Differences in ischemic damage between young and old hearts - Effects of blood cardioplegia

Experimental Gerontology

Volumn 67, Issue , 2015, Pages 3-8

  Böning, Andreas ^a   Rohrbach, Susanne ^a   Kohlhepp, Lukas ^a   Heep, Martina ^a   Hagmüller, Stefanie ^a   Niemann, Bernd ^a   Mühlfeld, Christian ^b  

^a JUSTUS LIEBIG UNIVERSITY   (Germany)

^b HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

Aging; Cardiac surgery; Cardioplegia; Ischemia reperfusion

Indexed keywords

LACTIC ACID;

ADULT; AGE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARDIOPLEGIA; CELL ULTRASTRUCTURE; CONTROLLED STUDY; CORONARY ARTERY BLOOD FLOW; EX VIVO STUDY; HEART FUNCTION; HEART HEMODYNAMICS; HEART INJURY; HEART LEFT VENTRICLE PRESSURE; HEART MUSCLE ISCHEMIA; HEART MUSCLE METABOLISM; HEART MUSCLE RELAXATION; ISOLATED HEART; MALE; NONHUMAN; OXYGEN CONSUMPTION; PRIORITY JOURNAL; RAT; TRANSMISSION ELECTRON MICROSCOPY; YOUNG ADULT; ADVERSE EFFECTS; AGING; ANIMAL; CARDIAC MUSCLE; CONVALESCENCE; ELECTRON MICROSCOPY; EVALUATION STUDY; HEART ARREST; HEART MITOCHONDRION; HEART SURGERY; HEMODYNAMICS; MYOCARDIAL ISCHEMIA; MYOCARDIAL REPERFUSION INJURY; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; PROCEDURES; ULTRASTRUCTURE; WISTAR RAT;

RATTUS; RATTUS NORVEGICUS;

AGING; ANIMALS; CARDIAC SURGICAL PROCEDURES; HEART ARREST, INDUCED; HEMODYNAMICS; MALE; MICROSCOPY, ELECTRON; MITOCHONDRIA, HEART; MYOCARDIAL ISCHEMIA; MYOCARDIAL REPERFUSION INJURY; MYOCARDIUM; RATS, WISTAR; RECOVERY OF FUNCTION;

EID: 84928751411     PISSN: 05315565     EISSN: 18736815     Source Type: Journal    
DOI: 10.1016/j.exger.2015.04.012     Document Type: Article

References (18)

1. Böning A., Lutter G., Mrowczynski W., Attmann T., Bödeker R.H., Scheibelhut C., Cremer J. Octogenarians undergoing combined aortic valve replacement and myocardial revascularisation: perioperative mortality and medium-term survival. Thorac. Cardiovasc. Surg. 2010, 58:159-163.
2. Böning A., Hagmüller S., Heep M., Rohrbach S., Niemann B., Mühlfeld C. Is warm or cold Calafiore blood cardioplegia better? Hemodynamic, metabolic, and electron microscopic differences. Thorac. Cardiovasc. Surg. 2014, 62:683-689.
3. Buckberg G.D. Strategies and logic of cardioplegic delivery to prevent, avoid, and reverse ischemic and reperfusion damage. J. Thorac. Cardiovasc. Surg. 1987, 93:127-139.
4. Buckberg G.D. Cardioplegic solutions - unproven herbal approach versus tested scientific study. Semin. Thorac. Cardiovasc. Surg. 2001, 13:52-55.
5. Caldarone A.C., Krukenkamp I.B., Burns P.G., Gaudette G.R., Schulman J., Levitsky S. Blood cardioplegia in the senescent heart. J. Thorac. Cardiovasc. Surg. 1995, 109:269-274.
6. DiBona D.R., Powell W.J. Quantitative correlation between cell swelling and necrosis in myocardial ischemia in dogs. Circ. Res. 1980, 47:653-665.
7. Funkat A.K., Beckmann A., Lewandowski J., Frie M., Schiller W., Ernst M., Hekmat K. Cardiac surgery in Germany during 2011: a report on behalf of the German Society for Thoracic and Cardiovascular Surgery. Thorac. Cardiovasc. Surg. 2012, 60:371-382.
8. Gorge G., Chatelain P., Schaper J., Lerch R. Effect of increasing degrees of ischemic injury on myocardial oxidative metabolism early after reperfusion in isolated rat hearts. Circ. Res. 1991, 68:1681-1692.
9. Jennings R.B., Reimer K.A. The cell biology of myocardial infarction. Annu. Rev. Med. 1991, 42:225-246.
10. McCully J.D., Toyoda Y., Wakiyama H., Rousou A.J., Parker R.A., Levitsky S. Age- and gender-related differences in ischemia-reperfusion injury and cardioprotection: effects of diazoxide. Ann. Thorac. Surg. 2006, 82:117-123.
11. Mühlfeld C., Richter J. High-pressure freezing and freeze substitution of rat myocardium for immunogold labeling of connexin 43. Anat. Rec. A: Discov. Mol. Cell. Evol. Biol. 2006, 288:1059-1067.
12. Murry C.E., Richard V.J., Reimer K.A., Jennings R.B. Ischemic preconditioning slows energy metabolism and delays ultrastructural damage during sustained ischemic episode. Circ. Res. 1990, 66:913-931.
13. Niemann B., Chen Y., Teschner M., Li L., Silber R.E., Rohrbach S. Obesity induces signs of premature cardiac aging in younger patients: the role of mitochondria. J. Am. Coll. Cardiol. 2011, 57:577-585.
14. Niemann B., Pan R., Teschner M., Boening A., Silber R.E., Rohrbach S. Age and obesity-associated changes in the expression and activation of components of the AMPK signaling pathway in human right atrial tissue. Exp. Gerontol. 2013, 48:55-63.
15. Schmiedl A., Schnabel P.A., Mall G., Gebhard M.M., Hunnemann D.H., Richter J., Bretschneider H.J. The surface to volume ratio of mitochondria: a suitable parameter for evaluating mitochondrial swelling. Correlations during the course of myocardial global ischemia. Virchows Arch. A Pathol. Anat. Histopathol. 1990, 416:305-315.
16. Sen B., Niemann B., Roth P., Aser R., Schönburg M., Böning A. Short- and long-term outcomes in octogenarians after coronary artery bypass surgery. Eur. J. Cardiothorac. Surg. 2011, 42:e102-e107.
17. Tsukube T., McCully J.D., Federman M., Krukenkamp I.B., Levitsky S. Developmental differences in cytosolic calcium accumulation associated with surgically induced global ischemia: optimization of cardioplegic protection and mechanism of action. J. Thorac. Cardiovasc. Surg. 1996, 112:175-184.
18. Tsukube T., McCully J.D., Metz K.R., Cook C.U., Levitsky S. Amelioration of ischemic calcium overload correlated with high-energy phosphates in senescent myocardium. Am. J. Physiol. 1997, 273:H418-H425.