Reduction of the natural Activated protein C pathway activity significantly prevents coagulopathy in a murine model of acute traumatic coagulopathy

Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine

Volumn 22, Issue 1, 2014, Pages

  Guerreiro, Maria ^a   Tremoleda, Jordi L ^a   Frith, Dan ^a   Thiemermann, Chris ^a   Brohi, Karim ^a  

^a QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84928751394     PISSN: None     EISSN: 17577241     Source Type: Journal    
DOI: 10.1186/1757-7241-22-S1-O6     Document Type: Article

References (2)

1. Brohi K, Cohen M, Ganter M, et al.: Acute coagulopathy of trauma: hypoperfusion induces systemic anticoagulation and hyperfibrinolysis. J Trauma 2008, 64:1211-1217. 10.1097/TA.0b013e318169cd3c
2. Chesebro B, Rahn P, Carles M, et al.: Increase in activated protein C mediates acute traumatic coagulopathy in mice. Shock 2009, 32:659-665. 10.1097/SHK.0b013e3181a5a632