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84928817272
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Dry compressed air (20.5?±?0.5?% O2 in N2) can also be used and gives similar yields of α-amino nitriles. See the Supporting Information for details.
-
Dry compressed air (20.5?±?0.5?% O2 in N2) can also be used and gives similar yields of α-amino nitriles. See the Supporting Information for details.
-
-
-
-
42
-
-
84928777183
-
-
See the Supporting Information for full experimental details.
-
See the Supporting Information for full experimental details.
-
-
-
-
43
-
-
84928811302
-
-
For data describing the relationship of photooxidation yield and lamp power, see Figures S1 and S2 in the Supporting Information.
-
For data describing the relationship of photooxidation yield and lamp power, see Figures S1 and S2 in the Supporting Information.
-
-
-
-
44
-
-
84928806475
-
-
Yield determined by 1H NMR spectroscopy with mesitylene as an internal standard.
-
Yield determined by 1H NMR spectroscopy with mesitylene as an internal standard.
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47
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84872745167
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48
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84928777632
-
-
The solvent from the previous step, THF, must be removed due to its undesired reaction and consumption of HCl, forming 4-chlorobutan-1-ol.
-
The solvent from the previous step, THF, must be removed due to its undesired reaction and consumption of HCl, forming 4-chlorobutan-1-ol.
-
-
-
-
49
-
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84928786236
-
-
The observed ratio of amino acid to ester was approximately 5:1.
-
The observed ratio of amino acid to ester was approximately 5:1.
-
-
-
-
50
-
-
84928810792
-
-
Aqueous work up was used to quench an excess of TMSCN and to remove TBAF. The yields of α-amino nitriles in 2-MeTHF were similar to those in THF.
-
Aqueous work up was used to quench an excess of TMSCN and to remove TBAF. The yields of α-amino nitriles in 2-MeTHF were similar to those in THF.
-
-
-
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51
-
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84928798640
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-
NMR analysis of the precipitate showed its silane/TPP nature.
-
NMR analysis of the precipitate showed its silane/TPP nature.
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