An efficient synthesis of 5-aminoimidazol-2-ones via cyclization reactions of 12-aminoacetonitriles and isocyanates

Tetrahedron Letters

Volumn 45, Issue 12, 2004, Pages 2677-2679

  Parcher, Benjamin W ^a   Erion, Derek M ^a   Dang, Qun ^a  

^a Metabasis Therapeutics Inc   (United States)

Author keywords

Cyclization; Imidazole; Isocyanate

Indexed keywords

AMINOACETONITRILE; FUNCTIONAL GROUP; IMIDAZOLE DERIVATIVE; ISOCYANIC ACID DERIVATIVE; PURINE;

ARTICLE; CYCLIZATION; PURINE SYNTHESIS; REACTION ANALYSIS; SYNTHESIS;

EID: 1542302394     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2004.01.088     Document Type: Article

References (23)

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20. 2-Phenylglycinonitrile ( 1a ) was obtained by free-basing its corresponding hydrogen chloride salt: A solution of 1a hydrogen chloride salt in methylenechloride was treated with aqueous potassium carbonate (3 equiv) at room temperature for 2 h. Extraction with methylenechloride (3 times) and evaporation gave 1a as a brown solid.
21. 3O: C, 71.70; H, 5.21; N, 16.72. Found: C, 71.63; H, 5.60; N, 16.83.
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23. 3: C, 58.29; H, 5.30; N, 16.99. Found: C, 58.22; H, 5.60; N, 17.17.