Discovery of a small-molecule probe for V-ATPase function

Journal of the American Chemical Society

Volumn 137, Issue 16, 2015, Pages 5563-5568

  Aldrich, Leslie N ^a,b   Kuo, Szu Yu ^b,c   Castoreno, Adam B ^b,f   Goel, Gautam ^b,d   Kuballa, Petric ^b,d,g   Rees, Matthew G ^b   Seashore Ludlow, Brinton A ^b   Cheah, Jaime H ^b,h   Latorre, Isabel J ^b   Schreiber, Stuart L ^a,b,e   Shamji, Alykhan F ^b   Xavier, Ramnik J ^b,d  

^a HARVARD UNIVERSITY   (United States)

^b BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^c HARVARD UNIVERSITY   (United States)

^d MASSACHUSETTS GENERAL HOSPITAL   (United States)

^e HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^f ALNYLAM PHARMACEUTICALS   (United States)

^g ROCHE DIAGNOSTICS GMBH   (Germany)

^h KOCH INSTITUTE FOR INTEGRATIVE CANCER RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOSYNTHESIS; DIAGNOSIS; MOBILE SECURITY; MOLECULES; PHYSIOLOGY; PROTEINS;

CELLULAR FUNCTION; CELLULAR PHYSIOLOGY; DIVERSITY-ORIENTED SYNTHESIS; HIGH-CONTENT SCREENING; MEMBRANE INTEGRITY; NATURAL PRODUCTS; PROTEIN SYNTHESIS; SMALL MOLECULES;

SYNTHESIS (CHEMICAL);

ADENOSINE TRIPHOSPHATASE; ANTINEOPLASTIC AGENT; BAFILOMYCIN A1; BRD 1240; PHOSPHATIDYLETHANOLAMINE; UNCLASSIFIED DRUG; VACOULAR H ADENOSINE TRIPHOSPHATASE; ENZYME INHIBITOR; MACROLIDE; MOLECULAR LIBRARY; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE;

ARTICLE; AUTOPHAGOSOME; CANCER CELL CULTURE; CONTROLLED STUDY; DRUG SYNTHESIS; HYDROGEN BOND; LYSOSOME; PROTEIN INTERACTION; PROTEIN STRUCTURE; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION; ANTAGONISTS AND INHIBITORS; CELL SURVIVAL; CHEMISTRY; DRUG EFFECTS; ENZYMOLOGY; HUMAN; METABOLISM; MOLECULAR LIBRARY; PHARMACOLOGY; TUMOR CELL LINE;

CELL LINE, TUMOR; CELL SURVIVAL; ENZYME INHIBITORS; HUMANS; LYSOSOMES; MACROLIDES; SMALL MOLECULE LIBRARIES; VACUOLAR PROTON-TRANSLOCATING ATPASES;

EID: 84928788868     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/jacs.5b02150     Document Type: Article

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