Serum retinol binding protein 4 is associated with visceral fat in human with nonalcoholic fatty liver disease without known diabetes: A cross-sectional study

Lipids in Health and Disease

Volumn 14, Issue 1, 2015, Pages

  Chang, Xinxia ^a   Yan, Hongmei ^a   Bian, Hua ^a   Xia, Mingfeng ^a   Zhang, Linshan ^a   Gao, Jian ^a   Gao, Xin ^a  

^a FUDAN UNIVERSITY   (China)

Author keywords

Hepatic fat content; Non alcoholic fatty liver disease; Retinol binding protein 4; Visceral abdominal fat

Indexed keywords

ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; GAMMA GLUTAMYLTRANSFERASE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; RETINOL BINDING PROTEIN 4; TRIACYLGLYCEROL; BIOLOGICAL MARKER; PLASMA RETINOL BINDING PROTEIN; RBP4 PROTEIN, HUMAN;

ABDOMINAL OBESITY; ADIPOSE TISSUE; ADULT; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BODY MASS; CHINESE; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; DIASTOLIC BLOOD PRESSURE; DISEASE ASSOCIATION; DISEASE MARKER; ENZYME IMMUNOASSAY; FAT CONTENT; FEMALE; GAMMA GLUTAMYL TRANSFERASE BLOOD LEVEL; HEPATIC FAT CONTENT; HUMAN; INTRAABDOMINAL FAT; LIPID ANALYSIS; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; NONALCOHOLIC FATTY LIVER; PATHOGENESIS; PROTEIN BLOOD LEVEL; SUBCUTANEOUS ABDOMINAL FAT AREA; SYSTOLIC BLOOD PRESSURE; WAIST CIRCUMFERENCE; WAIST HIP RATIO; WESTERN BLOTTING; ABDOMINAL SUBCUTANEOUS FAT; BLOOD; LIVER; PATHOLOGY;

ADULT; BIOMARKERS; CROSS-SECTIONAL STUDIES; FEMALE; HUMANS; INTRA-ABDOMINAL FAT; LIVER; MALE; MIDDLE AGED; NON-ALCOHOLIC FATTY LIVER DISEASE; RETINOL-BINDING PROTEINS, PLASMA; SUBCUTANEOUS FAT, ABDOMINAL;

EID: 84928745798     PISSN: None     EISSN: 1476511X     Source Type: Journal    
DOI: 10.1186/s12944-015-0033-2     Document Type: Article

References (37)

1. Blaner WS. Retinol-binding protein: the serum transport protein for vitamin A. Endocr Rev. 1989;10:308-16.
2. Flower DR. The lipocalin protein family: structure and function. Biochem J. 1996;318(Pt 1):1-14.
3. Meigs JB, Panhuysen CI, Myers RH, Wilson PW, Cupples LA. A genome-wide scan for loci linked to plasma levels of glucose and HbA(1c) in a community-based sample of caucasian pedigrees: the framingham offspring study. Diabetes. 2002;51:833-40.
4. Duggirala R, Blangero J, Almasy L, Dyer TD, Williams KL, Leach R, et al. Linkage of type 2 diabetes mellitus and of age at onset to a genetic location on chromosome 10q in Mexican Americans. Am J Hum Genet. 1999;64:1127-40.
5. Tsutsumi COM, Tannous L, Piantedosi R, Allan M, Goodman DS, Blaner WS. Retinoids and retinoid-binding protein expression in rat adipocytes.pdf. J Biol Chem. 1992;267:1805-10.
6. Zovich DC, Orologa A, Okuno M, Kong LW, Talmage DA, Piantedosi R, et al. Differentiation-dependent expression of retinoid-binding proteins in BFC-1 beta adipocytes. J Biol Chem. 1992;267:13884-9.
7. Yang Q, Graham TE, Mody N, Preitner F, Peroni OD, Zabolotny JM, et al. Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes. Nature. 2005;436:356-62.
8. Graham TE, Yang Q, Blüher M, Hammarstedt A, Ciaraldi TP, Henry RR, et al. Retinol-binding protein 4 and insulin resistance in lean, obese, and diabetic subjects. N Engl J Med. 2006;354:2552-63.
9. Seo JA, Kim NH, Park SY, Kim HY, Ryu OH, Lee KW, et al. Serum retinol-binding protein 4 levels are elevated in non-alcoholic fatty liver disease. Clin Endocrinol (Oxf). 2008;68:555-60.
10. Yoshida A, Matsutani Y, Fukuchi Y, Saito K, Naito M. Analysis of the factors contributing to serum retinol binding protein and transthyretin levels in Japanese adults. J Atheroscler Thromb. 2006;13:209-15.
11. Cho YM, Youn BS, Lee H, Lee N, Min SS, Kwak S, et al. Plasma retinol-binding protein-4 concentrations are elevated in human subjects with impaired glucose tolerance and type 2 diabetes. Diabetes Care. 2006;29:2457-61.
12. Stefan N, Hennige AM, Staiger H, Machann J, Schick F, Schleicher E, et al. High circulating retinol-binding protein 4 is associated with elevated liver fat but not with total, subcutaneous, visceral, or intramyocellular fat in humans. Diabetes Care. 2007;30:1173-8.
13. Haider DG, Schindler K, Prager G, Bohdjalian A, Luger A, Wolzt M, et al. Serum retinol-binding protein 4 is reduced after weight loss in morbidly obese subjects. J Clin Endocrinol Metab. 2007;92:1168-71.
14. Haider DG, Schindler K, Mittermayer F, Müller M, Nowotny P, Rieger A, et al. Effect of rosiglitazone on visfatin and retinol-binding protein-4 plasma concentrations in HIV-positive patients. Clin Pharmacol Ther. 2007;81:580-5.
15. Gavi S, Stuart LM, Kelly P, Melendez MM, Mynarcik DC, Gelato MC, et al. Retinol-binding protein 4 is associated with insulin resistance and body fat distribution in nonobese subjects without type 2 diabetes. J Clin Endocrinol Metab. 2007;92:1886-90.
16. Lee DC, Lee JW, Im JA. Association of serum retinol binding protein 4 and insulin resistance in apparently healthy adolescents. Metabolism. 2007;56:327-31.
17. Balagopal P, Graham TE, Kahn BB, Altomare A, Funanage V, George D. Reduction of elevated serum retinol binding protein in obese children by lifestyle intervention: association with subclinical inflammation. J Clin Endocrinol Metab. 2007;92:1971-4.
18. Kloting N, Graham TE, Berndt J, Kralisch S, Kovacs P, Wason CJ, et al. Serum retinol-binding protein is more highly expressed in visceral than in subcutaneous adipose tissue and is a marker of intra-abdominal fat mass. Cell Metab. 2007;6:79-87.
19. Wu H, Jia W, Bao Y, Lu J, Zhu J, Wang R, et al. Serum retinol binding protein 4 and nonalcoholic fatty liver disease in patients with type 2 diabetes mellitus. Diabetes Res Clin Pract. 2008;79:185-90.
20. Terra X, Auguet T, Broch M, Sabench F, Hernández M, Pastor RM, et al. Retinol binding protein-4 circulating levels were higher in nonalcoholic fatty liver disease vs. histologically normal liver from morbidly obese women. Obesity (Silver Spring). 2013;21:170-7.
21. Shaker O, El-Shehaby A, Zakaria A, Mostafa N, Talaat S, Katsiki N, et al. Plasma visfatin and retinol binding protein-4 levels in patients with type 2 diabetes mellitus and their relationship to adiposity and fatty liver. Clin Biochem. 2011;44:1457-63.
22. Cengiz C, Ardicoglu Y, Bulut S, Boyacioglu S. Serum retinol-binding protein 4 in patients with nonalcoholic fatty liver disease: does it have a significant impact on pathogenesis? Eur J Gastroenterol Hepatol. 2010;22:813-9.
23. Kashyap SR, Diab DL, Baker AR, Yerian L, Bajaj H, Gray-McGuire C, et al. Triglyceride levels and not adipokine concentrations are closely related to severity of nonalcoholic fatty liver disease in an obesity surgery cohort. Obesity (Silver Spring). 2009;17:1696-701.
24. Schina M, Koskinas J, Tiniakos D, Hadziyannis E, Savvas S, Karamanos B, et al. Circulating and liver tissue levels of retinol-binding protein-4 in non-alcoholic fatty liver disease. Hepatol Res. 2009;39:972-8.
25. Lee JW, Im JA, Lee HR, Shim JY, Youn BS, Lee DC. Visceral adiposity is associated with serum retinol binding protein-4 levels in healthy women. Obesity (Silver Spring). 2007;15:2225-32.
26. Jia W, Wu H, Bao Y, Wang C, Lu J, Zhu J, et al. Association of serum retinol-binding protein 4 and visceral adiposity in Chinese subjects with and without type 2 diabetes. J Clin Endocrinol Metab. 2007;92:3224-9.
27. Makino S, Fujiwara M, Suzukawa K, Handa H, Fujie T, Ohtaka Y, et al. Visceral obesity is associated with the metabolic syndrome and elevated plasma retinol binding protein-4 level in obstructive sleep apnea syndrome. Horm Metab Res. 2009;41(3):221-6.
28. Tschoner A, Sturm W, Engl J, Kaser S, Laimer E, Weiss H, et al. Retinol-binding protein 4, visceral fat, and the metabolic syndrome: effects of weight loss. Obesity (Silver Spring). 2008;16(11):2439-44.
29. Lee JW, Lee HR, Shim JY, Im JA, Lee DC. Abdominal visceral fat reduction is associated with favorable changes of serum retinol binding protein-4 in nondiabetic subjects. Endocr J. 2008;55:811-8.
30. Mansouri M, Nikooie R, Keshtkar A, Larijani B, Omidfar K. Effect of endurance training on retinol-binding protein 4 gene expression and its protein level in adipose tissue and the liver in diabetic rats induced by a high-fat diet and streptozotocin. J Diabetes Investig. 2014;5:484-91.
31. Sell H, Eckel J. Regulation of retinol binding protein 4 production in primary human adipocytes by adiponectin, troglitazone and TNF-alpha. Diabetologia. 2007;50:2221-3.
32. Kotnik P, Keuper M, Wabitsch M, Fischer-Posovszky P. Interleukin-1beta downregulates RBP4 secretion in human adipocytes. PLoS One. 2013;8:e57796.
33. Milner KL, van der Poorten D, Xu A, Bugianesi E, Kench JG, Lam KS, et al. Adipocyte fatty acid binding protein levels relate to inflammation and fibrosis in nonalcoholic fatty liver disease. Hepatology. 2009;49:1926-34.
34. Alkhouri N, Lopez R, Berk M, Feldstein AE. Serum retinol-binding protein 4 levels in patients with nonalcoholic fatty liver disease. J Clin Gastroenterol. 2009;43:985-9.
35. Graham TE, Wason CJ, Bluher M, Kahn BB. Shortcomings in methodology complicate measurements of serum retinol binding protein (RBP4) in insulin-resistant human subjects. Diabetologia. 2007;50:814-23.
36. Yan H, Chang X, Xia M, Bian H, Zhang LS, Lin HD, et al. Serum retinol binding protein 4 is negatively related to beta cell function in Chinese women with non-alcoholic fatty liver disease: a cross-sectional study. Lipids Health Dis. 2013;12:157.
37. An C, Wang H, Liu X, Li Y, Su Y, Gao X, et al. Serum retinol-binding protein 4 is elevated and positively associated with insulin resistance in postmenopausal women. Endocr J. 2009;56:987-96.