lLinked Immunosorbent Spot Assay for donor-reactive interferon-β-producing cells identifies T-cell presensitization and correlates with graft function at 6 and 12 months in renal-transplant recipients. Transplantation 78:1640-1646. PMID: 15591953
13. Augustine JJ, Siu DS, Clemente MJ, Schulak JA, Heeger PS, et al. (2005) Pre-transplant IFN-gamma ELISPOTs are associated with post-transplant renal function in African American renal transplant recipients. Am J Transplant 5:1971-1975. PMID: 15996247
14. Bestard O, Cruzado JM, Mestre M, Caldes A, Bas J, et al. (2007) Achieving donor-specific hyporesponsiveness is associated with FOXP3+ regulatory T cell recruitment in human renal allograft infiltrates. J Immunol 179:4901-4909. PMID: 17878390
15. Poggio ED, Augustine JJ, Clemente M, Danzig JM, Volokh N, et al. (2007) Pretransplant cellular alloimmunity as assessed by a panel of reactive T cells assay correlates with acute renal graft rejection. Transplantation 83:847-852. PMID: 17460554
16. Kim SH, Oh EJ, Kim MJ, Park YJ, Han K, et al. (2007) Pretransplant donor-specific interferon-gamma ELISPOT assay predicts acute rejection episodes in renal transplant recipients. Transplant Proc 39:3057-3060. PMID: 18089321
17. Hricik DE, Rodriguez V, Riley J, Bryan K, Tary-Lehmann M, et al. (2003) Enzyme linked immunosorbent spot (ELISPOT) assay for interferon-gamma independently predicts renal function in kidney transplant recipients. Am J Transplant 3:878-884. PMID: 12814480
18. Bestard O, Cruzado JM, Lucia M, Crespo E, Casis L, et al. (2013) Prospective assessment of antidonor cellular alloreactivity is a tool for guidance of immunosuppression in kidney transplantation. Kidney Int 84:1226-1236. doi: 10.1038/ki.2013.236 PMID: 23783240
19. Baxter-Lowe LA (2003) HLA-DR sequence-based typing. In: Noreen H (eds) Am Soc Histocompat Immunogenet Vol 2. 4.2 ed ASHI Laboratory Manual: V. C.8.1.
20. Gebel HM, Bray RA (2000) Sensitization and sensitivity: defining the unsensitized patient. Transplantation 69:1370-1374. PMID: 10798756
21. Bestard O, Crespo E, Stein M, Lucia M, Roelen DL, et al. (2013) Cross-Validation of IFN-γ Elispot Assay for Measuring Alloreactive Memory/Effector T Cell Responses in Renal Transplant Recipients. Am J Transplant 13:1880-1890.
22. Poggio ED, Clemente M, Hricik DE, Heeger PS (2006) Panel of reactive T cells as a measurement of primed cellular alloimmunity in kidney transplant candidates. J Am Soc Nephrol 17:564-572. PMID: 16382020
23. Augustine JJ, Poggio ED, Clemente M, Aeder MI, Bodziak KA, et al. (2007) Hemodialysis vintage, black ethnicity, and pretransplantation antidonor cellular immunity in kidney transplant recipients. J Am Soc Nephrol 18:1602-1606. PMID: 17389735
24. Adams AB, Williams MA, Jones TR, Shirasugi N, Durham MM, et al. (2003) Heterologous immunity provides a potent barrier to transplantation tolerance. J Clin Invest 111:1887-1895. PMID: 12813024
25. Brehm MA, Markees TG, Daniels KA, Greiner DL, Rossini AA, et al. (2003) Direct visualization of crossreactive effector and memory allo-specific CD8 T cells generated in response to viral infections. J Immunol 170:4077-4086. PMID: 12682237
26. Bestard O, Nickel P, Cruzado JM, Schoenemann C, Boenisch O, et al. (2008) Circulating alloreactive T cells correlate with graft function in longstanding renal transplant recipients. J Am Soc Nephrol 19:1419-1429. doi: 10.1681/ASN.2007050539 PMID: 18417724
27. Andree H, Nickel P, Nasiadko C, Hammer MH (2006) Identification of dialysis patients with panelreactive memory T Cells before kidney transplantation using an allogeneic cell bank. J Am Soc Nephrol 17:573-580. PMID: 16396965
28. Cicin-Sain L, Smyk-Paerson S, Currier N, Koudelka C, Robinson T, et al. (2010) Loss of naive T Cells and repertoire constriction predict poor response to vaccination in old primates. J Immunol 184:6739-6745. doi: 10.4049/jimmunol.0904193 PMID: 20483749
29. Kohlmeier JE, Connor LM, Roberts AD, Martin K, Woodland DL, et al. (2010) Nonmalignant clonal expansions of memory CD8+ T Cells that arise with age vary in their capacity to mount recall responses to infection. J Immunol 185:3456-3462. doi: 10.4049/jimmunol.1001745 PMID: 20720204
30. Martins PNA, Tullius SG, Markmann JF (2014) Immunosenescence and Immune Response in Organ Transplantation. Int Rev Immunol 33:162-173. doi: 10.3109/08830185.2013.829469 PMID: 24127845
31. Hricik DE, Poggio ED, Woodside KJ, Sarabu N, Sanchez EQ, et al. (2013) Effects of cellular sensitization and donor age on acute rejection and graft function after deceased-donor kidney transplantation. Transplantation 95:1254-1258. doi: 10.1097/TP.0b013e31828ad866 PMID: 23603792
32. Augustine JJ, Poggio ED, Heeger PS, Hricik DE (2008) Preferential benefit of antibody induction therapy in kidney recipients with high pretransplant frequencies of donor-reactive interferon-gamma enzyme-linked immunosorbent spots. Transplantation 86:529-534. doi: 10.1097/TP. 0b013e31818046db PMID: 18724221
33. Cherkassky L, Lanning M, Lalli PN, Czerr J, Siegel H, et al. (2011) Evaluation of alloreactivity in kidney transplant recipients treated with antithymocyte globulin versus IL-2 receptor blocker. Am J Transplant 11:1388-1396. doi: 10.1111/j.1600-6143.2011.03540.x PMID: 21564525